1EW8A

Alkaline phosphatase (e.c. 3.1.3.1) complex with phosphonoacetic acid
Total Genus 155
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
155
Knots found
sequence length
449
structure length
449
Chain Sequence
TPEMPVLENRAAQGDITAPGGARRLTGDQTAALRDSLSDKPAKNIILLIGDGMGDSEITAARNYAEGAGGFFKGIDALPLTGQYTHYALNKKTGKPDYVTDSAASATAWSTGVKTYNGALGVDIHEKDHPTILEMAKAAGLATGNVSTAELQDATPAALVAHVTSRKCYGPSATSEKCPGNALEKGGKGSITEQLLNARADVTLGGGAKTFAETATAGEWQGKTLREQAQARGYQLVSDAASLNSVTEANQQKPLLGLFADGNMPVRWLGPKATYHGNIDKPAVTCTPNPQRNDSVPTLAQMTDKAIELLSKNEKGFFLQVEGASIDKQDHAANPCGQIGETVDLDEAVQRALEFAKKEGNTLVIVTADHAHASQIVAPDTKAPGLTQALNTKDGAVMVMSYGNSEEDSQEHTGSQLRIAAYGPHAANVVGLTDQTDLFYTMKAALGLK
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

molecule keywords ALKALINE PHOSPHATASE
publication title Alternate modes of binding in two crystal structures of alkaline phosphatase-inhibitor complexes.
pubmed rcsb
source organism Escherichia coli
molecule tags Hydrolase
total genus 155
structure length 449
sequence length 449
chains with identical sequence B
other databases KnotProt 2.0: S +31
ec nomenclature ec 3.1.3.1: Alkaline phosphatase.
pdb deposition date 2000-04-24

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00245 Alk_phosphatase Alkaline phosphatase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.720.10 Alpha Beta 3-Layer(aba) Sandwich Alkaline Phosphatase, subunit A Alkaline Phosphatase, subunit A 1ew8A00
4ZG7A 2W5QA 3LXQA 2GSNA 1P49A 4KM4A 5LIAA 1HQAA 1ELZA 1E2SP 2XRGA 3KD8A 3WBHA 4CYSA 4QAXA 4UPKA 1KH7A 3TG0A 1ELYA 5INHA 3NKPA 1KHKA 1KHNA 1KH4A 3MK1A 4KAYA 3T00A 2W5RA 3SZZA 2W8SA 1HDHA 3B5QA 5TJ3A 1KHJA 1E3CP 5L0KA 1AUKA 1FSUA 1E1ZP 4LREA 3UO0A 1AJDA 3SZYA 5L0EA 1K7HA 4GTXA 4CXUA 4YR1A 4LR9A 2W8DA 3ED4A 2GSOA 3WAXA 4CYRA 4LRDA 4CXSA 4LRBA 4MHXA 5IJSA 3NKRA 5AJ9A 1Y7AA 3IGZB 4MY4A 5EGHA 3CMRA 3UN3A 1KHLA 5EGEA 2GA3A 3UNYA 4ZGAA 3NKQA 1EJJA 1AJAA 1ELXA 3WAWA 3T01A 3Q3QA 4UORA 2VQRA 3UN2A 1E33P 1EW9A 4LR2A 5KXAA 2GLQA 2IUCA 1KH9A 3IGYB 1AJCA 5LRMA 1EW2A 1ZEFA 3TX0A 3OT9A 3E2DA 2W5WA 3UN5A 3BDHA 4UPHA 3M8WA 1URBA 1ZEBA 5C66A 3T02A 4NWXA 1ZEDA 4TN0A 1O99A 4UOOA 5DLWA 2QZUA 3MK2A 4FDJA 3M8YA 3TWZA 1EW8A 4GTZA 2X98A 3A52A 4FDIA 4ZG6A 1SHNA 3DPCA 1N2KA 2ZKTA 5L0BA 1O98A 1B8JA 1KH5A 3BDGA 4LR8A 4ZG9A 4UPIA 1AJBA 1HJKA 3NVLA 4KJDA 3NKMA 4LQYA 3WAYA 5LRNA 2IUCB 4LR7A 1ALHA 5HRTA 1ED9A 1N2LA 1ALKA 1EI6A 5K4PA 3BDGB 2IFYA 2ANHA 2RH6A 2D1GA 2W5TA 3NKNA 5LQQA 4N7TA 4CXKA 5GRRA 4LRFA 1ALJA 4MIVA 3IDDA 5DLTA 2W5SA 3WAVA 2W5VA 4UOPA 3DYCA 1ALIA 2GSUA 4LRCA 3M8ZA 3M7VA 1EQJA 5IJQA 1Y6VA 3NKOA 5GOVA 4KJGA 1URAA 4LRAA 5DLVA 2G9YA 2W5XA 2XR9A 4NWJA 1ED8A 1ANIA 3BDFA 4B56A 1ANJA 4GTWA 4KAVA 4GTYA 1SHQA 4UPLA 3MK0A
chains in the Genus database with same CATH superfamily
4ZG7A 2W5QA 3LXQA 2GSNA 1P49A 4KM4A 5LIAA 1HQAA 1ELZA 1E2SP 2XRGA 3KD8A 3WBHA 4CYSA 4QAXA 4UPKA 1KH7A 3TG0A 1ELYA 5INHA 3NKPA 1KHKA 1KHNA 1KH4A 3MK1A 4KAYA 3T00A 2W5RA 3SZZA 2W8SA 1HDHA 3B5QA 5TJ3A 1KHJA 1E3CP 5L0KA 1AUKA 1FSUA 1E1ZP 4LREA 3UO0A 1AJDA 3SZYA 5L0EA 1K7HA 4GTXA 4CXUA 4YR1A 4LR9A 2W8DA 3ED4A 2GSOA 3WAXA 4CYRA 4LRDA 4CXSA 4LRBA 4MHXA 5IJSA 3NKRA 5AJ9A 1Y7AA 3IGZB 4MY4A 5EGHA 3CMRA 3UN3A 1KHLA 5EGEA 2GA3A 3UNYA 4ZGAA 3NKQA 1EJJA 1AJAA 1ELXA 3WAWA 3T01A 3Q3QA 4UORA 2VQRA 3UN2A 1E33P 1EW9A 4LR2A 5KXAA 2GLQA 2IUCA 1KH9A 3IGYB 1AJCA 5LRMA 1EW2A 1ZEFA 3TX0A 3OT9A 3E2DA 2W5WA 3UN5A 3BDHA 4UPHA 3M8WA 1URBA 1ZEBA 5C66A 3T02A 4NWXA 1ZEDA 4TN0A 1O99A 4UOOA 5DLWA 2QZUA 3MK2A 4FDJA 3M8YA 3TWZA 1EW8A 4GTZA 2X98A 3A52A 4FDIA 4ZG6A 1SHNA 3DPCA 1N2KA 2ZKTA 5L0BA 1O98A 1B8JA 1KH5A 3BDGA 4LR8A 4ZG9A 4UPIA 1AJBA 1HJKA 3NVLA 4KJDA 3NKMA 4LQYA 3WAYA 5LRNA 2IUCB 4LR7A 1ALHA 5HRTA 1ED9A 1N2LA 1ALKA 1EI6A 5K4PA 3BDGB 2IFYA 2ANHA 2RH6A 2D1GA 2W5TA 3NKNA 5LQQA 4N7TA 4CXKA 5GRRA 4LRFA 1ALJA 4MIVA 3IDDA 5DLTA 2W5SA 3WAVA 2W5VA 4UOPA 3DYCA 1ALIA 2GSUA 4LRCA 3M8ZA 3M7VA 1EQJA 5IJQA 1Y6VA 3NKOA 5GOVA 4KJGA 1URAA 4LRAA 5DLVA 2G9YA 2W5XA 2XR9A 4NWJA 1ED8A 1ANIA 3BDFA 4B56A 1ANJA 4GTWA 4KAVA 4GTYA 1SHQA 4UPLA 3MK0A
chains in the Genus database with same CATH topology
4ZG7A 2W5QA 3LXQA 2GSNA 1P49A 4KM4A 5LIAA 1HQAA 1ELZA 1E2SP 2XRGA 3KD8A 3WBHA 4CYSA 4QAXA 4UPKA 1KH7A 3TG0A 1ELYA 5INHA 3NKPA 1KHKA 1KHNA 1KH4A 3MK1A 4KAYA 3T00A 2W5RA 3SZZA 2W8SA 1HDHA 3B5QA 5TJ3A 1KHJA 1E3CP 5L0KA 1AUKA 1FSUA 1E1ZP 4LREA 3UO0A 1AJDA 3SZYA 5L0EA 1K7HA 4GTXA 4CXUA 4YR1A 4LR9A 2W8DA 3ED4A 2GSOA 3WAXA 4CYRA 4LRDA 4CXSA 4LRBA 4MHXA 5IJSA 3NKRA 5AJ9A 1Y7AA 3IGZB 4MY4A 5EGHA 3CMRA 3UN3A 1KHLA 5EGEA 2GA3A 3UNYA 4ZGAA 3NKQA 1EJJA 1AJAA 1ELXA 3WAWA 3T01A 3Q3QA 4UORA 2VQRA 3UN2A 1E33P 1EW9A 4LR2A 5KXAA 2GLQA 2IUCA 1KH9A 3IGYB 1AJCA 5LRMA 1EW2A 1ZEFA 3TX0A 3OT9A 3E2DA 2W5WA 3UN5A 3BDHA 4UPHA 3M8WA 1URBA 1ZEBA 5C66A 3T02A 4NWXA 1ZEDA 4TN0A 1O99A 4UOOA 5DLWA 2QZUA 3MK2A 4FDJA 3M8YA 3TWZA 1EW8A 4GTZA 2X98A 3A52A 4FDIA 4ZG6A 1SHNA 3DPCA 1N2KA 2ZKTA 5L0BA 1O98A 1B8JA 1KH5A 3BDGA 4LR8A 4ZG9A 4UPIA 1AJBA 1HJKA 3NVLA 4KJDA 3NKMA 4LQYA 3WAYA 5LRNA 2IUCB 4LR7A 1ALHA 5HRTA 1ED9A 1N2LA 1ALKA 1EI6A 5K4PA 3BDGB 2IFYA 2ANHA 2RH6A 2D1GA 2W5TA 3NKNA 5LQQA 4N7TA 4CXKA 5GRRA 4LRFA 1ALJA 4MIVA 3IDDA 5DLTA 2W5SA 3WAVA 2W5VA 4UOPA 3DYCA 1ALIA 2GSUA 4LRCA 3M8ZA 3M7VA 1EQJA 5IJQA 1Y6VA 3NKOA 5GOVA 4KJGA 1URAA 4LRAA 5DLVA 2G9YA 2W5XA 2XR9A 4NWJA 1ED8A 1ANIA 3BDFA 4B56A 1ANJA 4GTWA 4KAVA 4GTYA 1SHQA 4UPLA 3MK0A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4ZG7 A;  2W5Q A;  3LXQ A;  2GSN A;  1P49 A;  4KM4 A;  5LIA A;  1HQA A;  1ELZ A;  1E2S P;  2XRG A;  3KD8 A;  3WBH A;  4CYS A;  4QAX A;  4UPK A;  1KH7 A;  3TG0 A;  1ELY A;  5INH A;  3NKP A;  1KHK A;  1KHN A;  1KH4 A;  3MK1 A;  4KAY A;  3T00 A;  2W5R A;  3SZZ A;  2W8S A;  1HDH A;  3B5Q A;  5TJ3 A;  1KHJ A;  1E3C P;  5L0K A;  1AUK A;  1FSU A;  1E1Z P;  4LRE A;  3UO0 A;  1AJD A;  3SZY A;  5L0E A;  1K7H A;  4GTX A;  4CXU A;  4YR1 A;  4LR9 A;  2W8D A;  3ED4 A;  2GSO A;  3WAX A;  4CYR A;  4LRD A;  4CXS A;  4LRB A;  4MHX A;  5IJS A;  3NKR A;  5AJ9 A;  1Y7A A;  3IGZ B;  4MY4 A;  5EGH A;  3CMR A;  3UN3 A;  1KHL A;  5EGE A;  2GA3 A;  3UNY A;  4ZGA A;  3NKQ A;  1EJJ A;  1AJA A;  1ELX A;  3WAW A;  3T01 A;  3Q3Q A;  4UOR A;  2VQR A;  3UN2 A;  1E33 P;  1EW9 A;  4LR2 A;  5KXA A;  2GLQ A;  2IUC A;  1KH9 A;  3IGY B;  1AJC A;  5LRM A;  1EW2 A;  1ZEF A;  3TX0 A;  3OT9 A;  3E2D A;  2W5W A;  3UN5 A;  3BDH A;  4UPH A;  3M8W A;  1URB A;  1ZEB A;  5C66 A;  3T02 A;  4NWX A;  1ZED A;  4TN0 A;  1O99 A;  4UOO A;  5DLW A;  2QZU A;  3MK2 A;  4FDJ A;  3M8Y A;  3TWZ A;  1EW8 A;  4GTZ A;  2X98 A;  3A52 A;  4FDI A;  4ZG6 A;  1SHN A;  3DPC A;  1N2K A;  2ZKT A;  5L0B A;  1O98 A;  1B8J A;  1KH5 A;  3BDG A;  4LR8 A;  4ZG9 A;  4UPI A;  1AJB A;  1HJK A;  3NVL A;  4KJD A;  3NKM A;  4LQY A;  3WAY A;  5LRN A;  2IUC B;  4LR7 A;  1ALH A;  5HRT A;  1ED9 A;  1N2L A;  1ALK A;  1EI6 A;  5K4P A;  3BDG B;  2IFY A;  2ANH A;  2RH6 A;  2D1G A;  2W5T A;  3NKN A;  5LQQ A;  4N7T A;  4CXK A;  5GRR A;  4LRF A;  1ALJ A;  4MIV A;  3IDD A;  5DLT A;  2W5S A;  3WAV A;  2W5V A;  4UOP A;  3DYC A;  1ALI A;  2GSU A;  4LRC A;  3M8Z A;  3M7V A;  1EQJ A;  5IJQ A;  1Y6V A;  3NKO A;  5GOV A;  4KJG A;  1URA A;  4LRA A;  5DLV A;  2G9Y A;  2W5X A;  2XR9 A;  4NWJ A;  1ED8 A;  1ANI A;  3BDF A;  4B56 A;  1ANJ A;  4GTW A;  4KAV A;  4GTY A;  1SHQ A;  4UPL A;  3MK0 A; 
#chains in the Genus database with same CATH topology
 4ZG7 A;  2W5Q A;  3LXQ A;  2GSN A;  1P49 A;  4KM4 A;  5LIA A;  1HQA A;  1ELZ A;  1E2S P;  2XRG A;  3KD8 A;  3WBH A;  4CYS A;  4QAX A;  4UPK A;  1KH7 A;  3TG0 A;  1ELY A;  5INH A;  3NKP A;  1KHK A;  1KHN A;  1KH4 A;  3MK1 A;  4KAY A;  3T00 A;  2W5R A;  3SZZ A;  2W8S A;  1HDH A;  3B5Q A;  5TJ3 A;  1KHJ A;  1E3C P;  5L0K A;  1AUK A;  1FSU A;  1E1Z P;  4LRE A;  3UO0 A;  1AJD A;  3SZY A;  5L0E A;  1K7H A;  4GTX A;  4CXU A;  4YR1 A;  4LR9 A;  2W8D A;  3ED4 A;  2GSO A;  3WAX A;  4CYR A;  4LRD A;  4CXS A;  4LRB A;  4MHX A;  5IJS A;  3NKR A;  5AJ9 A;  1Y7A A;  3IGZ B;  4MY4 A;  5EGH A;  3CMR A;  3UN3 A;  1KHL A;  5EGE A;  2GA3 A;  3UNY A;  4ZGA A;  3NKQ A;  1EJJ A;  1AJA A;  1ELX A;  3WAW A;  3T01 A;  3Q3Q A;  4UOR A;  2VQR A;  3UN2 A;  1E33 P;  1EW9 A;  4LR2 A;  5KXA A;  2GLQ A;  2IUC A;  1KH9 A;  3IGY B;  1AJC A;  5LRM A;  1EW2 A;  1ZEF A;  3TX0 A;  3OT9 A;  3E2D A;  2W5W A;  3UN5 A;  3BDH A;  4UPH A;  3M8W A;  1URB A;  1ZEB A;  5C66 A;  3T02 A;  4NWX A;  1ZED A;  4TN0 A;  1O99 A;  4UOO A;  5DLW A;  2QZU A;  3MK2 A;  4FDJ A;  3M8Y A;  3TWZ A;  1EW8 A;  4GTZ A;  2X98 A;  3A52 A;  4FDI A;  4ZG6 A;  1SHN A;  3DPC A;  1N2K A;  2ZKT A;  5L0B A;  1O98 A;  1B8J A;  1KH5 A;  3BDG A;  4LR8 A;  4ZG9 A;  4UPI A;  1AJB A;  1HJK A;  3NVL A;  4KJD A;  3NKM A;  4LQY A;  3WAY A;  5LRN A;  2IUC B;  4LR7 A;  1ALH A;  5HRT A;  1ED9 A;  1N2L A;  1ALK A;  1EI6 A;  5K4P A;  3BDG B;  2IFY A;  2ANH A;  2RH6 A;  2D1G A;  2W5T A;  3NKN A;  5LQQ A;  4N7T A;  4CXK A;  5GRR A;  4LRF A;  1ALJ A;  4MIV A;  3IDD A;  5DLT A;  2W5S A;  3WAV A;  2W5V A;  4UOP A;  3DYC A;  1ALI A;  2GSU A;  4LRC A;  3M8Z A;  3M7V A;  1EQJ A;  5IJQ A;  1Y6V A;  3NKO A;  5GOV A;  4KJG A;  1URA A;  4LRA A;  5DLV A;  2G9Y A;  2W5X A;  2XR9 A;  4NWJ A;  1ED8 A;  1ANI A;  3BDF A;  4B56 A;  1ANJ A;  4GTW A;  4KAV A;  4GTY A;  1SHQ A;  4UPL A;  3MK0 A; 
#chains in the Genus database with same CATH homology
 4ZG7 A;  2W5Q A;  3LXQ A;  2GSN A;  1P49 A;  4KM4 A;  5LIA A;  1HQA A;  1ELZ A;  1E2S P;  2XRG A;  3KD8 A;  3WBH A;  4CYS A;  4QAX A;  4UPK A;  1KH7 A;  3TG0 A;  1ELY A;  5INH A;  3NKP A;  1KHK A;  1KHN A;  1KH4 A;  3MK1 A;  4KAY A;  3T00 A;  2W5R A;  3SZZ A;  2W8S A;  1HDH A;  3B5Q A;  5TJ3 A;  1KHJ A;  1E3C P;  5L0K A;  1AUK A;  1FSU A;  1E1Z P;  4LRE A;  3UO0 A;  1AJD A;  3SZY A;  5L0E A;  1K7H A;  4GTX A;  4CXU A;  4YR1 A;  4LR9 A;  2W8D A;  3ED4 A;  2GSO A;  3WAX A;  4CYR A;  4LRD A;  4CXS A;  4LRB A;  4MHX A;  5IJS A;  3NKR A;  5AJ9 A;  1Y7A A;  3IGZ B;  4MY4 A;  5EGH A;  3CMR A;  3UN3 A;  1KHL A;  5EGE A;  2GA3 A;  3UNY A;  4ZGA A;  3NKQ A;  1EJJ A;  1AJA A;  1ELX A;  3WAW A;  3T01 A;  3Q3Q A;  4UOR A;  2VQR A;  3UN2 A;  1E33 P;  1EW9 A;  4LR2 A;  5KXA A;  2GLQ A;  2IUC A;  1KH9 A;  3IGY B;  1AJC A;  5LRM A;  1EW2 A;  1ZEF A;  3TX0 A;  3OT9 A;  3E2D A;  2W5W A;  3UN5 A;  3BDH A;  4UPH A;  3M8W A;  1URB A;  1ZEB A;  5C66 A;  3T02 A;  4NWX A;  1ZED A;  4TN0 A;  1O99 A;  4UOO A;  5DLW A;  2QZU A;  3MK2 A;  4FDJ A;  3M8Y A;  3TWZ A;  1EW8 A;  4GTZ A;  2X98 A;  3A52 A;  4FDI A;  4ZG6 A;  1SHN A;  3DPC A;  1N2K A;  2ZKT A;  5L0B A;  1O98 A;  1B8J A;  1KH5 A;  3BDG A;  4LR8 A;  4ZG9 A;  4UPI A;  1AJB A;  1HJK A;  3NVL A;  4KJD A;  3NKM A;  4LQY A;  3WAY A;  5LRN A;  2IUC B;  4LR7 A;  1ALH A;  5HRT A;  1ED9 A;  1N2L A;  1ALK A;  1EI6 A;  5K4P A;  3BDG B;  2IFY A;  2ANH A;  2RH6 A;  2D1G A;  2W5T A;  3NKN A;  5LQQ A;  4N7T A;  4CXK A;  5GRR A;  4LRF A;  1ALJ A;  4MIV A;  3IDD A;  5DLT A;  2W5S A;  3WAV A;  2W5V A;  4UOP A;  3DYC A;  1ALI A;  2GSU A;  4LRC A;  3M8Z A;  3M7V A;  1EQJ A;  5IJQ A;  1Y6V A;  3NKO A;  5GOV A;  4KJG A;  1URA A;  4LRA A;  5DLV A;  2G9Y A;  2W5X A;  2XR9 A;  4NWJ A;  1ED8 A;  1ANI A;  3BDF A;  4B56 A;  1ANJ A;  4GTW A;  4KAV A;  4GTY A;  1SHQ A;  4UPL A;  3MK0 A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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