1ELZA

E. coli alkaline phosphatase mutant (s102g)
Total Genus 157
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
157
Knots found
sequence length
449
structure length
449
Chain Sequence
TPEMPVLENRAAQGDITAPGGARRLTGDQTAALRDSLSDKPAKNIILLIGDGMGDSEITAARNYAEGAGGFFKGIDALPLTGQYTHYALNKKTGKPDYVTDGAASATAWSTGVKTYNGALGVDIHEKDHPTILEMAKAAGLATGNVSTAELQDATPAALVAHVTSRKCYGPSATSEKCPGNALEKGGKGSITEQLLNARADVTLGGGAKTFAETATAGEWQGKTLREQAQARGYQLVSDAASLNSVTEANQQKPLLGLFADGNMPVRWLGPKATYHGNIDKPAVTCTPNPQRNDSVPTLAQMTDKAIELLSKNEKGFFLQVEGASIDKQDHAANPCGQIGETVDLDEAVQRALEFAKKEGNTLVIVTADHAHASQIVAPDTKAPGLTQALNTKDGAVMVMSYGNSEEDSQEHTGSQLRIAAYGPHAANVVGLTDQTDLFYTMKAALGLK
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

molecule keywords ALKALINE PHOSPHATASE
publication title Kinetic and X-ray structural studies of three mutant E. coli alkaline phosphatases: insights into the catalytic mechanism without the nucleophile Ser102.
pubmed doi rcsb
source organism Escherichia coli
molecule tags Hydrolase
total genus 157
structure length 449
sequence length 449
chains with identical sequence B
other databases KnotProt 2.0: S +31
ec nomenclature ec 3.1.3.1: Alkaline phosphatase.
pdb deposition date 1998-02-10

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00245 Alk_phosphatase Alkaline phosphatase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.720.10 Alpha Beta 3-Layer(aba) Sandwich Alkaline Phosphatase, subunit A Alkaline Phosphatase, subunit A 1elzA00
1AJAA 4GTWA 2GA3A 4ZGAA 4LRAA 2W5VA 3NKOA 4NWJA 1HQAA 1ANIA 3MK2A 1N2KA 2W5QA 5AJ9A 3M8YA 1E33P 5LRMA 5GOVA 3NKPA 4TN0A 3T01A 4GTZA 5IJQA 3OT9A 5IJSA 4FDIA 1ALJA 3BDGB 2ANHA 5LIAA 3IGYB 5DLTA 4UOPA 2RH6A 2W5TA 1HDHA 4MIVA 3NKMA 3B5QA 3LXQA 4LR9A 1HJKA 1SHNA 3M8ZA 1KH4A 4CXSA 4CXUA 3M7VA 3UN2A 1KHNA 5L0EA 1AJBA 1ALIA 4LRFA 3TX0A 4CYRA 1KH7A 4ZG6A 1AJCA 3BDFA 1KHKA 2IFYA 1ZEBA 3NKQA 2ZKTA 3NKRA 4GTYA 4MY4A 5L0BA 4QAXA 4LRCA 5LQQA 1EJJA 1KH9A 1O98A 1AUKA 4UPKA 1EW2A 3T02A 2GSNA 4CYSA 4N7TA 1ANJA 4KJDA 4NWXA 1URAA 2W8DA 1ZEFA 4KM4A 3A52A 3UNYA 1ALHA 1URBA 1Y6VA 5DLWA 4LR7A 1SHQA 1P49A 2GSUA 2W5XA 4CXKA 4KJGA 3WAWA 3SZZA 4B56A 3TWZA 3BDHA 5KXAA 4ZG7A 5EGHA 3DPCA 3WBHA 3MK1A 5HRTA 4MHXA 3MK0A 2XRGA 2IUCB 1ELZA 1EQJA 1N2LA 1B8JA 3NVLA 3Q3QA 1ED8A 4LQYA 1EI6A 2W8SA 4UPHA 3SZYA 4UPLA 4YR1A 2W5RA 5TJ3A 4ZG9A 1O99A 5L0KA 4KAVA 3WAVA 1ZEDA 3UN5A 4GTXA 3M8WA 5C66A 1KH5A 1E3CP 3CMRA 3T00A 4LR2A 5LRNA 4UORA 2QZUA 1ED9A 2XR9A 3KD8A 1ALKA 4LREA 1E2SP 1K7HA 1ELXA 5GRRA 3WAXA 4LRDA 3DYCA 2X98A 1FSUA 2W5WA 4LR8A 1AJDA 5EGEA 5DLVA 1Y7AA 2VQRA 3IGZB 2G9YA 2GSOA 3BDGA 4LRBA 2W5SA 2IUCA 3NKNA 3E2DA 1EW9A 1ELYA 4FDJA 1KHJA 4UOOA 3IDDA 3UO0A 3WAYA 4UPIA 3UN3A 1EW8A 5K4PA 3TG0A 3ED4A 2GLQA 4KAYA 5INHA 1E1ZP 1KHLA 2D1GA
chains in the Genus database with same CATH superfamily
1AJAA 4GTWA 2GA3A 4ZGAA 4LRAA 2W5VA 3NKOA 4NWJA 1HQAA 1ANIA 3MK2A 1N2KA 2W5QA 5AJ9A 3M8YA 1E33P 5LRMA 5GOVA 3NKPA 4TN0A 3T01A 4GTZA 5IJQA 3OT9A 5IJSA 4FDIA 1ALJA 3BDGB 2ANHA 5LIAA 3IGYB 5DLTA 4UOPA 2RH6A 2W5TA 1HDHA 4MIVA 3NKMA 3B5QA 3LXQA 4LR9A 1HJKA 1SHNA 3M8ZA 1KH4A 4CXSA 4CXUA 3M7VA 3UN2A 1KHNA 5L0EA 1AJBA 1ALIA 4LRFA 3TX0A 4CYRA 1KH7A 4ZG6A 1AJCA 3BDFA 1KHKA 2IFYA 1ZEBA 3NKQA 2ZKTA 3NKRA 4GTYA 4MY4A 5L0BA 4QAXA 4LRCA 5LQQA 1EJJA 1KH9A 1O98A 1AUKA 4UPKA 1EW2A 3T02A 2GSNA 4CYSA 4N7TA 1ANJA 4KJDA 4NWXA 1URAA 2W8DA 1ZEFA 4KM4A 3A52A 3UNYA 1ALHA 1URBA 1Y6VA 5DLWA 4LR7A 1SHQA 1P49A 2GSUA 2W5XA 4CXKA 4KJGA 3WAWA 3SZZA 4B56A 3TWZA 3BDHA 5KXAA 4ZG7A 5EGHA 3DPCA 3WBHA 3MK1A 5HRTA 4MHXA 3MK0A 2XRGA 2IUCB 1ELZA 1EQJA 1N2LA 1B8JA 3NVLA 3Q3QA 1ED8A 4LQYA 1EI6A 2W8SA 4UPHA 3SZYA 4UPLA 4YR1A 2W5RA 5TJ3A 4ZG9A 1O99A 5L0KA 4KAVA 3WAVA 1ZEDA 3UN5A 4GTXA 3M8WA 5C66A 1KH5A 1E3CP 3CMRA 3T00A 4LR2A 5LRNA 4UORA 2QZUA 1ED9A 2XR9A 3KD8A 1ALKA 4LREA 1E2SP 1K7HA 1ELXA 5GRRA 3WAXA 4LRDA 3DYCA 2X98A 1FSUA 2W5WA 4LR8A 1AJDA 5EGEA 5DLVA 1Y7AA 2VQRA 3IGZB 2G9YA 2GSOA 3BDGA 4LRBA 2W5SA 2IUCA 3NKNA 3E2DA 1EW9A 1ELYA 4FDJA 1KHJA 4UOOA 3IDDA 3UO0A 3WAYA 4UPIA 3UN3A 1EW8A 5K4PA 3TG0A 3ED4A 2GLQA 4KAYA 5INHA 1E1ZP 1KHLA 2D1GA
chains in the Genus database with same CATH topology
1AJAA 4GTWA 2GA3A 4ZGAA 4LRAA 2W5VA 3NKOA 4NWJA 1HQAA 1ANIA 3MK2A 1N2KA 2W5QA 5AJ9A 3M8YA 1E33P 5LRMA 5GOVA 3NKPA 4TN0A 3T01A 4GTZA 5IJQA 3OT9A 5IJSA 4FDIA 1ALJA 3BDGB 2ANHA 5LIAA 3IGYB 5DLTA 4UOPA 2RH6A 2W5TA 1HDHA 4MIVA 3NKMA 3B5QA 3LXQA 4LR9A 1HJKA 1SHNA 3M8ZA 1KH4A 4CXSA 4CXUA 3M7VA 3UN2A 1KHNA 5L0EA 1AJBA 1ALIA 4LRFA 3TX0A 4CYRA 1KH7A 4ZG6A 1AJCA 3BDFA 1KHKA 2IFYA 1ZEBA 3NKQA 2ZKTA 3NKRA 4GTYA 4MY4A 5L0BA 4QAXA 4LRCA 5LQQA 1EJJA 1KH9A 1O98A 1AUKA 4UPKA 1EW2A 3T02A 2GSNA 4CYSA 4N7TA 1ANJA 4KJDA 4NWXA 1URAA 2W8DA 1ZEFA 4KM4A 3A52A 3UNYA 1ALHA 1URBA 1Y6VA 5DLWA 4LR7A 1SHQA 1P49A 2GSUA 2W5XA 4CXKA 4KJGA 3WAWA 3SZZA 4B56A 3TWZA 3BDHA 5KXAA 4ZG7A 5EGHA 3DPCA 3WBHA 3MK1A 5HRTA 4MHXA 3MK0A 2XRGA 2IUCB 1ELZA 1EQJA 1N2LA 1B8JA 3NVLA 3Q3QA 1ED8A 4LQYA 1EI6A 2W8SA 4UPHA 3SZYA 4UPLA 4YR1A 2W5RA 5TJ3A 4ZG9A 1O99A 5L0KA 4KAVA 3WAVA 1ZEDA 3UN5A 4GTXA 3M8WA 5C66A 1KH5A 1E3CP 3CMRA 3T00A 4LR2A 5LRNA 4UORA 2QZUA 1ED9A 2XR9A 3KD8A 1ALKA 4LREA 1E2SP 1K7HA 1ELXA 5GRRA 3WAXA 4LRDA 3DYCA 2X98A 1FSUA 2W5WA 4LR8A 1AJDA 5EGEA 5DLVA 1Y7AA 2VQRA 3IGZB 2G9YA 2GSOA 3BDGA 4LRBA 2W5SA 2IUCA 3NKNA 3E2DA 1EW9A 1ELYA 4FDJA 1KHJA 4UOOA 3IDDA 3UO0A 3WAYA 4UPIA 3UN3A 1EW8A 5K4PA 3TG0A 3ED4A 2GLQA 4KAYA 5INHA 1E1ZP 1KHLA 2D1GA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1AJA A;  4GTW A;  2GA3 A;  4ZGA A;  4LRA A;  2W5V A;  3NKO A;  4NWJ A;  1HQA A;  1ANI A;  3MK2 A;  1N2K A;  2W5Q A;  5AJ9 A;  3M8Y A;  1E33 P;  5LRM A;  5GOV A;  3NKP A;  4TN0 A;  3T01 A;  4GTZ A;  5IJQ A;  3OT9 A;  5IJS A;  4FDI A;  1ALJ A;  3BDG B;  2ANH A;  5LIA A;  3IGY B;  5DLT A;  4UOP A;  2RH6 A;  2W5T A;  1HDH A;  4MIV A;  3NKM A;  3B5Q A;  3LXQ A;  4LR9 A;  1HJK A;  1SHN A;  3M8Z A;  1KH4 A;  4CXS A;  4CXU A;  3M7V A;  3UN2 A;  1KHN A;  5L0E A;  1AJB A;  1ALI A;  4LRF A;  3TX0 A;  4CYR A;  1KH7 A;  4ZG6 A;  1AJC A;  3BDF A;  1KHK A;  2IFY A;  1ZEB A;  3NKQ A;  2ZKT A;  3NKR A;  4GTY A;  4MY4 A;  5L0B A;  4QAX A;  4LRC A;  5LQQ A;  1EJJ A;  1KH9 A;  1O98 A;  1AUK A;  4UPK A;  1EW2 A;  3T02 A;  2GSN A;  4CYS A;  4N7T A;  1ANJ A;  4KJD A;  4NWX A;  1URA A;  2W8D A;  1ZEF A;  4KM4 A;  3A52 A;  3UNY A;  1ALH A;  1URB A;  1Y6V A;  5DLW A;  4LR7 A;  1SHQ A;  1P49 A;  2GSU A;  2W5X A;  4CXK A;  4KJG A;  3WAW A;  3SZZ A;  4B56 A;  3TWZ A;  3BDH A;  5KXA A;  4ZG7 A;  5EGH A;  3DPC A;  3WBH A;  3MK1 A;  5HRT A;  4MHX A;  3MK0 A;  2XRG A;  2IUC B;  1ELZ A;  1EQJ A;  1N2L A;  1B8J A;  3NVL A;  3Q3Q A;  1ED8 A;  4LQY A;  1EI6 A;  2W8S A;  4UPH A;  3SZY A;  4UPL A;  4YR1 A;  2W5R A;  5TJ3 A;  4ZG9 A;  1O99 A;  5L0K A;  4KAV A;  3WAV A;  1ZED A;  3UN5 A;  4GTX A;  3M8W A;  5C66 A;  1KH5 A;  1E3C P;  3CMR A;  3T00 A;  4LR2 A;  5LRN A;  4UOR A;  2QZU A;  1ED9 A;  2XR9 A;  3KD8 A;  1ALK A;  4LRE A;  1E2S P;  1K7H A;  1ELX A;  5GRR A;  3WAX A;  4LRD A;  3DYC A;  2X98 A;  1FSU A;  2W5W A;  4LR8 A;  1AJD A;  5EGE A;  5DLV A;  1Y7A A;  2VQR A;  3IGZ B;  2G9Y A;  2GSO A;  3BDG A;  4LRB A;  2W5S A;  2IUC A;  3NKN A;  3E2D A;  1EW9 A;  1ELY A;  4FDJ A;  1KHJ A;  4UOO A;  3IDD A;  3UO0 A;  3WAY A;  4UPI A;  3UN3 A;  1EW8 A;  5K4P A;  3TG0 A;  3ED4 A;  2GLQ A;  4KAY A;  5INH A;  1E1Z P;  1KHL A;  2D1G A; 
#chains in the Genus database with same CATH topology
 1AJA A;  4GTW A;  2GA3 A;  4ZGA A;  4LRA A;  2W5V A;  3NKO A;  4NWJ A;  1HQA A;  1ANI A;  3MK2 A;  1N2K A;  2W5Q A;  5AJ9 A;  3M8Y A;  1E33 P;  5LRM A;  5GOV A;  3NKP A;  4TN0 A;  3T01 A;  4GTZ A;  5IJQ A;  3OT9 A;  5IJS A;  4FDI A;  1ALJ A;  3BDG B;  2ANH A;  5LIA A;  3IGY B;  5DLT A;  4UOP A;  2RH6 A;  2W5T A;  1HDH A;  4MIV A;  3NKM A;  3B5Q A;  3LXQ A;  4LR9 A;  1HJK A;  1SHN A;  3M8Z A;  1KH4 A;  4CXS A;  4CXU A;  3M7V A;  3UN2 A;  1KHN A;  5L0E A;  1AJB A;  1ALI A;  4LRF A;  3TX0 A;  4CYR A;  1KH7 A;  4ZG6 A;  1AJC A;  3BDF A;  1KHK A;  2IFY A;  1ZEB A;  3NKQ A;  2ZKT A;  3NKR A;  4GTY A;  4MY4 A;  5L0B A;  4QAX A;  4LRC A;  5LQQ A;  1EJJ A;  1KH9 A;  1O98 A;  1AUK A;  4UPK A;  1EW2 A;  3T02 A;  2GSN A;  4CYS A;  4N7T A;  1ANJ A;  4KJD A;  4NWX A;  1URA A;  2W8D A;  1ZEF A;  4KM4 A;  3A52 A;  3UNY A;  1ALH A;  1URB A;  1Y6V A;  5DLW A;  4LR7 A;  1SHQ A;  1P49 A;  2GSU A;  2W5X A;  4CXK A;  4KJG A;  3WAW A;  3SZZ A;  4B56 A;  3TWZ A;  3BDH A;  5KXA A;  4ZG7 A;  5EGH A;  3DPC A;  3WBH A;  3MK1 A;  5HRT A;  4MHX A;  3MK0 A;  2XRG A;  2IUC B;  1ELZ A;  1EQJ A;  1N2L A;  1B8J A;  3NVL A;  3Q3Q A;  1ED8 A;  4LQY A;  1EI6 A;  2W8S A;  4UPH A;  3SZY A;  4UPL A;  4YR1 A;  2W5R A;  5TJ3 A;  4ZG9 A;  1O99 A;  5L0K A;  4KAV A;  3WAV A;  1ZED A;  3UN5 A;  4GTX A;  3M8W A;  5C66 A;  1KH5 A;  1E3C P;  3CMR A;  3T00 A;  4LR2 A;  5LRN A;  4UOR A;  2QZU A;  1ED9 A;  2XR9 A;  3KD8 A;  1ALK A;  4LRE A;  1E2S P;  1K7H A;  1ELX A;  5GRR A;  3WAX A;  4LRD A;  3DYC A;  2X98 A;  1FSU A;  2W5W A;  4LR8 A;  1AJD A;  5EGE A;  5DLV A;  1Y7A A;  2VQR A;  3IGZ B;  2G9Y A;  2GSO A;  3BDG A;  4LRB A;  2W5S A;  2IUC A;  3NKN A;  3E2D A;  1EW9 A;  1ELY A;  4FDJ A;  1KHJ A;  4UOO A;  3IDD A;  3UO0 A;  3WAY A;  4UPI A;  3UN3 A;  1EW8 A;  5K4P A;  3TG0 A;  3ED4 A;  2GLQ A;  4KAY A;  5INH A;  1E1Z P;  1KHL A;  2D1G A; 
#chains in the Genus database with same CATH homology
 1AJA A;  4GTW A;  2GA3 A;  4ZGA A;  4LRA A;  2W5V A;  3NKO A;  4NWJ A;  1HQA A;  1ANI A;  3MK2 A;  1N2K A;  2W5Q A;  5AJ9 A;  3M8Y A;  1E33 P;  5LRM A;  5GOV A;  3NKP A;  4TN0 A;  3T01 A;  4GTZ A;  5IJQ A;  3OT9 A;  5IJS A;  4FDI A;  1ALJ A;  3BDG B;  2ANH A;  5LIA A;  3IGY B;  5DLT A;  4UOP A;  2RH6 A;  2W5T A;  1HDH A;  4MIV A;  3NKM A;  3B5Q A;  3LXQ A;  4LR9 A;  1HJK A;  1SHN A;  3M8Z A;  1KH4 A;  4CXS A;  4CXU A;  3M7V A;  3UN2 A;  1KHN A;  5L0E A;  1AJB A;  1ALI A;  4LRF A;  3TX0 A;  4CYR A;  1KH7 A;  4ZG6 A;  1AJC A;  3BDF A;  1KHK A;  2IFY A;  1ZEB A;  3NKQ A;  2ZKT A;  3NKR A;  4GTY A;  4MY4 A;  5L0B A;  4QAX A;  4LRC A;  5LQQ A;  1EJJ A;  1KH9 A;  1O98 A;  1AUK A;  4UPK A;  1EW2 A;  3T02 A;  2GSN A;  4CYS A;  4N7T A;  1ANJ A;  4KJD A;  4NWX A;  1URA A;  2W8D A;  1ZEF A;  4KM4 A;  3A52 A;  3UNY A;  1ALH A;  1URB A;  1Y6V A;  5DLW A;  4LR7 A;  1SHQ A;  1P49 A;  2GSU A;  2W5X A;  4CXK A;  4KJG A;  3WAW A;  3SZZ A;  4B56 A;  3TWZ A;  3BDH A;  5KXA A;  4ZG7 A;  5EGH A;  3DPC A;  3WBH A;  3MK1 A;  5HRT A;  4MHX A;  3MK0 A;  2XRG A;  2IUC B;  1ELZ A;  1EQJ A;  1N2L A;  1B8J A;  3NVL A;  3Q3Q A;  1ED8 A;  4LQY A;  1EI6 A;  2W8S A;  4UPH A;  3SZY A;  4UPL A;  4YR1 A;  2W5R A;  5TJ3 A;  4ZG9 A;  1O99 A;  5L0K A;  4KAV A;  3WAV A;  1ZED A;  3UN5 A;  4GTX A;  3M8W A;  5C66 A;  1KH5 A;  1E3C P;  3CMR A;  3T00 A;  4LR2 A;  5LRN A;  4UOR A;  2QZU A;  1ED9 A;  2XR9 A;  3KD8 A;  1ALK A;  4LRE A;  1E2S P;  1K7H A;  1ELX A;  5GRR A;  3WAX A;  4LRD A;  3DYC A;  2X98 A;  1FSU A;  2W5W A;  4LR8 A;  1AJD A;  5EGE A;  5DLV A;  1Y7A A;  2VQR A;  3IGZ B;  2G9Y A;  2GSO A;  3BDG A;  4LRB A;  2W5S A;  2IUC A;  3NKN A;  3E2D A;  1EW9 A;  1ELY A;  4FDJ A;  1KHJ A;  4UOO A;  3IDD A;  3UO0 A;  3WAY A;  4UPI A;  3UN3 A;  1EW8 A;  5K4P A;  3TG0 A;  3ED4 A;  2GLQ A;  4KAY A;  5INH A;  1E1Z P;  1KHL A;  2D1G A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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