Finding intermodel H-bonds Finding intramodel H-bonds Constraints relaxed by 0.4 angstroms and 20 degrees Models used: #0 4hvs_A.cif H-bonds (donor, acceptor, hydrogen, D..A dist, D-H..A dist): HIS 2.A ND1 ASN 223.A O no hydrogen 2.656 N/A MET 5.A N HIS 2.A O no hydrogen 2.937 N/A TYR 6.A N MET 3.A O no hydrogen 2.853 N/A GLU 7.A N MET 3.A O no hydrogen 3.187 N/A LYS 11.A N ILE 184.A O no hydrogen 2.965 N/A VAL 13.A N ASN 182.A O no hydrogen 2.886 N/A GLU 14.A N SER 22.A O no hydrogen 2.867 N/A SER 16.A N ASN 20.A O no hydrogen 2.890 N/A SER 16.A OG ASN 17.A OD1 no hydrogen 3.327 N/A ASN 20.A N ASN 17.A O no hydrogen 2.929 N/A SER 22.A N GLU 14.A O no hydrogen 2.905 N/A ILE 24.A N VAL 12.A O no hydrogen 2.711 N/A THR 27.A N ASP 25.A OD1 no hydrogen 2.980 N/A THR 27.A OG1 ASP 25.A OD1 no hydrogen 2.795 N/A THR 27.A OG1 ASP 25.A OD2 no hydrogen 3.202 N/A GLN 28.A N ASP 25.A O no hydrogen 2.922 N/A LEU 29.A N PRO 26.A O no hydrogen 3.113 N/A TYR 31.A OH GLU 36.A OE2 no hydrogen 2.694 N/A LYS 34.A N ASP 32.A OD1 no hydrogen 3.297 N/A TRP 35.A N ASP 32.A O no hydrogen 3.075 N/A GLU 36.A N HIS 33.A O no hydrogen 3.122 N/A PHE 37.A N ALA 112.A O no hydrogen 2.830 N/A ARG 39.A NH1 HIS 115.A O no hydrogen 3.064 N/A ARG 39.A NH1 PRO 118.A O no hydrogen 2.804 N/A ARG 39.A NH2 PRO 118.A O no hydrogen 2.832 N/A ARG 41.A N PRO 38.A O no hydrogen 2.995 N/A ARG 41.A NE GLN 62.A O no hydrogen 2.669 N/A LEU 42.A N ARG 39.A O no hydrogen 3.275 N/A SER 43.A N THR 60.A O no hydrogen 2.935 N/A GLY 45.A N GLU 58.A O no hydrogen 2.679 N/A LYS 46.A NZ GLU 58.A OE1 no hydrogen 2.583 N/A LEU 48.A N VAL 56.A O no hydrogen 2.662 N/A GLY 49.A N VAL 56.A O no hydrogen 3.218 N/A GLY 51.A N GLY 54.A O no hydrogen 2.940 N/A LYS 55.A N MET 77.A O no hydrogen 2.747 N/A VAL 56.A N GLY 49.A O no hydrogen 2.871 N/A VAL 57.A N VAL 75.A O no hydrogen 2.916 N/A GLU 58.A N LYS 46.A O no hydrogen 2.778 N/A ALA 59.A N VAL 73.A O no hydrogen 2.935 N/A THR 60.A N SER 43.A O no hydrogen 2.963 N/A ALA 61.A N MET 71.A O no hydrogen 2.785 N/A GLN 62.A N ARG 41.A O no hydrogen 2.874 N/A GLY 63.A N ALA 69.A O no hydrogen 2.687 N/A ALA 69.A N LYS 66.A O no hydrogen 2.956 N/A MET 71.A N ALA 61.A O no hydrogen 2.970 N/A VAL 73.A N ALA 59.A O no hydrogen 2.861 N/A ALA 74.A N THR 123.A O no hydrogen 2.887 N/A VAL 75.A N VAL 57.A O no hydrogen 2.808 N/A LYS 76.A N VAL 121.A O no hydrogen 2.857 N/A LYS 76.A NZ GLU 93.A OE1 no hydrogen 2.737 N/A LYS 76.A NZ GLU 93.A OE2 no hydrogen 3.418 N/A LYS 76.A NZ ASP 205.A O no hydrogen 2.874 N/A LYS 76.A NZ PHE 206.A O no hydrogen 3.157 N/A MET 77.A N LYS 55.A O no hydrogen 2.945 N/A LYS 79.A N PHE 53.A O no hydrogen 2.849 N/A LYS 79.A NZ GLY 51.A O no hydrogen 2.676 N/A LYS 79.A NZ ALA 52.A O no hydrogen 3.289 N/A ALA 82.A N LYS 79.A O no hydrogen 3.049 N/A HIS 83.A N GLU 86.A OE2 no hydrogen 2.710 N/A HIS 83.A ND1 HIS 1.A NE2 no hydrogen 2.618 N/A THR 85.A OG1 GLU 86.A OE1 no hydrogen 3.116 N/A ARG 87.A N HIS 83.A O no hydrogen 3.068 N/A ARG 87.A NH1 ALA 82.A O no hydrogen 2.669 N/A GLU 88.A N SER 84.A O no hydrogen 2.801 N/A ALA 89.A N THR 85.A O no hydrogen 2.982 N/A LEU 90.A N GLU 86.A O no hydrogen 2.996 N/A MET 91.A N ARG 87.A O no hydrogen 3.249 N/A SER 92.A N GLU 88.A O no hydrogen 2.855 N/A SER 92.A OG GLU 88.A O no hydrogen 3.220 N/A GLU 93.A N ALA 89.A O no hydrogen 2.877 N/A LEU 94.A N LEU 90.A O no hydrogen 3.108 N/A LYS 95.A N MET 91.A O no hydrogen 2.910 N/A LYS 95.A NZ THR 27.A O no hydrogen 2.806 N/A VAL 96.A N SER 92.A O no hydrogen 3.014 N/A LEU 97.A N GLU 93.A O no hydrogen 3.006 N/A SER 98.A N LEU 94.A O no hydrogen 2.853 N/A TYR 99.A N LYS 95.A O no hydrogen 2.858 N/A TYR 99.A OH LYS 181.A O no hydrogen 2.585 N/A LEU 100.A N VAL 96.A O no hydrogen 2.812 N/A GLY 101.A N LEU 97.A O no hydrogen 3.415 N/A HIS 103.A N ASN 108.A OD1 no hydrogen 3.079 N/A ASN 105.A N HIS 103.A ND1 no hydrogen 2.958 N/A ASN 105.A ND2 GLN 170.A OE1 no hydrogen 3.075 N/A ASN 105.A ND2 THR 201.A O no hydrogen 3.107 N/A ILE 106.A N HIS 103.A O no hydrogen 3.325 N/A VAL 107.A N ILE 203.A O no hydrogen 2.875 N/A ASN 108.A N GLU 124.A OE1 no hydrogen 2.834 N/A ASN 108.A ND2 HIS 103.A O no hydrogen 2.819 N/A ASN 108.A ND2 GLU 124.A OE1 no hydrogen 2.892 N/A LEU 110.A N ILE 122.A O no hydrogen 2.866 N/A GLY 111.A N ILE 122.A O no hydrogen 3.210 N/A ALA 112.A N TRP 35.A O no hydrogen 3.007 N/A CYS 113.A N LEU 120.A O no hydrogen 3.014 N/A CYS 113.A SG PHE 37.A O no hydrogen 3.162 N/A THR 114.A N GLU 36.A OE1 no hydrogen 2.823 N/A THR 114.A OG1 GLU 36.A OE1 no hydrogen 3.345 N/A THR 114.A OG1 GLU 36.A OE2 no hydrogen 2.710 N/A LEU 120.A N CYS 113.A O no hydrogen 2.911 N/A VAL 121.A N LYS 76.A O no hydrogen 2.859 N/A ILE 122.A N GLY 111.A O no hydrogen 2.796 N/A THR 123.A N ALA 74.A O no hydrogen 2.770 N/A THR 123.A OG1 ALA 74.A O no hydrogen 3.446 N/A THR 123.A OG1 GLU 124.A O no hydrogen 3.343 N/A GLU 124.A N ASN 108.A O no hydrogen 3.015 N/A TYR 128.A N LEU 195.A O no hydrogen 2.967 N/A GLY 129.A N CYS 126.A O no hydrogen 3.077 N/A LEU 131.A N ILE 193.A O no hydrogen 2.608 N/A LEU 132.A N ALA 190.A O no hydrogen 3.287 N/A ASN 133.A N ASP 130.A OD2 no hydrogen 2.923 N/A ASN 133.A ND2 ASP 130.A OD1 no hydrogen 3.555 N/A ASN 133.A ND2 ASP 130.A OD2 no hydrogen 2.930 N/A PHE 134.A N ASP 130.A O no hydrogen 3.170 N/A LEU 135.A N LEU 131.A O no hydrogen 2.893 N/A ARG 136.A N LEU 132.A O no hydrogen 3.079 N/A ARG 136.A NE GLY 261.A O no hydrogen 2.718 N/A ARG 136.A NH1 GLY 261.A O no hydrogen 3.326 N/A ARG 137.A N ASN 133.A O no hydrogen 2.949 N/A LYS 138.A N PHE 134.A O no hydrogen 2.887 N/A LYS 138.A NZ ASN 157.A O no hydrogen 2.815 N/A ARG 139.A N ARG 136.A O no hydrogen 3.465 N/A ARG 139.A NH1 SER 262.A OG no hydrogen 3.381 N/A ARG 139.A NH2 SER 262.A OG no hydrogen 2.909 N/A SER 141.A N LYS 138.A O no hydrogen 2.954 N/A SER 141.A OG LYS 138.A O no hydrogen 3.083 N/A PHE 142.A N ARG 139.A O no hydrogen 3.365 N/A HIS 143.A N LEU 159.A O no hydrogen 2.646 N/A ALA 150.A N SER 148.A OG no hydrogen 2.980 N/A SER 151.A N SER 148.A O no hydrogen 2.819 N/A SER 151.A OG SER 148.A O no hydrogen 2.943 N/A MET 152.A N PRO 149.A O no hydrogen 3.154 N/A ASN 157.A N ASP 154.A O no hydrogen 2.947 N/A ASN 157.A ND2 ASP 154.A OD2 no hydrogen 2.623 N/A ALA 158.A N ASP 155.A O no hydrogen 3.286 N/A LEU 159.A N SER 141.A O no hydrogen 3.491 N/A ASP 160.A N ASP 163.A OD1 no hydrogen 2.896 N/A ASP 163.A N ASP 160.A OD1 no hydrogen 3.087 N/A LEU 164.A N ASP 160.A O no hydrogen 3.242 N/A LEU 165.A N LEU 161.A O no hydrogen 2.866 N/A SER 166.A N GLU 162.A O no hydrogen 2.948 N/A PHE 167.A N ASP 163.A O no hydrogen 2.871 N/A SER 168.A N LEU 164.A O no hydrogen 3.064 N/A SER 168.A OG LEU 165.A O no hydrogen 2.759 N/A TYR 169.A N LEU 165.A O no hydrogen 3.031 N/A TYR 169.A OH GLU 320.A OE2 no hydrogen 3.151 N/A GLN 170.A N SER 166.A O no hydrogen 2.903 N/A GLN 170.A NE2 SER 166.A O no hydrogen 3.655 N/A GLN 170.A NE2 SER 166.A OG no hydrogen 2.873 N/A GLN 170.A NE2 ARG 199.A O no hydrogen 3.248 N/A VAL 171.A N PHE 167.A O no hydrogen 2.990 N/A ALA 172.A N SER 168.A O no hydrogen 3.084 N/A LYS 173.A N TYR 169.A O no hydrogen 2.925 N/A GLY 174.A N GLN 170.A O no hydrogen 3.013 N/A MET 175.A N VAL 171.A O no hydrogen 2.966 N/A ALA 176.A N ALA 172.A O no hydrogen 2.843 N/A PHE 177.A N LYS 173.A O no hydrogen 3.031 N/A LEU 178.A N GLY 174.A O no hydrogen 3.005 N/A ALA 179.A N MET 175.A O no hydrogen 2.899 N/A SER 180.A N ALA 176.A O no hydrogen 2.962 N/A SER 180.A OG PHE 177.A O no hydrogen 2.557 N/A LYS 181.A N LEU 178.A O no hydrogen 2.964 N/A ASN 182.A N ALA 179.A O no hydrogen 2.931 N/A ASN 182.A ND2 VAL 13.A O no hydrogen 3.479 N/A CYS 183.A N LEU 178.A O no hydrogen 2.907 N/A CYS 183.A SG LYS 11.A O no hydrogen 3.995 N/A ILE 184.A N LYS 11.A O no hydrogen 2.764 N/A HIS 185.A N ASP 246.A OD1 no hydrogen 2.779 N/A HIS 185.A NE2 CYS 204.A O no hydrogen 2.756 N/A ARG 186.A N ASP 246.A OD2 no hydrogen 2.970 N/A ARG 186.A NE GLN 9.A O no hydrogen 2.743 N/A ARG 186.A NH2 GLN 9.A O no hydrogen 2.832 N/A ASP 187.A N HIS 185.A ND1 no hydrogen 3.065 N/A ALA 190.A N GLU 256.A OE2 no hydrogen 2.827 N/A ARG 191.A NE TYR 218.A OH no hydrogen 2.816 N/A ARG 191.A NH1 ASP 187.A OD2 no hydrogen 2.999 N/A ASN 192.A N ALA 189.A O no hydrogen 2.886 N/A ASN 192.A ND2 ASP 187.A O no hydrogen 2.814 N/A ILE 193.A N ALA 190.A O no hydrogen 3.209 N/A LEU 194.A N LYS 202.A O no hydrogen 2.718 N/A LEU 195.A N GLY 129.A O no hydrogen 2.906 N/A THR 196.A N ILE 200.A O no hydrogen 2.894 N/A HIS 197.A N THR 196.A OG1 no hydrogen 2.621 N/A ARG 199.A NH1 ASN 157.A O no hydrogen 3.169 N/A ARG 199.A NH1 ALA 158.A O no hydrogen 3.318 N/A ARG 199.A NH2 ALA 158.A O no hydrogen 3.030 N/A ARG 199.A NH2 ASP 163.A OD2 no hydrogen 3.298 N/A ILE 200.A N THR 196.A O no hydrogen 3.310 N/A THR 201.A N GLN 170.A OE1 no hydrogen 3.046 N/A LYS 202.A N LEU 194.A O no hydrogen 2.878 N/A LYS 202.A NZ GLU 104.A O no hydrogen 2.804 N/A LYS 202.A NZ ILE 106.A O no hydrogen 2.973 N/A LYS 202.A NZ GLU 124.A OE1 no hydrogen 2.784 N/A ILE 203.A N ASN 105.A O no hydrogen 3.068 N/A CYS 204.A N ASN 192.A O no hydrogen 2.951 N/A PHE 206.A N ASN 192.A OD1 no hydrogen 3.394 N/A GLY 207.A N ASP 205.A OD1 no hydrogen 2.856 N/A ALA 209.A N PHE 206.A O no hydrogen 2.992 N/A ARG 210.A N GLY 207.A O no hydrogen 3.143 N/A ARG 210.A NH1 ASN 192.A OD1 no hydrogen 2.974 N/A ARG 210.A NH2 ASN 192.A OD1 no hydrogen 3.086 N/A ARG 210.A NH2 ASP 205.A OD1 no hydrogen 3.301 N/A ASN 214.A N ASP 211.A O no hydrogen 3.216 N/A ASN 214.A ND2 ASP 211.A OD1 no hydrogen 3.547 N/A ASN 214.A ND2 ASP 211.A OD2 no hydrogen 2.777 N/A ASP 215.A N ILE 212.A O no hydrogen 3.133 N/A ASN 217.A N ASP 215.A OD1 no hydrogen 2.959 N/A ASN 217.A ND2 ASP 215.A OD1 no hydrogen 2.840 N/A TYR 218.A N ASP 215.A O no hydrogen 3.014 N/A TYR 218.A OH ASP 187.A OD1 no hydrogen 2.668 N/A TYR 218.A OH ASP 187.A OD2 no hydrogen 3.414 N/A VAL 219.A N LEU 226.A O no hydrogen 2.835 N/A LYS 221.A N ALA 224.A O no hydrogen 2.894 N/A LYS 221.A NZ ILE 236.A O no hydrogen 3.123 N/A ARG 225.A N PRO 4.A O no hydrogen 3.183 N/A ARG 225.A NE ASP 220.A OD1 no hydrogen 3.212 N/A ARG 225.A NH1 MET 5.A O no hydrogen 2.882 N/A LEU 226.A N VAL 219.A O no hydrogen 2.850 N/A VAL 228.A N LEU 226.A O no hydrogen 2.785 N/A LYS 229.A NZ PRO 264.A O no hydrogen 3.155 N/A LYS 229.A NZ TYR 265.A O no hydrogen 2.931 N/A LYS 229.A NZ MET 268.A O no hydrogen 2.760 N/A TRP 230.A N PRO 227.A O no hydrogen 2.850 N/A TRP 230.A NE1 GLU 256.A OE2 no hydrogen 2.993 N/A MET 231.A N VAL 228.A O no hydrogen 2.931 N/A GLU 234.A N GLU 234.A OE1 no hydrogen 2.673 N/A SER 235.A N ALA 232.A O no hydrogen 3.026 N/A SER 235.A OG VAL 240.A O no hydrogen 2.847 N/A ILE 236.A N ALA 232.A O no hydrogen 3.121 N/A PHE 237.A N PRO 233.A O no hydrogen 2.998 N/A ASN 238.A N GLU 234.A O no hydrogen 2.925 N/A SER 239.A N SER 235.A O no hydrogen 3.023 N/A VAL 240.A N GLU 234.A O no hydrogen 3.126 N/A THR 242.A N SER 245.A OG no hydrogen 2.852 N/A GLU 244.A N GLU 244.A OE2 no hydrogen 2.966 N/A SER 245.A N THR 242.A O no hydrogen 3.166 N/A SER 245.A N THR 242.A OG1 no hydrogen 3.121 N/A SER 245.A OG THR 242.A O no hydrogen 2.870 N/A ASP 246.A N THR 242.A O no hydrogen 3.249 N/A VAL 247.A N PHE 243.A O no hydrogen 3.141 N/A TRP 248.A N GLU 244.A O no hydrogen 3.234 N/A SER 249.A N SER 245.A O no hydrogen 3.215 N/A SER 249.A OG TRP 230.A O no hydrogen 2.772 N/A SER 249.A OG SER 245.A O no hydrogen 3.276 N/A TYR 250.A N ASP 246.A O no hydrogen 2.913 N/A TYR 250.A OH SER 168.A O no hydrogen 2.644 N/A GLY 251.A N VAL 247.A O no hydrogen 2.995 N/A ILE 252.A N TRP 248.A O no hydrogen 3.115 N/A PHE 253.A N SER 249.A O no hydrogen 2.774 N/A LEU 254.A N TYR 250.A O no hydrogen 2.885 N/A TRP 255.A N GLY 251.A O no hydrogen 3.043 N/A GLU 256.A N ILE 252.A O no hydrogen 2.972 N/A LEU 257.A N PHE 253.A O no hydrogen 2.827 N/A PHE 258.A N LEU 254.A O no hydrogen 2.907 N/A SER 259.A N TRP 255.A O no hydrogen 3.000 N/A SER 259.A OG TRP 255.A O no hydrogen 2.710 N/A LEU 260.A N LEU 257.A O no hydrogen 3.039 N/A GLY 261.A N GLU 256.A O no hydrogen 2.707 N/A SER 262.A OG SER 259.A O no hydrogen 3.211 N/A MET 268.A N TYR 265.A O no hydrogen 3.135 N/A PHE 274.A N ASP 271.A OD2 no hydrogen 3.086 N/A TYR 275.A N ASP 271.A O no hydrogen 3.268 N/A LYS 276.A N SER 272.A O no hydrogen 3.051 N/A MET 277.A N LYS 273.A O no hydrogen 3.036 N/A ILE 278.A N PHE 274.A O no hydrogen 2.993 N/A LYS 279.A N TYR 275.A O no hydrogen 2.992 N/A GLU 280.A N LYS 276.A O no hydrogen 2.911 N/A GLY 281.A N ILE 278.A O no hydrogen 3.121 N/A PHE 282.A N MET 277.A O no hydrogen 2.909 N/A ARG 283.A NE TRP 302.A O no hydrogen 2.901 N/A ARG 283.A NH1 ILE 278.A O no hydrogen 3.084 N/A ARG 283.A NH1 PHE 282.A O no hydrogen 2.815 N/A ARG 283.A NH2 TRP 302.A O no hydrogen 3.221 N/A SER 286.A OG PRO 287.A O no hydrogen 3.170 N/A ALA 290.A N PRO 287.A O no hydrogen 3.156 N/A MET 294.A N PRO 291.A O no hydrogen 2.887 N/A TYR 295.A N PRO 291.A O no hydrogen 2.928 N/A TYR 295.A OH MET 284.A O no hydrogen 2.995 N/A ASP 296.A N ALA 292.A O no hydrogen 2.853 N/A ILE 297.A N GLU 293.A O no hydrogen 3.299 N/A MET 298.A N MET 294.A O no hydrogen 3.119 N/A LYS 299.A N TYR 295.A O no hydrogen 3.046 N/A THR 300.A N ASP 296.A O no hydrogen 3.289 N/A THR 300.A OG1 ASP 296.A O no hydrogen 3.543 N/A THR 300.A OG1 ILE 297.A O no hydrogen 2.669 N/A CYS 301.A N ILE 297.A O no hydrogen 2.955 N/A CYS 301.A SG VAL 247.A O no hydrogen 3.599 N/A CYS 301.A SG ILE 297.A O no hydrogen 3.417 N/A TRP 302.A N MET 298.A O no hydrogen 3.132 N/A TRP 302.A N LYS 299.A O no hydrogen 3.147 N/A ASP 303.A N THR 300.A O no hydrogen 3.312 N/A ASP 305.A N ASP 303.A OD2 no hydrogen 3.019 N/A ASP 307.A N ASP 305.A OD2 no hydrogen 3.079 N/A LYS 308.A N ASP 305.A O no hydrogen 2.931 N/A ARG 309.A N PRO 306.A O no hydrogen 3.172 N/A ARG 309.A NE ASP 303.A O no hydrogen 2.814 N/A ARG 309.A NH1 GLU 234.A OE2 no hydrogen 2.666 N/A ARG 309.A NH1 GLU 244.A O no hydrogen 2.907 N/A ARG 309.A NH2 GLU 234.A OE1 no hydrogen 2.957 N/A ARG 309.A NH2 GLU 234.A OE2 no hydrogen 3.433 N/A ARG 309.A NH2 ASP 303.A O no hydrogen 3.046 N/A THR 311.A N GLN 314.A OE1 no hydrogen 3.040 N/A GLN 314.A N THR 311.A OG1 no hydrogen 3.125 N/A ILE 315.A N THR 311.A O no hydrogen 3.065 N/A VAL 316.A N PHE 312.A O no hydrogen 2.887 N/A GLN 317.A N LYS 313.A O no hydrogen 3.258 N/A ASP 318.A N GLN 314.A O no hydrogen 2.826 N/A ILE 319.A N ILE 315.A O no hydrogen 2.859 N/A GLU 320.A N VAL 316.A O no hydrogen 2.880 N/A LYS 321.A N GLN 317.A O no hydrogen 3.422 N/A GLN 322.A N ASP 318.A O no hydrogen 3.278 N/A GLN 322.A NE2 ASP 318.A OD1 no hydrogen 3.037 N/A ILE 323.A N ILE 319.A O no hydrogen 2.941 N/A SER 324.A N GLU 320.A O no hydrogen 3.006 N/A GLU 325.A N LYS 321.A O no hydrogen 2.748 N/A SER 326.A N ILE 323.A O no hydrogen 3.171 N/A SER 326.A OG GLN 322.A O no hydrogen 3.362 N/A