1EW9A

Alkaline phosphatase (e.c. 3.1.3.1) complex with mercaptomethyl phosphonate
Total Genus 159
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
159
Knots found
sequence length
449
structure length
449
Chain Sequence
TPEMPVLENRAAQGDITAPGGARRLTGDQTAALRDSLSDKPAKNIILLIGDGMGDSEITAARNYAEGAGGFFKGIDALPLTGQYTHYALNKKTGKPDYVTDSAASATAWSTGVKTYNGALGVDIHEKDHPTILEMAKAAGLATGNVSTAELQDATPAALVAHVTSRKCYGPSATSEKCPGNALEKGGKGSITEQLLNARADVTLGGGAKTFAETATAGEWQGKTLREQAQARGYQLVSDAASLNSVTEANQQKPLLGLFADGNMPVRWLGPKATYHGNIDKPAVTCTPNPQRNDSVPTLAQMTDKAIELLSKNEKGFFLQVEGASIDKQDHAANPCGQIGETVDLDEAVQRALEFAKKEGNTLVIVTADHAHASQIVAPDTKAPGLTQALNTKDGAVMVMSYGNSEEDSQEHTGSQLRIAAYGPHAANVVGLTDQTDLFYTMKAALGLK
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

molecule keywords ALKALINE PHOSPHATASE
publication title Alternate modes of binding in two crystal structures of alkaline phosphatase-inhibitor complexes.
pubmed rcsb
source organism Escherichia coli
molecule tags Hydrolase
total genus 159
structure length 449
sequence length 449
chains with identical sequence B
other databases KnotProt 2.0: S +31
ec nomenclature ec 3.1.3.1: Alkaline phosphatase.
pdb deposition date 2000-04-24

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00245 Alk_phosphatase Alkaline phosphatase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.720.10 Alpha Beta 3-Layer(aba) Sandwich Alkaline Phosphatase, subunit A Alkaline Phosphatase, subunit A 1ew9A00
3Q3QA 1ED9A 5GOVA 2IUCA 2D1GA 2GSOA 4LR9A 1KHLA 3M8WA 4N7TA 3M7VA 4B56A 1KHNA 1B8JA 3KD8A 4GTWA 1P49A 4KM4A 1Y6VA 3M8YA 1EW2A 1KHJA 3NKMA 1EW8A 4LRFA 1FSUA 5LRMA 4YR1A 3LXQA 3NKQA 5EGEA 1N2KA 4LR2A 1E33P 2W8SA 3IDDA 1KH9A 2GA3A 2W5QA 3MK2A 4LRAA 4KAVA 3NVLA 4LQYA 4UPHA 2RH6A 1O98A 3ED4A 1ZEDA 3UO0A 3UN3A 1K7HA 4UPLA 2GLQA 1ELYA 3BDGB 3NKNA 3UNYA 1E1ZP 2VQRA 1E3CP 1N2LA 2ZKTA 1HDHA 3MK0A 4CXUA 1AJAA 5KXAA 1EW9A 3CMRA 4UORA 3E2DA 1URAA 3DYCA 4UPIA 3B5QA 2X98A 3UN5A 4LR7A 4FDJA 4LRBA 1ELZA 3T00A 4UOPA 5K4PA 1O99A 1SHQA 3WAVA 4CXSA 3WAWA 5LIAA 1ZEBA 5C66A 1KH7A 3WAYA 3NKPA 2IFYA 1EJJA 4ZG9A 5IJSA 3A52A 4MIVA 1ALHA 3SZYA 5IJQA 3T02A 1ALKA 3SZZA 3BDHA 2W5SA 1AJCA 1ZEFA 3DPCA 1EQJA 3WAXA 1HJKA 2IUCB 5L0EA 2W5TA 4KJDA 5INHA 3OT9A 2W5VA 4CYRA 5TJ3A 1URBA 4ZG7A 1AJBA 4UOOA 4ZGAA 2QZUA 3TWZA 5HRTA 2XRGA 2W5WA 1KHKA 1Y7AA 4FDIA 4NWJA 2W8DA 5DLWA 5L0BA 3TX0A 3TG0A 5EGHA 1SHNA 2GSUA 1AUKA 5DLVA 4GTXA 1ED8A 4TN0A 2ANHA 2XR9A 5LRNA 4QAXA 2GSNA 4GTZA 3BDGA 4CXKA 2W5XA 4KJGA 5GRRA 3WBHA 5LQQA 4MHXA 3NKOA 1AJDA 4LRCA 4UPKA 1ELXA 1HQAA 3NKRA 5DLTA 3BDFA 3MK1A 4LRDA 1ANJA 3M8ZA 2G9YA 1ALJA 1E2SP 4MY4A 1ALIA 3T01A 1EI6A 4CYSA 4LR8A 4LREA 5AJ9A 4ZG6A 1ANIA 2W5RA 3IGYB 3UN2A 1KH5A 3IGZB 4GTYA 4NWXA 1KH4A 5L0KA 4KAYA
chains in the Genus database with same CATH superfamily
3Q3QA 1ED9A 5GOVA 2IUCA 2D1GA 2GSOA 4LR9A 1KHLA 3M8WA 4N7TA 3M7VA 4B56A 1KHNA 1B8JA 3KD8A 4GTWA 1P49A 4KM4A 1Y6VA 3M8YA 1EW2A 1KHJA 3NKMA 1EW8A 4LRFA 1FSUA 5LRMA 4YR1A 3LXQA 3NKQA 5EGEA 1N2KA 4LR2A 1E33P 2W8SA 3IDDA 1KH9A 2GA3A 2W5QA 3MK2A 4LRAA 4KAVA 3NVLA 4LQYA 4UPHA 2RH6A 1O98A 3ED4A 1ZEDA 3UO0A 3UN3A 1K7HA 4UPLA 2GLQA 1ELYA 3BDGB 3NKNA 3UNYA 1E1ZP 2VQRA 1E3CP 1N2LA 2ZKTA 1HDHA 3MK0A 4CXUA 1AJAA 5KXAA 1EW9A 3CMRA 4UORA 3E2DA 1URAA 3DYCA 4UPIA 3B5QA 2X98A 3UN5A 4LR7A 4FDJA 4LRBA 1ELZA 3T00A 4UOPA 5K4PA 1O99A 1SHQA 3WAVA 4CXSA 3WAWA 5LIAA 1ZEBA 5C66A 1KH7A 3WAYA 3NKPA 2IFYA 1EJJA 4ZG9A 5IJSA 3A52A 4MIVA 1ALHA 3SZYA 5IJQA 3T02A 1ALKA 3SZZA 3BDHA 2W5SA 1AJCA 1ZEFA 3DPCA 1EQJA 3WAXA 1HJKA 2IUCB 5L0EA 2W5TA 4KJDA 5INHA 3OT9A 2W5VA 4CYRA 5TJ3A 1URBA 4ZG7A 1AJBA 4UOOA 4ZGAA 2QZUA 3TWZA 5HRTA 2XRGA 2W5WA 1KHKA 1Y7AA 4FDIA 4NWJA 2W8DA 5DLWA 5L0BA 3TX0A 3TG0A 5EGHA 1SHNA 2GSUA 1AUKA 5DLVA 4GTXA 1ED8A 4TN0A 2ANHA 2XR9A 5LRNA 4QAXA 2GSNA 4GTZA 3BDGA 4CXKA 2W5XA 4KJGA 5GRRA 3WBHA 5LQQA 4MHXA 3NKOA 1AJDA 4LRCA 4UPKA 1ELXA 1HQAA 3NKRA 5DLTA 3BDFA 3MK1A 4LRDA 1ANJA 3M8ZA 2G9YA 1ALJA 1E2SP 4MY4A 1ALIA 3T01A 1EI6A 4CYSA 4LR8A 4LREA 5AJ9A 4ZG6A 1ANIA 2W5RA 3IGYB 3UN2A 1KH5A 3IGZB 4GTYA 4NWXA 1KH4A 5L0KA 4KAYA
chains in the Genus database with same CATH topology
3Q3QA 1ED9A 5GOVA 2IUCA 2D1GA 2GSOA 4LR9A 1KHLA 3M8WA 4N7TA 3M7VA 4B56A 1KHNA 1B8JA 3KD8A 4GTWA 1P49A 4KM4A 1Y6VA 3M8YA 1EW2A 1KHJA 3NKMA 1EW8A 4LRFA 1FSUA 5LRMA 4YR1A 3LXQA 3NKQA 5EGEA 1N2KA 4LR2A 1E33P 2W8SA 3IDDA 1KH9A 2GA3A 2W5QA 3MK2A 4LRAA 4KAVA 3NVLA 4LQYA 4UPHA 2RH6A 1O98A 3ED4A 1ZEDA 3UO0A 3UN3A 1K7HA 4UPLA 2GLQA 1ELYA 3BDGB 3NKNA 3UNYA 1E1ZP 2VQRA 1E3CP 1N2LA 2ZKTA 1HDHA 3MK0A 4CXUA 1AJAA 5KXAA 1EW9A 3CMRA 4UORA 3E2DA 1URAA 3DYCA 4UPIA 3B5QA 2X98A 3UN5A 4LR7A 4FDJA 4LRBA 1ELZA 3T00A 4UOPA 5K4PA 1O99A 1SHQA 3WAVA 4CXSA 3WAWA 5LIAA 1ZEBA 5C66A 1KH7A 3WAYA 3NKPA 2IFYA 1EJJA 4ZG9A 5IJSA 3A52A 4MIVA 1ALHA 3SZYA 5IJQA 3T02A 1ALKA 3SZZA 3BDHA 2W5SA 1AJCA 1ZEFA 3DPCA 1EQJA 3WAXA 1HJKA 2IUCB 5L0EA 2W5TA 4KJDA 5INHA 3OT9A 2W5VA 4CYRA 5TJ3A 1URBA 4ZG7A 1AJBA 4UOOA 4ZGAA 2QZUA 3TWZA 5HRTA 2XRGA 2W5WA 1KHKA 1Y7AA 4FDIA 4NWJA 2W8DA 5DLWA 5L0BA 3TX0A 3TG0A 5EGHA 1SHNA 2GSUA 1AUKA 5DLVA 4GTXA 1ED8A 4TN0A 2ANHA 2XR9A 5LRNA 4QAXA 2GSNA 4GTZA 3BDGA 4CXKA 2W5XA 4KJGA 5GRRA 3WBHA 5LQQA 4MHXA 3NKOA 1AJDA 4LRCA 4UPKA 1ELXA 1HQAA 3NKRA 5DLTA 3BDFA 3MK1A 4LRDA 1ANJA 3M8ZA 2G9YA 1ALJA 1E2SP 4MY4A 1ALIA 3T01A 1EI6A 4CYSA 4LR8A 4LREA 5AJ9A 4ZG6A 1ANIA 2W5RA 3IGYB 3UN2A 1KH5A 3IGZB 4GTYA 4NWXA 1KH4A 5L0KA 4KAYA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 3Q3Q A;  1ED9 A;  5GOV A;  2IUC A;  2D1G A;  2GSO A;  4LR9 A;  1KHL A;  3M8W A;  4N7T A;  3M7V A;  4B56 A;  1KHN A;  1B8J A;  3KD8 A;  4GTW A;  1P49 A;  4KM4 A;  1Y6V A;  3M8Y A;  1EW2 A;  1KHJ A;  3NKM A;  1EW8 A;  4LRF A;  1FSU A;  5LRM A;  4YR1 A;  3LXQ A;  3NKQ A;  5EGE A;  1N2K A;  4LR2 A;  1E33 P;  2W8S A;  3IDD A;  1KH9 A;  2GA3 A;  2W5Q A;  3MK2 A;  4LRA A;  4KAV A;  3NVL A;  4LQY A;  4UPH A;  2RH6 A;  1O98 A;  3ED4 A;  1ZED A;  3UO0 A;  3UN3 A;  1K7H A;  4UPL A;  2GLQ A;  1ELY A;  3BDG B;  3NKN A;  3UNY A;  1E1Z P;  2VQR A;  1E3C P;  1N2L A;  2ZKT A;  1HDH A;  3MK0 A;  4CXU A;  1AJA A;  5KXA A;  1EW9 A;  3CMR A;  4UOR A;  3E2D A;  1URA A;  3DYC A;  4UPI A;  3B5Q A;  2X98 A;  3UN5 A;  4LR7 A;  4FDJ A;  4LRB A;  1ELZ A;  3T00 A;  4UOP A;  5K4P A;  1O99 A;  1SHQ A;  3WAV A;  4CXS A;  3WAW A;  5LIA A;  1ZEB A;  5C66 A;  1KH7 A;  3WAY A;  3NKP A;  2IFY A;  1EJJ A;  4ZG9 A;  5IJS A;  3A52 A;  4MIV A;  1ALH A;  3SZY A;  5IJQ A;  3T02 A;  1ALK A;  3SZZ A;  3BDH A;  2W5S A;  1AJC A;  1ZEF A;  3DPC A;  1EQJ A;  3WAX A;  1HJK A;  2IUC B;  5L0E A;  2W5T A;  4KJD A;  5INH A;  3OT9 A;  2W5V A;  4CYR A;  5TJ3 A;  1URB A;  4ZG7 A;  1AJB A;  4UOO A;  4ZGA A;  2QZU A;  3TWZ A;  5HRT A;  2XRG A;  2W5W A;  1KHK A;  1Y7A A;  4FDI A;  4NWJ A;  2W8D A;  5DLW A;  5L0B A;  3TX0 A;  3TG0 A;  5EGH A;  1SHN A;  2GSU A;  1AUK A;  5DLV A;  4GTX A;  1ED8 A;  4TN0 A;  2ANH A;  2XR9 A;  5LRN A;  4QAX A;  2GSN A;  4GTZ A;  3BDG A;  4CXK A;  2W5X A;  4KJG A;  5GRR A;  3WBH A;  5LQQ A;  4MHX A;  3NKO A;  1AJD A;  4LRC A;  4UPK A;  1ELX A;  1HQA A;  3NKR A;  5DLT A;  3BDF A;  3MK1 A;  4LRD A;  1ANJ A;  3M8Z A;  2G9Y A;  1ALJ A;  1E2S P;  4MY4 A;  1ALI A;  3T01 A;  1EI6 A;  4CYS A;  4LR8 A;  4LRE A;  5AJ9 A;  4ZG6 A;  1ANI A;  2W5R A;  3IGY B;  3UN2 A;  1KH5 A;  3IGZ B;  4GTY A;  4NWX A;  1KH4 A;  5L0K A;  4KAY A; 
#chains in the Genus database with same CATH topology
 3Q3Q A;  1ED9 A;  5GOV A;  2IUC A;  2D1G A;  2GSO A;  4LR9 A;  1KHL A;  3M8W A;  4N7T A;  3M7V A;  4B56 A;  1KHN A;  1B8J A;  3KD8 A;  4GTW A;  1P49 A;  4KM4 A;  1Y6V A;  3M8Y A;  1EW2 A;  1KHJ A;  3NKM A;  1EW8 A;  4LRF A;  1FSU A;  5LRM A;  4YR1 A;  3LXQ A;  3NKQ A;  5EGE A;  1N2K A;  4LR2 A;  1E33 P;  2W8S A;  3IDD A;  1KH9 A;  2GA3 A;  2W5Q A;  3MK2 A;  4LRA A;  4KAV A;  3NVL A;  4LQY A;  4UPH A;  2RH6 A;  1O98 A;  3ED4 A;  1ZED A;  3UO0 A;  3UN3 A;  1K7H A;  4UPL A;  2GLQ A;  1ELY A;  3BDG B;  3NKN A;  3UNY A;  1E1Z P;  2VQR A;  1E3C P;  1N2L A;  2ZKT A;  1HDH A;  3MK0 A;  4CXU A;  1AJA A;  5KXA A;  1EW9 A;  3CMR A;  4UOR A;  3E2D A;  1URA A;  3DYC A;  4UPI A;  3B5Q A;  2X98 A;  3UN5 A;  4LR7 A;  4FDJ A;  4LRB A;  1ELZ A;  3T00 A;  4UOP A;  5K4P A;  1O99 A;  1SHQ A;  3WAV A;  4CXS A;  3WAW A;  5LIA A;  1ZEB A;  5C66 A;  1KH7 A;  3WAY A;  3NKP A;  2IFY A;  1EJJ A;  4ZG9 A;  5IJS A;  3A52 A;  4MIV A;  1ALH A;  3SZY A;  5IJQ A;  3T02 A;  1ALK A;  3SZZ A;  3BDH A;  2W5S A;  1AJC A;  1ZEF A;  3DPC A;  1EQJ A;  3WAX A;  1HJK A;  2IUC B;  5L0E A;  2W5T A;  4KJD A;  5INH A;  3OT9 A;  2W5V A;  4CYR A;  5TJ3 A;  1URB A;  4ZG7 A;  1AJB A;  4UOO A;  4ZGA A;  2QZU A;  3TWZ A;  5HRT A;  2XRG A;  2W5W A;  1KHK A;  1Y7A A;  4FDI A;  4NWJ A;  2W8D A;  5DLW A;  5L0B A;  3TX0 A;  3TG0 A;  5EGH A;  1SHN A;  2GSU A;  1AUK A;  5DLV A;  4GTX A;  1ED8 A;  4TN0 A;  2ANH A;  2XR9 A;  5LRN A;  4QAX A;  2GSN A;  4GTZ A;  3BDG A;  4CXK A;  2W5X A;  4KJG A;  5GRR A;  3WBH A;  5LQQ A;  4MHX A;  3NKO A;  1AJD A;  4LRC A;  4UPK A;  1ELX A;  1HQA A;  3NKR A;  5DLT A;  3BDF A;  3MK1 A;  4LRD A;  1ANJ A;  3M8Z A;  2G9Y A;  1ALJ A;  1E2S P;  4MY4 A;  1ALI A;  3T01 A;  1EI6 A;  4CYS A;  4LR8 A;  4LRE A;  5AJ9 A;  4ZG6 A;  1ANI A;  2W5R A;  3IGY B;  3UN2 A;  1KH5 A;  3IGZ B;  4GTY A;  4NWX A;  1KH4 A;  5L0K A;  4KAY A; 
#chains in the Genus database with same CATH homology
 3Q3Q A;  1ED9 A;  5GOV A;  2IUC A;  2D1G A;  2GSO A;  4LR9 A;  1KHL A;  3M8W A;  4N7T A;  3M7V A;  4B56 A;  1KHN A;  1B8J A;  3KD8 A;  4GTW A;  1P49 A;  4KM4 A;  1Y6V A;  3M8Y A;  1EW2 A;  1KHJ A;  3NKM A;  1EW8 A;  4LRF A;  1FSU A;  5LRM A;  4YR1 A;  3LXQ A;  3NKQ A;  5EGE A;  1N2K A;  4LR2 A;  1E33 P;  2W8S A;  3IDD A;  1KH9 A;  2GA3 A;  2W5Q A;  3MK2 A;  4LRA A;  4KAV A;  3NVL A;  4LQY A;  4UPH A;  2RH6 A;  1O98 A;  3ED4 A;  1ZED A;  3UO0 A;  3UN3 A;  1K7H A;  4UPL A;  2GLQ A;  1ELY A;  3BDG B;  3NKN A;  3UNY A;  1E1Z P;  2VQR A;  1E3C P;  1N2L A;  2ZKT A;  1HDH A;  3MK0 A;  4CXU A;  1AJA A;  5KXA A;  1EW9 A;  3CMR A;  4UOR A;  3E2D A;  1URA A;  3DYC A;  4UPI A;  3B5Q A;  2X98 A;  3UN5 A;  4LR7 A;  4FDJ A;  4LRB A;  1ELZ A;  3T00 A;  4UOP A;  5K4P A;  1O99 A;  1SHQ A;  3WAV A;  4CXS A;  3WAW A;  5LIA A;  1ZEB A;  5C66 A;  1KH7 A;  3WAY A;  3NKP A;  2IFY A;  1EJJ A;  4ZG9 A;  5IJS A;  3A52 A;  4MIV A;  1ALH A;  3SZY A;  5IJQ A;  3T02 A;  1ALK A;  3SZZ A;  3BDH A;  2W5S A;  1AJC A;  1ZEF A;  3DPC A;  1EQJ A;  3WAX A;  1HJK A;  2IUC B;  5L0E A;  2W5T A;  4KJD A;  5INH A;  3OT9 A;  2W5V A;  4CYR A;  5TJ3 A;  1URB A;  4ZG7 A;  1AJB A;  4UOO A;  4ZGA A;  2QZU A;  3TWZ A;  5HRT A;  2XRG A;  2W5W A;  1KHK A;  1Y7A A;  4FDI A;  4NWJ A;  2W8D A;  5DLW A;  5L0B A;  3TX0 A;  3TG0 A;  5EGH A;  1SHN A;  2GSU A;  1AUK A;  5DLV A;  4GTX A;  1ED8 A;  4TN0 A;  2ANH A;  2XR9 A;  5LRN A;  4QAX A;  2GSN A;  4GTZ A;  3BDG A;  4CXK A;  2W5X A;  4KJG A;  5GRR A;  3WBH A;  5LQQ A;  4MHX A;  3NKO A;  1AJD A;  4LRC A;  4UPK A;  1ELX A;  1HQA A;  3NKR A;  5DLT A;  3BDF A;  3MK1 A;  4LRD A;  1ANJ A;  3M8Z A;  2G9Y A;  1ALJ A;  1E2S P;  4MY4 A;  1ALI A;  3T01 A;  1EI6 A;  4CYS A;  4LR8 A;  4LRE A;  5AJ9 A;  4ZG6 A;  1ANI A;  2W5R A;  3IGY B;  3UN2 A;  1KH5 A;  3IGZ B;  4GTY A;  4NWX A;  1KH4 A;  5L0K A;  4KAY A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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