Finding intermodel H-bonds Finding intramodel H-bonds Constraints relaxed by 0.4 angstroms and 20 degrees Models used: #0 4czu_A.cif H-bonds (donor, acceptor, hydrogen, D..A dist, D-H..A dist): HIS 4.A N GLU 14.A OE2 no hydrogen 2.645 N/A GLY 6.A N HIS 4.A ND1 no hydrogen 3.286 N/A ARG 7.A N HIS 4.A O no hydrogen 2.844 N/A VAL 10.A N TYR 13.A O no hydrogen 2.748 N/A TYR 13.A N VAL 10.A O no hydrogen 2.911 N/A GLU 14.A N ARG 31.A O no hydrogen 2.856 N/A LEU 15.A N THR 8.A O no hydrogen 2.748 N/A GLY 16.A N PHE 29.A O no hydrogen 2.746 N/A LEU 19.A N VAL 27.A O no hydrogen 2.709 N/A GLY 20.A N VAL 27.A O no hydrogen 3.344 N/A GLY 22.A N ALA 25.A O no hydrogen 2.811 N/A LYS 26.A N VAL 43.A O no hydrogen 2.937 N/A VAL 27.A N GLY 20.A O no hydrogen 2.909 N/A LYS 28.A N ILE 41.A O no hydrogen 2.954 N/A ALA 30.A N VAL 39.A O no hydrogen 3.093 N/A ARG 31.A N GLU 14.A O no hydrogen 3.019 N/A ARG 31.A NH2 GLY 2.A O no hydrogen 2.790 N/A ASN 32.A N ASP 37.A O no hydrogen 2.760 N/A VAL 33.A N LYS 12.A O no hydrogen 2.792 N/A GLU 34.A N ASN 32.A OD1 no hydrogen 2.633 N/A ASN 35.A N ASN 32.A OD1 no hydrogen 3.144 N/A ASN 35.A ND2 ASP 37.A OD2 no hydrogen 2.913 N/A GLY 36.A N ASN 32.A O no hydrogen 2.854 N/A ASP 37.A N ASN 35.A OD1 no hydrogen 3.015 N/A VAL 39.A N ALA 30.A O no hydrogen 2.882 N/A ALA 40.A N LEU 90.A O no hydrogen 2.945 N/A ILE 41.A N LYS 28.A O no hydrogen 2.809 N/A LYS 42.A N PHE 88.A O no hydrogen 2.956 N/A LYS 42.A NZ ARG 165.A O no hydrogen 2.975 N/A LYS 42.A NZ ASP 167.A OD2 no hydrogen 2.681 N/A LYS 42.A NZ ASP 172.A OD2 no hydrogen 2.905 N/A VAL 43.A N LYS 26.A O no hydrogen 2.885 N/A ILE 44.A N ILE 86.A O no hydrogen 2.908 N/A ASP 45.A N PHE 24.A O no hydrogen 2.953 N/A LYS 46.A N THR 84.A O no hydrogen 2.857 N/A LYS 46.A NZ SER 82.A O no hydrogen 3.036 N/A LYS 46.A NZ PHE 286.A O no hydrogen 2.685 N/A LYS 48.A N ASP 45.A OD1.A no hydrogen 3.024 N/A VAL 49.A N ASP 45.A O no hydrogen 3.246 N/A LEU 50.A N LYS 46.A O no hydrogen 2.973 N/A LYS 51.A N GLU 47.A O no hydrogen 3.013 N/A ASN 52.A N LEU 50.A O no hydrogen 2.987 N/A MET 54.A N ASN 52.A OD1 no hydrogen 2.716 N/A ILE 55.A N ASN 52.A O no hydrogen 3.222 N/A ILE 58.A N MET 54.A O no hydrogen 2.976 N/A LYS 59.A N ILE 55.A O no hydrogen 2.873 N/A LYS 59.A NZ ASP 283.A O no hydrogen 3.017 N/A LYS 59.A NZ ASP 283.A OD1 no hydrogen 3.384 N/A ARG 60.A N ALA 56.A O no hydrogen 3.031 N/A GLU 61.A N GLN 57.A O no hydrogen 2.886 N/A ILE 62.A N ILE 58.A O no hydrogen 2.944 N/A SER 63.A N LYS 59.A O no hydrogen 2.869 N/A SER 63.A OG LYS 59.A O no hydrogen 2.752 N/A THR 64.A N ARG 60.A O no hydrogen 2.986 N/A THR 64.A OG1 ARG 60.A O no hydrogen 3.129 N/A MET 65.A N GLU 61.A O no hydrogen 2.997 N/A LYS 66.A N ILE 62.A O no hydrogen 3.032 N/A LEU 67.A N THR 64.A O no hydrogen 2.982 N/A ILE 68.A N THR 64.A O no hydrogen 3.054 N/A ILE 68.A N MET 65.A O no hydrogen 3.327 N/A HIS 70.A NE2 ASN 122.A OD1.B no hydrogen 2.937 N/A ASN 72.A N HIS 70.A ND1 no hydrogen 2.933 N/A ASN 72.A ND2 LEU 150.A O no hydrogen 3.026 N/A VAL 73.A N HIS 70.A O no hydrogen 3.296 N/A ILE 74.A N VAL 152.A O no hydrogen 2.965 N/A ARG 75.A N GLU 91.A OE1 no hydrogen 2.836 N/A PHE 77.A N VAL 89.A O no hydrogen 2.845 N/A MET 80.A N TYR 87.A O no hydrogen 3.016 N/A ALA 81.A N SER 289.A OG no hydrogen 3.104 N/A SER 82.A N LYS 85.A O no hydrogen 2.830 N/A THR 84.A N SER 82.A OG no hydrogen 3.068 N/A LYS 85.A N SER 82.A OG no hydrogen 2.963 N/A LYS 85.A NZ ASP 45.A OD1.B no hydrogen 2.517 N/A ILE 86.A N ILE 44.A O no hydrogen 2.856 N/A TYR 87.A N MET 80.A O no hydrogen 2.766 N/A PHE 88.A N LYS 42.A O no hydrogen 2.891 N/A VAL 89.A N GLU 78.A O no hydrogen 2.903 N/A LEU 90.A N ALA 40.A O no hydrogen 2.850 N/A GLU 91.A N ARG 75.A O no hydrogen 3.033 N/A GLY 95.A N LEU 144.A O no hydrogen 2.900 N/A GLU 97.A N ASP 100.A OD2 no hydrogen 3.152 N/A LEU 98.A N LEU 142.A O no hydrogen 2.853 N/A ASP 100.A N GLU 97.A O no hydrogen 3.144 N/A LYS 101.A N LEU 98.A O no hydrogen 3.277 N/A LYS 101.A NZ GLU 112.A OE2 no hydrogen 3.253 N/A SER 103.A N PHE 99.A O no hydrogen 2.828 N/A SER 104.A N LYS 101.A O no hydrogen 3.335 N/A SER 104.A OG.A ASP 100.A O no hydrogen 3.191 N/A SER 104.A OG.A LYS 101.A O no hydrogen 3.089 N/A SER 104.A OG.B ASP 100.A O no hydrogen 3.325 N/A ASN 105.A N LYS 101.A O no hydrogen 2.715 N/A GLY 106.A N ILE 102.A O no hydrogen 2.639 N/A LEU 108.A N LEU 207.A O no hydrogen 2.847 N/A ALA 113.A N LYS 109.A O no hydrogen 2.919 N/A ARG 114.A N GLU 110.A O no hydrogen 2.777 N/A ARG 114.A NE TRP 267.A O no hydrogen 3.025 N/A ARG 114.A NH1 ASP 111.A OD1 no hydrogen 2.720 N/A ARG 114.A NH2 ASP 111.A OD1 no hydrogen 3.323 N/A LYS 115.A N ASP 111.A O no hydrogen 2.961 N/A TYR 116.A N GLU 112.A O no hydrogen 3.155 N/A TYR 116.A OH GLY 148.A O no hydrogen 2.531 N/A PHE 117.A N ALA 113.A O no hydrogen 2.993 N/A GLN 118.A N ARG 114.A O no hydrogen 2.956 N/A GLN 118.A NE2 PHE 268.A O no hydrogen 2.784 N/A GLN 118.A NE2 LYS 270.A O no hydrogen 3.086 N/A GLN 119.A N LYS 115.A O no hydrogen 3.073 N/A LEU 120.A N TYR 116.A O no hydrogen 2.925 N/A ILE 121.A N PHE 117.A O no hydrogen 2.809 N/A ASN 122.A N GLN 118.A O no hydrogen 2.971 N/A ASN 122.A ND2.B TYR 272.A OH no hydrogen 2.886 N/A ALA 123.A N GLN 119.A O no hydrogen 3.197 N/A VAL 124.A N LEU 120.A O no hydrogen 3.022 N/A ASP 125.A N ILE 121.A O no hydrogen 2.952 N/A TYR 126.A N ASN 122.A O no hydrogen 2.917 N/A CYS 127.A N ALA 123.A O no hydrogen 3.027 N/A CYS 127.A SG ALA 123.A O no hydrogen 3.482 N/A HIS 128.A N VAL 124.A O no hydrogen 2.901 N/A HIS 128.A NE2 ASP 196.A OD2 no hydrogen 2.751 N/A SER 129.A N ASP 125.A O no hydrogen 2.945 N/A SER 129.A OG TYR 126.A O no hydrogen 2.608 N/A ARG 130.A N CYS 127.A O no hydrogen 2.977 N/A ARG 130.A NE SER 129.A OG no hydrogen 3.398 N/A GLY 131.A N HIS 128.A O no hydrogen 2.795 N/A VAL 132.A N CYS 127.A O no hydrogen 2.914 N/A TYR 133.A N GLU 61.A OE2 no hydrogen 3.189 N/A HIS 134.A N ASP 196.A OD2 no hydrogen 2.923 N/A HIS 134.A NE2 SER 153.A O no hydrogen 2.882 N/A ARG 135.A N ASP 196.A OD1 no hydrogen 2.757 N/A ARG 135.A NH1 GLY 189.A O no hydrogen 3.227 N/A ARG 135.A NH2 GLY 189.A O no hydrogen 2.644 N/A ASP 136.A N HIS 134.A ND1 no hydrogen 3.051 N/A LYS 138.A NZ ASP 136.A O no hydrogen 2.841 N/A LYS 138.A NZ ASP 136.A OD2 no hydrogen 2.667 N/A LYS 138.A NZ ASN 141.A OD1 no hydrogen 2.632 N/A GLU 140.A N GLU 140.A OE1 no hydrogen 2.860 N/A ASN 141.A N LYS 138.A O no hydrogen 2.930 N/A ASN 141.A ND2 SER 153.A OG no hydrogen 3.052 N/A LEU 142.A N PRO 139.A O no hydrogen 2.989 N/A LEU 143.A N LYS 151.A O no hydrogen 3.066 N/A LEU 144.A N GLY 96.A O no hydrogen 2.971 N/A ASP 145.A N ALA 149.A O no hydrogen 2.810 N/A GLY 148.A N ASP 145.A O no hydrogen 2.667 N/A ALA 149.A N ASP 145.A OD1 no hydrogen 2.540 N/A LEU 150.A N GLN 119.A OE1 no hydrogen 2.915 N/A LYS 151.A N LEU 143.A O no hydrogen 2.826 N/A LYS 151.A NZ PRO 71.A O no hydrogen 2.380 N/A VAL 152.A N ASN 72.A O no hydrogen 2.886 N/A SER 153.A N ASN 141.A O no hydrogen 2.947 N/A SER 158.A N ASP 154.A O no hydrogen 2.886 N/A SER 158.A OG HIS 134.A O no hydrogen 2.814 N/A SER 158.A OG ASP 154.A O no hydrogen 3.316 N/A ALA 159.A N GLY 156.A O no hydrogen 2.965 N/A LEU 160.A N LEU 157.A O no hydrogen 2.919 N/A VAL 164.A N PRO 161.A O no hydrogen 2.953 N/A ARG 165.A N PRO 161.A O no hydrogen 3.106 N/A ARG 165.A NE LEU 160.A O no hydrogen 2.980 N/A ARG 165.A NH1 ASP 136.A OD2 no hydrogen 3.422 N/A ARG 165.A NH1 ASP 172.A OD1 no hydrogen 3.230 N/A ARG 165.A NH2 LEU 160.A O no hydrogen 3.197 N/A GLU 166.A N GLN 162.A O no hydrogen 2.971 N/A GLY 168.A N GLU 166.A OE2 no hydrogen 2.947 N/A LEU 169.A N ASP 167.A OD1 no hydrogen 3.149 N/A THR 173.A N GLU 166.A OE1 no hydrogen 3.080 N/A THR 173.A OG1 GLU 166.A OE1 no hydrogen 2.740 N/A CYS 174.A SG LEU 170.A O no hydrogen 3.721 N/A CYS 174.A SG HIS 171.A O no hydrogen 3.501 N/A ASN 178.A ND2 PHE 214.A O no hydrogen 2.986 N/A TYR 179.A N THR 176.A O no hydrogen 3.508 N/A VAL 180.A N PRO 177.A O no hydrogen 3.042 N/A GLU 183.A N GLU 183.A OE1 no hydrogen 2.814 N/A VAL 184.A N ALA 181.A O no hydrogen 3.024 N/A ILE 185.A N ALA 181.A O no hydrogen 3.011 N/A ASN 186.A N PRO 182.A O no hydrogen 2.917 N/A ASN 187.A N VAL 184.A O no hydrogen 2.946 N/A LYS 188.A N GLU 183.A O no hydrogen 2.732 N/A LYS 188.A NZ ASN 186.A OD1 no hydrogen 3.517 N/A TYR 190.A N LYS 188.A O no hydrogen 2.961 N/A LYS 194.A N ASP 191.A OD1 no hydrogen 3.037 N/A LYS 194.A NZ PRO 253.A O no hydrogen 2.698 N/A LYS 194.A NZ ARG 256.A O no hydrogen 3.325 N/A ALA 195.A N ASP 191.A O no hydrogen 3.143 N/A ASP 196.A N GLY 192.A O no hydrogen 2.996 N/A LEU 197.A N ALA 193.A O no hydrogen 2.997 N/A TRP 198.A N LYS 194.A O no hydrogen 3.112 N/A SER 199.A N ALA 195.A O no hydrogen 3.389 N/A SER 199.A OG TYR 179.A O no hydrogen 2.699 N/A CYS 200.A N ASP 196.A O no hydrogen 3.014 N/A CYS 200.A SG ASP 196.A O no hydrogen 3.300 N/A GLY 201.A N LEU 197.A O no hydrogen 2.894 N/A VAL 202.A N TRP 198.A O no hydrogen 2.993 N/A ILE 203.A N SER 199.A O no hydrogen 2.963 N/A LEU 204.A N CYS 200.A O no hydrogen 2.861 N/A PHE 205.A N GLY 201.A O no hydrogen 2.997 N/A VAL 206.A N VAL 202.A O no hydrogen 3.057 N/A LEU 207.A N ILE 203.A O no hydrogen 3.082 N/A MET 208.A N LEU 204.A O no hydrogen 3.143 N/A ALA 209.A N PHE 205.A O no hydrogen 2.760 N/A GLY 210.A N VAL 206.A O no hydrogen 2.674 N/A ASN 218.A N ASP 216.A OD1 no hydrogen 2.999 N/A SER 221.A N ASN 218.A OD1 no hydrogen 3.007 N/A SER 221.A OG ASN 218.A OD1 no hydrogen 3.318 N/A LEU 222.A N ASN 218.A O no hydrogen 2.917 N/A TYR 223.A N LEU 219.A O no hydrogen 3.052 N/A LYS 224.A N THR 220.A O no hydrogen 3.036 N/A LYS 225.A N SER 221.A O no hydrogen 2.888 N/A LYS 225.A NZ GLU 215.A O no hydrogen 2.752 N/A LYS 225.A NZ ASP 216.A OD2 no hydrogen 3.049 N/A ILE 226.A N LEU 222.A O no hydrogen 3.048 N/A PHE 227.A N TYR 223.A O no hydrogen 2.900 N/A LYS 228.A N LYS 224.A O no hydrogen 3.137 N/A ALA 229.A N ILE 226.A O no hydrogen 3.023 N/A GLU 230.A N LYS 225.A O no hydrogen 2.968 N/A TRP 236.A NE1 MET 208.A O no hydrogen 2.923 N/A PHE 237.A N PRO 234.A O no hydrogen 3.396 N/A SER 238.A OG GLU 110.A OE2 no hydrogen 3.101 N/A SER 238.A OG SER 240.A OG no hydrogen 3.174 N/A SER 240.A OG SER 238.A OG no hydrogen 3.174 N/A ALA 241.A N SER 238.A OG no hydrogen 3.246 N/A LYS 242.A N SER 238.A O no hydrogen 3.093 N/A LYS 243.A N ALA 239.A O no hydrogen 3.004 N/A LEU 244.A N SER 240.A O no hydrogen 3.083 N/A ILE 245.A N ALA 241.A O no hydrogen 2.926 N/A LYS 246.A N LYS 242.A O no hydrogen 3.126 N/A ARG 247.A N LYS 243.A O no hydrogen 3.327 N/A ARG 247.A N LEU 244.A O no hydrogen 3.050 N/A ILE 248.A N LEU 244.A O no hydrogen 2.997 N/A LEU 249.A N ILE 245.A O no hydrogen 2.776 N/A ASN 252.A N ASP 250.A OD1 no hydrogen 3.037 N/A ALA 254.A N ASN 252.A OD1 no hydrogen 2.964 N/A THR 255.A N ASN 252.A O no hydrogen 3.151 N/A THR 255.A OG1 ASP 250.A OD1 no hydrogen 3.381 N/A THR 255.A OG1 ASP 250.A OD2 no hydrogen 2.580 N/A THR 255.A OG1 ASN 252.A O no hydrogen 3.361 N/A ARG 256.A N ASN 252.A O no hydrogen 2.948 N/A ARG 256.A NE ASP 250.A O no hydrogen 2.852 N/A ARG 256.A NH1 GLU 183.A OE2 no hydrogen 2.653 N/A ARG 256.A NH1 LYS 194.A O no hydrogen 2.844 N/A ARG 256.A NH2 GLU 183.A OE1 no hydrogen 2.878 N/A ARG 256.A NH2 GLU 183.A OE2 no hydrogen 3.450 N/A ARG 256.A NH2 ASP 250.A O no hydrogen 2.905 N/A ILE 257.A N ARG 247.A O no hydrogen 3.277 N/A THR 258.A N GLU 261.A OE1 no hydrogen 2.991 N/A GLU 261.A N THR 258.A OG1 no hydrogen 3.102 N/A VAL 262.A N THR 258.A O no hydrogen 3.017 N/A ILE 263.A N PHE 259.A O no hydrogen 3.109 N/A GLU 264.A N GLU 261.A O no hydrogen 3.177 N/A ASN 265.A N VAL 262.A O no hydrogen 2.907 N/A TRP 267.A NE1 GLU 110.A OE2 no hydrogen 2.805 N/A PHE 268.A N ASN 265.A OD1 no hydrogen 2.826 N/A LYS 269.A N ASN 265.A O no hydrogen 2.975 N/A LYS 269.A NZ GLU 266.A OE2 no hydrogen 2.627 N/A LYS 270.A N TRP 267.A O no hydrogen 3.403 N/A LYS 270.A NZ GLU 266.A O no hydrogen 3.111 N/A TYR 272.A N LYS 269.A O no hydrogen 2.971 N/A TYR 272.A OH ASN 122.A OD1.A no hydrogen 2.171 N/A ALA 284.A N ASP 281.A O no hydrogen 3.073 N/A ALA 284.A N ASP 281.A OD1 no hydrogen 3.189 N/A ILE 285.A N VAL 282.A O no hydrogen 3.221 N/A ASP 287.A N ALA 284.A O no hydrogen 3.070 N/A SER 289.A N ALA 81.A O no hydrogen 2.802 N/A GLY 290.A N ASP 288.A OD1 no hydrogen 2.981 N/A ASN 294.A ND2 SER 5.A O no hydrogen 2.545 N/A ASN 294.A ND2 ARG 7.A O no hydrogen 2.578 N/A VAL 296.A N ASN 294.A OD1 no hydrogen 3.069 N/A VAL 297.A N ASN 294.A O no hydrogen 3.380 N/A