1ALKA

Reaction mechanism of alkaline phosphatase based on crystal structures. two metal ion catalysis
Total Genus 158
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
158
Knots found
sequence length
449
structure length
449
Chain Sequence
TPEMPVLENRAAQGNITAPGGARRLTGDQTAALRNSLSDKPAKNIILLIGDGMGDSEITAARNYAEGAGGFFKGIDALPLTGQYTHYALNKKTGKPDYVTDSAASATAWSTGVKTYNGALGVDIHEKDHPTILEMAKAAGLATGNVSTAELQDATPAALVAHVTSRKCYGPSATSQKCPGNALEKGGKGSITEQLLNARADVTLGGGAKTFAETATAGEWQGKTLREEAEARGYQLVSDAASLNSVTEANQQKPLLGLFADGNMPVRWLGPKATYHGNIDKPAVTCTPNPQRNDSVPTLAQMTDKAIELLSKNEKGFFLQVEGASIDKQDHAANPCGQIGETVDLDEAVQRALEFAKKEGNTLVIVTADHAHASQIVAPDTKAPGLTQALNTKDGAVMVMSYGNSEEDSQEHTGSQLRIAAYGPHAANVVGLTDQTDLFYTMKAALGLK
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

molecule tags Alkaline phosphatase
molecule keywords ALKALINE PHOSPHATASE
publication title Reaction mechanism of alkaline phosphatase based on crystal structures. Two-metal ion catalysis.
pubmed doi rcsb
source organism Escherichia coli
total genus 158
structure length 449
sequence length 449
chains with identical sequence B
other databases KnotProt 2.0: S +31
ec nomenclature ec 3.1.3.1: Alkaline phosphatase.
pdb deposition date 1993-03-03

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00245 Alk_phosphatase Alkaline phosphatase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.720.10 Alpha Beta 3-Layer(aba) Sandwich Alkaline Phosphatase, subunit A Alkaline Phosphatase, subunit A 1alkA00
2XR9A 3CMRA 1B8JA 1HQAA 3UN2A 3NVLA 1KHNA 4MY4A 3IGYB 5IJQA 1EJJA 3MK2A 4LR2A 5TJ3A 3T01A 4B56A 1AJAA 3SZYA 4N7TA 2W5VA 1AJBA 1EQJA 2GLQA 3NKRA 1EW2A 2GSUA 1URBA 2W5SA 4LR9A 5EGHA 3Q3QA 5KXAA 1E33P 2W8SA 3KD8A 4FDJA 4UPHA 3BDFA 4UPLA 4LQYA 3WAVA 4ZGAA 5IJSA 4KM4A 3DPCA 3M8ZA 4NWXA 3MK0A 5LRMA 1ALHA 1ALIA 1ANJA 4CXUA 5HRTA 4ZG9A 2W5RA 2W5TA 1EW8A 4QAXA 2X98A 1EI6A 4GTWA 4GTYA 1ELYA 2IUCB 2W5QA 3BDHA 1ELZA 5EGEA 5C66A 4LREA 4LR8A 5L0EA 3WAXA 1E3CP 1EW9A 3NKOA 2W5XA 1AJCA 4UORA 2G9YA 5K4PA 4ZG6A 1N2KA 3M8WA 1ED8A 3E2DA 2IFYA 3A52A 1SHQA 4NWJA 5LIAA 4GTXA 1ANIA 1K7HA 1N2LA 3UN3A 5L0KA 3M8YA 1HDHA 3UO0A 3TX0A 1ZEFA 5DLWA 4CYRA 5LQQA 1P49A 5DLVA 2GSNA 5GOVA 1KHLA 3BDGB 4LRAA 2GA3A 1ZEBA 4KJDA 2IUCA 4LRCA 1O99A 5DLTA 5L0BA 1ALJA 3IDDA 4KAYA 3TG0A 3ED4A 5INHA 1FSUA 1AUKA 1KH4A 5AJ9A 1KH5A 3MK1A 3M7VA 2RH6A 1ZEDA 4LRDA 3TWZA 4LR7A 1O98A 2GSOA 1KH7A 3NKMA 3T02A 4CYSA 2XRGA 2ANHA 3WBHA 3IGZB 1ED9A 4LRBA 3WAYA 2W8DA 4KAVA 4UOOA 5GRRA 2W5WA 1KHJA 3BDGA 4UOPA 1ALKA 1Y6VA 1SHNA 3NKNA 4MIVA 3T00A 4TN0A 3OT9A 4UPKA 4CXSA 1Y7AA 4YR1A 1KHKA 3WAWA 4CXKA 4FDIA 3NKPA 4MHXA 4ZG7A 3UNYA 1URAA 2ZKTA 3NKQA 3UN5A 1KH9A 1AJDA 4GTZA 1ELXA 1E1ZP 3B5QA 5LRNA 1HJKA 4KJGA 4LRFA 3LXQA 1E2SP 4UPIA 2D1GA 3SZZA 2VQRA 3DYCA 2QZUA
chains in the Genus database with same CATH superfamily
2XR9A 3CMRA 1B8JA 1HQAA 3UN2A 3NVLA 1KHNA 4MY4A 3IGYB 5IJQA 1EJJA 3MK2A 4LR2A 5TJ3A 3T01A 4B56A 1AJAA 3SZYA 4N7TA 2W5VA 1AJBA 1EQJA 2GLQA 3NKRA 1EW2A 2GSUA 1URBA 2W5SA 4LR9A 5EGHA 3Q3QA 5KXAA 1E33P 2W8SA 3KD8A 4FDJA 4UPHA 3BDFA 4UPLA 4LQYA 3WAVA 4ZGAA 5IJSA 4KM4A 3DPCA 3M8ZA 4NWXA 3MK0A 5LRMA 1ALHA 1ALIA 1ANJA 4CXUA 5HRTA 4ZG9A 2W5RA 2W5TA 1EW8A 4QAXA 2X98A 1EI6A 4GTWA 4GTYA 1ELYA 2IUCB 2W5QA 3BDHA 1ELZA 5EGEA 5C66A 4LREA 4LR8A 5L0EA 3WAXA 1E3CP 1EW9A 3NKOA 2W5XA 1AJCA 4UORA 2G9YA 5K4PA 4ZG6A 1N2KA 3M8WA 1ED8A 3E2DA 2IFYA 3A52A 1SHQA 4NWJA 5LIAA 4GTXA 1ANIA 1K7HA 1N2LA 3UN3A 5L0KA 3M8YA 1HDHA 3UO0A 3TX0A 1ZEFA 5DLWA 4CYRA 5LQQA 1P49A 5DLVA 2GSNA 5GOVA 1KHLA 3BDGB 4LRAA 2GA3A 1ZEBA 4KJDA 2IUCA 4LRCA 1O99A 5DLTA 5L0BA 1ALJA 3IDDA 4KAYA 3TG0A 3ED4A 5INHA 1FSUA 1AUKA 1KH4A 5AJ9A 1KH5A 3MK1A 3M7VA 2RH6A 1ZEDA 4LRDA 3TWZA 4LR7A 1O98A 2GSOA 1KH7A 3NKMA 3T02A 4CYSA 2XRGA 2ANHA 3WBHA 3IGZB 1ED9A 4LRBA 3WAYA 2W8DA 4KAVA 4UOOA 5GRRA 2W5WA 1KHJA 3BDGA 4UOPA 1ALKA 1Y6VA 1SHNA 3NKNA 4MIVA 3T00A 4TN0A 3OT9A 4UPKA 4CXSA 1Y7AA 4YR1A 1KHKA 3WAWA 4CXKA 4FDIA 3NKPA 4MHXA 4ZG7A 3UNYA 1URAA 2ZKTA 3NKQA 3UN5A 1KH9A 1AJDA 4GTZA 1ELXA 1E1ZP 3B5QA 5LRNA 1HJKA 4KJGA 4LRFA 3LXQA 1E2SP 4UPIA 2D1GA 3SZZA 2VQRA 3DYCA 2QZUA
chains in the Genus database with same CATH topology
2XR9A 3CMRA 1B8JA 1HQAA 3UN2A 3NVLA 1KHNA 4MY4A 3IGYB 5IJQA 1EJJA 3MK2A 4LR2A 5TJ3A 3T01A 4B56A 1AJAA 3SZYA 4N7TA 2W5VA 1AJBA 1EQJA 2GLQA 3NKRA 1EW2A 2GSUA 1URBA 2W5SA 4LR9A 5EGHA 3Q3QA 5KXAA 1E33P 2W8SA 3KD8A 4FDJA 4UPHA 3BDFA 4UPLA 4LQYA 3WAVA 4ZGAA 5IJSA 4KM4A 3DPCA 3M8ZA 4NWXA 3MK0A 5LRMA 1ALHA 1ALIA 1ANJA 4CXUA 5HRTA 4ZG9A 2W5RA 2W5TA 1EW8A 4QAXA 2X98A 1EI6A 4GTWA 4GTYA 1ELYA 2IUCB 2W5QA 3BDHA 1ELZA 5EGEA 5C66A 4LREA 4LR8A 5L0EA 3WAXA 1E3CP 1EW9A 3NKOA 2W5XA 1AJCA 4UORA 2G9YA 5K4PA 4ZG6A 1N2KA 3M8WA 1ED8A 3E2DA 2IFYA 3A52A 1SHQA 4NWJA 5LIAA 4GTXA 1ANIA 1K7HA 1N2LA 3UN3A 5L0KA 3M8YA 1HDHA 3UO0A 3TX0A 1ZEFA 5DLWA 4CYRA 5LQQA 1P49A 5DLVA 2GSNA 5GOVA 1KHLA 3BDGB 4LRAA 2GA3A 1ZEBA 4KJDA 2IUCA 4LRCA 1O99A 5DLTA 5L0BA 1ALJA 3IDDA 4KAYA 3TG0A 3ED4A 5INHA 1FSUA 1AUKA 1KH4A 5AJ9A 1KH5A 3MK1A 3M7VA 2RH6A 1ZEDA 4LRDA 3TWZA 4LR7A 1O98A 2GSOA 1KH7A 3NKMA 3T02A 4CYSA 2XRGA 2ANHA 3WBHA 3IGZB 1ED9A 4LRBA 3WAYA 2W8DA 4KAVA 4UOOA 5GRRA 2W5WA 1KHJA 3BDGA 4UOPA 1ALKA 1Y6VA 1SHNA 3NKNA 4MIVA 3T00A 4TN0A 3OT9A 4UPKA 4CXSA 1Y7AA 4YR1A 1KHKA 3WAWA 4CXKA 4FDIA 3NKPA 4MHXA 4ZG7A 3UNYA 1URAA 2ZKTA 3NKQA 3UN5A 1KH9A 1AJDA 4GTZA 1ELXA 1E1ZP 3B5QA 5LRNA 1HJKA 4KJGA 4LRFA 3LXQA 1E2SP 4UPIA 2D1GA 3SZZA 2VQRA 3DYCA 2QZUA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 2XR9 A;  3CMR A;  1B8J A;  1HQA A;  3UN2 A;  3NVL A;  1KHN A;  4MY4 A;  3IGY B;  5IJQ A;  1EJJ A;  3MK2 A;  4LR2 A;  5TJ3 A;  3T01 A;  4B56 A;  1AJA A;  3SZY A;  4N7T A;  2W5V A;  1AJB A;  1EQJ A;  2GLQ A;  3NKR A;  1EW2 A;  2GSU A;  1URB A;  2W5S A;  4LR9 A;  5EGH A;  3Q3Q A;  5KXA A;  1E33 P;  2W8S A;  3KD8 A;  4FDJ A;  4UPH A;  3BDF A;  4UPL A;  4LQY A;  3WAV A;  4ZGA A;  5IJS A;  4KM4 A;  3DPC A;  3M8Z A;  4NWX A;  3MK0 A;  5LRM A;  1ALH A;  1ALI A;  1ANJ A;  4CXU A;  5HRT A;  4ZG9 A;  2W5R A;  2W5T A;  1EW8 A;  4QAX A;  2X98 A;  1EI6 A;  4GTW A;  4GTY A;  1ELY A;  2IUC B;  2W5Q A;  3BDH A;  1ELZ A;  5EGE A;  5C66 A;  4LRE A;  4LR8 A;  5L0E A;  3WAX A;  1E3C P;  1EW9 A;  3NKO A;  2W5X A;  1AJC A;  4UOR A;  2G9Y A;  5K4P A;  4ZG6 A;  1N2K A;  3M8W A;  1ED8 A;  3E2D A;  2IFY A;  3A52 A;  1SHQ A;  4NWJ A;  5LIA A;  4GTX A;  1ANI A;  1K7H A;  1N2L A;  3UN3 A;  5L0K A;  3M8Y A;  1HDH A;  3UO0 A;  3TX0 A;  1ZEF A;  5DLW A;  4CYR A;  5LQQ A;  1P49 A;  5DLV A;  2GSN A;  5GOV A;  1KHL A;  3BDG B;  4LRA A;  2GA3 A;  1ZEB A;  4KJD A;  2IUC A;  4LRC A;  1O99 A;  5DLT A;  5L0B A;  1ALJ A;  3IDD A;  4KAY A;  3TG0 A;  3ED4 A;  5INH A;  1FSU A;  1AUK A;  1KH4 A;  5AJ9 A;  1KH5 A;  3MK1 A;  3M7V A;  2RH6 A;  1ZED A;  4LRD A;  3TWZ A;  4LR7 A;  1O98 A;  2GSO A;  1KH7 A;  3NKM A;  3T02 A;  4CYS A;  2XRG A;  2ANH A;  3WBH A;  3IGZ B;  1ED9 A;  4LRB A;  3WAY A;  2W8D A;  4KAV A;  4UOO A;  5GRR A;  2W5W A;  1KHJ A;  3BDG A;  4UOP A;  1ALK A;  1Y6V A;  1SHN A;  3NKN A;  4MIV A;  3T00 A;  4TN0 A;  3OT9 A;  4UPK A;  4CXS A;  1Y7A A;  4YR1 A;  1KHK A;  3WAW A;  4CXK A;  4FDI A;  3NKP A;  4MHX A;  4ZG7 A;  3UNY A;  1URA A;  2ZKT A;  3NKQ A;  3UN5 A;  1KH9 A;  1AJD A;  4GTZ A;  1ELX A;  1E1Z P;  3B5Q A;  5LRN A;  1HJK A;  4KJG A;  4LRF A;  3LXQ A;  1E2S P;  4UPI A;  2D1G A;  3SZZ A;  2VQR A;  3DYC A;  2QZU A; 
#chains in the Genus database with same CATH topology
 2XR9 A;  3CMR A;  1B8J A;  1HQA A;  3UN2 A;  3NVL A;  1KHN A;  4MY4 A;  3IGY B;  5IJQ A;  1EJJ A;  3MK2 A;  4LR2 A;  5TJ3 A;  3T01 A;  4B56 A;  1AJA A;  3SZY A;  4N7T A;  2W5V A;  1AJB A;  1EQJ A;  2GLQ A;  3NKR A;  1EW2 A;  2GSU A;  1URB A;  2W5S A;  4LR9 A;  5EGH A;  3Q3Q A;  5KXA A;  1E33 P;  2W8S A;  3KD8 A;  4FDJ A;  4UPH A;  3BDF A;  4UPL A;  4LQY A;  3WAV A;  4ZGA A;  5IJS A;  4KM4 A;  3DPC A;  3M8Z A;  4NWX A;  3MK0 A;  5LRM A;  1ALH A;  1ALI A;  1ANJ A;  4CXU A;  5HRT A;  4ZG9 A;  2W5R A;  2W5T A;  1EW8 A;  4QAX A;  2X98 A;  1EI6 A;  4GTW A;  4GTY A;  1ELY A;  2IUC B;  2W5Q A;  3BDH A;  1ELZ A;  5EGE A;  5C66 A;  4LRE A;  4LR8 A;  5L0E A;  3WAX A;  1E3C P;  1EW9 A;  3NKO A;  2W5X A;  1AJC A;  4UOR A;  2G9Y A;  5K4P A;  4ZG6 A;  1N2K A;  3M8W A;  1ED8 A;  3E2D A;  2IFY A;  3A52 A;  1SHQ A;  4NWJ A;  5LIA A;  4GTX A;  1ANI A;  1K7H A;  1N2L A;  3UN3 A;  5L0K A;  3M8Y A;  1HDH A;  3UO0 A;  3TX0 A;  1ZEF A;  5DLW A;  4CYR A;  5LQQ A;  1P49 A;  5DLV A;  2GSN A;  5GOV A;  1KHL A;  3BDG B;  4LRA A;  2GA3 A;  1ZEB A;  4KJD A;  2IUC A;  4LRC A;  1O99 A;  5DLT A;  5L0B A;  1ALJ A;  3IDD A;  4KAY A;  3TG0 A;  3ED4 A;  5INH A;  1FSU A;  1AUK A;  1KH4 A;  5AJ9 A;  1KH5 A;  3MK1 A;  3M7V A;  2RH6 A;  1ZED A;  4LRD A;  3TWZ A;  4LR7 A;  1O98 A;  2GSO A;  1KH7 A;  3NKM A;  3T02 A;  4CYS A;  2XRG A;  2ANH A;  3WBH A;  3IGZ B;  1ED9 A;  4LRB A;  3WAY A;  2W8D A;  4KAV A;  4UOO A;  5GRR A;  2W5W A;  1KHJ A;  3BDG A;  4UOP A;  1ALK A;  1Y6V A;  1SHN A;  3NKN A;  4MIV A;  3T00 A;  4TN0 A;  3OT9 A;  4UPK A;  4CXS A;  1Y7A A;  4YR1 A;  1KHK A;  3WAW A;  4CXK A;  4FDI A;  3NKP A;  4MHX A;  4ZG7 A;  3UNY A;  1URA A;  2ZKT A;  3NKQ A;  3UN5 A;  1KH9 A;  1AJD A;  4GTZ A;  1ELX A;  1E1Z P;  3B5Q A;  5LRN A;  1HJK A;  4KJG A;  4LRF A;  3LXQ A;  1E2S P;  4UPI A;  2D1G A;  3SZZ A;  2VQR A;  3DYC A;  2QZU A; 
#chains in the Genus database with same CATH homology
 2XR9 A;  3CMR A;  1B8J A;  1HQA A;  3UN2 A;  3NVL A;  1KHN A;  4MY4 A;  3IGY B;  5IJQ A;  1EJJ A;  3MK2 A;  4LR2 A;  5TJ3 A;  3T01 A;  4B56 A;  1AJA A;  3SZY A;  4N7T A;  2W5V A;  1AJB A;  1EQJ A;  2GLQ A;  3NKR A;  1EW2 A;  2GSU A;  1URB A;  2W5S A;  4LR9 A;  5EGH A;  3Q3Q A;  5KXA A;  1E33 P;  2W8S A;  3KD8 A;  4FDJ A;  4UPH A;  3BDF A;  4UPL A;  4LQY A;  3WAV A;  4ZGA A;  5IJS A;  4KM4 A;  3DPC A;  3M8Z A;  4NWX A;  3MK0 A;  5LRM A;  1ALH A;  1ALI A;  1ANJ A;  4CXU A;  5HRT A;  4ZG9 A;  2W5R A;  2W5T A;  1EW8 A;  4QAX A;  2X98 A;  1EI6 A;  4GTW A;  4GTY A;  1ELY A;  2IUC B;  2W5Q A;  3BDH A;  1ELZ A;  5EGE A;  5C66 A;  4LRE A;  4LR8 A;  5L0E A;  3WAX A;  1E3C P;  1EW9 A;  3NKO A;  2W5X A;  1AJC A;  4UOR A;  2G9Y A;  5K4P A;  4ZG6 A;  1N2K A;  3M8W A;  1ED8 A;  3E2D A;  2IFY A;  3A52 A;  1SHQ A;  4NWJ A;  5LIA A;  4GTX A;  1ANI A;  1K7H A;  1N2L A;  3UN3 A;  5L0K A;  3M8Y A;  1HDH A;  3UO0 A;  3TX0 A;  1ZEF A;  5DLW A;  4CYR A;  5LQQ A;  1P49 A;  5DLV A;  2GSN A;  5GOV A;  1KHL A;  3BDG B;  4LRA A;  2GA3 A;  1ZEB A;  4KJD A;  2IUC A;  4LRC A;  1O99 A;  5DLT A;  5L0B A;  1ALJ A;  3IDD A;  4KAY A;  3TG0 A;  3ED4 A;  5INH A;  1FSU A;  1AUK A;  1KH4 A;  5AJ9 A;  1KH5 A;  3MK1 A;  3M7V A;  2RH6 A;  1ZED A;  4LRD A;  3TWZ A;  4LR7 A;  1O98 A;  2GSO A;  1KH7 A;  3NKM A;  3T02 A;  4CYS A;  2XRG A;  2ANH A;  3WBH A;  3IGZ B;  1ED9 A;  4LRB A;  3WAY A;  2W8D A;  4KAV A;  4UOO A;  5GRR A;  2W5W A;  1KHJ A;  3BDG A;  4UOP A;  1ALK A;  1Y6V A;  1SHN A;  3NKN A;  4MIV A;  3T00 A;  4TN0 A;  3OT9 A;  4UPK A;  4CXS A;  1Y7A A;  4YR1 A;  1KHK A;  3WAW A;  4CXK A;  4FDI A;  3NKP A;  4MHX A;  4ZG7 A;  3UNY A;  1URA A;  2ZKT A;  3NKQ A;  3UN5 A;  1KH9 A;  1AJD A;  4GTZ A;  1ELX A;  1E1Z P;  3B5Q A;  5LRN A;  1HJK A;  4KJG A;  4LRF A;  3LXQ A;  1E2S P;  4UPI A;  2D1G A;  3SZZ A;  2VQR A;  3DYC A;  2QZU A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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