Finding intermodel H-bonds Finding intramodel H-bonds Constraints relaxed by 0.4 angstroms and 20 degrees Models used: #0 3cot_A.cif H-bonds (donor, acceptor, hydrogen, D..A dist, D-H..A dist): SER 3.A N SER 6.A O no hydrogen 2.923 N/A SER 3.A OG SER 6.A O no hydrogen 3.520 N/A SER 6.A N SER 3.A O no hydrogen 3.105 N/A SER 6.A N SER 3.A OG no hydrogen 2.999 N/A HIS 7.A ND1 SER 3.A O no hydrogen 2.814 N/A ARG 8.A NH1 SER 16.A OG no hydrogen 2.893 N/A ARG 8.A NH2 ASP 80.A O no hydrogen 3.515 N/A ILE 9.A N ILE 17.A O no hydrogen 2.856 N/A LEU 11.A N ASN 15.A O no hydrogen 2.717 N/A GLY 14.A N LEU 11.A O no hydrogen 3.062 N/A ASN 15.A N ASP 13.A OD1 no hydrogen 3.035 N/A ASN 15.A ND2 ASP 13.A OD1 no hydrogen 3.360 N/A ASN 15.A ND2 ASP 13.A OD2 no hydrogen 3.241 N/A ASN 15.A ND2 SER 164.A OG no hydrogen 3.126 N/A ILE 17.A N ILE 9.A O no hydrogen 2.778 N/A ILE 19.A N HIS 7.A O no hydrogen 2.782 N/A GLY 21.A N VAL 269.A O no hydrogen 2.899 N/A LEU 22.A N HIS 50.A O no hydrogen 2.819 N/A GLY 23.A N PRO 271.A O no hydrogen 3.038 N/A THR 24.A OG1 ASP 52.A O no hydrogen 2.690 N/A SER 26.A OG THR 31.A OG1 no hydrogen 2.598 N/A SER 30.A OG GLU 27.A OE2 no hydrogen 2.571 N/A THR 31.A N PRO 28.A O no hydrogen 3.123 N/A THR 31.A OG1 SER 26.A OG no hydrogen 2.598 N/A THR 31.A OG1 GLU 27.A O no hydrogen 2.487 N/A GLY 34.A N GLU 62.A OE2 no hydrogen 2.995 N/A ALA 35.A N PRO 32.A O no hydrogen 3.228 N/A ALA 37.A N GLU 62.A OE1 no hydrogen 2.789 N/A THR 38.A N GLY 34.A O no hydrogen 3.011 N/A THR 38.A OG1 GLY 34.A O no hydrogen 3.177 N/A SER 39.A N ALA 35.A O no hydrogen 3.063 N/A SER 39.A OG ALA 35.A O no hydrogen 2.887 N/A VAL 40.A N CYS 36.A O no hydrogen 2.958 N/A LYS 41.A N ALA 37.A O no hydrogen 3.137 N/A LYS 41.A NZ GLU 65.A OE2 no hydrogen 3.536 N/A LYS 41.A NZ GLU 69.A OE2 no hydrogen 2.597 N/A VAL 42.A N THR 38.A O no hydrogen 2.974 N/A ALA 43.A N SER 39.A O no hydrogen 2.820 N/A ILE 44.A N VAL 40.A O no hydrogen 2.883 N/A ASP 45.A N LYS 41.A O no hydrogen 3.068 N/A THR 46.A N VAL 42.A O no hydrogen 2.842 N/A THR 46.A OG1 VAL 42.A O no hydrogen 2.857 N/A GLY 47.A N ALA 43.A O no hydrogen 3.063 N/A GLY 47.A N ILE 44.A O no hydrogen 3.266 N/A TYR 48.A N ALA 43.A O no hydrogen 2.879 N/A TYR 48.A OH ILE 279.A O no hydrogen 2.610 N/A ARG 49.A NH1 ILE 44.A O no hydrogen 2.919 N/A ARG 49.A NH1 TYR 48.A O no hydrogen 2.699 N/A HIS 50.A ND1 PRO 18.A O no hydrogen 3.197 N/A ILE 51.A N PHE 82.A O no hydrogen 2.856 N/A ASP 52.A N LEU 22.A O no hydrogen 2.928 N/A GLY 53.A N CYS 84.A O no hydrogen 2.965 N/A TYR 57.A N ALA 54.A O no hydrogen 2.872 N/A GLN 58.A N TYR 55.A O no hydrogen 3.001 N/A ASN 59.A ND2 THR 24.A O no hydrogen 2.885 N/A GLU 62.A N ASN 59.A O no hydrogen 2.950 N/A VAL 63.A N ASN 59.A O no hydrogen 3.143 N/A GLY 64.A N GLU 60.A O no hydrogen 3.075 N/A GLU 65.A N HIS 61.A O no hydrogen 2.965 N/A ALA 66.A N GLU 62.A O no hydrogen 2.986 N/A ILE 67.A N VAL 63.A O no hydrogen 3.008 N/A ARG 68.A N GLY 64.A O no hydrogen 2.914 N/A ARG 68.A NE LEU 108.A O no hydrogen 3.005 N/A GLU 69.A N GLU 65.A O no hydrogen 3.097 N/A LYS 70.A N ALA 66.A O no hydrogen 3.110 N/A LYS 70.A NZ ASP 45.A OD1 no hydrogen 3.132 N/A LYS 70.A NZ ASP 45.A OD2 no hydrogen 3.551 N/A LYS 70.A NZ GLU 73.A OE2 no hydrogen 2.992 N/A ILE 71.A N ILE 67.A O no hydrogen 3.024 N/A ALA 72.A N ARG 68.A O no hydrogen 2.800 N/A GLU 73.A N GLU 69.A O no hydrogen 3.153 N/A GLY 74.A N ILE 71.A O no hydrogen 3.065 N/A LYS 75.A N LYS 70.A O no hydrogen 2.897 N/A VAL 76.A N LYS 70.A O no hydrogen 3.340 N/A ARG 77.A N ASP 80.A OD2 no hydrogen 3.070 N/A ARG 77.A NE ASP 80.A OD2 no hydrogen 2.923 N/A ARG 77.A NH2 ASP 80.A OD1 no hydrogen 3.015 N/A ARG 77.A NH2 ASP 80.A OD2 no hydrogen 3.478 N/A ARG 78.A NH1 ARG 78.A O no hydrogen 2.746 N/A ARG 78.A NH1 ILE 81.A O no hydrogen 2.898 N/A ARG 78.A NH1 ASP 114.A OD2 no hydrogen 3.205 N/A ARG 78.A NH2 TYR 112.A O no hydrogen 2.769 N/A ARG 78.A NH2 ASP 114.A OD2 no hydrogen 3.178 N/A ASP 80.A N ARG 77.A O no hydrogen 2.866 N/A ILE 81.A N ARG 78.A O no hydrogen 3.131 N/A PHE 82.A N ARG 49.A O no hydrogen 2.901 N/A TYR 83.A N ASP 114.A OD2 no hydrogen 2.770 N/A TYR 83.A OH GLU 60.A OE2 no hydrogen 2.813 N/A CYS 84.A N ILE 51.A O no hydrogen 3.066 N/A CYS 84.A SG ASP 52.A OD1 no hydrogen 3.492 N/A CYS 84.A SG GLY 85.A O no hydrogen 3.722 N/A CYS 84.A SG LEU 115.A O no hydrogen 3.909 N/A GLY 85.A N LEU 115.A O no hydrogen 2.864 N/A LYS 86.A NZ ASP 52.A OD1 no hydrogen 3.294 N/A LYS 86.A NZ ASP 52.A OD2 no hydrogen 2.753 N/A LYS 86.A NZ GLY 53.A O no hydrogen 2.795 N/A LYS 86.A NZ TYR 57.A OH no hydrogen 3.199 N/A LEU 87.A N ILE 117.A O no hydrogen 2.760 N/A TRP 88.A NE1 ILE 130.A O no hydrogen 2.762 N/A THR 90.A OG1 ASN 91.A OD1 no hydrogen 2.707 N/A ASN 91.A N TRP 88.A O no hydrogen 2.999 N/A ASN 91.A ND2 THR 100.A OG1 no hydrogen 2.782 N/A MET 96.A N VAL 93.A O no hydrogen 2.709 N/A VAL 97.A N PRO 94.A O no hydrogen 3.200 N/A ARG 98.A NE GLU 102.A OE2 no hydrogen 3.265 N/A THR 100.A N MET 96.A O no hydrogen 3.008 N/A THR 100.A OG1 MET 96.A O no hydrogen 2.727 N/A LEU 101.A N VAL 97.A O no hydrogen 3.006 N/A GLU 102.A N ARG 98.A O no hydrogen 2.874 N/A ARG 103.A N PRO 99.A O no hydrogen 3.017 N/A THR 104.A N THR 100.A O no hydrogen 3.311 N/A THR 104.A OG1 GLU 60.A OE1 no hydrogen 2.779 N/A THR 104.A OG1 GLU 60.A OE2 no hydrogen 3.519 N/A LEU 105.A N LEU 101.A O no hydrogen 2.937 N/A ARG 106.A N GLU 102.A O no hydrogen 2.876 N/A VAL 107.A N ARG 103.A O no hydrogen 2.769 N/A LEU 108.A N THR 104.A O no hydrogen 2.872 N/A GLN 109.A N LEU 105.A O no hydrogen 2.655 N/A LEU 110.A N LEU 105.A O no hydrogen 3.012 N/A VAL 113.A N LEU 161.A O no hydrogen 3.168 N/A LEU 115.A N TYR 83.A O no hydrogen 3.119 N/A TYR 116.A N SER 164.A O no hydrogen 3.079 N/A ILE 117.A N GLY 85.A O no hydrogen 3.102 N/A ILE 118.A N GLY 166.A O no hydrogen 3.272 N/A GLU 119.A N LEU 87.A O no hydrogen 2.852 N/A ALA 123.A N HIS 316.A NE2 no hydrogen 3.277 N/A PHE 124.A N ALA 89.A O no hydrogen 2.827 N/A LYS 125.A N LEU 140.A O no hydrogen 3.068 N/A ASP 134.A N LYS 138.A O no hydrogen 2.872 N/A GLY 137.A N ASP 134.A O no hydrogen 2.818 N/A LEU 140.A N PRO 132.A O no hydrogen 2.606 N/A TYR 141.A OH ASP 315.A OD1 no hydrogen 2.656 N/A HIS 142.A ND1 LYS 143.A O no hydrogen 3.046 N/A SER 144.A OG PRO 121.A O no hydrogen 3.515 N/A CYS 147.A SG LEU 177.A O no hydrogen 3.602 N/A ALA 148.A N ASN 145.A OD1 no hydrogen 3.104 N/A THR 149.A N ASN 145.A O no hydrogen 3.027 N/A THR 149.A OG1 HIS 92.A O no hydrogen 2.745 N/A THR 149.A OG1 ASN 145.A O no hydrogen 3.443 N/A TRP 150.A N LEU 146.A O no hydrogen 2.762 N/A TRP 150.A NE1 HIS 186.A O no hydrogen 2.732 N/A GLU 151.A N CYS 147.A O no hydrogen 3.081 N/A ALA 152.A N ALA 148.A O no hydrogen 3.294 N/A MET 153.A N THR 149.A O no hydrogen 3.071 N/A GLU 154.A N TRP 150.A O no hydrogen 2.850 N/A ALA 155.A N GLU 151.A O no hydrogen 3.163 N/A CYS 156.A N ALA 152.A O no hydrogen 3.403 N/A CYS 156.A SG ALA 152.A O no hydrogen 3.484 N/A LYS 157.A N MET 153.A O no hydrogen 3.247 N/A LYS 157.A NZ ASP 13.A OD2 no hydrogen 3.176 N/A LYS 157.A NZ LYS 163.A O no hydrogen 2.760 N/A ASP 158.A N GLU 154.A O no hydrogen 2.928 N/A ALA 159.A N ALA 155.A O no hydrogen 2.950 N/A GLY 160.A N LYS 157.A O no hydrogen 2.923 N/A LEU 161.A N CYS 156.A O no hydrogen 3.090 N/A LYS 163.A N VAL 113.A O no hydrogen 3.150 N/A SER 164.A N ASP 114.A O no hydrogen 2.918 N/A SER 164.A OG ASP 13.A OD1 no hydrogen 3.478 N/A SER 164.A OG ASP 13.A OD2 no hydrogen 2.522 N/A GLY 166.A N TYR 116.A O no hydrogen 3.118 N/A VAL 167.A N SER 190.A O no hydrogen 2.822 N/A SER 168.A OG GLN 192.A O no hydrogen 2.751 N/A ASN 169.A N GLN 192.A O no hydrogen 3.040 N/A ASN 169.A ND2 GLU 119.A O no hydrogen 3.046 N/A ASN 171.A N GLN 174.A OE1 no hydrogen 2.949 N/A ASN 171.A ND2 PRO 320.A O no hydrogen 3.338 N/A ARG 172.A N TYR 325.A O no hydrogen 2.884 N/A ARG 172.A NH1 GLU 176.A OE1 no hydrogen 2.717 N/A ARG 173.A NH2 GLU 318.A OE1 no hydrogen 3.037 N/A GLN 174.A N ASN 171.A OD1 no hydrogen 2.808 N/A GLN 174.A NE2 GLU 318.A O no hydrogen 2.889 N/A GLN 174.A NE2 GLU 318.A OE1 no hydrogen 2.955 N/A LEU 175.A N ASN 171.A O no hydrogen 2.994 N/A GLU 176.A N ARG 172.A O no hydrogen 3.012 N/A LEU 177.A N ARG 173.A O no hydrogen 3.082 N/A LEU 179.A N LEU 175.A O no hydrogen 2.973 N/A ASN 180.A N GLU 176.A O no hydrogen 2.765 N/A LYS 181.A N ILE 178.A O no hydrogen 2.922 N/A LYS 181.A NZ GLU 151.A OE1 no hydrogen 3.137 N/A LYS 181.A NZ PRO 182.A O no hydrogen 3.265 N/A LYS 185.A N GLU 154.A OE2 no hydrogen 2.887 N/A LYS 185.A NZ ASP 158.A OD2 no hydrogen 3.284 N/A HIS 186.A N GLU 154.A OE2 no hydrogen 2.683 N/A HIS 186.A NE2 ASP 158.A OD1 no hydrogen 2.802 N/A VAL 189.A N LEU 165.A O no hydrogen 2.904 N/A SER 190.A OG VAL 214.A O no hydrogen 3.346 N/A ASN 191.A N VAL 214.A O no hydrogen 3.139 N/A ASN 191.A ND2 PHE 170.A O no hydrogen 2.971 N/A GLN 192.A N VAL 167.A O no hydrogen 2.829 N/A GLN 192.A NE2 ASP 52.A OD1 no hydrogen 2.944 N/A VAL 193.A N THR 216.A O no hydrogen 2.935 N/A CYS 195.A N TYR 218.A O no hydrogen 3.410 N/A CYS 195.A SG PHE 199.A O no hydrogen 3.965 N/A CYS 195.A SG THR 200.A O no hydrogen 3.684 N/A CYS 195.A SG ASN 262.A OD1 no hydrogen 3.545 N/A HIS 196.A N PHE 199.A O no hydrogen 3.211 N/A HIS 196.A NE2 GLU 194.A OE2 no hydrogen 2.735 N/A TYR 198.A N HIS 196.A ND1 no hydrogen 3.130 N/A TYR 198.A OH ASP 240.A OD2 no hydrogen 2.721 N/A PHE 199.A N HIS 196.A O no hydrogen 2.867 N/A THR 200.A N ASN 302.A OD1 no hydrogen 3.133 N/A THR 200.A OG1 GLU 299.A OE1 no hydrogen 3.049 N/A GLN 201.A NE2 GLU 194.A O no hydrogen 2.810 N/A LYS 203.A NZ GLU 324.A OE1 no hydrogen 2.809 N/A LEU 205.A N GLN 201.A O no hydrogen 2.933 N/A LYS 206.A N PRO 202.A O no hydrogen 3.290 N/A PHE 207.A N LYS 203.A O no hydrogen 3.104 N/A CYS 208.A N LEU 204.A O no hydrogen 3.004 N/A CYS 208.A SG LEU 204.A O no hydrogen 3.364 N/A GLN 209.A N LEU 205.A O no hydrogen 2.946 N/A GLN 210.A N LYS 206.A O no hydrogen 3.074 N/A GLN 210.A N PHE 207.A O no hydrogen 3.042 N/A HIS 211.A N CYS 208.A O no hydrogen 3.090 N/A ASP 212.A N GLN 209.A O no hydrogen 3.172 N/A ILE 213.A N CYS 208.A O no hydrogen 2.686 N/A VAL 214.A N VAL 189.A O no hydrogen 3.072 N/A THR 216.A N ASN 191.A O no hydrogen 3.194 N/A ALA 217.A N VAL 268.A O no hydrogen 2.568 N/A TYR 218.A N VAL 193.A O no hydrogen 2.987 N/A TYR 218.A OH ASN 169.A OD1 no hydrogen 2.890 N/A GLY 222.A N SER 219.A O no hydrogen 2.982 N/A THR 223.A OG1 GLY 222.A O no hydrogen 2.406 N/A ARG 225.A N THR 223.A OG1 no hydrogen 2.830 N/A ARG 225.A NH1 SER 234.A O no hydrogen 3.203 N/A ARG 225.A NH2 SER 234.A O no hydrogen 2.856 N/A ASN 226.A ND2 GLU 27.A OE1 no hydrogen 3.055 N/A ILE 228.A N ASN 226.A OD1 no hydrogen 2.869 N/A TRP 229.A N ASN 226.A O no hydrogen 3.240 N/A VAL 230.A N ASN 226.A O no hydrogen 2.689 N/A ASN 231.A N PHE 307.A O no hydrogen 2.742 N/A ASN 231.A ND2 ARG 306.A O no hydrogen 2.881 N/A SER 233.A N ASN 231.A OD1 no hydrogen 3.271 N/A LYS 239.A N PRO 236.A O no hydrogen 2.974 N/A ASP 240.A N LEU 237.A O no hydrogen 2.941 N/A LEU 243.A N ASP 240.A OD1 no hydrogen 3.170 N/A ASN 244.A N ASP 240.A O no hydrogen 3.045 N/A ASN 244.A ND2 LEU 238.A O no hydrogen 3.015 N/A ASN 244.A ND2 ASP 240.A O no hydrogen 2.616 N/A SER 245.A N ALA 241.A O no hydrogen 2.806 N/A LEU 246.A N LEU 242.A O no hydrogen 2.741 N/A GLY 247.A N LEU 243.A O no hydrogen 2.944 N/A LYS 248.A N ASN 244.A O no hydrogen 3.057 N/A ARG 249.A N SER 245.A O no hydrogen 3.318 N/A TYR 250.A N LEU 246.A O no hydrogen 3.262 N/A TYR 250.A N GLY 247.A O no hydrogen 3.211 N/A TYR 250.A OH SER 289.A O no hydrogen 3.261 N/A TYR 250.A OH GLU 294.A OE1 no hydrogen 2.476 N/A TYR 250.A OH GLU 294.A OE2 no hydrogen 3.378 N/A ASN 251.A N LYS 248.A O no hydrogen 3.179 N/A LYS 252.A N GLY 247.A O no hydrogen 2.683 N/A LYS 252.A NZ GLN 284.A O no hydrogen 3.151 N/A LYS 252.A NZ ASP 287.A OD1 no hydrogen 2.848 N/A LYS 252.A NZ ASP 287.A OD2 no hydrogen 3.069 N/A THR 253.A N GLN 256.A OE1 no hydrogen 2.838 N/A THR 253.A OG1 GLN 256.A OE1 no hydrogen 3.417 N/A THR 253.A OG1 GLU 281.A OE1 no hydrogen 2.675 N/A GLN 256.A N THR 253.A OG1 no hydrogen 3.179 N/A GLN 256.A NE2 GLU 281.A O no hydrogen 2.841 N/A ILE 257.A N THR 253.A O no hydrogen 3.048 N/A VAL 258.A N ALA 254.A O no hydrogen 2.874 N/A LEU 259.A N ALA 255.A O no hydrogen 3.029 N/A ARG 260.A N GLN 256.A O no hydrogen 3.046 N/A ARG 260.A NE GLN 264.A OE1 no hydrogen 2.970 N/A ARG 260.A NH1 ILE 285.A O no hydrogen 2.834 N/A PHE 261.A N ILE 257.A O no hydrogen 2.993 N/A ASN 262.A N VAL 258.A O no hydrogen 3.346 N/A ASN 262.A ND2 CYS 195.A O no hydrogen 3.484 N/A ILE 263.A N LEU 259.A O no hydrogen 3.111 N/A GLN 264.A N ARG 260.A O no hydrogen 2.899 N/A GLN 264.A NE2 LEU 290.A O no hydrogen 2.630 N/A ARG 265.A N ASN 262.A O no hydrogen 3.181 N/A ARG 265.A NH1 THR 200.A O no hydrogen 3.155 N/A ARG 265.A NH1 ASN 262.A OD1 no hydrogen 3.164 N/A ARG 265.A NH2 THR 200.A O no hydrogen 3.250 N/A GLY 266.A N ILE 263.A O no hydrogen 3.018 N/A VAL 267.A N ASN 262.A O no hydrogen 2.735 N/A VAL 268.A N ILE 215.A O no hydrogen 3.002 N/A VAL 269.A N ILE 19.A O no hydrogen 2.962 N/A ILE 270.A N ALA 217.A O no hydrogen 3.377 N/A SER 273.A OG ASN 275.A O no hydrogen 3.415 N/A ASN 275.A N SER 273.A OG no hydrogen 3.241 N/A ARG 278.A N ASN 275.A OD1 no hydrogen 2.967 N/A ILE 279.A N ASN 275.A O no hydrogen 2.870 N/A LYS 280.A N LEU 276.A O no hydrogen 3.473 N/A GLU 281.A N GLU 277.A O no hydrogen 2.978 N/A ASN 282.A N ARG 278.A O no hydrogen 3.009 N/A PHE 283.A N LYS 280.A O no hydrogen 3.197 N/A GLN 284.A N GLU 281.A O no hydrogen 3.119 N/A GLN 284.A NE2 LYS 280.A O no hydrogen 2.810 N/A ILE 285.A N PHE 283.A O no hydrogen 2.984 N/A LEU 290.A N GLN 264.A OE1 no hydrogen 2.905 N/A THR 291.A N GLU 294.A OE1 no hydrogen 2.848 N/A GLU 294.A N THR 291.A OG1 no hydrogen 3.038 N/A MET 295.A N THR 291.A O no hydrogen 2.887 N/A LYS 296.A N GLU 292.A O no hydrogen 3.004 N/A ASP 297.A N GLU 293.A O no hydrogen 3.079 N/A ILE 298.A N GLU 294.A O no hydrogen 2.817 N/A GLU 299.A N MET 295.A O no hydrogen 2.983 N/A ALA 300.A N LYS 296.A O no hydrogen 2.941 N/A LEU 301.A N ILE 298.A O no hydrogen 2.886 N/A ASN 302.A N GLU 299.A O no hydrogen 3.115 N/A LYS 303.A N TYR 198.A O no hydrogen 2.840 N/A ASN 304.A N TYR 198.A O no hydrogen 3.215 N/A ASN 304.A N ASN 302.A OD1 no hydrogen 3.203 N/A PHE 307.A N GLU 194.A OE1 no hydrogen 3.163 N/A PHE 307.A N GLU 194.A OE2 no hydrogen 2.748 N/A VAL 308.A N GLU 194.A OE1 no hydrogen 2.866 N/A TRP 313.A N LEU 310.A O no hydrogen 2.905 N/A ARG 314.A N LEU 311.A O no hydrogen 2.802 N/A ASP 315.A N ASP 315.A OD1 no hydrogen 2.594 N/A HIS 316.A N TRP 313.A O no hydrogen 3.090 N/A HIS 316.A NE2 ALA 123.A O no hydrogen 3.089 N/A GLU 318.A N HIS 316.A ND1 no hydrogen 2.707 N/A TYR 319.A N HIS 316.A O no hydrogen 3.055 N/A TYR 319.A OH GLU 309.A O no hydrogen 2.600 N/A HIS 322.A NE2 ARG 314.A O no hydrogen 2.626 N/A