1I7SA

Anthranilate synthase from serratia marcescens in complex with its end product inhibitor l-tryptophan
Total Genus 166
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
166
sequence length
517
structure length
511
Chain Sequence
TKPQLTLLKVQASYRGDPTTLFHQLCGARPATLLLESAELQSLLVIDSALRITALGHTVSVQALTANGPALLPLLDEALPPEVRNQARPNGRELTFPAIDAVQDEDARLRSLSVFDALRTILTLVDSPADEREAVMLGGLFAYDLVAGFENLPALRQDQRCPDFCFYLAETLLVLDHQRGSARLQASVFSEQASEAQRLQHRLEQLQAELQQPPQPIPHQKLENMQLSCNQSDEEYGAVVSELQEAIRQGEIFQVVPSRRFSLPCPAPLGPYQTLKDNNPSPYMFFMQDDDFTLFGASPESALKYDAGNRQIEIYPIAGTRPRGRRADGSLDLDLDSRIELEMRTDHKELAEHLMLVDLARNDLARICQAGSRYVADLTKVDRYSFVMHLVSRVVGTLRADLDVLHAYQACMNMGTLSGAPKVRAMQLIAALRSTRRGSYGGRVGYFTAVRNLDTCIVIRSAYVEDGHRTVQAGAGVVQDSIPEREADETRNKARAVLRAIATAHHAKEVF
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

molecule tags Lyase
molecule keywords ANTHRANILATE SYNTHASE
publication title The structures of anthranilate synthase of Serratia marcescens crystallized in the presence of (i) its substrates, chorismate and glutamine, and a product, glutamate, and (ii) its end-product inhibitor, L-tryptophan.
pubmed doi rcsb
source organism Serratia marcescens
total genus 166
structure length 511
sequence length 517
chains with identical sequence C
ec nomenclature ec 4.1.3.27: Anthranilate synthase.
pdb deposition date 2001-03-10

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00425 Chorismate_bind chorismate binding enzyme
A PF04715 Anth_synt_I_N Anthranilate synthase component I, N terminal region
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.60.120.10 Alpha Beta 4-Layer Sandwich Anthranilate synthase Anthranilate synthase 1i7sA00
3VEHA 3BZMA 3ST6A 3R76A 4GRHA 5CWAA 1K0EA 3HWOA 3LOGA 1QDLA 2EUAA 3GSEA 3H9MA 2FN1A 3R74A 1I7QA 5JY8A 1I7SA 5JXZA 5JY4A 1K0GA 1I1QA 3R75A 3RV6A 5JZDA 3RV9A 5JY4B 5JY9A 3RV7A 2G5FA 3BZNA 2FN0A 3RV8A 3OS6A 2I6YA 5KCKA
chains in the Genus database with same CATH superfamily
3VEHA 3BZMA 3ST6A 3R76A 4GRHA 5CWAA 1K0EA 3HWOA 3LOGA 1QDLA 2EUAA 3GSEA 3H9MA 2FN1A 3R74A 1I7QA 5JY8A 1I7SA 5JXZA 5JY4A 1K0GA 1I1QA 3R75A 3RV6A 5JZDA 3RV9A 5JY4B 5JY9A 3RV7A 2G5FA 3BZNA 2FN0A 3RV8A 3OS6A 2I6YA 5KCKA
chains in the Genus database with same CATH topology
3VEHA 3BZMA 3ST6A 3R76A 4GRHA 5CWAA 1K0EA 3HWOA 3LOGA 1QDLA 2EUAA 3GSEA 3H9MA 2FN1A 3R74A 1I7QA 5JY8A 1I7SA 5JXZA 5JY4A 1K0GA 1I1QA 3R75A 3RV6A 5JZDA 3RV9A 5JY4B 5JY9A 3RV7A 2G5FA 3BZNA 2FN0A 3RV8A 3OS6A 2I6YA 5KCKA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 3VEH A;  3BZM A;  3ST6 A;  3R76 A;  4GRH A;  5CWA A;  1K0E A;  3HWO A;  3LOG A;  1QDL A;  2EUA A;  3GSE A;  3H9M A;  2FN1 A;  3R74 A;  1I7Q A;  5JY8 A;  1I7S A;  5JXZ A;  5JY4 A;  1K0G A;  1I1Q A;  3R75 A;  3RV6 A;  5JZD A;  3RV9 A;  5JY4 B;  5JY9 A;  3RV7 A;  2G5F A;  3BZN A;  2FN0 A;  3RV8 A;  3OS6 A;  2I6Y A;  5KCK A; 
#chains in the Genus database with same CATH topology
 3VEH A;  3BZM A;  3ST6 A;  3R76 A;  4GRH A;  5CWA A;  1K0E A;  3HWO A;  3LOG A;  1QDL A;  2EUA A;  3GSE A;  3H9M A;  2FN1 A;  3R74 A;  1I7Q A;  5JY8 A;  1I7S A;  5JXZ A;  5JY4 A;  1K0G A;  1I1Q A;  3R75 A;  3RV6 A;  5JZD A;  3RV9 A;  5JY4 B;  5JY9 A;  3RV7 A;  2G5F A;  3BZN A;  2FN0 A;  3RV8 A;  3OS6 A;  2I6Y A;  5KCK A; 
#chains in the Genus database with same CATH homology
 3VEH A;  3BZM A;  3ST6 A;  3R76 A;  4GRH A;  5CWA A;  1K0E A;  3HWO A;  3LOG A;  1QDL A;  2EUA A;  3GSE A;  3H9M A;  2FN1 A;  3R74 A;  1I7Q A;  5JY8 A;  1I7S A;  5JXZ A;  5JY4 A;  1K0G A;  1I1Q A;  3R75 A;  3RV6 A;  5JZD A;  3RV9 A;  5JY4 B;  5JY9 A;  3RV7 A;  2G5F A;  3BZN A;  2FN0 A;  3RV8 A;  3OS6 A;  2I6Y A;  5KCK A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
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#similar chains, but unknotted
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