1HP7A

A 2.1 angstrom structure of an uncleaved alpha-1-antitrypsin shows variability of the reactive center and other loops
Total Genus 98
Loading diagram...

The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
98
sequence length
376
structure length
376
Chain Sequence
DHPTFNKITPNLAEFAFSLYRQLAHQSNSTNIFFSPVSIATAFAMLSLGTKGDTHDEILEGLNFNLTEIPEAQIHEGFQELLHTLNQPDSQLQLTTGNGLFLSEGLKLVDKFLEDVKKLYHSEAFTVNFGDTEEAKKQINDYVEKGTQGKIVDLVKELDRDTVFALVNYIFFKGKWERPFEVKDTEEEDFHVDQVTTVKVPMMKRLGMFNIQHCKKLSSWVLLMKYLGNATAIFFLPDEGKLQHLENELTHDIITKFLENEDRRSASLHLPKLSITGTYDLKSVLGQLGITKVFSNGADLSGVTEEAPLKLSKAVHKAVLTIDEKGTEAAGAMFLEAIPMSIPPEVKFNKPFVFLMIDQNTKSPLFMGKVVNPTQK
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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molecule tags Protein binding
molecule keywords ALPHA-1-ANTITRYPSIN
publication title A 2.1 A resolution structure of an uncleaved alpha(1)-antitrypsin shows variability of the reactive center and other loops.
pubmed doi rcsb
source organism Homo sapiens
total genus 98
structure length 376
sequence length 376
ec nomenclature
pdb deposition date 2000-12-12

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00079 Serpin Serpin (serine protease inhibitor)
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.30.39.10 Mainly Beta Roll Alpha-1-antitrypsin; domain 1 Alpha-1-antitrypsin, domain 1 1hp7A01
3.30.497.10 Alpha Beta 2-Layer Sandwich Antithrombin; Chain I, domain 2 Antithrombin, subunit I, domain 2 1hp7A02
1TB6I 7APIA 1LQ8A 2WXYC 1DZGL 2DUTA 1OVAA 3Q02A 1F0CA 9PAIA 2XN3A 1C8OA 2ACHA 2CEOA 1NQ9I 2GD4C 1OYHI 2WXZA 4AU2A 3CWMA 3UT3A 4R9IA 4RO9A 5HGCA 2BEHI 1ANTI 3R4LA 1BY7A 1OC0A 9APIA 4Y40A 4AU3B 1LK6I 2B4XL 2QUGA 3F02A 1JTIA 2PEFA 3B9FI 1XU8A 1XQJA 3NDAA 4DTEA 1E03I 1AZXI 4EB1I 1EZXA 8APIA 1SNGA 2WXWA 1OVAB 1DZGI 1JMOA 1ATUA 2XN7A 3LE2A 2RIVA 4G8OA 3CAAA 4P0OA 1B3KA 5INWA 1HLEA 3DY0A 1PSIA 2XN6A 2WXZC 3DLWA 4PYWA 3PZFA 4P0FA 5EI0A 2VDXA 1DVMA 5BRRI 4C41A 2H4RA 1DB2A 2RIWA 1SEKA 5CDXA 4ZK3A 1JRRA 2B4XI 5CDZA 1QMBA 1A7CA 2ARQA 3F5NA 4C49A 3ZHAA 1QLPA 1ATTA 4X30A 2OL2A 2B5TI 1WZ9A 4AJUA 4AJTA 3Q03A 4IF8A 1D5SA 2XN5A 2PEEA 2V95A 1K9OI 2WXXA 4ROBA 1JMJA 3PB1I 1OPHA 4ZK0A 1OVAC 2VDYA 3F1SA 1DZHL 1JJOC 3VVJA 3NDFA 2D26A 3CWLA 2R9YA 3H5CA 1SR5A 2WY0C 3EOXA 3KCGI 1YXAA 5IO1A 4DY0A 4Y3KA 1IMVA 1OO8A 3STOA 3DRUA 3OZQA 3LW2A 3NDDA 4YIAA 1M93B 4IC0A 1XQGA 5CE0A 1AS4A 1T1FA 2OAYA 2HIJL 1DZHI 1BR8I 4RSQA 4GA7A 3CVMA 3FGQA 2VH4A 2ZNHA 1E05I 1C5GA 2ANTI 4KDSA 3T1PA 1DVNA 1HP7A 1UHGA 4AU4A 3EVJI 1KCTA 1OYHL 2H4QA 2ZV6A 1ATHA 2ARRA 4G8RA 4DY7C 2H4PA 4BB2A 3NE4A 2BEHL 4CAAA 2HI9A 3DRMA 2WY1A 5C98A 1E04I 4AU3A 4AQHA 4AFXA 1JVQI 1R1LI 1LJ5A 1MTPA 2HIJI 4EB1L 1QMNA 1IZ2A 4ROAA
chains in the Genus database with same CATH superfamily
1TB6I 7APIA 1LQ8A 2WXYC 1DZGL 2DUTA 1OVAA 3Q02A 1F0CA 9PAIA 2XN3A 1C8OA 2ACHA 2CEOA 1NQ9I 2GD4C 1OYHI 2WXZA 4AU2A 3CWMA 3UT3A 4R9IA 4RO9A 5HGCA 2BEHI 1ANTI 3R4LA 1BY7A 1OC0A 9APIA 4Y40A 4AU3B 1LK6I 2B4XL 2QUGA 3F02A 1JTIA 2PEFA 3B9FI 1XU8A 1XQJA 3NDAA 4DTEA 1E03I 1AZXI 4EB1I 1EZXA 8APIA 1SNGA 2WXWA 1OVAB 1DZGI 1JMOA 1ATUA 2XN7A 3LE2A 2RIVA 4G8OA 3CAAA 4P0OA 1B3KA 5INWA 1HLEA 3DY0A 1PSIA 2XN6A 2WXZC 3DLWA 4PYWA 3PZFA 4P0FA 5EI0A 2VDXA 1DVMA 5BRRI 4C41A 2H4RA 1DB2A 2RIWA 1SEKA 5CDXA 4ZK3A 1JRRA 2B4XI 5CDZA 1QMBA 1A7CA 2ARQA 3F5NA 4C49A 3ZHAA 1QLPA 1ATTA 4X30A 2OL2A 2B5TI 1WZ9A 4AJUA 4AJTA 3Q03A 4IF8A 1D5SA 2XN5A 2PEEA 2V95A 1K9OI 2WXXA 4ROBA 1JMJA 3PB1I 1OPHA 4ZK0A 1OVAC 2VDYA 3F1SA 1DZHL 1JJOC 3VVJA 3NDFA 2D26A 3CWLA 2R9YA 3H5CA 1SR5A 2WY0C 3EOXA 3KCGI 1YXAA 5IO1A 4DY0A 4Y3KA 1IMVA 1OO8A 3STOA 3DRUA 3OZQA 3LW2A 3NDDA 4YIAA 1M93B 4IC0A 1XQGA 5CE0A 1AS4A 1T1FA 2OAYA 2HIJL 1DZHI 1BR8I 4RSQA 4GA7A 3CVMA 3FGQA 2VH4A 2ZNHA 1E05I 1C5GA 2ANTI 4KDSA 3T1PA 1DVNA 1HP7A 1UHGA 4AU4A 3EVJI 1KCTA 1OYHL 2H4QA 2ZV6A 1ATHA 2ARRA 4G8RA 4DY7C 2H4PA 4BB2A 3NE4A 2BEHL 4CAAA 2HI9A 3DRMA 2WY1A 5C98A 1E04I 4AU3A 4AQHA 4AFXA 1JVQI 1R1LI 1LJ5A 1MTPA 2HIJI 4EB1L 1QMNA 1IZ2A 4ROAA
chains in the Genus database with same CATH topology
1TB6I 7APIA 1LQ8A 2WXYC 1DZGL 2DUTA 1OVAA 3Q02A 1F0CA 9PAIA 2XN3A 1C8OA 2ACHA 2CEOA 1NQ9I 2GD4C 1OYHI 2WXZA 4AU2A 3CWMA 3UT3A 4R9IA 4RO9A 5HGCA 2BEHI 1ANTI 3R4LA 1BY7A 1OC0A 9APIA 4Y40A 4AU3B 1LK6I 2B4XL 2QUGA 3F02A 1JTIA 2PEFA 3B9FI 1XU8A 1XQJA 3NDAA 4DTEA 1E03I 1AZXI 4EB1I 1EZXA 8APIA 1SNGA 2WXWA 1OVAB 1DZGI 1JMOA 1ATUA 2XN7A 3LE2A 2RIVA 4G8OA 3CAAA 4P0OA 1B3KA 5INWA 1HLEA 3DY0A 1PSIA 2XN6A 2WXZC 3DLWA 4PYWA 3PZFA 4P0FA 5EI0A 2VDXA 1DVMA 5BRRI 4C41A 2H4RA 1DB2A 2RIWA 1SEKA 5CDXA 4ZK3A 1JRRA 2B4XI 5CDZA 1QMBA 1A7CA 2ARQA 3F5NA 4C49A 3ZHAA 1QLPA 1ATTA 4X30A 2OL2A 2B5TI 1WZ9A 4AJUA 4AJTA 3Q03A 4IF8A 1D5SA 2XN5A 2PEEA 2V95A 1K9OI 2WXXA 4ROBA 1JMJA 3PB1I 1OPHA 4ZK0A 1OVAC 2VDYA 3F1SA 1DZHL 1JJOC 3VVJA 3NDFA 2D26A 3CWLA 2R9YA 3H5CA 1SR5A 2WY0C 3EOXA 3KCGI 1YXAA 5IO1A 4DY0A 4Y3KA 1IMVA 1OO8A 3STOA 3DRUA 3OZQA 3LW2A 3NDDA 4YIAA 1M93B 4IC0A 1XQGA 5CE0A 1AS4A 1T1FA 2OAYA 2HIJL 1DZHI 1BR8I 4RSQA 4GA7A 3CVMA 3FGQA 2VH4A 2ZNHA 1E05I 1C5GA 2ANTI 4KDSA 3T1PA 1DVNA 1HP7A 1UHGA 4AU4A 3EVJI 1KCTA 1OYHL 2H4QA 2ZV6A 1ATHA 2ARRA 4G8RA 4DY7C 2H4PA 4BB2A 3NE4A 2BEHL 4CAAA 2HI9A 3DRMA 2WY1A 5C98A 1E04I 4AU3A 4AQHA 4AFXA 1JVQI 1R1LI 1LJ5A 1MTPA 2HIJI 4EB1L 1QMNA 1IZ2A 4ROAA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1TB6 I;  7API A;  1LQ8 A;  2WXY C;  1DZG L;  2DUT A;  1OVA A;  3Q02 A;  1F0C A;  9PAI A;  2XN3 A;  1C8O A;  2ACH A;  2CEO A;  1NQ9 I;  2GD4 C;  1OYH I;  2WXZ A;  4AU2 A;  3CWM A;  3UT3 A;  4R9I A;  4RO9 A;  5HGC A;  2BEH I;  1ANT I;  3R4L A;  1BY7 A;  1OC0 A;  9API A;  4Y40 A;  4AU3 B;  1LK6 I;  2B4X L;  2QUG A;  3F02 A;  1JTI A;  2PEF A;  3B9F I;  1XU8 A;  1XQJ A;  3NDA A;  4DTE A;  1E03 I;  1AZX I;  4EB1 I;  1EZX A;  8API A;  1SNG A;  2WXW A;  1OVA B;  1DZG I;  1JMO A;  1ATU A;  2XN7 A;  3LE2 A;  2RIV A;  4G8O A;  3CAA A;  4P0O A;  1B3K A;  5INW A;  1HLE A;  3DY0 A;  1PSI A;  2XN6 A;  2WXZ C;  3DLW A;  4PYW A;  3PZF A;  4P0F A;  5EI0 A;  2VDX A;  1DVM A;  5BRR I;  4C41 A;  2H4R A;  1DB2 A;  2RIW A;  1SEK A;  5CDX A;  4ZK3 A;  1JRR A;  2B4X I;  5CDZ A;  1QMB A;  1A7C A;  2ARQ A;  3F5N A;  4C49 A;  3ZHA A;  1QLP A;  1ATT A;  4X30 A;  2OL2 A;  2B5T I;  1WZ9 A;  4AJU A;  4AJT A;  3Q03 A;  4IF8 A;  1D5S A;  2XN5 A;  2PEE A;  2V95 A;  1K9O I;  2WXX A;  4ROB A;  1JMJ A;  3PB1 I;  1OPH A;  4ZK0 A;  1OVA C;  2VDY A;  3F1S A;  1DZH L;  1JJO C;  3VVJ A;  3NDF A;  2D26 A;  3CWL A;  2R9Y A;  3H5C A;  1SR5 A;  2WY0 C;  3EOX A;  3KCG I;  1YXA A;  5IO1 A;  4DY0 A;  4Y3K A;  1IMV A;  1OO8 A;  3STO A;  3DRU A;  3OZQ A;  3LW2 A;  3NDD A;  4YIA A;  1M93 B;  4IC0 A;  1XQG A;  5CE0 A;  1AS4 A;  1T1F A;  2OAY A;  2HIJ L;  1DZH I;  1BR8 I;  4RSQ A;  4GA7 A;  3CVM A;  3FGQ A;  2VH4 A;  2ZNH A;  1E05 I;  1C5G A;  2ANT I;  4KDS A;  3T1P A;  1DVN A;  1HP7 A;  1UHG A;  4AU4 A;  3EVJ I;  1KCT A;  1OYH L;  2H4Q A;  2ZV6 A;  1ATH A;  2ARR A;  4G8R A;  4DY7 C;  2H4P A;  4BB2 A;  3NE4 A;  2BEH L;  4CAA A;  2HI9 A;  3DRM A;  2WY1 A;  5C98 A;  1E04 I;  4AU3 A;  4AQH A;  4AFX A;  1JVQ I;  1R1L I;  1LJ5 A;  1MTP A;  2HIJ I;  4EB1 L;  1QMN A;  1IZ2 A;  4ROA A; 
#chains in the Genus database with same CATH topology
 1TB6 I;  7API A;  1LQ8 A;  2WXY C;  1DZG L;  2DUT A;  1OVA A;  3Q02 A;  1F0C A;  9PAI A;  2XN3 A;  1C8O A;  2ACH A;  2CEO A;  1NQ9 I;  2GD4 C;  1OYH I;  2WXZ A;  4AU2 A;  3CWM A;  3UT3 A;  4R9I A;  4RO9 A;  5HGC A;  2BEH I;  1ANT I;  3R4L A;  1BY7 A;  1OC0 A;  9API A;  4Y40 A;  4AU3 B;  1LK6 I;  2B4X L;  2QUG A;  3F02 A;  1JTI A;  2PEF A;  3B9F I;  1XU8 A;  1XQJ A;  3NDA A;  4DTE A;  1E03 I;  1AZX I;  4EB1 I;  1EZX A;  8API A;  1SNG A;  2WXW A;  1OVA B;  1DZG I;  1JMO A;  1ATU A;  2XN7 A;  3LE2 A;  2RIV A;  4G8O A;  3CAA A;  4P0O A;  1B3K A;  5INW A;  1HLE A;  3DY0 A;  1PSI A;  2XN6 A;  2WXZ C;  3DLW A;  4PYW A;  3PZF A;  4P0F A;  5EI0 A;  2VDX A;  1DVM A;  5BRR I;  4C41 A;  2H4R A;  1DB2 A;  2RIW A;  1SEK A;  5CDX A;  4ZK3 A;  1JRR A;  2B4X I;  5CDZ A;  1QMB A;  1A7C A;  2ARQ A;  3F5N A;  4C49 A;  3ZHA A;  1QLP A;  1ATT A;  4X30 A;  2OL2 A;  2B5T I;  1WZ9 A;  4AJU A;  4AJT A;  3Q03 A;  4IF8 A;  1D5S A;  2XN5 A;  2PEE A;  2V95 A;  1K9O I;  2WXX A;  4ROB A;  1JMJ A;  3PB1 I;  1OPH A;  4ZK0 A;  1OVA C;  2VDY A;  3F1S A;  1DZH L;  1JJO C;  3VVJ A;  3NDF A;  2D26 A;  3CWL A;  2R9Y A;  3H5C A;  1SR5 A;  2WY0 C;  3EOX A;  3KCG I;  1YXA A;  5IO1 A;  4DY0 A;  4Y3K A;  1IMV A;  1OO8 A;  3STO A;  3DRU A;  3OZQ A;  3LW2 A;  3NDD A;  4YIA A;  1M93 B;  4IC0 A;  1XQG A;  5CE0 A;  1AS4 A;  1T1F A;  2OAY A;  2HIJ L;  1DZH I;  1BR8 I;  4RSQ A;  4GA7 A;  3CVM A;  3FGQ A;  2VH4 A;  2ZNH A;  1E05 I;  1C5G A;  2ANT I;  4KDS A;  3T1P A;  1DVN A;  1HP7 A;  1UHG A;  4AU4 A;  3EVJ I;  1KCT A;  1OYH L;  2H4Q A;  2ZV6 A;  1ATH A;  2ARR A;  4G8R A;  4DY7 C;  2H4P A;  4BB2 A;  3NE4 A;  2BEH L;  4CAA A;  2HI9 A;  3DRM A;  2WY1 A;  5C98 A;  1E04 I;  4AU3 A;  4AQH A;  4AFX A;  1JVQ I;  1R1L I;  1LJ5 A;  1MTP A;  2HIJ I;  4EB1 L;  1QMN A;  1IZ2 A;  4ROA A; 
#chains in the Genus database with same CATH homology
 1TB6 I;  7API A;  1LQ8 A;  2WXY C;  1DZG L;  2DUT A;  1OVA A;  3Q02 A;  1F0C A;  9PAI A;  2XN3 A;  1C8O A;  2ACH A;  2CEO A;  1NQ9 I;  2GD4 C;  1OYH I;  2WXZ A;  4AU2 A;  3CWM A;  3UT3 A;  4R9I A;  4RO9 A;  5HGC A;  2BEH I;  1ANT I;  3R4L A;  1BY7 A;  1OC0 A;  9API A;  4Y40 A;  4AU3 B;  1LK6 I;  2B4X L;  2QUG A;  3F02 A;  1JTI A;  2PEF A;  3B9F I;  1XU8 A;  1XQJ A;  3NDA A;  4DTE A;  1E03 I;  1AZX I;  4EB1 I;  1EZX A;  8API A;  1SNG A;  2WXW A;  1OVA B;  1DZG I;  1JMO A;  1ATU A;  2XN7 A;  3LE2 A;  2RIV A;  4G8O A;  3CAA A;  4P0O A;  1B3K A;  5INW A;  1HLE A;  3DY0 A;  1PSI A;  2XN6 A;  2WXZ C;  3DLW A;  4PYW A;  3PZF A;  4P0F A;  5EI0 A;  2VDX A;  1DVM A;  5BRR I;  4C41 A;  2H4R A;  1DB2 A;  2RIW A;  1SEK A;  5CDX A;  4ZK3 A;  1JRR A;  2B4X I;  5CDZ A;  1QMB A;  1A7C A;  2ARQ A;  3F5N A;  4C49 A;  3ZHA A;  1QLP A;  1ATT A;  4X30 A;  2OL2 A;  2B5T I;  1WZ9 A;  4AJU A;  4AJT A;  3Q03 A;  4IF8 A;  1D5S A;  2XN5 A;  2PEE A;  2V95 A;  1K9O I;  2WXX A;  4ROB A;  1JMJ A;  3PB1 I;  1OPH A;  4ZK0 A;  1OVA C;  2VDY A;  3F1S A;  1DZH L;  1JJO C;  3VVJ A;  3NDF A;  2D26 A;  3CWL A;  2R9Y A;  3H5C A;  1SR5 A;  2WY0 C;  3EOX A;  3KCG I;  1YXA A;  5IO1 A;  4DY0 A;  4Y3K A;  1IMV A;  1OO8 A;  3STO A;  3DRU A;  3OZQ A;  3LW2 A;  3NDD A;  4YIA A;  1M93 B;  4IC0 A;  1XQG A;  5CE0 A;  1AS4 A;  1T1F A;  2OAY A;  2HIJ L;  1DZH I;  1BR8 I;  4RSQ A;  4GA7 A;  3CVM A;  3FGQ A;  2VH4 A;  2ZNH A;  1E05 I;  1C5G A;  2ANT I;  4KDS A;  3T1P A;  1DVN A;  1HP7 A;  1UHG A;  4AU4 A;  3EVJ I;  1KCT A;  1OYH L;  2H4Q A;  2ZV6 A;  1ATH A;  2ARR A;  4G8R A;  4DY7 C;  2H4P A;  4BB2 A;  3NE4 A;  2BEH L;  4CAA A;  2HI9 A;  3DRM A;  2WY1 A;  5C98 A;  1E04 I;  4AU3 A;  4AQH A;  4AFX A;  1JVQ I;  1R1L I;  1LJ5 A;  1MTP A;  2HIJ I;  4EB1 L;  1QMN A;  1IZ2 A;  4ROA A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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