1KH9A

E. coli alkaline phosphatase mutant (d153gd330n) complex with phosphate
Total Genus 144
Loading diagram...

The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
144
Knots found
sequence length
444
structure length
444
Chain Sequence
VLENRAAQGNITAPGGARRLTGDQTAALRNSLSDKPAKNIILLIGDGMGDSEITAARNYAEGAGGFFKGIDALPLTGQYTHYALNKKTGKPDYVTDSAASATAWSTGVKTYNGALGVDIHEKDHPTILEMAKAAGLATGNVSTAELQDATPAALVAHVTSRKCYGPSATSQKCPGNALEKGGKGSITEQLLNARADVTLGGGAKTFAETATAGEWQGKTLREEAEARGYQLVSDAASLNSVTEANQQKPLLGLFADGNMPVRWLGPKATYHGNIDKPAVTCTPNPQRNDSVPTLAQMTDKAIELLSKNEKGFFLQVEGASIDKQNHAANPCGQIGETVDLDEAVQRALEFAKKEGNTLVIVTADHAHASQIVAPDTKAPGLTQALNTKDGAVMVMSYGNSEEDSQEHTGSQLRIAAYGPHAANVVGLTDQTDLFYTMKAALGLK
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
{{ tooltip.sname }} connected with {{ tooltip.tname }} : {{qFormat(tooltip.svalue) }}
molecule keywords Alkaline phosphatase
publication title Artificial evolution of an enzyme active site: structural studies of three highly active mutants of Escherichia coli alkaline phosphatase.
pubmed doi rcsb
source organism Escherichia coli
molecule tags Hydrolase
total genus 144
structure length 444
sequence length 444
chains with identical sequence B
other databases KnotProt 2.0: S +31
ec nomenclature ec 3.1.3.1: Alkaline phosphatase.
pdb deposition date 2001-11-29

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00245 Alk_phosphatase Alkaline phosphatase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.720.10 Alpha Beta 3-Layer(aba) Sandwich Alkaline Phosphatase, subunit A Alkaline Phosphatase, subunit A 1kh9A00
3BDFA 3Q3QA 1ALIA 1HDHA 4MIVA 2GLQA 3SZZA 1N2KA 4LRDA 4CYSA 2W8SA 1EI6A 3CMRA 2W5WA 4MHXA 4KJDA 4CXKA 5HRTA 3UN2A 1ALJA 2W5TA 2W5QA 1N2LA 3WAYA 1AJBA 5EGEA 5GRRA 1E33P 3UN5A 4ZG9A 3T02A 1AJDA 1SHNA 1AUKA 3MK0A 4UORA 3M8WA 5TJ3A 1HQAA 1ZEDA 3E2DA 3DYCA 1AJAA 5LQQA 4NWJA 1O98A 1AJCA 1FSUA 4LRAA 1EW2A 1HJKA 1ANJA 5IJSA 2D1GA 2W5RA 4LQYA 1KH5A 4LREA 1EQJA 1KH4A 4LR8A 1B8JA 1KHKA 4GTWA 3B5QA 1ELYA 3ED4A 3NKMA 4GTZA 2GA3A 4QAXA 1ELXA 3OT9A 4LRBA 4FDIA 3KD8A 4GTYA 1KH7A 3IGZB 5GOVA 3DPCA 5LRNA 5L0EA 5INHA 4ZGAA 1URBA 3NKQA 4UPLA 4NWXA 2W5VA 2ZKTA 4YR1A 2IUCA 1E3CP 3MK1A 4MY4A 4CYRA 5EGHA 4ZG6A 1Y7AA 3M8ZA 1EJJA 3TG0A 3BDHA 3SZYA 4ZG7A 1ZEFA 1ANIA 5IJQA 3NKPA 3M7VA 4B56A 3UNYA 3WBHA 5KXAA 3IDDA 3UN3A 5L0KA 3TWZA 5LRMA 1Y6VA 3M8YA 2XR9A 3BDGA 4KM4A 3TX0A 2IUCB 1O99A 3NKOA 1ELZA 3BDGB 4LRFA 2W5XA 5L0BA 1ED8A 3NKRA 2GSOA 4UOOA 2GSUA 2QZUA 1KHNA 2G9YA 4N7TA 4LRCA 4UPIA 4CXSA 2RH6A 5DLWA 1EW8A 1ALKA 1K7HA 4GTXA 4CXUA 4TN0A 2VQRA 4UOPA 3WAXA 2ANHA 4LR2A 1URAA 3IGYB 1E1ZP 5AJ9A 4KAYA 1KHJA 4LR7A 1P49A 4UPHA 5DLTA 3LXQA 1SHQA 3T01A 5C66A 3WAVA 3NKNA 4LR9A 2W8DA 5K4PA 4KJGA 4FDJA 2IFYA 1KH9A 3WAWA 5LIAA 3T00A 1EW9A 4UPKA 1E2SP 2X98A 2GSNA 5DLVA 3A52A 1ED9A 4KAVA 2W5SA 3MK2A 2XRGA 1ZEBA 1ALHA 1KHLA 3UO0A 3NVLA
chains in the Genus database with same CATH superfamily
3BDFA 3Q3QA 1ALIA 1HDHA 4MIVA 2GLQA 3SZZA 1N2KA 4LRDA 4CYSA 2W8SA 1EI6A 3CMRA 2W5WA 4MHXA 4KJDA 4CXKA 5HRTA 3UN2A 1ALJA 2W5TA 2W5QA 1N2LA 3WAYA 1AJBA 5EGEA 5GRRA 1E33P 3UN5A 4ZG9A 3T02A 1AJDA 1SHNA 1AUKA 3MK0A 4UORA 3M8WA 5TJ3A 1HQAA 1ZEDA 3E2DA 3DYCA 1AJAA 5LQQA 4NWJA 1O98A 1AJCA 1FSUA 4LRAA 1EW2A 1HJKA 1ANJA 5IJSA 2D1GA 2W5RA 4LQYA 1KH5A 4LREA 1EQJA 1KH4A 4LR8A 1B8JA 1KHKA 4GTWA 3B5QA 1ELYA 3ED4A 3NKMA 4GTZA 2GA3A 4QAXA 1ELXA 3OT9A 4LRBA 4FDIA 3KD8A 4GTYA 1KH7A 3IGZB 5GOVA 3DPCA 5LRNA 5L0EA 5INHA 4ZGAA 1URBA 3NKQA 4UPLA 4NWXA 2W5VA 2ZKTA 4YR1A 2IUCA 1E3CP 3MK1A 4MY4A 4CYRA 5EGHA 4ZG6A 1Y7AA 3M8ZA 1EJJA 3TG0A 3BDHA 3SZYA 4ZG7A 1ZEFA 1ANIA 5IJQA 3NKPA 3M7VA 4B56A 3UNYA 3WBHA 5KXAA 3IDDA 3UN3A 5L0KA 3TWZA 5LRMA 1Y6VA 3M8YA 2XR9A 3BDGA 4KM4A 3TX0A 2IUCB 1O99A 3NKOA 1ELZA 3BDGB 4LRFA 2W5XA 5L0BA 1ED8A 3NKRA 2GSOA 4UOOA 2GSUA 2QZUA 1KHNA 2G9YA 4N7TA 4LRCA 4UPIA 4CXSA 2RH6A 5DLWA 1EW8A 1ALKA 1K7HA 4GTXA 4CXUA 4TN0A 2VQRA 4UOPA 3WAXA 2ANHA 4LR2A 1URAA 3IGYB 1E1ZP 5AJ9A 4KAYA 1KHJA 4LR7A 1P49A 4UPHA 5DLTA 3LXQA 1SHQA 3T01A 5C66A 3WAVA 3NKNA 4LR9A 2W8DA 5K4PA 4KJGA 4FDJA 2IFYA 1KH9A 3WAWA 5LIAA 3T00A 1EW9A 4UPKA 1E2SP 2X98A 2GSNA 5DLVA 3A52A 1ED9A 4KAVA 2W5SA 3MK2A 2XRGA 1ZEBA 1ALHA 1KHLA 3UO0A 3NVLA
chains in the Genus database with same CATH topology
3BDFA 3Q3QA 1ALIA 1HDHA 4MIVA 2GLQA 3SZZA 1N2KA 4LRDA 4CYSA 2W8SA 1EI6A 3CMRA 2W5WA 4MHXA 4KJDA 4CXKA 5HRTA 3UN2A 1ALJA 2W5TA 2W5QA 1N2LA 3WAYA 1AJBA 5EGEA 5GRRA 1E33P 3UN5A 4ZG9A 3T02A 1AJDA 1SHNA 1AUKA 3MK0A 4UORA 3M8WA 5TJ3A 1HQAA 1ZEDA 3E2DA 3DYCA 1AJAA 5LQQA 4NWJA 1O98A 1AJCA 1FSUA 4LRAA 1EW2A 1HJKA 1ANJA 5IJSA 2D1GA 2W5RA 4LQYA 1KH5A 4LREA 1EQJA 1KH4A 4LR8A 1B8JA 1KHKA 4GTWA 3B5QA 1ELYA 3ED4A 3NKMA 4GTZA 2GA3A 4QAXA 1ELXA 3OT9A 4LRBA 4FDIA 3KD8A 4GTYA 1KH7A 3IGZB 5GOVA 3DPCA 5LRNA 5L0EA 5INHA 4ZGAA 1URBA 3NKQA 4UPLA 4NWXA 2W5VA 2ZKTA 4YR1A 2IUCA 1E3CP 3MK1A 4MY4A 4CYRA 5EGHA 4ZG6A 1Y7AA 3M8ZA 1EJJA 3TG0A 3BDHA 3SZYA 4ZG7A 1ZEFA 1ANIA 5IJQA 3NKPA 3M7VA 4B56A 3UNYA 3WBHA 5KXAA 3IDDA 3UN3A 5L0KA 3TWZA 5LRMA 1Y6VA 3M8YA 2XR9A 3BDGA 4KM4A 3TX0A 2IUCB 1O99A 3NKOA 1ELZA 3BDGB 4LRFA 2W5XA 5L0BA 1ED8A 3NKRA 2GSOA 4UOOA 2GSUA 2QZUA 1KHNA 2G9YA 4N7TA 4LRCA 4UPIA 4CXSA 2RH6A 5DLWA 1EW8A 1ALKA 1K7HA 4GTXA 4CXUA 4TN0A 2VQRA 4UOPA 3WAXA 2ANHA 4LR2A 1URAA 3IGYB 1E1ZP 5AJ9A 4KAYA 1KHJA 4LR7A 1P49A 4UPHA 5DLTA 3LXQA 1SHQA 3T01A 5C66A 3WAVA 3NKNA 4LR9A 2W8DA 5K4PA 4KJGA 4FDJA 2IFYA 1KH9A 3WAWA 5LIAA 3T00A 1EW9A 4UPKA 1E2SP 2X98A 2GSNA 5DLVA 3A52A 1ED9A 4KAVA 2W5SA 3MK2A 2XRGA 1ZEBA 1ALHA 1KHLA 3UO0A 3NVLA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 3BDF A;  3Q3Q A;  1ALI A;  1HDH A;  4MIV A;  2GLQ A;  3SZZ A;  1N2K A;  4LRD A;  4CYS A;  2W8S A;  1EI6 A;  3CMR A;  2W5W A;  4MHX A;  4KJD A;  4CXK A;  5HRT A;  3UN2 A;  1ALJ A;  2W5T A;  2W5Q A;  1N2L A;  3WAY A;  1AJB A;  5EGE A;  5GRR A;  1E33 P;  3UN5 A;  4ZG9 A;  3T02 A;  1AJD A;  1SHN A;  1AUK A;  3MK0 A;  4UOR A;  3M8W A;  5TJ3 A;  1HQA A;  1ZED A;  3E2D A;  3DYC A;  1AJA A;  5LQQ A;  4NWJ A;  1O98 A;  1AJC A;  1FSU A;  4LRA A;  1EW2 A;  1HJK A;  1ANJ A;  5IJS A;  2D1G A;  2W5R A;  4LQY A;  1KH5 A;  4LRE A;  1EQJ A;  1KH4 A;  4LR8 A;  1B8J A;  1KHK A;  4GTW A;  3B5Q A;  1ELY A;  3ED4 A;  3NKM A;  4GTZ A;  2GA3 A;  4QAX A;  1ELX A;  3OT9 A;  4LRB A;  4FDI A;  3KD8 A;  4GTY A;  1KH7 A;  3IGZ B;  5GOV A;  3DPC A;  5LRN A;  5L0E A;  5INH A;  4ZGA A;  1URB A;  3NKQ A;  4UPL A;  4NWX A;  2W5V A;  2ZKT A;  4YR1 A;  2IUC A;  1E3C P;  3MK1 A;  4MY4 A;  4CYR A;  5EGH A;  4ZG6 A;  1Y7A A;  3M8Z A;  1EJJ A;  3TG0 A;  3BDH A;  3SZY A;  4ZG7 A;  1ZEF A;  1ANI A;  5IJQ A;  3NKP A;  3M7V A;  4B56 A;  3UNY A;  3WBH A;  5KXA A;  3IDD A;  3UN3 A;  5L0K A;  3TWZ A;  5LRM A;  1Y6V A;  3M8Y A;  2XR9 A;  3BDG A;  4KM4 A;  3TX0 A;  2IUC B;  1O99 A;  3NKO A;  1ELZ A;  3BDG B;  4LRF A;  2W5X A;  5L0B A;  1ED8 A;  3NKR A;  2GSO A;  4UOO A;  2GSU A;  2QZU A;  1KHN A;  2G9Y A;  4N7T A;  4LRC A;  4UPI A;  4CXS A;  2RH6 A;  5DLW A;  1EW8 A;  1ALK A;  1K7H A;  4GTX A;  4CXU A;  4TN0 A;  2VQR A;  4UOP A;  3WAX A;  2ANH A;  4LR2 A;  1URA A;  3IGY B;  1E1Z P;  5AJ9 A;  4KAY A;  1KHJ A;  4LR7 A;  1P49 A;  4UPH A;  5DLT A;  3LXQ A;  1SHQ A;  3T01 A;  5C66 A;  3WAV A;  3NKN A;  4LR9 A;  2W8D A;  5K4P A;  4KJG A;  4FDJ A;  2IFY A;  1KH9 A;  3WAW A;  5LIA A;  3T00 A;  1EW9 A;  4UPK A;  1E2S P;  2X98 A;  2GSN A;  5DLV A;  3A52 A;  1ED9 A;  4KAV A;  2W5S A;  3MK2 A;  2XRG A;  1ZEB A;  1ALH A;  1KHL A;  3UO0 A;  3NVL A; 
#chains in the Genus database with same CATH topology
 3BDF A;  3Q3Q A;  1ALI A;  1HDH A;  4MIV A;  2GLQ A;  3SZZ A;  1N2K A;  4LRD A;  4CYS A;  2W8S A;  1EI6 A;  3CMR A;  2W5W A;  4MHX A;  4KJD A;  4CXK A;  5HRT A;  3UN2 A;  1ALJ A;  2W5T A;  2W5Q A;  1N2L A;  3WAY A;  1AJB A;  5EGE A;  5GRR A;  1E33 P;  3UN5 A;  4ZG9 A;  3T02 A;  1AJD A;  1SHN A;  1AUK A;  3MK0 A;  4UOR A;  3M8W A;  5TJ3 A;  1HQA A;  1ZED A;  3E2D A;  3DYC A;  1AJA A;  5LQQ A;  4NWJ A;  1O98 A;  1AJC A;  1FSU A;  4LRA A;  1EW2 A;  1HJK A;  1ANJ A;  5IJS A;  2D1G A;  2W5R A;  4LQY A;  1KH5 A;  4LRE A;  1EQJ A;  1KH4 A;  4LR8 A;  1B8J A;  1KHK A;  4GTW A;  3B5Q A;  1ELY A;  3ED4 A;  3NKM A;  4GTZ A;  2GA3 A;  4QAX A;  1ELX A;  3OT9 A;  4LRB A;  4FDI A;  3KD8 A;  4GTY A;  1KH7 A;  3IGZ B;  5GOV A;  3DPC A;  5LRN A;  5L0E A;  5INH A;  4ZGA A;  1URB A;  3NKQ A;  4UPL A;  4NWX A;  2W5V A;  2ZKT A;  4YR1 A;  2IUC A;  1E3C P;  3MK1 A;  4MY4 A;  4CYR A;  5EGH A;  4ZG6 A;  1Y7A A;  3M8Z A;  1EJJ A;  3TG0 A;  3BDH A;  3SZY A;  4ZG7 A;  1ZEF A;  1ANI A;  5IJQ A;  3NKP A;  3M7V A;  4B56 A;  3UNY A;  3WBH A;  5KXA A;  3IDD A;  3UN3 A;  5L0K A;  3TWZ A;  5LRM A;  1Y6V A;  3M8Y A;  2XR9 A;  3BDG A;  4KM4 A;  3TX0 A;  2IUC B;  1O99 A;  3NKO A;  1ELZ A;  3BDG B;  4LRF A;  2W5X A;  5L0B A;  1ED8 A;  3NKR A;  2GSO A;  4UOO A;  2GSU A;  2QZU A;  1KHN A;  2G9Y A;  4N7T A;  4LRC A;  4UPI A;  4CXS A;  2RH6 A;  5DLW A;  1EW8 A;  1ALK A;  1K7H A;  4GTX A;  4CXU A;  4TN0 A;  2VQR A;  4UOP A;  3WAX A;  2ANH A;  4LR2 A;  1URA A;  3IGY B;  1E1Z P;  5AJ9 A;  4KAY A;  1KHJ A;  4LR7 A;  1P49 A;  4UPH A;  5DLT A;  3LXQ A;  1SHQ A;  3T01 A;  5C66 A;  3WAV A;  3NKN A;  4LR9 A;  2W8D A;  5K4P A;  4KJG A;  4FDJ A;  2IFY A;  1KH9 A;  3WAW A;  5LIA A;  3T00 A;  1EW9 A;  4UPK A;  1E2S P;  2X98 A;  2GSN A;  5DLV A;  3A52 A;  1ED9 A;  4KAV A;  2W5S A;  3MK2 A;  2XRG A;  1ZEB A;  1ALH A;  1KHL A;  3UO0 A;  3NVL A; 
#chains in the Genus database with same CATH homology
 3BDF A;  3Q3Q A;  1ALI A;  1HDH A;  4MIV A;  2GLQ A;  3SZZ A;  1N2K A;  4LRD A;  4CYS A;  2W8S A;  1EI6 A;  3CMR A;  2W5W A;  4MHX A;  4KJD A;  4CXK A;  5HRT A;  3UN2 A;  1ALJ A;  2W5T A;  2W5Q A;  1N2L A;  3WAY A;  1AJB A;  5EGE A;  5GRR A;  1E33 P;  3UN5 A;  4ZG9 A;  3T02 A;  1AJD A;  1SHN A;  1AUK A;  3MK0 A;  4UOR A;  3M8W A;  5TJ3 A;  1HQA A;  1ZED A;  3E2D A;  3DYC A;  1AJA A;  5LQQ A;  4NWJ A;  1O98 A;  1AJC A;  1FSU A;  4LRA A;  1EW2 A;  1HJK A;  1ANJ A;  5IJS A;  2D1G A;  2W5R A;  4LQY A;  1KH5 A;  4LRE A;  1EQJ A;  1KH4 A;  4LR8 A;  1B8J A;  1KHK A;  4GTW A;  3B5Q A;  1ELY A;  3ED4 A;  3NKM A;  4GTZ A;  2GA3 A;  4QAX A;  1ELX A;  3OT9 A;  4LRB A;  4FDI A;  3KD8 A;  4GTY A;  1KH7 A;  3IGZ B;  5GOV A;  3DPC A;  5LRN A;  5L0E A;  5INH A;  4ZGA A;  1URB A;  3NKQ A;  4UPL A;  4NWX A;  2W5V A;  2ZKT A;  4YR1 A;  2IUC A;  1E3C P;  3MK1 A;  4MY4 A;  4CYR A;  5EGH A;  4ZG6 A;  1Y7A A;  3M8Z A;  1EJJ A;  3TG0 A;  3BDH A;  3SZY A;  4ZG7 A;  1ZEF A;  1ANI A;  5IJQ A;  3NKP A;  3M7V A;  4B56 A;  3UNY A;  3WBH A;  5KXA A;  3IDD A;  3UN3 A;  5L0K A;  3TWZ A;  5LRM A;  1Y6V A;  3M8Y A;  2XR9 A;  3BDG A;  4KM4 A;  3TX0 A;  2IUC B;  1O99 A;  3NKO A;  1ELZ A;  3BDG B;  4LRF A;  2W5X A;  5L0B A;  1ED8 A;  3NKR A;  2GSO A;  4UOO A;  2GSU A;  2QZU A;  1KHN A;  2G9Y A;  4N7T A;  4LRC A;  4UPI A;  4CXS A;  2RH6 A;  5DLW A;  1EW8 A;  1ALK A;  1K7H A;  4GTX A;  4CXU A;  4TN0 A;  2VQR A;  4UOP A;  3WAX A;  2ANH A;  4LR2 A;  1URA A;  3IGY B;  1E1Z P;  5AJ9 A;  4KAY A;  1KHJ A;  4LR7 A;  1P49 A;  4UPH A;  5DLT A;  3LXQ A;  1SHQ A;  3T01 A;  5C66 A;  3WAV A;  3NKN A;  4LR9 A;  2W8D A;  5K4P A;  4KJG A;  4FDJ A;  2IFY A;  1KH9 A;  3WAW A;  5LIA A;  3T00 A;  1EW9 A;  4UPK A;  1E2S P;  2X98 A;  2GSN A;  5DLV A;  3A52 A;  1ED9 A;  4KAV A;  2W5S A;  3MK2 A;  2XRG A;  1ZEB A;  1ALH A;  1KHL A;  3UO0 A;  3NVL A; 
...loading similar chains, please wait...
similar chains in the Genus database (?% sequence similarity)
...loading similar chains, please wait...
similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
...loading similar chains, please wait...
#similar chains, but unknotted
...loading similar chains, please wait...
#similar chains in the pdb database (?% sequence similarity)
...loading similar chains, please wait...