1T67A

Crystal structure of human hdac8 complexed with ms-344
Total Genus 127
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
127
sequence length
364
structure length
357
Chain Sequence
LVPVYIYSPEYVSMCDSLAKIPKRASMVHSLIEAYALHKQMRIVKPKVASMEEMATFHTDAYLQHLQKVSQDSIEYGLGYDCPATEGIFDYAAAIGGATITAAQCLIDGMCKVAINWSGGWHHAKKDEASGFCYLNDAVLGILRLRRKFERILYVDLDLHHGDGVEDAFSFTSKVMTVSLHKFSPGFFPGTGDVSDVGLGKGRYYSVNVPIQDGIQDEKYYQICESVLKEVYQAFNPKAVVLQLGADTIAGDPMCSFNMTPVGIGKCLKYILQWQLATLILGGGGYNLANTARCWTYLTGVILGKTLSSEIPDHEFFTAYGPDYVLEITPSCRPDRNEPHRIQQILNYIKGNLKHVV
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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molecule tags Hydrolase
molecule keywords Histone deacetylase 8
publication title Structural Snapshots of Human HDAC8 Provide Insights into the Class I Histone Deacetylases
pubmed doi rcsb
source organism Homo sapiens
total genus 127
structure length 357
sequence length 364
ec nomenclature ec 3.5.1.98: Histone deacetylase.
pdb deposition date 2004-05-05

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00850 Hist_deacetyl Histone deacetylase domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.800.20 Alpha Beta 3-Layer(aba) Sandwich Arginase; Chain A Histone deacetylase domain 1t67A00
4QA0A 5EEKA 1T64A 4RN1A 5G3WA 5G0JA 3F0RA 5G10A 2VQWG 3MZ4A 5DC5A 4RN2A 5EFBD 4BZ7A 1T69A 2VCGA 4QA4A 2VQJA 3C0YA 5THTA 5ICNB 5EFNA 3SFFA 5A2SA 4LY1A 5EF7A 1C3PA 5EFKB 5IWGA 4ZUPA 4RN0A 5DC7A 5IX0A 4ZURA 1C3RA 2V5WA 1ZZ1A 4ZUNA 3Q9FA 4ZUOA 4ZUMA 5G1BA 5G12A 4A69A 5G0GA 5FCWA 3C10A 4CBTA 5EEFA 1VKGA 1T67A 4BZ8A 5D1DA 1ZZ0A 2VQQA 5DC6A 1C3SA 5G0YA 5EFJD 5BWZA 5THVA 5EFHA 2VQOA 4BZ9A 5G1AA 3MZ6A 5EFGA 5EF8A 3EWFA 5DC8A 5G0XA 5THUA 5THSA 5G11A 4QA2A 5G17A 3Q9CA 4QA1A 4ZUQA 5EEMA 3ZNRA 3C0ZA 4CQFA 4QA5A 5G0HA 5D1BA 5G0IA 3EZPA 3F07A 3RQDA 3EW8A 5JI5A 3MENA 4BZ6A 3F06A 3MZ3A 5G1CA 5EENA 3MZ7A 3Q9EA 4LXZA 4BKXB 5EEIA 3SFHA 3Q9BA 5FUEA 1W22A 4BZ5A 5D1CA 4QA6A 3ZNSA 1ZZ3A 2V5XA 4QA3A 3MAXA 4CBYA 2VQMA 5LI3A 5G13A 2VQVA 4QA7A 2GH6A 3EZTA
chains in the Genus database with same CATH superfamily
1ZPEA 4MYFA 3E9BA 1T5FA 1P8NA 4QA0A 4HXQA 1P8QA 1T64A 4IE2A 4RN1A 5EEKA 5G3WA 5G0JA 3GN0A 2CEVA 3F0RA 5G10A 3LP4A 1D3VA 1GQ6A 1TBHA 2VQWG 3MZ4A 4HZEA 3TF3A 4FCKA 4IXVA 3DJ8A 4IE3A 1WVAA 5DC5A 4RHKA 3THEA 4RN2A 5EFBD 4BZ7A 1T69A 1T4RA 2VCGA 4MYKA 2VQJA 3C0YA 3MFVA 4Q3QA 4QA4A 1TBLA 5THTA 3SL1A 3SJTA 1WOHA 4GWCA 4RHJA 5ICNB 5EFNA 4RHIA 3NIQA 3SFFA 5A2SA 4LY1A 5EF7A 2PHOA 1C3PA 3E6KA 1HQXA 4GSZA 4MYNA 5EFKB 5IWGA 4ZUPA 4RN0A 3CEVA 5DC7A 5IX0A 1WOIA 1RLAA 4ZURA 1P8PA 1C3RA 3SKKA 3MMRA 1WVBA 2V5WA 3KV2A 1ZZ1A 4ZUNA 4IU1A 3Q9FA 4ZUOA 4ZUMA 5G1BA 5G12A 2PLLA 4A69A 5G0GA 5HJAA 2ZAVA 5FCWA 3C10A 4Q41A 3MFWA 4CBTA 5EEFA 3M1RA 1VKGA 4Q3RA 1T67A 3LHLA 3LP7A 1PQ3A 3NIPA 2RLAA 1ZZ0A 4Q3SA 4Q3RC 5D1DA 1TBJA 1P8MA 4BZ8A 4HWWA 3PZLA 4QA7A 2VQQA 5DC6A 1C3SA 5G0YA 5EFJD 5BWZA 1XFKA 4ITYA 5THVA 4FCIA 5EFHA 1P8SA 2VQOA 4BZ9A 5G1AA 3MZ6A 1T4TA 5EFGA 5EF8A 3EWFA 5DC8A 3SL0A 1WOGA 5G0XA 5THUA 1R1OA 2PHAA 4IE1A 5THSA 5G11A 4QA2A 5G17A 3Q9CA 4RHQA 4QA1A 4ZUQA 1HQHA 5EEMA 3ZNRA 4IU0A 5CEVA 3C0ZA 4CQFA 2EF5A 4QA5A 5G0HA 3GMZA 3MJLA 5D1BA 2EF4A 5G0IA 4RHLA 3EZPA 3RLAA 4IU5A 1T4SA 4DZ4A 3F07A 4IU4A 3RQDA 3EW8A 4MXRA 5HJ9A 5JI5A 4RLAA 4Q3TA 4Q40A 1HQ5A 4BZ6A 1GQ7A 1P8OA 3F06A 3MZ3A 4RHMA 2EIVA 5G1CA 1HQFA 5EENA 4Q42A 1HQGA 3MZ7A 4IXUA 5RLAA 3Q9EA 4LXZA 4I06A 3THHA 3TH7A 4BKXB 1CEVA 5EEIA 3SFHA 3Q9BA 4G3HA 1TA1A 5FUEA 1W22A 4Q3UA 4BZ5A 3E8ZA 5D1CA 4QA6A 3ZNSA 1ZZ3A 4CEVA 1ZPGA 2AEBA 3E8QA 2V5XA 3E6VA 4Q3PA 4QA3A 1T5GA 3MAXA 4GWDA 2A0MA 3NIOA 4MYLA 4Q3VA 2VQMA 1T4PA 4GSMA 4CBYA 3F80A 5LI3A 5G13A 1P8RA 3THJA 2VQVA 4GSVA 3MENA 2GH6A 3EZTA
chains in the Genus database with same CATH topology
4QA0A 5EEKA 1T64A 4RN1A 5G3WA 5G0JA 3F0RA 5G10A 2VQWG 3MZ4A 5DC5A 4RN2A 5EFBD 4BZ7A 1T69A 2VCGA 4QA4A 2VQJA 3C0YA 5THTA 5ICNB 5EFNA 3SFFA 5A2SA 4LY1A 5EF7A 1C3PA 5EFKB 5IWGA 4ZUPA 4RN0A 5DC7A 5IX0A 4ZURA 1C3RA 2V5WA 1ZZ1A 4ZUNA 3Q9FA 4ZUOA 4ZUMA 5G1BA 5G12A 4A69A 5G0GA 5FCWA 3C10A 4CBTA 5EEFA 1VKGA 1T67A 4BZ8A 5D1DA 1ZZ0A 2VQQA 5DC6A 1C3SA 5G0YA 5EFJD 5BWZA 5THVA 5EFHA 2VQOA 4BZ9A 5G1AA 3MZ6A 5EFGA 5EF8A 3EWFA 5DC8A 5G0XA 5THUA 5THSA 5G11A 4QA2A 5G17A 3Q9CA 4QA1A 4ZUQA 5EEMA 3ZNRA 3C0ZA 4CQFA 4QA5A 5G0HA 5D1BA 5G0IA 3EZPA 3F07A 3RQDA 3EW8A 5JI5A 3MENA 4BZ6A 3F06A 3MZ3A 5G1CA 5EENA 3MZ7A 3Q9EA 4LXZA 4BKXB 5EEIA 3SFHA 3Q9BA 5FUEA 1W22A 4BZ5A 5D1CA 4QA6A 3ZNSA 1ZZ3A 2V5XA 4QA3A 3MAXA 4CBYA 2VQMA 5LI3A 5G13A 2VQVA 4QA7A 2GH6A 3EZTA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4QA0 A;  5EEK A;  1T64 A;  4RN1 A;  5G3W A;  5G0J A;  3F0R A;  5G10 A;  2VQW G;  3MZ4 A;  5DC5 A;  4RN2 A;  5EFB D;  4BZ7 A;  1T69 A;  2VCG A;  4QA4 A;  2VQJ A;  3C0Y A;  5THT A;  5ICN B;  5EFN A;  3SFF A;  5A2S A;  4LY1 A;  5EF7 A;  1C3P A;  5EFK B;  5IWG A;  4ZUP A;  4RN0 A;  5DC7 A;  5IX0 A;  4ZUR A;  1C3R A;  2V5W A;  1ZZ1 A;  4ZUN A;  3Q9F A;  4ZUO A;  4ZUM A;  5G1B A;  5G12 A;  4A69 A;  5G0G A;  5FCW A;  3C10 A;  4CBT A;  5EEF A;  1VKG A;  1T67 A;  4BZ8 A;  5D1D A;  1ZZ0 A;  2VQQ A;  5DC6 A;  1C3S A;  5G0Y A;  5EFJ D;  5BWZ A;  5THV A;  5EFH A;  2VQO A;  4BZ9 A;  5G1A A;  3MZ6 A;  5EFG A;  5EF8 A;  3EWF A;  5DC8 A;  5G0X A;  5THU A;  5THS A;  5G11 A;  4QA2 A;  5G17 A;  3Q9C A;  4QA1 A;  4ZUQ A;  5EEM A;  3ZNR A;  3C0Z A;  4CQF A;  4QA5 A;  5G0H A;  5D1B A;  5G0I A;  3EZP A;  3F07 A;  3RQD A;  3EW8 A;  5JI5 A;  3MEN A;  4BZ6 A;  3F06 A;  3MZ3 A;  5G1C A;  5EEN A;  3MZ7 A;  3Q9E A;  4LXZ A;  4BKX B;  5EEI A;  3SFH A;  3Q9B A;  5FUE A;  1W22 A;  4BZ5 A;  5D1C A;  4QA6 A;  3ZNS A;  1ZZ3 A;  2V5X A;  4QA3 A;  3MAX A;  4CBY A;  2VQM A;  5LI3 A;  5G13 A;  2VQV A;  4QA7 A;  2GH6 A;  3EZT A; 
#chains in the Genus database with same CATH topology
 1ZPE A;  4MYF A;  3E9B A;  1T5F A;  1P8N A;  4QA0 A;  4HXQ A;  1P8Q A;  1T64 A;  4IE2 A;  4RN1 A;  5EEK A;  5G3W A;  5G0J A;  3GN0 A;  2CEV A;  3F0R A;  5G10 A;  3LP4 A;  1D3V A;  1GQ6 A;  1TBH A;  2VQW G;  3MZ4 A;  4HZE A;  3TF3 A;  4FCK A;  4IXV A;  3DJ8 A;  4IE3 A;  1WVA A;  5DC5 A;  4RHK A;  3THE A;  4RN2 A;  5EFB D;  4BZ7 A;  1T69 A;  1T4R A;  2VCG A;  4MYK A;  2VQJ A;  3C0Y A;  3MFV A;  4Q3Q A;  4QA4 A;  1TBL A;  5THT A;  3SL1 A;  3SJT A;  1WOH A;  4GWC A;  4RHJ A;  5ICN B;  5EFN A;  4RHI A;  3NIQ A;  3SFF A;  5A2S A;  4LY1 A;  5EF7 A;  2PHO A;  1C3P A;  3E6K A;  1HQX A;  4GSZ A;  4MYN A;  5EFK B;  5IWG A;  4ZUP A;  4RN0 A;  3CEV A;  5DC7 A;  5IX0 A;  1WOI A;  1RLA A;  4ZUR A;  1P8P A;  1C3R A;  3SKK A;  3MMR A;  1WVB A;  2V5W A;  3KV2 A;  1ZZ1 A;  4ZUN A;  4IU1 A;  3Q9F A;  4ZUO A;  4ZUM A;  5G1B A;  5G12 A;  2PLL A;  4A69 A;  5G0G A;  5HJA A;  2ZAV A;  5FCW A;  3C10 A;  4Q41 A;  3MFW A;  4CBT A;  5EEF A;  3M1R A;  1VKG A;  4Q3R A;  1T67 A;  3LHL A;  3LP7 A;  1PQ3 A;  3NIP A;  2RLA A;  1ZZ0 A;  4Q3S A;  4Q3R C;  5D1D A;  1TBJ A;  1P8M A;  4BZ8 A;  4HWW A;  3PZL A;  4QA7 A;  2VQQ A;  5DC6 A;  1C3S A;  5G0Y A;  5EFJ D;  5BWZ A;  1XFK A;  4ITY A;  5THV A;  4FCI A;  5EFH A;  1P8S A;  2VQO A;  4BZ9 A;  5G1A A;  3MZ6 A;  1T4T A;  5EFG A;  5EF8 A;  3EWF A;  5DC8 A;  3SL0 A;  1WOG A;  5G0X A;  5THU A;  1R1O A;  2PHA A;  4IE1 A;  5THS A;  5G11 A;  4QA2 A;  5G17 A;  3Q9C A;  4RHQ A;  4QA1 A;  4ZUQ A;  1HQH A;  5EEM A;  3ZNR A;  4IU0 A;  5CEV A;  3C0Z A;  4CQF A;  2EF5 A;  4QA5 A;  5G0H A;  3GMZ A;  3MJL A;  5D1B A;  2EF4 A;  5G0I A;  4RHL A;  3EZP A;  3RLA A;  4IU5 A;  1T4S A;  4DZ4 A;  3F07 A;  4IU4 A;  3RQD A;  3EW8 A;  4MXR A;  5HJ9 A;  5JI5 A;  4RLA A;  4Q3T A;  4Q40 A;  1HQ5 A;  4BZ6 A;  1GQ7 A;  1P8O A;  3F06 A;  3MZ3 A;  4RHM A;  2EIV A;  5G1C A;  1HQF A;  5EEN A;  4Q42 A;  1HQG A;  3MZ7 A;  4IXU A;  5RLA A;  3Q9E A;  4LXZ A;  4I06 A;  3THH A;  3TH7 A;  4BKX B;  1CEV A;  5EEI A;  3SFH A;  3Q9B A;  4G3H A;  1TA1 A;  5FUE A;  1W22 A;  4Q3U A;  4BZ5 A;  3E8Z A;  5D1C A;  4QA6 A;  3ZNS A;  1ZZ3 A;  4CEV A;  1ZPG A;  2AEB A;  3E8Q A;  2V5X A;  3E6V A;  4Q3P A;  4QA3 A;  1T5G A;  3MAX A;  4GWD A;  2A0M A;  3NIO A;  4MYL A;  4Q3V A;  2VQM A;  1T4P A;  4GSM A;  4CBY A;  3F80 A;  5LI3 A;  5G13 A;  1P8R A;  3THJ A;  2VQV A;  4GSV A;  3MEN A;  2GH6 A;  3EZT A; 
#chains in the Genus database with same CATH homology
 4QA0 A;  5EEK A;  1T64 A;  4RN1 A;  5G3W A;  5G0J A;  3F0R A;  5G10 A;  2VQW G;  3MZ4 A;  5DC5 A;  4RN2 A;  5EFB D;  4BZ7 A;  1T69 A;  2VCG A;  4QA4 A;  2VQJ A;  3C0Y A;  5THT A;  5ICN B;  5EFN A;  3SFF A;  5A2S A;  4LY1 A;  5EF7 A;  1C3P A;  5EFK B;  5IWG A;  4ZUP A;  4RN0 A;  5DC7 A;  5IX0 A;  4ZUR A;  1C3R A;  2V5W A;  1ZZ1 A;  4ZUN A;  3Q9F A;  4ZUO A;  4ZUM A;  5G1B A;  5G12 A;  4A69 A;  5G0G A;  5FCW A;  3C10 A;  4CBT A;  5EEF A;  1VKG A;  1T67 A;  4BZ8 A;  5D1D A;  1ZZ0 A;  2VQQ A;  5DC6 A;  1C3S A;  5G0Y A;  5EFJ D;  5BWZ A;  5THV A;  5EFH A;  2VQO A;  4BZ9 A;  5G1A A;  3MZ6 A;  5EFG A;  5EF8 A;  3EWF A;  5DC8 A;  5G0X A;  5THU A;  5THS A;  5G11 A;  4QA2 A;  5G17 A;  3Q9C A;  4QA1 A;  4ZUQ A;  5EEM A;  3ZNR A;  3C0Z A;  4CQF A;  4QA5 A;  5G0H A;  5D1B A;  5G0I A;  3EZP A;  3F07 A;  3RQD A;  3EW8 A;  5JI5 A;  3MEN A;  4BZ6 A;  3F06 A;  3MZ3 A;  5G1C A;  5EEN A;  3MZ7 A;  3Q9E A;  4LXZ A;  4BKX B;  5EEI A;  3SFH A;  3Q9B A;  5FUE A;  1W22 A;  4BZ5 A;  5D1C A;  4QA6 A;  3ZNS A;  1ZZ3 A;  2V5X A;  4QA3 A;  3MAX A;  4CBY A;  2VQM A;  5LI3 A;  5G13 A;  2VQV A;  4QA7 A;  2GH6 A;  3EZT A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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