1KH5A

E. coli alkaline phosphatase mutant (d330n) mimic of the transition states with aluminium fluoride
Total Genus 151
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
151
Knots found
sequence length
444
structure length
444
Chain Sequence
VLENRAAQGNITAPGGARRLTGDQTAALRNSLSDKPAKNIILLIGDGMGDSEITAARNYAEGAGGFFKGIDALPLTGQYTHYALNKKTGKPDYVTDSAASATAWSTGVKTYNGALGVDIHEKDHPTILEMAKAAGLATGNVSTAELQDATPAALVAHVTSRKCYGPSATSQKCPGNALEKGGKGSITEQLLNARADVTLGGGAKTFAETATAGEWQGKTLREEAEARGYQLVSDAASLNSVTEANQQKPLLGLFADGNMPVRWLGPKATYHGNIDKPAVTCTPNPQRNDSVPTLAQMTDKAIELLSKNEKGFFLQVEGASIDKQNHAANPCGQIGETVDLDEAVQRALEFAKKEGNTLVIVTADHAHASQIVAPDTKAPGLTQALNTKDGAVMVMSYGNSEEDSQEHTGSQLRIAAYGPHAANVVGLTDQTDLFYTMKAALGLK
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

molecule keywords ALKALINE PHOSPHATASE
publication title Artificial evolution of an enzyme active site: structural studies of three highly active mutants of Escherichia coli alkaline phosphatase.
pubmed doi rcsb
source organism Escherichia coli
molecule tags Hydrolase
total genus 151
structure length 444
sequence length 444
chains with identical sequence B
other databases KnotProt 2.0: S +31
ec nomenclature ec 3.1.3.1: Alkaline phosphatase.
pdb deposition date 2001-11-29

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00245 Alk_phosphatase Alkaline phosphatase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.720.10 Alpha Beta 3-Layer(aba) Sandwich Alkaline Phosphatase, subunit A Alkaline Phosphatase, subunit A 1kh5A00
1ALJA 3BDFA 5INHA 2ANHA 1N2LA 1O98A 3NVLA 5GRRA 2W5VA 4UOOA 1SHQA 3WAYA 2VQRA 1KHNA 3TX0A 1KHKA 3IGZB 3WAXA 2G9YA 1HJKA 4ZG7A 2IUCA 5L0BA 4LR7A 5EGEA 1AJCA 1ED9A 3MK2A 3SZYA 4LRBA 2XRGA 5EGHA 3IGYB 1EW9A 2D1GA 3UN5A 3UN3A 4GTZA 4ZGAA 4NWXA 5DLVA 4UPHA 3TG0A 1E2SP 1K7HA 1KH4A 2IFYA 1P49A 5IJQA 3IDDA 3UN2A 3UO0A 4NWJA 2GSUA 3Q3QA 5K4PA 2W5WA 3NKMA 4ZG9A 3NKRA 1ANIA 3WAVA 1ELYA 3MK0A 3T00A 1E33P 1EQJA 3NKNA 1ELXA 3T01A 1HDHA 1AJBA 2XR9A 4MHXA 2W5RA 5AJ9A 2IUCB 1ZEBA 3CMRA 3M8ZA 5DLTA 5C66A 4MY4A 3A52A 3UNYA 4LR8A 1E3CP 4YR1A 5L0EA 4KJDA 3ED4A 2W8SA 4QAXA 2X98A 4UPIA 4FDJA 4UOPA 1Y6VA 3T02A 1ZEDA 3NKQA 4LR9A 1AJAA 2GSOA 2GA3A 5KXAA 1ELZA 1E1ZP 1URAA 3DYCA 5TJ3A 1KH5A 4ZG6A 1B8JA 3TWZA 5GOVA 3BDGB 5LQQA 1HQAA 1KH7A 4GTXA 3BDGA 4UORA 4GTYA 4KAYA 4B56A 3M7VA 1KHLA 5L0KA 2RH6A 3SZZA 1ANJA 4CXSA 1ALHA 4KAVA 4CYRA 1KH9A 3LXQA 1AUKA 3M8YA 2W5XA 3NKPA 4LQYA 5DLWA 1ED8A 4LRDA 1FSUA 4CYSA 4LRFA 5HRTA 1KHJA 2W5SA 1EW2A 4LRCA 2W5QA 5LIAA 4KJGA 1EJJA 1URBA 1ZEFA 3WBHA 4CXKA 3KD8A 1EI6A 1Y7AA 3NKOA 4TN0A 3OT9A 4GTWA 3WAWA 5LRMA 3B5QA 1ALIA 2W8DA 4FDIA 4CXUA 4N7TA 3DPCA 2QZUA 4UPLA 3E2DA 1AJDA 4LR2A 4KM4A 1EW8A 1SHNA 1ALKA 2GLQA 4MIVA 3BDHA 4UPKA 5LRNA 2GSNA 1N2KA 2W5TA 2ZKTA 3MK1A 4LREA 4LRAA 5IJSA 3M8WA 1O99A
chains in the Genus database with same CATH superfamily
1ALJA 3BDFA 5INHA 2ANHA 1N2LA 1O98A 3NVLA 5GRRA 2W5VA 4UOOA 1SHQA 3WAYA 2VQRA 1KHNA 3TX0A 1KHKA 3IGZB 3WAXA 2G9YA 1HJKA 4ZG7A 2IUCA 5L0BA 4LR7A 5EGEA 1AJCA 1ED9A 3MK2A 3SZYA 4LRBA 2XRGA 5EGHA 3IGYB 1EW9A 2D1GA 3UN5A 3UN3A 4GTZA 4ZGAA 4NWXA 5DLVA 4UPHA 3TG0A 1E2SP 1K7HA 1KH4A 2IFYA 1P49A 5IJQA 3IDDA 3UN2A 3UO0A 4NWJA 2GSUA 3Q3QA 5K4PA 2W5WA 3NKMA 4ZG9A 3NKRA 1ANIA 3WAVA 1ELYA 3MK0A 3T00A 1E33P 1EQJA 3NKNA 1ELXA 3T01A 1HDHA 1AJBA 2XR9A 4MHXA 2W5RA 5AJ9A 2IUCB 1ZEBA 3CMRA 3M8ZA 5DLTA 5C66A 4MY4A 3A52A 3UNYA 4LR8A 1E3CP 4YR1A 5L0EA 4KJDA 3ED4A 2W8SA 4QAXA 2X98A 4UPIA 4FDJA 4UOPA 1Y6VA 3T02A 1ZEDA 3NKQA 4LR9A 1AJAA 2GSOA 2GA3A 5KXAA 1ELZA 1E1ZP 1URAA 3DYCA 5TJ3A 1KH5A 4ZG6A 1B8JA 3TWZA 5GOVA 3BDGB 5LQQA 1HQAA 1KH7A 4GTXA 3BDGA 4UORA 4GTYA 4KAYA 4B56A 3M7VA 1KHLA 5L0KA 2RH6A 3SZZA 1ANJA 4CXSA 1ALHA 4KAVA 4CYRA 1KH9A 3LXQA 1AUKA 3M8YA 2W5XA 3NKPA 4LQYA 5DLWA 1ED8A 4LRDA 1FSUA 4CYSA 4LRFA 5HRTA 1KHJA 2W5SA 1EW2A 4LRCA 2W5QA 5LIAA 4KJGA 1EJJA 1URBA 1ZEFA 3WBHA 4CXKA 3KD8A 1EI6A 1Y7AA 3NKOA 4TN0A 3OT9A 4GTWA 3WAWA 5LRMA 3B5QA 1ALIA 2W8DA 4FDIA 4CXUA 4N7TA 3DPCA 2QZUA 4UPLA 3E2DA 1AJDA 4LR2A 4KM4A 1EW8A 1SHNA 1ALKA 2GLQA 4MIVA 3BDHA 4UPKA 5LRNA 2GSNA 1N2KA 2W5TA 2ZKTA 3MK1A 4LREA 4LRAA 5IJSA 3M8WA 1O99A
chains in the Genus database with same CATH topology
1ALJA 3BDFA 5INHA 2ANHA 1N2LA 1O98A 3NVLA 5GRRA 2W5VA 4UOOA 1SHQA 3WAYA 2VQRA 1KHNA 3TX0A 1KHKA 3IGZB 3WAXA 2G9YA 1HJKA 4ZG7A 2IUCA 5L0BA 4LR7A 5EGEA 1AJCA 1ED9A 3MK2A 3SZYA 4LRBA 2XRGA 5EGHA 3IGYB 1EW9A 2D1GA 3UN5A 3UN3A 4GTZA 4ZGAA 4NWXA 5DLVA 4UPHA 3TG0A 1E2SP 1K7HA 1KH4A 2IFYA 1P49A 5IJQA 3IDDA 3UN2A 3UO0A 4NWJA 2GSUA 3Q3QA 5K4PA 2W5WA 3NKMA 4ZG9A 3NKRA 1ANIA 3WAVA 1ELYA 3MK0A 3T00A 1E33P 1EQJA 3NKNA 1ELXA 3T01A 1HDHA 1AJBA 2XR9A 4MHXA 2W5RA 5AJ9A 2IUCB 1ZEBA 3CMRA 3M8ZA 5DLTA 5C66A 4MY4A 3A52A 3UNYA 4LR8A 1E3CP 4YR1A 5L0EA 4KJDA 3ED4A 2W8SA 4QAXA 2X98A 4UPIA 4FDJA 4UOPA 1Y6VA 3T02A 1ZEDA 3NKQA 4LR9A 1AJAA 2GSOA 2GA3A 5KXAA 1ELZA 1E1ZP 1URAA 3DYCA 5TJ3A 1KH5A 4ZG6A 1B8JA 3TWZA 5GOVA 3BDGB 5LQQA 1HQAA 1KH7A 4GTXA 3BDGA 4UORA 4GTYA 4KAYA 4B56A 3M7VA 1KHLA 5L0KA 2RH6A 3SZZA 1ANJA 4CXSA 1ALHA 4KAVA 4CYRA 1KH9A 3LXQA 1AUKA 3M8YA 2W5XA 3NKPA 4LQYA 5DLWA 1ED8A 4LRDA 1FSUA 4CYSA 4LRFA 5HRTA 1KHJA 2W5SA 1EW2A 4LRCA 2W5QA 5LIAA 4KJGA 1EJJA 1URBA 1ZEFA 3WBHA 4CXKA 3KD8A 1EI6A 1Y7AA 3NKOA 4TN0A 3OT9A 4GTWA 3WAWA 5LRMA 3B5QA 1ALIA 2W8DA 4FDIA 4CXUA 4N7TA 3DPCA 2QZUA 4UPLA 3E2DA 1AJDA 4LR2A 4KM4A 1EW8A 1SHNA 1ALKA 2GLQA 4MIVA 3BDHA 4UPKA 5LRNA 2GSNA 1N2KA 2W5TA 2ZKTA 3MK1A 4LREA 4LRAA 5IJSA 3M8WA 1O99A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1ALJ A;  3BDF A;  5INH A;  2ANH A;  1N2L A;  1O98 A;  3NVL A;  5GRR A;  2W5V A;  4UOO A;  1SHQ A;  3WAY A;  2VQR A;  1KHN A;  3TX0 A;  1KHK A;  3IGZ B;  3WAX A;  2G9Y A;  1HJK A;  4ZG7 A;  2IUC A;  5L0B A;  4LR7 A;  5EGE A;  1AJC A;  1ED9 A;  3MK2 A;  3SZY A;  4LRB A;  2XRG A;  5EGH A;  3IGY B;  1EW9 A;  2D1G A;  3UN5 A;  3UN3 A;  4GTZ A;  4ZGA A;  4NWX A;  5DLV A;  4UPH A;  3TG0 A;  1E2S P;  1K7H A;  1KH4 A;  2IFY A;  1P49 A;  5IJQ A;  3IDD A;  3UN2 A;  3UO0 A;  4NWJ A;  2GSU A;  3Q3Q A;  5K4P A;  2W5W A;  3NKM A;  4ZG9 A;  3NKR A;  1ANI A;  3WAV A;  1ELY A;  3MK0 A;  3T00 A;  1E33 P;  1EQJ A;  3NKN A;  1ELX A;  3T01 A;  1HDH A;  1AJB A;  2XR9 A;  4MHX A;  2W5R A;  5AJ9 A;  2IUC B;  1ZEB A;  3CMR A;  3M8Z A;  5DLT A;  5C66 A;  4MY4 A;  3A52 A;  3UNY A;  4LR8 A;  1E3C P;  4YR1 A;  5L0E A;  4KJD A;  3ED4 A;  2W8S A;  4QAX A;  2X98 A;  4UPI A;  4FDJ A;  4UOP A;  1Y6V A;  3T02 A;  1ZED A;  3NKQ A;  4LR9 A;  1AJA A;  2GSO A;  2GA3 A;  5KXA A;  1ELZ A;  1E1Z P;  1URA A;  3DYC A;  5TJ3 A;  1KH5 A;  4ZG6 A;  1B8J A;  3TWZ A;  5GOV A;  3BDG B;  5LQQ A;  1HQA A;  1KH7 A;  4GTX A;  3BDG A;  4UOR A;  4GTY A;  4KAY A;  4B56 A;  3M7V A;  1KHL A;  5L0K A;  2RH6 A;  3SZZ A;  1ANJ A;  4CXS A;  1ALH A;  4KAV A;  4CYR A;  1KH9 A;  3LXQ A;  1AUK A;  3M8Y A;  2W5X A;  3NKP A;  4LQY A;  5DLW A;  1ED8 A;  4LRD A;  1FSU A;  4CYS A;  4LRF A;  5HRT A;  1KHJ A;  2W5S A;  1EW2 A;  4LRC A;  2W5Q A;  5LIA A;  4KJG A;  1EJJ A;  1URB A;  1ZEF A;  3WBH A;  4CXK A;  3KD8 A;  1EI6 A;  1Y7A A;  3NKO A;  4TN0 A;  3OT9 A;  4GTW A;  3WAW A;  5LRM A;  3B5Q A;  1ALI A;  2W8D A;  4FDI A;  4CXU A;  4N7T A;  3DPC A;  2QZU A;  4UPL A;  3E2D A;  1AJD A;  4LR2 A;  4KM4 A;  1EW8 A;  1SHN A;  1ALK A;  2GLQ A;  4MIV A;  3BDH A;  4UPK A;  5LRN A;  2GSN A;  1N2K A;  2W5T A;  2ZKT A;  3MK1 A;  4LRE A;  4LRA A;  5IJS A;  3M8W A;  1O99 A; 
#chains in the Genus database with same CATH topology
 1ALJ A;  3BDF A;  5INH A;  2ANH A;  1N2L A;  1O98 A;  3NVL A;  5GRR A;  2W5V A;  4UOO A;  1SHQ A;  3WAY A;  2VQR A;  1KHN A;  3TX0 A;  1KHK A;  3IGZ B;  3WAX A;  2G9Y A;  1HJK A;  4ZG7 A;  2IUC A;  5L0B A;  4LR7 A;  5EGE A;  1AJC A;  1ED9 A;  3MK2 A;  3SZY A;  4LRB A;  2XRG A;  5EGH A;  3IGY B;  1EW9 A;  2D1G A;  3UN5 A;  3UN3 A;  4GTZ A;  4ZGA A;  4NWX A;  5DLV A;  4UPH A;  3TG0 A;  1E2S P;  1K7H A;  1KH4 A;  2IFY A;  1P49 A;  5IJQ A;  3IDD A;  3UN2 A;  3UO0 A;  4NWJ A;  2GSU A;  3Q3Q A;  5K4P A;  2W5W A;  3NKM A;  4ZG9 A;  3NKR A;  1ANI A;  3WAV A;  1ELY A;  3MK0 A;  3T00 A;  1E33 P;  1EQJ A;  3NKN A;  1ELX A;  3T01 A;  1HDH A;  1AJB A;  2XR9 A;  4MHX A;  2W5R A;  5AJ9 A;  2IUC B;  1ZEB A;  3CMR A;  3M8Z A;  5DLT A;  5C66 A;  4MY4 A;  3A52 A;  3UNY A;  4LR8 A;  1E3C P;  4YR1 A;  5L0E A;  4KJD A;  3ED4 A;  2W8S A;  4QAX A;  2X98 A;  4UPI A;  4FDJ A;  4UOP A;  1Y6V A;  3T02 A;  1ZED A;  3NKQ A;  4LR9 A;  1AJA A;  2GSO A;  2GA3 A;  5KXA A;  1ELZ A;  1E1Z P;  1URA A;  3DYC A;  5TJ3 A;  1KH5 A;  4ZG6 A;  1B8J A;  3TWZ A;  5GOV A;  3BDG B;  5LQQ A;  1HQA A;  1KH7 A;  4GTX A;  3BDG A;  4UOR A;  4GTY A;  4KAY A;  4B56 A;  3M7V A;  1KHL A;  5L0K A;  2RH6 A;  3SZZ A;  1ANJ A;  4CXS A;  1ALH A;  4KAV A;  4CYR A;  1KH9 A;  3LXQ A;  1AUK A;  3M8Y A;  2W5X A;  3NKP A;  4LQY A;  5DLW A;  1ED8 A;  4LRD A;  1FSU A;  4CYS A;  4LRF A;  5HRT A;  1KHJ A;  2W5S A;  1EW2 A;  4LRC A;  2W5Q A;  5LIA A;  4KJG A;  1EJJ A;  1URB A;  1ZEF A;  3WBH A;  4CXK A;  3KD8 A;  1EI6 A;  1Y7A A;  3NKO A;  4TN0 A;  3OT9 A;  4GTW A;  3WAW A;  5LRM A;  3B5Q A;  1ALI A;  2W8D A;  4FDI A;  4CXU A;  4N7T A;  3DPC A;  2QZU A;  4UPL A;  3E2D A;  1AJD A;  4LR2 A;  4KM4 A;  1EW8 A;  1SHN A;  1ALK A;  2GLQ A;  4MIV A;  3BDH A;  4UPK A;  5LRN A;  2GSN A;  1N2K A;  2W5T A;  2ZKT A;  3MK1 A;  4LRE A;  4LRA A;  5IJS A;  3M8W A;  1O99 A; 
#chains in the Genus database with same CATH homology
 1ALJ A;  3BDF A;  5INH A;  2ANH A;  1N2L A;  1O98 A;  3NVL A;  5GRR A;  2W5V A;  4UOO A;  1SHQ A;  3WAY A;  2VQR A;  1KHN A;  3TX0 A;  1KHK A;  3IGZ B;  3WAX A;  2G9Y A;  1HJK A;  4ZG7 A;  2IUC A;  5L0B A;  4LR7 A;  5EGE A;  1AJC A;  1ED9 A;  3MK2 A;  3SZY A;  4LRB A;  2XRG A;  5EGH A;  3IGY B;  1EW9 A;  2D1G A;  3UN5 A;  3UN3 A;  4GTZ A;  4ZGA A;  4NWX A;  5DLV A;  4UPH A;  3TG0 A;  1E2S P;  1K7H A;  1KH4 A;  2IFY A;  1P49 A;  5IJQ A;  3IDD A;  3UN2 A;  3UO0 A;  4NWJ A;  2GSU A;  3Q3Q A;  5K4P A;  2W5W A;  3NKM A;  4ZG9 A;  3NKR A;  1ANI A;  3WAV A;  1ELY A;  3MK0 A;  3T00 A;  1E33 P;  1EQJ A;  3NKN A;  1ELX A;  3T01 A;  1HDH A;  1AJB A;  2XR9 A;  4MHX A;  2W5R A;  5AJ9 A;  2IUC B;  1ZEB A;  3CMR A;  3M8Z A;  5DLT A;  5C66 A;  4MY4 A;  3A52 A;  3UNY A;  4LR8 A;  1E3C P;  4YR1 A;  5L0E A;  4KJD A;  3ED4 A;  2W8S A;  4QAX A;  2X98 A;  4UPI A;  4FDJ A;  4UOP A;  1Y6V A;  3T02 A;  1ZED A;  3NKQ A;  4LR9 A;  1AJA A;  2GSO A;  2GA3 A;  5KXA A;  1ELZ A;  1E1Z P;  1URA A;  3DYC A;  5TJ3 A;  1KH5 A;  4ZG6 A;  1B8J A;  3TWZ A;  5GOV A;  3BDG B;  5LQQ A;  1HQA A;  1KH7 A;  4GTX A;  3BDG A;  4UOR A;  4GTY A;  4KAY A;  4B56 A;  3M7V A;  1KHL A;  5L0K A;  2RH6 A;  3SZZ A;  1ANJ A;  4CXS A;  1ALH A;  4KAV A;  4CYR A;  1KH9 A;  3LXQ A;  1AUK A;  3M8Y A;  2W5X A;  3NKP A;  4LQY A;  5DLW A;  1ED8 A;  4LRD A;  1FSU A;  4CYS A;  4LRF A;  5HRT A;  1KHJ A;  2W5S A;  1EW2 A;  4LRC A;  2W5Q A;  5LIA A;  4KJG A;  1EJJ A;  1URB A;  1ZEF A;  3WBH A;  4CXK A;  3KD8 A;  1EI6 A;  1Y7A A;  3NKO A;  4TN0 A;  3OT9 A;  4GTW A;  3WAW A;  5LRM A;  3B5Q A;  1ALI A;  2W8D A;  4FDI A;  4CXU A;  4N7T A;  3DPC A;  2QZU A;  4UPL A;  3E2D A;  1AJD A;  4LR2 A;  4KM4 A;  1EW8 A;  1SHN A;  1ALK A;  2GLQ A;  4MIV A;  3BDH A;  4UPK A;  5LRN A;  2GSN A;  1N2K A;  2W5T A;  2ZKT A;  3MK1 A;  4LRE A;  4LRA A;  5IJS A;  3M8W A;  1O99 A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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