1OO8A

Crystal structure of a1pi-pittsburgh in the native conformation
Total Genus 104
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
104
sequence length
370
structure length
370
Chain Sequence
NKITPNLAEFAFSLYRQLAHQSNSTNILFSPVSIAAAFAMLSLGAKGDTHDEILEGLNFNLTEIPEAQIHEGFQELLRTLNQPDSQLQLTTGNGLFLSEGLKLVDKFLEDVKKLYHSEAFTVNFGDTEEAKKQINDYVEKGTQGKIVDLVKELDRDTVFALVNYIFFKGKWERPFEVKDTEEEDFHVDQVTTVKVPMMKRLGMFNIQHSKKLSSWVLLMKYLGNATAIFFLPDEGKLQHLENELTHDIITKFLENEDRRSASLHLPKLSITGTYDLKSVLGQLGITKVFSNGADLSGVTEEAPLKLSKAVHKAVLTIDEKGTEAAGAMFLEAIPRSIPPEVKFNKPFVFLIIEQNTKAPLFMGRVVNPTQ
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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molecule tags Hydrolase inhibitor
molecule keywords Alpha-1-antitrypsin precursor
publication title Canonical inhibitor-like interactions explain reactivity of alpha1-proteinase inhibitor Pittsburgh and antithrombin with proteinases
pubmed doi rcsb
source organism Homo sapiens
total genus 104
structure length 370
sequence length 370
ec nomenclature
pdb deposition date 2003-03-03

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00079 Serpin Serpin (serine protease inhibitor)
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.30.39.10 Mainly Beta Roll Alpha-1-antitrypsin; domain 1 Alpha-1-antitrypsin, domain 1 1oo8A01
3.30.497.10 Alpha Beta 2-Layer Sandwich Antithrombin; Chain I, domain 2 Antithrombin, subunit I, domain 2 1oo8A02
2PEEA 1ATHA 2ANTI 1LJ5A 5C98A 3F02A 3UT3A 1OC0A 2BEHL 2HIJI 2V95A 3LW2A 4PYWA 1JJOC 1LK6I 2H4PA 4RSQA 4G8OA 1DZHI 1DVNA 4Y40A 1QMBA 3Q02A 4AU3A 3VVJA 2QUGA 1A7CA 1SR5A 2XN6A 3OZQA 1OPHA 1SNGA 4DY7C 4DTEA 1E03I 2GD4C 4P0FA 4BB2A 5CDXA 1ATUA 4CAAA 4AQHA 2WXXA 3DRUA 2BEHI 4AU2A 8APIA 1XQGA 1OVAA 1XU8A 7APIA 1DZGI 2ACHA 2PEFA 4G8RA 1HLEA 4DY0A 2VDYA 1DB2A 4Y3KA 4AJTA 4RO9A 2D26A 2WY0C 2ARRA 3NE4A 2VDXA 3H5CA 4R9IA 4ROBA 3STOA 1OVAC 1K9OI 5CDZA 2OAYA 1NQ9I 3NDFA 2HI9A 2R9YA 1OYHL 3CWLA 1E04I 2VH4A 3F5NA 3LE2A 4EB1I 4C49A 1BY7A 3Q03A 4P0OA 3R4LA 1DVMA 2H4QA 3CAAA 4IF8A 4KDSA 1PSIA 1HP7A 4X30A 1ANTI 2RIVA 1EZXA 5BRRI 1XQJA 1IZ2A 2WXWA 4IC0A 2WXYC 1C8OA 1WZ9A 1QMNA 1JTIA 2ZNHA 4AJUA 4AU4A 1OO8A 1QLPA 3B9FI 3FGQA 4AU3B 5EI0A 1ATTA 2DUTA 3EOXA 1BR8I 3PZFA 1LQ8A 3NDDA 3NDAA 4AFXA 1YXAA 1C5GA 1KCTA 1SEKA 4C41A 2XN3A 1DZHL 1IMVA 1T1FA 1UHGA 2B4XL 5INWA 1OVAB 1F0CA 1JRRA 1JVQI 2WXZA 1B3KA 3DRMA 3DY0A 1TB6I 9PAIA 1AZXI 2B5TI 2ZV6A 2RIWA 3DLWA 1D5SA 1R1LI 4ROAA 1DZGL 2WXZC 5HGCA 2ARQA 1E05I 4YIAA 4GA7A 1OYHI 2CEOA 3F1SA 3EVJI 1JMOA 2B4XI 2XN5A 3ZHAA 2HIJL 1M93B 2XN7A 3CWMA 4ZK3A 9APIA 1MTPA 3T1PA 3CVMA 1AS4A 4ZK0A 1JMJA 3KCGI 2OL2A 3PB1I 5IO1A 4EB1L 2H4RA 2WY1A 5CE0A
chains in the Genus database with same CATH superfamily
2PEEA 1ATHA 2ANTI 1LJ5A 5C98A 3F02A 3UT3A 1OC0A 2BEHL 2HIJI 2V95A 3LW2A 4PYWA 1JJOC 1LK6I 2H4PA 4RSQA 4G8OA 1DZHI 1DVNA 4Y40A 1QMBA 3Q02A 4AU3A 3VVJA 2QUGA 1A7CA 1SR5A 2XN6A 3OZQA 1OPHA 1SNGA 4DY7C 4DTEA 1E03I 2GD4C 4P0FA 4BB2A 5CDXA 1ATUA 4CAAA 4AQHA 2WXXA 3DRUA 2BEHI 4AU2A 8APIA 1XQGA 1OVAA 1XU8A 7APIA 1DZGI 2ACHA 2PEFA 4G8RA 1HLEA 4DY0A 2VDYA 1DB2A 4Y3KA 4AJTA 4RO9A 2D26A 2WY0C 2ARRA 3NE4A 2VDXA 3H5CA 4R9IA 4ROBA 3STOA 1OVAC 1K9OI 5CDZA 2OAYA 1NQ9I 3NDFA 2HI9A 2R9YA 1OYHL 3CWLA 1E04I 2VH4A 3F5NA 3LE2A 4EB1I 4C49A 1BY7A 3Q03A 4P0OA 3R4LA 1DVMA 2H4QA 3CAAA 4IF8A 4KDSA 1PSIA 1HP7A 4X30A 1ANTI 2RIVA 1EZXA 5BRRI 1XQJA 1IZ2A 2WXWA 4IC0A 2WXYC 1C8OA 1WZ9A 1QMNA 1JTIA 2ZNHA 4AJUA 4AU4A 1OO8A 1QLPA 3B9FI 3FGQA 4AU3B 5EI0A 1ATTA 2DUTA 3EOXA 1BR8I 3PZFA 1LQ8A 3NDDA 3NDAA 4AFXA 1YXAA 1C5GA 1KCTA 1SEKA 4C41A 2XN3A 1DZHL 1IMVA 1T1FA 1UHGA 2B4XL 5INWA 1OVAB 1F0CA 1JRRA 1JVQI 2WXZA 1B3KA 3DRMA 3DY0A 1TB6I 9PAIA 1AZXI 2B5TI 2ZV6A 2RIWA 3DLWA 1D5SA 1R1LI 4ROAA 1DZGL 2WXZC 5HGCA 2ARQA 1E05I 4YIAA 4GA7A 1OYHI 2CEOA 3F1SA 3EVJI 1JMOA 2B4XI 2XN5A 3ZHAA 2HIJL 1M93B 2XN7A 3CWMA 4ZK3A 9APIA 1MTPA 3T1PA 3CVMA 1AS4A 4ZK0A 1JMJA 3KCGI 2OL2A 3PB1I 5IO1A 4EB1L 2H4RA 2WY1A 5CE0A
chains in the Genus database with same CATH topology
2PEEA 1ATHA 2ANTI 1LJ5A 5C98A 3F02A 3UT3A 1OC0A 2BEHL 2HIJI 2V95A 3LW2A 4PYWA 1JJOC 1LK6I 2H4PA 4RSQA 4G8OA 1DZHI 1DVNA 4Y40A 1QMBA 3Q02A 4AU3A 3VVJA 2QUGA 1A7CA 1SR5A 2XN6A 3OZQA 1OPHA 1SNGA 4DY7C 4DTEA 1E03I 2GD4C 4P0FA 4BB2A 5CDXA 1ATUA 4CAAA 4AQHA 2WXXA 3DRUA 2BEHI 4AU2A 8APIA 1XQGA 1OVAA 1XU8A 7APIA 1DZGI 2ACHA 2PEFA 4G8RA 1HLEA 4DY0A 2VDYA 1DB2A 4Y3KA 4AJTA 4RO9A 2D26A 2WY0C 2ARRA 3NE4A 2VDXA 3H5CA 4R9IA 4ROBA 3STOA 1OVAC 1K9OI 5CDZA 2OAYA 1NQ9I 3NDFA 2HI9A 2R9YA 1OYHL 3CWLA 1E04I 2VH4A 3F5NA 3LE2A 4EB1I 4C49A 1BY7A 3Q03A 4P0OA 3R4LA 1DVMA 2H4QA 3CAAA 4IF8A 4KDSA 1PSIA 1HP7A 4X30A 1ANTI 2RIVA 1EZXA 5BRRI 1XQJA 1IZ2A 2WXWA 4IC0A 2WXYC 1C8OA 1WZ9A 1QMNA 1JTIA 2ZNHA 4AJUA 4AU4A 1OO8A 1QLPA 3B9FI 3FGQA 4AU3B 5EI0A 1ATTA 2DUTA 3EOXA 1BR8I 3PZFA 1LQ8A 3NDDA 3NDAA 4AFXA 1YXAA 1C5GA 1KCTA 1SEKA 4C41A 2XN3A 1DZHL 1IMVA 1T1FA 1UHGA 2B4XL 5INWA 1OVAB 1F0CA 1JRRA 1JVQI 2WXZA 1B3KA 3DRMA 3DY0A 1TB6I 9PAIA 1AZXI 2B5TI 2ZV6A 2RIWA 3DLWA 1D5SA 1R1LI 4ROAA 1DZGL 2WXZC 5HGCA 2ARQA 1E05I 4YIAA 4GA7A 1OYHI 2CEOA 3F1SA 3EVJI 1JMOA 2B4XI 2XN5A 3ZHAA 2HIJL 1M93B 2XN7A 3CWMA 4ZK3A 9APIA 1MTPA 3T1PA 3CVMA 1AS4A 4ZK0A 1JMJA 3KCGI 2OL2A 3PB1I 5IO1A 4EB1L 2H4RA 2WY1A 5CE0A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 2PEE A;  1ATH A;  2ANT I;  1LJ5 A;  5C98 A;  3F02 A;  3UT3 A;  1OC0 A;  2BEH L;  2HIJ I;  2V95 A;  3LW2 A;  4PYW A;  1JJO C;  1LK6 I;  2H4P A;  4RSQ A;  4G8O A;  1DZH I;  1DVN A;  4Y40 A;  1QMB A;  3Q02 A;  4AU3 A;  3VVJ A;  2QUG A;  1A7C A;  1SR5 A;  2XN6 A;  3OZQ A;  1OPH A;  1SNG A;  4DY7 C;  4DTE A;  1E03 I;  2GD4 C;  4P0F A;  4BB2 A;  5CDX A;  1ATU A;  4CAA A;  4AQH A;  2WXX A;  3DRU A;  2BEH I;  4AU2 A;  8API A;  1XQG A;  1OVA A;  1XU8 A;  7API A;  1DZG I;  2ACH A;  2PEF A;  4G8R A;  1HLE A;  4DY0 A;  2VDY A;  1DB2 A;  4Y3K A;  4AJT A;  4RO9 A;  2D26 A;  2WY0 C;  2ARR A;  3NE4 A;  2VDX A;  3H5C A;  4R9I A;  4ROB A;  3STO A;  1OVA C;  1K9O I;  5CDZ A;  2OAY A;  1NQ9 I;  3NDF A;  2HI9 A;  2R9Y A;  1OYH L;  3CWL A;  1E04 I;  2VH4 A;  3F5N A;  3LE2 A;  4EB1 I;  4C49 A;  1BY7 A;  3Q03 A;  4P0O A;  3R4L A;  1DVM A;  2H4Q A;  3CAA A;  4IF8 A;  4KDS A;  1PSI A;  1HP7 A;  4X30 A;  1ANT I;  2RIV A;  1EZX A;  5BRR I;  1XQJ A;  1IZ2 A;  2WXW A;  4IC0 A;  2WXY C;  1C8O A;  1WZ9 A;  1QMN A;  1JTI A;  2ZNH A;  4AJU A;  4AU4 A;  1OO8 A;  1QLP A;  3B9F I;  3FGQ A;  4AU3 B;  5EI0 A;  1ATT A;  2DUT A;  3EOX A;  1BR8 I;  3PZF A;  1LQ8 A;  3NDD A;  3NDA A;  4AFX A;  1YXA A;  1C5G A;  1KCT A;  1SEK A;  4C41 A;  2XN3 A;  1DZH L;  1IMV A;  1T1F A;  1UHG A;  2B4X L;  5INW A;  1OVA B;  1F0C A;  1JRR A;  1JVQ I;  2WXZ A;  1B3K A;  3DRM A;  3DY0 A;  1TB6 I;  9PAI A;  1AZX I;  2B5T I;  2ZV6 A;  2RIW A;  3DLW A;  1D5S A;  1R1L I;  4ROA A;  1DZG L;  2WXZ C;  5HGC A;  2ARQ A;  1E05 I;  4YIA A;  4GA7 A;  1OYH I;  2CEO A;  3F1S A;  3EVJ I;  1JMO A;  2B4X I;  2XN5 A;  3ZHA A;  2HIJ L;  1M93 B;  2XN7 A;  3CWM A;  4ZK3 A;  9API A;  1MTP A;  3T1P A;  3CVM A;  1AS4 A;  4ZK0 A;  1JMJ A;  3KCG I;  2OL2 A;  3PB1 I;  5IO1 A;  4EB1 L;  2H4R A;  2WY1 A;  5CE0 A; 
#chains in the Genus database with same CATH topology
 2PEE A;  1ATH A;  2ANT I;  1LJ5 A;  5C98 A;  3F02 A;  3UT3 A;  1OC0 A;  2BEH L;  2HIJ I;  2V95 A;  3LW2 A;  4PYW A;  1JJO C;  1LK6 I;  2H4P A;  4RSQ A;  4G8O A;  1DZH I;  1DVN A;  4Y40 A;  1QMB A;  3Q02 A;  4AU3 A;  3VVJ A;  2QUG A;  1A7C A;  1SR5 A;  2XN6 A;  3OZQ A;  1OPH A;  1SNG A;  4DY7 C;  4DTE A;  1E03 I;  2GD4 C;  4P0F A;  4BB2 A;  5CDX A;  1ATU A;  4CAA A;  4AQH A;  2WXX A;  3DRU A;  2BEH I;  4AU2 A;  8API A;  1XQG A;  1OVA A;  1XU8 A;  7API A;  1DZG I;  2ACH A;  2PEF A;  4G8R A;  1HLE A;  4DY0 A;  2VDY A;  1DB2 A;  4Y3K A;  4AJT A;  4RO9 A;  2D26 A;  2WY0 C;  2ARR A;  3NE4 A;  2VDX A;  3H5C A;  4R9I A;  4ROB A;  3STO A;  1OVA C;  1K9O I;  5CDZ A;  2OAY A;  1NQ9 I;  3NDF A;  2HI9 A;  2R9Y A;  1OYH L;  3CWL A;  1E04 I;  2VH4 A;  3F5N A;  3LE2 A;  4EB1 I;  4C49 A;  1BY7 A;  3Q03 A;  4P0O A;  3R4L A;  1DVM A;  2H4Q A;  3CAA A;  4IF8 A;  4KDS A;  1PSI A;  1HP7 A;  4X30 A;  1ANT I;  2RIV A;  1EZX A;  5BRR I;  1XQJ A;  1IZ2 A;  2WXW A;  4IC0 A;  2WXY C;  1C8O A;  1WZ9 A;  1QMN A;  1JTI A;  2ZNH A;  4AJU A;  4AU4 A;  1OO8 A;  1QLP A;  3B9F I;  3FGQ A;  4AU3 B;  5EI0 A;  1ATT A;  2DUT A;  3EOX A;  1BR8 I;  3PZF A;  1LQ8 A;  3NDD A;  3NDA A;  4AFX A;  1YXA A;  1C5G A;  1KCT A;  1SEK A;  4C41 A;  2XN3 A;  1DZH L;  1IMV A;  1T1F A;  1UHG A;  2B4X L;  5INW A;  1OVA B;  1F0C A;  1JRR A;  1JVQ I;  2WXZ A;  1B3K A;  3DRM A;  3DY0 A;  1TB6 I;  9PAI A;  1AZX I;  2B5T I;  2ZV6 A;  2RIW A;  3DLW A;  1D5S A;  1R1L I;  4ROA A;  1DZG L;  2WXZ C;  5HGC A;  2ARQ A;  1E05 I;  4YIA A;  4GA7 A;  1OYH I;  2CEO A;  3F1S A;  3EVJ I;  1JMO A;  2B4X I;  2XN5 A;  3ZHA A;  2HIJ L;  1M93 B;  2XN7 A;  3CWM A;  4ZK3 A;  9API A;  1MTP A;  3T1P A;  3CVM A;  1AS4 A;  4ZK0 A;  1JMJ A;  3KCG I;  2OL2 A;  3PB1 I;  5IO1 A;  4EB1 L;  2H4R A;  2WY1 A;  5CE0 A; 
#chains in the Genus database with same CATH homology
 2PEE A;  1ATH A;  2ANT I;  1LJ5 A;  5C98 A;  3F02 A;  3UT3 A;  1OC0 A;  2BEH L;  2HIJ I;  2V95 A;  3LW2 A;  4PYW A;  1JJO C;  1LK6 I;  2H4P A;  4RSQ A;  4G8O A;  1DZH I;  1DVN A;  4Y40 A;  1QMB A;  3Q02 A;  4AU3 A;  3VVJ A;  2QUG A;  1A7C A;  1SR5 A;  2XN6 A;  3OZQ A;  1OPH A;  1SNG A;  4DY7 C;  4DTE A;  1E03 I;  2GD4 C;  4P0F A;  4BB2 A;  5CDX A;  1ATU A;  4CAA A;  4AQH A;  2WXX A;  3DRU A;  2BEH I;  4AU2 A;  8API A;  1XQG A;  1OVA A;  1XU8 A;  7API A;  1DZG I;  2ACH A;  2PEF A;  4G8R A;  1HLE A;  4DY0 A;  2VDY A;  1DB2 A;  4Y3K A;  4AJT A;  4RO9 A;  2D26 A;  2WY0 C;  2ARR A;  3NE4 A;  2VDX A;  3H5C A;  4R9I A;  4ROB A;  3STO A;  1OVA C;  1K9O I;  5CDZ A;  2OAY A;  1NQ9 I;  3NDF A;  2HI9 A;  2R9Y A;  1OYH L;  3CWL A;  1E04 I;  2VH4 A;  3F5N A;  3LE2 A;  4EB1 I;  4C49 A;  1BY7 A;  3Q03 A;  4P0O A;  3R4L A;  1DVM A;  2H4Q A;  3CAA A;  4IF8 A;  4KDS A;  1PSI A;  1HP7 A;  4X30 A;  1ANT I;  2RIV A;  1EZX A;  5BRR I;  1XQJ A;  1IZ2 A;  2WXW A;  4IC0 A;  2WXY C;  1C8O A;  1WZ9 A;  1QMN A;  1JTI A;  2ZNH A;  4AJU A;  4AU4 A;  1OO8 A;  1QLP A;  3B9F I;  3FGQ A;  4AU3 B;  5EI0 A;  1ATT A;  2DUT A;  3EOX A;  1BR8 I;  3PZF A;  1LQ8 A;  3NDD A;  3NDA A;  4AFX A;  1YXA A;  1C5G A;  1KCT A;  1SEK A;  4C41 A;  2XN3 A;  1DZH L;  1IMV A;  1T1F A;  1UHG A;  2B4X L;  5INW A;  1OVA B;  1F0C A;  1JRR A;  1JVQ I;  2WXZ A;  1B3K A;  3DRM A;  3DY0 A;  1TB6 I;  9PAI A;  1AZX I;  2B5T I;  2ZV6 A;  2RIW A;  3DLW A;  1D5S A;  1R1L I;  4ROA A;  1DZG L;  2WXZ C;  5HGC A;  2ARQ A;  1E05 I;  4YIA A;  4GA7 A;  1OYH I;  2CEO A;  3F1S A;  3EVJ I;  1JMO A;  2B4X I;  2XN5 A;  3ZHA A;  2HIJ L;  1M93 B;  2XN7 A;  3CWM A;  4ZK3 A;  9API A;  1MTP A;  3T1P A;  3CVM A;  1AS4 A;  4ZK0 A;  1JMJ A;  3KCG I;  2OL2 A;  3PB1 I;  5IO1 A;  4EB1 L;  2H4R A;  2WY1 A;  5CE0 A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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