1BR8I

Implications for function and therapy of a 2.9a structure of binary-complexed antithrombin
Total Genus 95
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
95
sequence length
425
structure length
404
Chain Sequence
ICTAKPRDIPMNPMCIYRSPETNRRVWELSKANSRFATTFYQHLADSKNDNDNIFLSPLSISTAFAMTKLGACNDTLQQLMEVFKFDTISEKTSDQIHFFFAKLNCRLYRKANKSSKLVSANRLFGDKSLTFNETYQDISELVYGAKLQPLDFKENAEQSRAAINKWVSNKTEGRITDVIPSEAINELTVLVLVNTIYFKGLWKSKFSPENTRKELFYKADGESCSASMMYQEGKFRYRRVAEGTQVLELPFKGDDITMVLILPKPEKSLAKVEKELTPEVLQEWLDELEEMMLVVHMPRFRIEDGFSLKEQLQDMGLVDLFSPEKSKLPGIVAEGRDDLYVSDAFHKAFLEVNEEASTAVVIAGRSLNPNRVTFKANRPFLVFIREVPLNTIIFMGRVANPCV
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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molecule tags Blood clotting
molecule keywords PROTEIN (ANTITHROMBIN-III)
publication title Implications for function and therapy of a 2.9 A structure of binary-complexed antithrombin.
pubmed doi rcsb
total genus 95
structure length 404
sequence length 425
chains with identical sequence L
ec nomenclature
pdb deposition date 1998-08-26

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
I PF00079 Serpin Serpin (serine protease inhibitor)
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.30.39.10 Mainly Beta Roll Alpha-1-antitrypsin; domain 1 Alpha-1-antitrypsin, domain 1 1br8I01
3.30.497.10 Alpha Beta 2-Layer Sandwich Antithrombin; Chain I, domain 2 Antithrombin, subunit I, domain 2 1br8I02
2VH4A 3CWLA 3CVMA 2ZNHA 1IZ2A 4X30A 2ACHA 1QMBA 3LW2A 1DVMA 1JTIA 1WZ9A 4AFXA 1LJ5A 1PSIA 4YIAA 1OVAC 3DY0A 2PEFA 3EVJI 2OL2A 1AS4A 2XN7A 4AU3B 1XU8A 2OAYA 2B5TI 5CE0A 9APIA 4ROBA 2RIVA 5EI0A 1K9OI 2PEEA 3EOXA 1XQGA 2VDYA 4GA7A 1AZXI 7APIA 3OZQA 1OVAA 4RO9A 4PYWA 1JMJA 1ATUA 5INWA 4AQHA 4Y3KA 4C41A 2WXZC 1OPHA 1QLPA 2ZV6A 3FGQA 3ZHAA 4CAAA 1R1LI 1SNGA 1BY7A 2WXXA 3Q02A 1TB6I 1F0CA 1DZHL 1E05I 3R4LA 3T1PA 1JJOC 1OC0A 1SR5A 2V95A 1M93B 2WXWA 1E03I 1MTPA 1KCTA 2WXZA 1XQJA 1BR8I 1DZHI 1DZGL 4P0OA 4EB1L 3Q03A 4C49A 8APIA 2RIWA 9PAIA 5BRRI 1SEKA 4RSQA 1HP7A 4ZK3A 2H4RA 2WY1A 4DY7C 1JMOA 3NE4A 2ANTI 3B9FI 1ATHA 4EB1I 1DZGI 4R9IA 3UT3A 3VVJA 1E04I 1T1FA 1HLEA 4IF8A 5IO1A 4AU2A 1D5SA 3NDAA 3DRUA 4AJTA 4AU3A 2HIJL 1JRRA 2ARQA 1DB2A 3PB1I 1A7CA 2HI9A 1ATTA 2XN3A 2B4XL 2WXYC 1YXAA 3F1SA 1EZXA 2HIJI 2ARRA 1ANTI 4G8OA 1JVQI 2BEHL 1LQ8A 2B4XI 3F02A 3LE2A 3STOA 2VDXA 2XN5A 4IC0A 2DUTA 4AJUA 5C98A 1C8OA 4BB2A 4Y40A 2BEHI 1LK6I 4ZK0A 2WY0C 2R9YA 4KDSA 4DTEA 1OYHL 2D26A 4DY0A 2GD4C 4G8RA 3CWMA 1B3KA 2H4QA 2H4PA 3NDFA 1DVNA 3KCGI 2QUGA 1IMVA 1OVAB 1QMNA 2XN6A 1OYHI 3NDDA 4P0FA 3CAAA 3DRMA 1NQ9I 3F5NA 5HGCA 5CDZA 3H5CA 2CEOA 5CDXA 3PZFA 4AU4A 1OO8A 1C5GA 4ROAA 3DLWA 1UHGA
chains in the Genus database with same CATH superfamily
2VH4A 3CWLA 3CVMA 2ZNHA 1IZ2A 4X30A 2ACHA 1QMBA 3LW2A 1DVMA 1JTIA 1WZ9A 4AFXA 1LJ5A 1PSIA 4YIAA 1OVAC 3DY0A 2PEFA 3EVJI 2OL2A 1AS4A 2XN7A 4AU3B 1XU8A 2OAYA 2B5TI 5CE0A 9APIA 4ROBA 2RIVA 5EI0A 1K9OI 2PEEA 3EOXA 1XQGA 2VDYA 4GA7A 1AZXI 7APIA 3OZQA 1OVAA 4RO9A 4PYWA 1JMJA 1ATUA 5INWA 4AQHA 4Y3KA 4C41A 2WXZC 1OPHA 1QLPA 2ZV6A 3FGQA 3ZHAA 4CAAA 1R1LI 1SNGA 1BY7A 2WXXA 3Q02A 1TB6I 1F0CA 1DZHL 1E05I 3R4LA 3T1PA 1JJOC 1OC0A 1SR5A 2V95A 1M93B 2WXWA 1E03I 1MTPA 1KCTA 2WXZA 1XQJA 1BR8I 1DZHI 1DZGL 4P0OA 4EB1L 3Q03A 4C49A 8APIA 2RIWA 9PAIA 5BRRI 1SEKA 4RSQA 1HP7A 4ZK3A 2H4RA 2WY1A 4DY7C 1JMOA 3NE4A 2ANTI 3B9FI 1ATHA 4EB1I 1DZGI 4R9IA 3UT3A 3VVJA 1E04I 1T1FA 1HLEA 4IF8A 5IO1A 4AU2A 1D5SA 3NDAA 3DRUA 4AJTA 4AU3A 2HIJL 1JRRA 2ARQA 1DB2A 3PB1I 1A7CA 2HI9A 1ATTA 2XN3A 2B4XL 2WXYC 1YXAA 3F1SA 1EZXA 2HIJI 2ARRA 1ANTI 4G8OA 1JVQI 2BEHL 1LQ8A 2B4XI 3F02A 3LE2A 3STOA 2VDXA 2XN5A 4IC0A 2DUTA 4AJUA 5C98A 1C8OA 4BB2A 4Y40A 2BEHI 1LK6I 4ZK0A 2WY0C 2R9YA 4KDSA 4DTEA 1OYHL 2D26A 4DY0A 2GD4C 4G8RA 3CWMA 1B3KA 2H4QA 2H4PA 3NDFA 1DVNA 3KCGI 2QUGA 1IMVA 1OVAB 1QMNA 2XN6A 1OYHI 3NDDA 4P0FA 3CAAA 3DRMA 1NQ9I 3F5NA 5HGCA 5CDZA 3H5CA 2CEOA 5CDXA 3PZFA 4AU4A 1OO8A 1C5GA 4ROAA 3DLWA 1UHGA
chains in the Genus database with same CATH topology
2VH4A 3CWLA 3CVMA 2ZNHA 1IZ2A 4X30A 2ACHA 1QMBA 3LW2A 1DVMA 1JTIA 1WZ9A 4AFXA 1LJ5A 1PSIA 4YIAA 1OVAC 3DY0A 2PEFA 3EVJI 2OL2A 1AS4A 2XN7A 4AU3B 1XU8A 2OAYA 2B5TI 5CE0A 9APIA 4ROBA 2RIVA 5EI0A 1K9OI 2PEEA 3EOXA 1XQGA 2VDYA 4GA7A 1AZXI 7APIA 3OZQA 1OVAA 4RO9A 4PYWA 1JMJA 1ATUA 5INWA 4AQHA 4Y3KA 4C41A 2WXZC 1OPHA 1QLPA 2ZV6A 3FGQA 3ZHAA 4CAAA 1R1LI 1SNGA 1BY7A 2WXXA 3Q02A 1TB6I 1F0CA 1DZHL 1E05I 3R4LA 3T1PA 1JJOC 1OC0A 1SR5A 2V95A 1M93B 2WXWA 1E03I 1MTPA 1KCTA 2WXZA 1XQJA 1BR8I 1DZHI 1DZGL 4P0OA 4EB1L 3Q03A 4C49A 8APIA 2RIWA 9PAIA 5BRRI 1SEKA 4RSQA 1HP7A 4ZK3A 2H4RA 2WY1A 4DY7C 1JMOA 3NE4A 2ANTI 3B9FI 1ATHA 4EB1I 1DZGI 4R9IA 3UT3A 3VVJA 1E04I 1T1FA 1HLEA 4IF8A 5IO1A 4AU2A 1D5SA 3NDAA 3DRUA 4AJTA 4AU3A 2HIJL 1JRRA 2ARQA 1DB2A 3PB1I 1A7CA 2HI9A 1ATTA 2XN3A 2B4XL 2WXYC 1YXAA 3F1SA 1EZXA 2HIJI 2ARRA 1ANTI 4G8OA 1JVQI 2BEHL 1LQ8A 2B4XI 3F02A 3LE2A 3STOA 2VDXA 2XN5A 4IC0A 2DUTA 4AJUA 5C98A 1C8OA 4BB2A 4Y40A 2BEHI 1LK6I 4ZK0A 2WY0C 2R9YA 4KDSA 4DTEA 1OYHL 2D26A 4DY0A 2GD4C 4G8RA 3CWMA 1B3KA 2H4QA 2H4PA 3NDFA 1DVNA 3KCGI 2QUGA 1IMVA 1OVAB 1QMNA 2XN6A 1OYHI 3NDDA 4P0FA 3CAAA 3DRMA 1NQ9I 3F5NA 5HGCA 5CDZA 3H5CA 2CEOA 5CDXA 3PZFA 4AU4A 1OO8A 1C5GA 4ROAA 3DLWA 1UHGA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 2VH4 A;  3CWL A;  3CVM A;  2ZNH A;  1IZ2 A;  4X30 A;  2ACH A;  1QMB A;  3LW2 A;  1DVM A;  1JTI A;  1WZ9 A;  4AFX A;  1LJ5 A;  1PSI A;  4YIA A;  1OVA C;  3DY0 A;  2PEF A;  3EVJ I;  2OL2 A;  1AS4 A;  2XN7 A;  4AU3 B;  1XU8 A;  2OAY A;  2B5T I;  5CE0 A;  9API A;  4ROB A;  2RIV A;  5EI0 A;  1K9O I;  2PEE A;  3EOX A;  1XQG A;  2VDY A;  4GA7 A;  1AZX I;  7API A;  3OZQ A;  1OVA A;  4RO9 A;  4PYW A;  1JMJ A;  1ATU A;  5INW A;  4AQH A;  4Y3K A;  4C41 A;  2WXZ C;  1OPH A;  1QLP A;  2ZV6 A;  3FGQ A;  3ZHA A;  4CAA A;  1R1L I;  1SNG A;  1BY7 A;  2WXX A;  3Q02 A;  1TB6 I;  1F0C A;  1DZH L;  1E05 I;  3R4L A;  3T1P A;  1JJO C;  1OC0 A;  1SR5 A;  2V95 A;  1M93 B;  2WXW A;  1E03 I;  1MTP A;  1KCT A;  2WXZ A;  1XQJ A;  1BR8 I;  1DZH I;  1DZG L;  4P0O A;  4EB1 L;  3Q03 A;  4C49 A;  8API A;  2RIW A;  9PAI A;  5BRR I;  1SEK A;  4RSQ A;  1HP7 A;  4ZK3 A;  2H4R A;  2WY1 A;  4DY7 C;  1JMO A;  3NE4 A;  2ANT I;  3B9F I;  1ATH A;  4EB1 I;  1DZG I;  4R9I A;  3UT3 A;  3VVJ A;  1E04 I;  1T1F A;  1HLE A;  4IF8 A;  5IO1 A;  4AU2 A;  1D5S A;  3NDA A;  3DRU A;  4AJT A;  4AU3 A;  2HIJ L;  1JRR A;  2ARQ A;  1DB2 A;  3PB1 I;  1A7C A;  2HI9 A;  1ATT A;  2XN3 A;  2B4X L;  2WXY C;  1YXA A;  3F1S A;  1EZX A;  2HIJ I;  2ARR A;  1ANT I;  4G8O A;  1JVQ I;  2BEH L;  1LQ8 A;  2B4X I;  3F02 A;  3LE2 A;  3STO A;  2VDX A;  2XN5 A;  4IC0 A;  2DUT A;  4AJU A;  5C98 A;  1C8O A;  4BB2 A;  4Y40 A;  2BEH I;  1LK6 I;  4ZK0 A;  2WY0 C;  2R9Y A;  4KDS A;  4DTE A;  1OYH L;  2D26 A;  4DY0 A;  2GD4 C;  4G8R A;  3CWM A;  1B3K A;  2H4Q A;  2H4P A;  3NDF A;  1DVN A;  3KCG I;  2QUG A;  1IMV A;  1OVA B;  1QMN A;  2XN6 A;  1OYH I;  3NDD A;  4P0F A;  3CAA A;  3DRM A;  1NQ9 I;  3F5N A;  5HGC A;  5CDZ A;  3H5C A;  2CEO A;  5CDX A;  3PZF A;  4AU4 A;  1OO8 A;  1C5G A;  4ROA A;  3DLW A;  1UHG A; 
#chains in the Genus database with same CATH topology
 2VH4 A;  3CWL A;  3CVM A;  2ZNH A;  1IZ2 A;  4X30 A;  2ACH A;  1QMB A;  3LW2 A;  1DVM A;  1JTI A;  1WZ9 A;  4AFX A;  1LJ5 A;  1PSI A;  4YIA A;  1OVA C;  3DY0 A;  2PEF A;  3EVJ I;  2OL2 A;  1AS4 A;  2XN7 A;  4AU3 B;  1XU8 A;  2OAY A;  2B5T I;  5CE0 A;  9API A;  4ROB A;  2RIV A;  5EI0 A;  1K9O I;  2PEE A;  3EOX A;  1XQG A;  2VDY A;  4GA7 A;  1AZX I;  7API A;  3OZQ A;  1OVA A;  4RO9 A;  4PYW A;  1JMJ A;  1ATU A;  5INW A;  4AQH A;  4Y3K A;  4C41 A;  2WXZ C;  1OPH A;  1QLP A;  2ZV6 A;  3FGQ A;  3ZHA A;  4CAA A;  1R1L I;  1SNG A;  1BY7 A;  2WXX A;  3Q02 A;  1TB6 I;  1F0C A;  1DZH L;  1E05 I;  3R4L A;  3T1P A;  1JJO C;  1OC0 A;  1SR5 A;  2V95 A;  1M93 B;  2WXW A;  1E03 I;  1MTP A;  1KCT A;  2WXZ A;  1XQJ A;  1BR8 I;  1DZH I;  1DZG L;  4P0O A;  4EB1 L;  3Q03 A;  4C49 A;  8API A;  2RIW A;  9PAI A;  5BRR I;  1SEK A;  4RSQ A;  1HP7 A;  4ZK3 A;  2H4R A;  2WY1 A;  4DY7 C;  1JMO A;  3NE4 A;  2ANT I;  3B9F I;  1ATH A;  4EB1 I;  1DZG I;  4R9I A;  3UT3 A;  3VVJ A;  1E04 I;  1T1F A;  1HLE A;  4IF8 A;  5IO1 A;  4AU2 A;  1D5S A;  3NDA A;  3DRU A;  4AJT A;  4AU3 A;  2HIJ L;  1JRR A;  2ARQ A;  1DB2 A;  3PB1 I;  1A7C A;  2HI9 A;  1ATT A;  2XN3 A;  2B4X L;  2WXY C;  1YXA A;  3F1S A;  1EZX A;  2HIJ I;  2ARR A;  1ANT I;  4G8O A;  1JVQ I;  2BEH L;  1LQ8 A;  2B4X I;  3F02 A;  3LE2 A;  3STO A;  2VDX A;  2XN5 A;  4IC0 A;  2DUT A;  4AJU A;  5C98 A;  1C8O A;  4BB2 A;  4Y40 A;  2BEH I;  1LK6 I;  4ZK0 A;  2WY0 C;  2R9Y A;  4KDS A;  4DTE A;  1OYH L;  2D26 A;  4DY0 A;  2GD4 C;  4G8R A;  3CWM A;  1B3K A;  2H4Q A;  2H4P A;  3NDF A;  1DVN A;  3KCG I;  2QUG A;  1IMV A;  1OVA B;  1QMN A;  2XN6 A;  1OYH I;  3NDD A;  4P0F A;  3CAA A;  3DRM A;  1NQ9 I;  3F5N A;  5HGC A;  5CDZ A;  3H5C A;  2CEO A;  5CDX A;  3PZF A;  4AU4 A;  1OO8 A;  1C5G A;  4ROA A;  3DLW A;  1UHG A; 
#chains in the Genus database with same CATH homology
 2VH4 A;  3CWL A;  3CVM A;  2ZNH A;  1IZ2 A;  4X30 A;  2ACH A;  1QMB A;  3LW2 A;  1DVM A;  1JTI A;  1WZ9 A;  4AFX A;  1LJ5 A;  1PSI A;  4YIA A;  1OVA C;  3DY0 A;  2PEF A;  3EVJ I;  2OL2 A;  1AS4 A;  2XN7 A;  4AU3 B;  1XU8 A;  2OAY A;  2B5T I;  5CE0 A;  9API A;  4ROB A;  2RIV A;  5EI0 A;  1K9O I;  2PEE A;  3EOX A;  1XQG A;  2VDY A;  4GA7 A;  1AZX I;  7API A;  3OZQ A;  1OVA A;  4RO9 A;  4PYW A;  1JMJ A;  1ATU A;  5INW A;  4AQH A;  4Y3K A;  4C41 A;  2WXZ C;  1OPH A;  1QLP A;  2ZV6 A;  3FGQ A;  3ZHA A;  4CAA A;  1R1L I;  1SNG A;  1BY7 A;  2WXX A;  3Q02 A;  1TB6 I;  1F0C A;  1DZH L;  1E05 I;  3R4L A;  3T1P A;  1JJO C;  1OC0 A;  1SR5 A;  2V95 A;  1M93 B;  2WXW A;  1E03 I;  1MTP A;  1KCT A;  2WXZ A;  1XQJ A;  1BR8 I;  1DZH I;  1DZG L;  4P0O A;  4EB1 L;  3Q03 A;  4C49 A;  8API A;  2RIW A;  9PAI A;  5BRR I;  1SEK A;  4RSQ A;  1HP7 A;  4ZK3 A;  2H4R A;  2WY1 A;  4DY7 C;  1JMO A;  3NE4 A;  2ANT I;  3B9F I;  1ATH A;  4EB1 I;  1DZG I;  4R9I A;  3UT3 A;  3VVJ A;  1E04 I;  1T1F A;  1HLE A;  4IF8 A;  5IO1 A;  4AU2 A;  1D5S A;  3NDA A;  3DRU A;  4AJT A;  4AU3 A;  2HIJ L;  1JRR A;  2ARQ A;  1DB2 A;  3PB1 I;  1A7C A;  2HI9 A;  1ATT A;  2XN3 A;  2B4X L;  2WXY C;  1YXA A;  3F1S A;  1EZX A;  2HIJ I;  2ARR A;  1ANT I;  4G8O A;  1JVQ I;  2BEH L;  1LQ8 A;  2B4X I;  3F02 A;  3LE2 A;  3STO A;  2VDX A;  2XN5 A;  4IC0 A;  2DUT A;  4AJU A;  5C98 A;  1C8O A;  4BB2 A;  4Y40 A;  2BEH I;  1LK6 I;  4ZK0 A;  2WY0 C;  2R9Y A;  4KDS A;  4DTE A;  1OYH L;  2D26 A;  4DY0 A;  2GD4 C;  4G8R A;  3CWM A;  1B3K A;  2H4Q A;  2H4P A;  3NDF A;  1DVN A;  3KCG I;  2QUG A;  1IMV A;  1OVA B;  1QMN A;  2XN6 A;  1OYH I;  3NDD A;  4P0F A;  3CAA A;  3DRM A;  1NQ9 I;  3F5N A;  5HGC A;  5CDZ A;  3H5C A;  2CEO A;  5CDX A;  3PZF A;  4AU4 A;  1OO8 A;  1C5G A;  4ROA A;  3DLW A;  1UHG A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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