Finding intermodel H-bonds Finding intramodel H-bonds Constraints relaxed by 0.4 angstroms and 20 degrees Models used: #0 4es9_A.cif H-bonds (donor, acceptor, hydrogen, D..A dist, D-H..A dist): LEU 6.A N ILE 192.A O no hydrogen 2.782 N/A MET 7.A N ASP 5.A OD1 no hydrogen 3.097 N/A ASN 8.A N ASN 85.A O no hydrogen 2.811 N/A ASN 8.A ND2 ASP 18.A OD1 no hydrogen 3.192 N/A LYS 10.A N GLY 19.A O no hydrogen 2.928 N/A LYS 10.A NZ ASN 8.A OD1 no hydrogen 3.328 N/A GLU 14.A N THR 12.A OG1 no hydrogen 3.057 N/A ALA 17.A N GLU 14.A O no hydrogen 3.047 N/A SER 20.A N ALA 17.A O no hydrogen 3.381 N/A SER 20.A OG VAL 15.A O no hydrogen 3.039 N/A SER 20.A OG ALA 17.A O no hydrogen 3.230 N/A SER 21.A N THR 12.A O no hydrogen 3.204 N/A GLY 22.A N LYS 83.A O no hydrogen 2.975 N/A ARG 23.A NH1 HIS 36.A O no hydrogen 2.780 N/A ARG 23.A NH2 TRP 13.A O no hydrogen 3.245 N/A PHE 24.A N ALA 81.A O no hydrogen 2.924 N/A PHE 25.A N VAL 34.A O no hydrogen 2.863 N/A SER 26.A N SER 79.A O no hydrogen 2.789 N/A SER 26.A OG THR 30.A O no hydrogen 3.320 N/A SER 26.A OG THR 30.A OG1 no hydrogen 3.314 N/A SER 26.A OG SER 32.A O no hydrogen 2.892 N/A ALA 29.A N SER 26.A O no hydrogen 3.065 N/A THR 30.A N SER 26.A OG no hydrogen 2.759 N/A THR 30.A OG1 SER 26.A OG no hydrogen 3.314 N/A THR 30.A OG1 SER 32.A O no hydrogen 3.452 N/A SER 32.A N THR 30.A OG1 no hydrogen 3.176 N/A TYR 33.A N PHE 126.A O no hydrogen 2.913 N/A TYR 33.A OH SER 79.A OG no hydrogen 2.594 N/A VAL 34.A N PHE 25.A O no hydrogen 3.035 N/A HIS 36.A N ARG 23.A O no hydrogen 2.804 N/A HIS 36.A NE2 SER 57.A OG no hydrogen 2.640 N/A ASP 42.A N PRO 39.A O no hydrogen 2.919 N/A LYS 45.A N ASP 42.A O no hydrogen 2.887 N/A LYS 45.A NZ LYS 41.A O no hydrogen 3.247 N/A LYS 45.A NZ ASP 42.A OD1 no hydrogen 3.118 N/A ARG 49.A N ILE 59.A O no hydrogen 2.801 N/A ARG 49.A NH1 LYS 45.A O no hydrogen 2.986 N/A ARG 49.A NH1 PRO 46.A O no hydrogen 2.775 N/A HIS 51.A N SER 57.A O no hydrogen 2.826 N/A HIS 51.A ND1 ASP 56.A OD1 no hydrogen 2.814 N/A ASN 52.A N LEU 37.A O no hydrogen 2.921 N/A VAL 54.A N ASN 52.A O no hydrogen 2.817 N/A LYS 55.A N HIS 51.A O no hydrogen 2.808 N/A SER 57.A N ASP 56.A OD1 no hydrogen 2.933 N/A SER 57.A OG HIS 36.A NE2 no hydrogen 2.640 N/A SER 57.A OG TYR 78.A OH no hydrogen 2.880 N/A TYR 58.A N ARG 69.A O no hydrogen 2.897 N/A ILE 59.A N ARG 49.A O no hydrogen 2.873 N/A LYS 60.A N ALA 67.A O no hydrogen 2.897 N/A ASP 62.A N SER 65.A O no hydrogen 3.042 N/A GLN 64.A N ASP 62.A OD1 no hydrogen 3.046 N/A SER 65.A N ASP 62.A OD1 no hydrogen 2.781 N/A SER 65.A OG ASP 62.A OD1 no hydrogen 2.794 N/A SER 65.A OG ASP 62.A OD2 no hydrogen 3.278 N/A ILE 66.A N PHE 187.A O no hydrogen 2.974 N/A ALA 67.A N LYS 60.A O no hydrogen 2.783 N/A ALA 68.A N VAL 185.A O no hydrogen 2.908 N/A ARG 69.A N TYR 58.A O no hydrogen 2.809 N/A ARG 69.A NE ASP 184.A OD1 no hydrogen 2.794 N/A ARG 69.A NH2 ASP 184.A OD2 no hydrogen 2.975 N/A TYR 70.A N LEU 183.A O no hydrogen 2.834 N/A TYR 70.A OH SER 173.A OG no hydrogen 2.660 N/A LYS 71.A N ASP 56.A O no hydrogen 2.941 N/A LYS 71.A NZ ASP 182.A OD1 no hydrogen 2.824 N/A LYS 71.A NZ ASP 182.A OD2 no hydrogen 3.463 N/A SER 73.A OG LYS 55.A O no hydrogen 3.108 N/A THR 74.A N LYS 71.A O no hydrogen 3.106 N/A THR 74.A OG1 ASP 56.A O no hydrogen 2.844 N/A THR 74.A OG1 LYS 71.A O no hydrogen 2.936 N/A TYR 78.A N VAL 175.A O no hydrogen 3.088 N/A TYR 78.A OH HIS 51.A ND1 no hydrogen 3.278 N/A TYR 78.A OH SER 57.A OG no hydrogen 2.880 N/A SER 79.A N SER 26.A O no hydrogen 3.267 N/A SER 79.A OG TYR 33.A OH no hydrogen 2.594 N/A SER 79.A OG SER 173.A O no hydrogen 2.707 N/A VAL 80.A N TYR 70.A OH no hydrogen 3.064 N/A VAL 80.A N SER 173.A O no hydrogen 3.272 N/A ALA 81.A N PHE 24.A O no hydrogen 2.905 N/A PHE 82.A N LEU 171.A O no hydrogen 2.905 N/A LYS 83.A N GLY 22.A O no hydrogen 3.089 N/A LYS 83.A NZ SER 116.A O no hydrogen 2.833 N/A VAL 84.A N LEU 169.A O no hydrogen 2.855 N/A ASN 85.A ND2 PHE 118.A O no hydrogen 3.164 N/A THR 86.A N MET 167.A O no hydrogen 2.873 N/A THR 86.A OG1 LYS 87.A O no hydrogen 2.791 N/A THR 86.A OG1 MET 167.A O no hydrogen 3.381 N/A LYS 87.A N LEU 6.A O no hydrogen 2.725 N/A LEU 89.A N GLY 165.A O no hydrogen 2.987 N/A ILE 90.A N TYR 95.A OH no hydrogen 2.819 N/A ASP 92.A N THR 161.A O no hydrogen 3.033 N/A HIS 93.A N THR 161.A OG1 no hydrogen 3.271 N/A HIS 93.A ND1 ASP 194.A OD2 no hydrogen 2.632 N/A HIS 93.A NE2 GLU 227.A O no hydrogen 2.958 N/A ASP 94.A N THR 196.A OG1 no hydrogen 2.846 N/A TYR 95.A N PHE 159.A O no hydrogen 2.965 N/A LYS 96.A N ILE 193.A O no hydrogen 2.871 N/A ILE 97.A N ILE 157.A O no hydrogen 2.748 N/A THR 98.A N LYS 191.A O no hydrogen 2.903 N/A PHE 99.A N LYS 155.A O no hydrogen 3.264 N/A GLU 100.A N LYS 188.A O no hydrogen 2.810 N/A GLN 101.A N GLY 153.A O no hydrogen 2.722 N/A GLN 101.A NE2 GLY 102.A O no hydrogen 3.058 N/A GLY 102.A N GLU 186.A O no hydrogen 2.915 N/A ILE 104.A N GLN 152.A OE1 no hydrogen 3.029 N/A ALA 105.A N ASP 184.A O no hydrogen 3.037 N/A ILE 108.A N ALA 105.A O no hydrogen 3.036 N/A THR 109.A N LYS 174.A O no hydrogen 3.111 N/A VAL 110.A N LYS 148.A O no hydrogen 2.846 N/A ASP 111.A N LEU 172.A O no hydrogen 2.888 N/A TYR 112.A OH GLN 101.A OE1 no hydrogen 2.596 N/A ARG 113.A N VAL 170.A O no hydrogen 3.040 N/A ARG 113.A NE ASP 111.A OD2 no hydrogen 2.937 N/A ARG 113.A NH1 GLU 131.A OE1 no hydrogen 3.001 N/A ARG 113.A NH2 ASP 111.A OD2 no hydrogen 3.491 N/A ILE 114.A N GLU 131.A OE2 no hydrogen 2.932 N/A GLY 115.A N SER 168.A O no hydrogen 3.017 N/A PHE 118.A N ASN 85.A OD1 no hydrogen 2.686 N/A ASN 119.A N ASP 124.A OD2 no hydrogen 2.898 N/A LYS 120.A NZ VAL 15.A O no hydrogen 3.360 N/A LYS 120.A NZ ALA 17.A O no hydrogen 2.456 N/A LYS 120.A NZ SER 20.A OG no hydrogen 2.861 N/A THR 121.A OG1 ASN 119.A OD1 no hydrogen 2.688 N/A ASP 123.A N THR 121.A OG1 no hydrogen 3.345 N/A ASP 124.A N THR 121.A O no hydrogen 3.513 N/A SER 125.A N ASP 124.A OD1 no hydrogen 2.942 N/A PHE 126.A N TYR 33.A O no hydrogen 3.171 N/A LYS 127.A N ASP 130.A OD2 no hydrogen 3.277 N/A LYS 127.A NZ ASP 31.A OD2 no hydrogen 3.165 N/A ILE 128.A N ASP 31.A O no hydrogen 2.906 N/A SER 129.A N ASP 31.A OD1 no hydrogen 2.870 N/A SER 129.A OG ASP 31.A OD1 no hydrogen 3.522 N/A SER 129.A OG ASP 31.A OD2 no hydrogen 2.832 N/A ASP 130.A N LYS 127.A O no hydrogen 3.022 N/A GLU 131.A N ILE 128.A O no hydrogen 3.119 N/A SER 132.A OG SER 129.A O no hydrogen 3.290 N/A LYS 133.A N ASP 130.A O no hydrogen 2.961 N/A TYR 134.A N GLU 131.A O no hydrogen 3.041 N/A ALA 135.A N GLU 131.A O no hydrogen 2.956 N/A SER 136.A N ARG 160.A O no hydrogen 2.865 N/A SER 136.A OG ARG 160.A O no hydrogen 3.496 N/A LYS 139.A N SER 158.A O no hydrogen 2.885 N/A GLU 141.A N THR 156.A O no hydrogen 2.803 N/A GLU 143.A N ILE 140.A O no hydrogen 3.142 N/A GLN 145.A NE2 TYR 112.A O no hydrogen 2.890 N/A GLN 145.A NE2 GLU 131.A OE1 no hydrogen 3.556 N/A GLN 145.A NE2 GLU 131.A OE2 no hydrogen 3.004 N/A GLY 146.A N ASP 111.A OD1 no hydrogen 2.736 N/A LYS 148.A N VAL 110.A O no hydrogen 3.059 N/A ARG 150.A NE VAL 110.A O no hydrogen 2.805 N/A ARG 150.A NH1 GLU 143.A OE1 no hydrogen 2.861 N/A ARG 150.A NH1 GLU 144.A O no hydrogen 3.049 N/A ARG 150.A NH2 VAL 110.A O no hydrogen 3.440 N/A ARG 150.A NH2 GLU 144.A O no hydrogen 2.970 N/A ARG 150.A NH2 GLY 146.A O no hydrogen 2.687 N/A GLY 153.A N GLN 101.A O no hydrogen 2.900 N/A LYS 155.A N PHE 99.A O no hydrogen 2.757 N/A LYS 155.A NZ GLU 143.A OE2 no hydrogen 2.774 N/A LYS 155.A NZ GLU 151.A O no hydrogen 2.794 N/A ILE 157.A N ILE 97.A O no hydrogen 2.790 N/A SER 158.A N LYS 139.A O no hydrogen 2.940 N/A PHE 159.A N TYR 95.A O no hydrogen 3.239 N/A ARG 160.A N SER 136.A O no hydrogen 2.979 N/A ARG 160.A NE ASP 94.A OD1 no hydrogen 2.792 N/A ARG 160.A NH1 ASP 221.A O no hydrogen 2.940 N/A ARG 160.A NH2 ASP 94.A OD1 no hydrogen 3.397 N/A ARG 160.A NH2 ASP 94.A OD2 no hydrogen 3.143 N/A ARG 160.A NH2 ASP 221.A O no hydrogen 3.035 N/A THR 161.A N HIS 93.A O no hydrogen 3.163 N/A THR 161.A OG1 ILE 90.A O no hydrogen 2.666 N/A THR 161.A OG1 HIS 93.A O no hydrogen 3.470 N/A LEU 162.A N TYR 134.A O no hydrogen 2.863 N/A GLY 165.A N LEU 89.A O no hydrogen 2.885 N/A MET 167.A N THR 86.A OG1 no hydrogen 3.051 N/A SER 168.A N GLY 115.A O no hydrogen 2.930 N/A SER 168.A OG SER 116.A O no hydrogen 2.767 N/A LEU 169.A N VAL 84.A O no hydrogen 2.769 N/A VAL 170.A N ARG 113.A O no hydrogen 2.753 N/A LEU 171.A N PHE 82.A O no hydrogen 2.916 N/A LEU 172.A N ASP 111.A O no hydrogen 2.976 N/A SER 173.A N VAL 80.A O no hydrogen 3.166 N/A SER 173.A OG TYR 70.A OH no hydrogen 2.660 N/A LYS 174.A N THR 109.A O no hydrogen 3.000 N/A VAL 175.A N TYR 78.A O no hydrogen 2.996 N/A LYS 178.A NZ THR 72.A O no hydrogen 2.869 N/A LYS 178.A NZ THR 74.A O no hydrogen 2.969 N/A LEU 183.A N TYR 70.A O no hydrogen 2.847 N/A VAL 185.A N ALA 68.A O no hydrogen 2.945 N/A GLU 186.A N GLN 103.A O no hydrogen 3.048 N/A PHE 187.A N ILE 66.A O no hydrogen 2.900 N/A LYS 188.A N GLU 100.A O no hydrogen 2.961 N/A ASN 189.A N GLN 64.A O no hydrogen 3.002 N/A ASN 189.A ND2 GLU 100.A OE2 no hydrogen 2.736 N/A LYS 191.A N THR 98.A O no hydrogen 2.900 N/A ILE 192.A N ASP 5.A OD1 no hydrogen 3.223 N/A ILE 193.A N LYS 96.A O no hydrogen 3.061 N/A VAL 195.A N ASP 94.A O no hydrogen 2.768 N/A THR 196.A N ASP 194.A OD1 no hydrogen 2.923 N/A THR 196.A OG1 ASP 94.A O no hydrogen 3.412 N/A THR 196.A OG1 ASP 194.A OD1 no hydrogen 2.552 N/A SER 199.A N ASP 229.A OD2 no hydrogen 2.966 N/A SER 199.A OG ASP 229.A OD2 no hydrogen 2.803 N/A GLN 200.A N LYS 218.A O no hydrogen 2.819 N/A ASP 202.A N THR 216.A O no hydrogen 2.725 N/A LYS 203.A N THR 216.A O no hydrogen 3.439 N/A VAL 205.A N GLN 214.A O no hydrogen 2.809 N/A GLY 209.A N ALA 263.A O no hydrogen 2.776 N/A ASN 210.A N TYR 207.A O no hydrogen 2.966 N/A ASN 212.A N ASN 210.A OD1 no hydrogen 2.987 N/A VAL 213.A N ILE 256.A O no hydrogen 2.909 N/A GLN 214.A N VAL 205.A O no hydrogen 2.960 N/A LEU 215.A N ILE 254.A O no hydrogen 2.879 N/A THR 216.A N LYS 203.A O no hydrogen 2.844 N/A LEU 217.A N ASN 252.A OD1 no hydrogen 3.008 N/A LYS 218.A N GLN 200.A O no hydrogen 2.793 N/A SER 219.A OG ASP 221.A OD1 no hydrogen 2.765 N/A ARG 223.A NE ASN 225.A O no hydrogen 2.847 N/A ARG 223.A NH1 ASP 229.A OD1 no hydrogen 3.018 N/A ARG 223.A NH1 ASP 229.A OD2 no hydrogen 2.973 N/A ARG 223.A NH2 ASN 225.A O no hydrogen 3.199 N/A ARG 223.A NH2 ASP 229.A OD1 no hydrogen 2.680 N/A THR 224.A N ASP 92.A OD2 no hydrogen 2.629 N/A THR 224.A OG1 ASP 92.A OD2 no hydrogen 3.228 N/A ASN 225.A N ASP 92.A OD2 no hydrogen 2.781 N/A ASN 225.A ND2 LYS 91.A O no hydrogen 2.789 N/A ASN 225.A ND2 GLU 227.A OE1 no hydrogen 3.178 N/A GLU 227.A N ASN 225.A OD1 no hydrogen 3.270 N/A GLY 228.A N VAL 246.A O no hydrogen 3.020 N/A ASP 229.A N PHE 226.A O no hydrogen 3.061 N/A GLU 230.A N LYS 277.A O no hydrogen 2.714 N/A ILE 231.A N VAL 244.A O no hydrogen 2.761 N/A SER 232.A N SER 275.A O no hydrogen 2.899 N/A SER 232.A OG THR 243.A OG1 no hydrogen 3.226 N/A LEU 233.A N GLN 242.A O no hydrogen 2.842 N/A PHE 234.A N LYS 273.A O no hydrogen 2.831 N/A ASN 235.A N GLU 239.A O no hydrogen 2.951 N/A ASN 235.A ND2 GLU 239.A OE1 no hydrogen 2.877 N/A SER 236.A N GLU 270.A OE2 no hydrogen 3.393 N/A SER 236.A OG GLU 270.A OE2 no hydrogen 2.749 N/A ARG 237.A N ASN 235.A OD1 no hydrogen 3.004 N/A GLY 238.A N ASN 235.A O no hydrogen 2.994 N/A GLU 239.A N ASN 235.A OD1 no hydrogen 3.102 N/A LEU 241.A N LEU 233.A O no hydrogen 2.734 N/A GLN 242.A N LEU 233.A O no hydrogen 3.381 N/A GLN 242.A NE2 GLN 262.A OE1 no hydrogen 2.932 N/A THR 243.A OG1 SER 232.A OG no hydrogen 3.226 N/A VAL 244.A N ILE 231.A O no hydrogen 2.934 N/A VAL 246.A N ASP 229.A O no hydrogen 3.046 N/A THR 247.A N GLN 250.A OE1 no hydrogen 3.212 N/A THR 247.A OG1 GLN 250.A OE1 no hydrogen 3.344 N/A ASP 249.A N ASN 225.A OD1 no hydrogen 2.780 N/A GLN 250.A N THR 247.A O no hydrogen 3.189 N/A ASN 252.A ND2 LEU 217.A O no hydrogen 2.845 N/A ILE 254.A N LEU 215.A O no hydrogen 2.706 N/A ILE 256.A N VAL 213.A O no hydrogen 2.922 N/A LEU 258.A N LYS 211.A O no hydrogen 2.741 N/A SER 259.A N GLN 262.A OE1 no hydrogen 2.955 N/A GLN 262.A N SER 259.A OG no hydrogen 3.295 N/A GLN 262.A NE2 LEU 241.A O no hydrogen 2.932 N/A ALA 263.A N SER 259.A O no hydrogen 2.988 N/A LYS 264.A N GLU 260.A O no hydrogen 3.027 N/A SER 265.A N ASP 261.A O no hydrogen 2.977 N/A SER 265.A OG ASP 261.A O no hydrogen 2.834 N/A LYS 267.A N GLU 270.A OE1 no hydrogen 3.454 N/A LYS 269.A N VAL 292.A O no hydrogen 2.794 N/A GLU 270.A N LYS 267.A O no hydrogen 3.222 N/A LEU 272.A N PHE 290.A O no hydrogen 2.760 N/A LYS 273.A N PHE 234.A O no hydrogen 2.926 N/A VAL 274.A N PHE 288.A O no hydrogen 2.788 N/A SER 275.A N SER 232.A O no hydrogen 3.112 N/A ILE 276.A N SER 285.A OG no hydrogen 2.982 N/A LYS 277.A N GLU 230.A O no hydrogen 2.907 N/A GLN 278.A N LYS 283.A O no hydrogen 2.809 N/A GLN 278.A NE2 ASP 229.A OD1 no hydrogen 3.001 N/A GLN 278.A NE2 GLN 280.A OE1 no hydrogen 2.941 N/A LYS 279.A N GLY 228.A O no hydrogen 3.018 N/A GLN 280.A N GLN 278.A OE1 no hydrogen 2.926 N/A SER 281.A N GLN 278.A OE1 no hydrogen 2.996 N/A SER 281.A OG THR 196.A O no hydrogen 2.521 N/A LYS 282.A N GLN 278.A O no hydrogen 2.831 N/A LYS 282.A NZ LEU 2.A O no hydrogen 3.051 N/A LYS 283.A N SER 281.A OG no hydrogen 3.342 N/A LYS 283.A NZ VAL 195.A O no hydrogen 2.761 N/A SER 285.A N ILE 276.A O no hydrogen 2.791 N/A SER 285.A OG ILE 276.A O no hydrogen 3.408 N/A SER 285.A OG LYS 286.A O no hydrogen 2.846 N/A PHE 288.A N VAL 274.A O no hydrogen 2.860 N/A PHE 290.A N LEU 272.A O no hydrogen 3.097 N/A VAL 292.A N GLU 270.A O no hydrogen 2.879 N/A GLY 293.A N ALA 206.A O no hydrogen 2.872 N/A