|
123
|
312
|
7qq4A |
Discovery of lu af11167, a phosphodiesterase 10a inhibitor clinical candidate |
|
127
|
319
|
7qpfA |
Discovery of lu af11167, a phosphodiesterase 10a inhibitor clinical candidate |
|
130
|
315
|
7qpmA |
Discovery of lu af11167, a phosphodiesterase 10a inhibitor clinical candidate |
|
122
|
312
|
7qpvA |
Discovery of lu af11167, a phosphodiesterase 10a inhibitor clinical candidate |
|
129
|
312
|
7qpqA |
Discovery of lu af11167, a phosphodiesterase 10a inhibitor clinical candidate |
|
126
|
320
|
8di4A |
Discovery of mk-8189, a highly potent and selective pde10a inhibitor for the treatment of schizophrenia |
|
124
|
313
|
5se6A |
Crystal structure of human phosphodiesterase 10 in complex with 2,9-dimethyl-6-[(1-methyl-4-phenylimidazol-2-yl)methoxy]purine |
|
125
|
313
|
5sehA |
Crystal structure of human phosphodiesterase 10 in complex with 4-(azetidine-1-carbonyl)-2-methyl-n-(2-morpholin-4-yl-[1,2,4]triazolo[1,5-a]pyridin-7-yl)pyrazole-3-carboxamide |
|
126
|
312
|
5se8A |
Crystal structure of human phosphodiesterase 10 in complex with 4-(azetidine-1-carbonyl)-2-methyl-n-[2-(2-methyl-5-phenyl-1,2,4-triazol-3-yl)ethyl]pyrazole-3-carboxamide |
|
127
|
313
|
5skgA |
Crystal structure of human phosphodiesterase 10 in complex with 2-chloro-6-(cyclopropylamino)-n-(2-phenyl-[1,2,4]triazolo[1,5-a]pyridin-7-yl)pyridine-4-carboxamide |
|
126
|
313
|
5skjA |
Crystal structure of human phosphodiesterase 10 in complex with 6-cyclopropyl-n-[2-[2-(methylamino)-2-oxoethyl]phenyl]-3-(pyrimidin-5-ylamino)pyridine-2-carboxamide |
|
121
|
313
|
5skiA |
Crystal structure of human phosphodiesterase 10 in complex with n-[(5,8-dimethyl-[1,2,4]triazolo[1,5-a]pyrazin-2-yl)methyl]-2-methyl-5-phenyl-1,2,4-triazol-3-amine |
|
126
|
313
|
5skhA |
Crystal structure of human phosphodiesterase 10 in complex with 3-[2-(3-fluorophenyl)pyrazol-3-yl]-1-[3-(trifluoromethoxy)phenyl]pyridazin-4-one |
|
125
|
313
|
5sepA |
Crystal structure of human phosphodiesterase 10 in complex with 2-[2-(4-cyclopentyl-1-methylimidazol-2-yl)ethyl]-5,8-dimethyl-[1,2,4]triazolo[1,5-a]pyrazine |
|
127
|
313
|
5sfeA |
Crystal structure of human phosphodiesterase 10 in complex with 3-n-[2-(3-fluorophenyl)imidazo[1,2-a]pyrimidin-7-yl]-4-n,4-n,2-trimethylpyrazole-3,4-dicarboxamide |
|
128
|
315
|
5shrB |
Crystal structure of human phosphodiesterase 10 in complex with n-[(5,8-dimethyl-[1,2,4]triazolo[1,5-a]pyrazin-2-yl)methyl]-n,2-dimethyl-5-phenyl-1,2,4-triazol-3-amine |
|
127
|
313
|
5skmA |
Crystal structure of human phosphodiesterase 10 in complex with 6-chloro-n,n-dimethyl-2-[2-(1-pyridin-2-ylpyrrolidin-3-yl)ethyl]quinazolin-4-amine |
|
124
|
313
|
5sklA |
Crystal structure of human phosphodiesterase 10 in complex with n-(6-cyano-2-phenylimidazo[1,2-a]pyridin-7-yl)-2-methyl-4-(morpholine-4-carbonyl)pyrazole-3-carboxamide |
|
126
|
313
|
5skuA |
Crystal structure of human phosphodiesterase 10 in complex with 3-[4-[2-[2-(2-ethoxy-4-fluorophenyl)-5-methyl-1,3-oxazol-4-yl]ethoxy]naphthalen-1-yl]-2-methoxypropanoic acid |
|
124
|
313
|
5skkA |
Crystal structure of human phosphodiesterase 10 in complex with n-[1-methyl-5-(methylcarbamoyl)pyrazol-4-yl]-6-[(3s)-oxolan-3-yl]-3-(pyrimidin-5-ylamino)pyrazine-2-carboxamide |
|
123
|
313
|
5sknA |
Crystal structure of human phosphodiesterase 10 in complex with n-[3-[3-[2-(2-fluorophenyl)pyrazol-3-yl]-4-oxopyridazin-1-yl]phenyl]acetamide |
|
126
|
312
|
5sksA |
Crystal structure of human phosphodiesterase 10 in complex with ethyl 1-[3-[3-(4-ethoxycarbonyl-5-methyl-imidazol-1-yl)phenoxy]phenyl]-5-methyl-imidazole-4-carboxylate |
|
126
|
313
|
5se9A |
Crystal structure of human phosphodiesterase 10 in complex with 2,3-dimethyl-6-[(1-methyl-4-phenylimidazol-2-yl)methoxy]imidazo[1,2-b]pyridazine |
|
127
|
312
|
5shrA |
Crystal structure of human phosphodiesterase 10 in complex with n-[(5,8-dimethyl-[1,2,4]triazolo[1,5-a]pyrazin-2-yl)methyl]-n,2-dimethyl-5-phenyl-1,2,4-triazol-3-amine |
|
124
|
314
|
5sgiA |
Crystal structure of human phosphodiesterase 10 in complex with 6-(3-methylphenoxy)-2-(4-pyridin-2-ylpiperazin-1-yl)-9h-purine |
|
123
|
313
|
5skrA |
Crystal structure of human phosphodiesterase 10 in complex with 1-methyl-n-(2-methyl-5-pyridin-2-ylpyrazol-3-yl)-4-pyridin-4-ylpyrazole-3-carboxamide |
|
127
|
313
|
5skfA |
Crystal structure of human phosphodiesterase 10 in complex with 3-[5-[1-(2,2-difluoro-1,3-benzodioxol-4-yl)-4-oxopyridazin-3-yl]pyrazol-1-yl]benzonitrile |
|
129
|
313
|
5skbA |
Crystal structure of human phosphodiesterase 10 in complex with 9-methoxy-3,5-dihydropyrimido[5,4-b]indol-4-one |
|
123
|
313
|
5skvA |
Crystal structure of human phosphodiesterase 10 in complex with 6-cyclopropyl-n-[3-[(2-hydroxy-2-methylpropyl)carbamoyl]-1-methylpyrazol-4-yl]-3-(pyrimidin-5-ylamino)pyridine-2-carboxamide |
|
126
|
314
|
5skpA |
Crystal structure of human phosphodiesterase 10 in complex with [4-(2-methoxyphenyl)piperazin-1-yl]-(3-methyl-1-phenylthieno[2,3-c]pyrazol-5-yl)methanone |
|
125
|
314
|
5setA |
Crystal structure of human phosphodiesterase 10 in complex with 6-cyclopropyl-n-(2-methyl-5-pyridin-2-ylpyrazol-3-yl)-3-(pyrimidin-5-ylamino)pyridine-2-carboxamide |
|
120
|
313
|
5skeA |
Crystal structure of human phosphodiesterase 10 in complex with 2-tert-butyl-5-(pyrimidin-5-ylamino)-n-[3-(trifluoromethoxy)phenyl]pyrimidine-4-carboxamide |
|
130
|
313
|
5skqA |
Crystal structure of human phosphodiesterase 10 in complex with n-ethyl-6-(4-fluorophenyl)sulfanyl-n-methyl-9h-purin-2-amine |
|
126
|
313
|
5shbA |
Crystal structure of human phosphodiesterase 10 in complex with 3-[2-(3-bromophenyl)pyrazol-3-yl]-1-pyridin-4-ylpyridazin-4-one |
|
123
|
312
|
5sfiA |
Crystal structure of human phosphodiesterase 10 in complex with 5,8-dimethyl-2-[2-[2-methyl-5-(2-methylpyrrolidin-1-yl)-1,2,4-triazol-3-yl]ethyl]-[1,2,4]triazolo[1,5-a]pyrazine |
|
124
|
313
|
5sh8A |
Crystal structure of human phosphodiesterase 10 in complex with 6-methyl-n-(5-methyl-2-phenylpyrazol-3-yl)-3-(pyrimidin-5-ylamino)pyridine-2-carboxamide |
|
123
|
313
|
5sg8A |
Crystal structure of human phosphodiesterase 10 in complex with 5-butoxy-4-ethoxypyrimidin-2-amine |
|
126
|
313
|
5sfnA |
Crystal structure of human phosphodiesterase 10 in complex with 4-(azetidine-1-carbonyl)-2-methyl-n-[2-(1-methylbenzimidazol-2-yl)ethyl]pyrazole-3-carboxamide |
|
126
|
313
|
5sijA |
Crystal structure of human phosphodiesterase 10 in complex with 5,8-dimethyl-2-[2-(1-methyl-4-phenylimidazol-2-yl)ethyl]-[1,2,4]triazolo[1,5-a]pyrazine |
|
121
|
313
|
5sgjA |
Crystal structure of human phosphodiesterase 10 in complex with 6-[(3,6-dimethylpyridine-2-carbonyl)amino]-n-methyl-2-phenyl-3h-benzimidazole-5-carboxamide |
|
124
|
312
|
5sfyA |
Crystal structure of human phosphodiesterase 10 in complex with 5,8-dimethyl-2-[(e)-2-[2-methyl-5-(1h-pyrazol-4-yl)-1,2,4-triazol-3-yl]ethenyl]-[1,2,4]triazolo[1,5-a]pyrazine |
|
125
|
313
|
5sk2A |
Crystal structure of human phosphodiesterase 10 in complex with 2-(4-fluorophenyl)-4-(2-isoquinolin-3-yloxyethyl)-5-methyl-1,3-oxazole |
|
126
|
313
|
5sgcA |
Crystal structure of human phosphodiesterase 10 in complex with 4-(azetidine-1-carbonyl)-2-methyl-n-(2-morpholin-4-yl-[1,2,4]triazolo[1,5-c]pyrimidin-7-yl)pyrazole-3-carboxamide |
|
127
|
313
|
5sh2A |
Crystal structure of human phosphodiesterase 10 in complex with 4-(azetidine-1-carbonyl)-2-methyl-n-(2-morpholin-4-yl-1,3-benzothiazol-5-yl)pyrazole-3-carboxamide |
|
122
|
313
|
5sfhA |
Crystal structure of human phosphodiesterase 10 in complex with n-cyclopropyl-5-[2-(5,8-dimethyl-[1,2,4]triazolo[1,5-a]pyrazin-2-yl)ethyl]-n,1-dimethyl-1,2,4-triazol-3-amine |
|
126
|
313
|
5sgwA |
Crystal structure of human phosphodiesterase 10 in complex with 2-phenyl-6-(2-phenylpyrazol-3-yl)-3,4-dihydropyridazin-5-one |
|
125
|
313
|
5sezA |
Crystal structure of human phosphodiesterase 10 in complex with 2-chloro-6-ethyl-n-(2-phenyl-[1,2,4]triazolo[1,5-a]pyridin-7-yl)pyridine-4-carboxamide |
|
123
|
313
|
5sffA |
Crystal structure of human phosphodiesterase 10 in complex with [2-methyl-6-[2-(1-methyl-4-phenylimidazol-2-yl)ethynyl]imidazo[1,2-b]pyridazin-3-yl]methanol |
|
129
|
316
|
5sgoA |
Crystal structure of human phosphodiesterase 10 in complex with n-[3-[3-[5-(4-fluorophenyl)thieno[2,3-d]pyrimidin-4-yl]oxypropoxy]phenyl]acetamide |
|
125
|
313
|
5sk3A |
Crystal structure of human phosphodiesterase 10 in complex with [2-cyclopropyl-6-[2-(1-methyl-4-phenylimidazol-2-yl)ethyl]imidazo[1,2-b]pyridazin-3-yl]methanol |
