1W22A

Crystal structure of inhibited human hdac8
Total Genus 122
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
122
sequence length
362
structure length
352
Chain Sequence
SLVPVYIYSPEYVSMCDSLAKIPKRASMVHSLIEAYALHKQMRIVKPKVASMEEMATFHTDAYLQHLQKVSQEYGLGYDCPATEGIFDYAAAIGGATITAAQCLIDGMCKVAINWSGGWHHAKKDEASGFCYLNDAVLGILRLRRKFERILYVDLDLHHGDGVEDAFSFTSKVMTVSLHKFSPGFFPGTGDVSDVGLGKGRYYSVNVPIQDGIQDEKYYQICESVLKEVYQAFNPKAVVLQLGADTIAGDPMCSFNMTPVGIGKCLKYILQWQLATLILGGGGYNLANTARCWTYLTGVILGKTLSSEIPDHEFFTAYGPDYVLEITPSCRPDRNEPHRIQQILNYIKGNLK
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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molecule tags Hydrolase
molecule keywords HISTONE DEACETYLASE 8
publication title Crystal Structure of a Eukaryotic Zn-Dependent Histone Deacetylase,Human Hdac8,Complexed with a Hydroxamic Acid Inhibitor
pubmed doi rcsb
source organism Homo sapiens
total genus 122
structure length 352
sequence length 362
chains with identical sequence B
ec nomenclature ec 3.5.1.98: Histone deacetylase.
pdb deposition date 2004-06-25

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00850 Hist_deacetyl Histone deacetylase domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.800.20 Alpha Beta 3-Layer(aba) Sandwich Arginase; Chain A Histone deacetylase domain 1w22A00
4RN2A 5G1BA 2V5WA 1ZZ3A 3C0YA 3SFFA 5G0XA 3F06A 5DC5A 4CQFA 1T69A 3EZTA 5THVA 5G11A 4QA6A 5EF7A 5G17A 5THTA 2VCGA 5G13A 5D1CA 3ZNRA 3MZ4A 5D1DA 2VQVA 3F07A 3RQDA 5IX0A 3Q9FA 5THSA 4CBTA 1VKGA 3Q9BA 5A2SA 5EEIA 1W22A 4BKXB 5EFKB 1C3PA 4ZUQA 5G0JA 5DC7A 5EFGA 5EFJD 4ZUPA 4QA1A 5EEMA 1C3RA 4QA2A 5EFNA 4BZ8A 2V5XA 5LI3A 2VQJA 3C10A 4LY1A 4ZUOA 5G0GA 4BZ6A 4BZ5A 2VQWG 3MAXA 5BWZA 5ICNB 5EENA 4CBYA 1T67A 5EFBD 5JI5A 4ZURA 5G3WA 3Q9CA 5EEFA 5DC8A 3F0RA 5EFHA 4LXZA 5G0HA 5G10A 3EW8A 3SFHA 1ZZ1A 5G0YA 5G1AA 5FUEA 4ZUMA 3C0ZA 5IWGA 3MZ3A 1ZZ0A 4A69A 3EZPA 1C3SA 3MZ7A 5THUA 4RN1A 4ZUNA 3EWFA 4QA7A 4BZ7A 5DC6A 5D1BA 4BZ9A 3MENA 5EF8A 5G12A 1T64A 5G0IA 4QA3A 5G1CA 4QA4A 3ZNSA 3Q9EA 4QA5A 4RN0A 4QA0A 5EEKA 2GH6A 3MZ6A 2VQQA 5FCWA 2VQMA 2VQOA
chains in the Genus database with same CATH superfamily
4RN2A 5G1BA 1T5GA 2V5WA 1P8SA 4RHKA 1ZZ3A 1TBJA 3THJA 3E8ZA 4Q3QA 4Q3UA 3C0YA 4G3HA 3SFFA 5G0XA 3F06A 4Q3VA 5DC5A 1GQ6A 4MYNA 1T69A 3EZTA 5THVA 4CQFA 1WVAA 5G11A 4QA6A 5EF7A 5G17A 5THTA 2VCGA 1WOGA 5G13A 3NIPA 5D1CA 3ZNRA 1P8NA 3MZ4A 3TH7A 4MYLA 4Q3SA 5D1DA 2VQVA 2PLLA 1HQGA 3F07A 1P8QA 3RQDA 4Q41A 1P8OA 5IX0A 3MFWA 3Q9FA 4IE3A 5THSA 4CBTA 1VKGA 3Q9BA 5A2SA 3NIQA 1CEVA 3E8QA 5EEIA 1W22A 1HQHA 4Q3TA 4BKXB 5EFKB 1P8MA 3MMRA 2PHOA 1C3PA 4Q42A 1WOHA 4IU1A 4ZUQA 5G0JA 4MYFA 5DC7A 4I06A 3PZLA 5HJAA 3RLAA 5EFGA 5EFJD 4ZUPA 2RLAA 1HQXA 2PHAA 2VQMA 2EF5A 1C3RA 4QA1A 5EEMA 5CEVA 1R1OA 4QA2A 5EFNA 4IU4A 3E9BA 2AEBA 4BZ8A 5RLAA 2V5XA 4FCIA 2VQJA 4Q40A 5HJ9A 5LI3A 3LP7A 3C10A 4IXVA 4HXQA 3THHA 3THEA 4LY1A 4ZUOA 3SL0A 4RHLA 3LHLA 3LP4A 4HWWA 5DC8A 4DZ4A 1RLAA 5G0GA 2CEVA 1P8PA 3GN0A 4BZ6A 4BZ5A 2VQWG 4RHIA 4RLAA 3GMZA 4GWDA 3MAXA 4GWCA 4IXUA 1XFKA 5BWZA 2EF4A 3SJTA 5ICNB 4GSZA 4Q3RC 3DJ8A 5EENA 4CBYA 3KV2A 1T67A 5EFBD 1P8RA 1T5FA 4ZURA 3MFVA 3Q9CA 4MXRA 5G3WA 5JI5A 5EEFA 3F80A 3M1RA 3F0RA 4IE2A 4IU5A 1TBLA 4LXZA 4MYKA 4RHMA 1HQ5A 2EIVA 3EW8A 5EFHA 5G0HA 5G10A 3SFHA 1HQFA 1ZZ1A 4HZEA 5G1AA 4ITYA 5G0YA 3E6KA 1WOIA 5FUEA 1ZPEA 4ZUMA 3C0ZA 5IWGA 3E6VA 2A0MA 3MJLA 1ZZ0A 3MZ3A 4RHJA 4RHQA 4A69A 1GQ7A 1T4PA 3EZPA 4GSVA 1C3SA 3MZ7A 1T4RA 5THUA 3SL1A 4RN1A 1T4SA 1TA1A 4ZUNA 3EWFA 4GSMA 4QA7A 4IU0A 4BZ7A 5DC6A 5D1BA 4BZ9A 3MENA 3CEVA 5EF8A 5G12A 1T64A 3SKKA 2ZAVA 5G0IA 1TBHA 4Q3RA 4QA3A 5G1CA 4QA4A 3ZNSA 3Q9EA 4QA5A 4RN0A 4QA0A 5EEKA 2GH6A 1WVBA 1PQ3A 3NIOA 4Q3PA 4CEVA 3TF3A 3MZ6A 2VQQA 5FCWA 1D3VA 1ZPGA 1T4TA 2VQOA 4IE1A 4FCKA
chains in the Genus database with same CATH topology
4RN2A 5G1BA 2V5WA 1ZZ3A 3C0YA 3SFFA 5G0XA 3F06A 5DC5A 4CQFA 1T69A 3EZTA 5THVA 5G11A 4QA6A 5EF7A 5G17A 5THTA 2VCGA 5G13A 5D1CA 3ZNRA 3MZ4A 5D1DA 2VQVA 3F07A 3RQDA 5IX0A 3Q9FA 5THSA 4CBTA 1VKGA 3Q9BA 5A2SA 5EEIA 1W22A 4BKXB 5EFKB 1C3PA 4ZUQA 5G0JA 5DC7A 5EFGA 5EFJD 4ZUPA 4QA1A 5EEMA 1C3RA 4QA2A 5EFNA 4BZ8A 2V5XA 5LI3A 2VQJA 3C10A 4LY1A 4ZUOA 5G0GA 4BZ6A 4BZ5A 2VQWG 3MAXA 5BWZA 5ICNB 5EENA 4CBYA 1T67A 5EFBD 5JI5A 4ZURA 5G3WA 3Q9CA 5EEFA 5DC8A 3F0RA 5EFHA 4LXZA 5G0HA 5G10A 3EW8A 3SFHA 1ZZ1A 5G0YA 5G1AA 5FUEA 4ZUMA 3C0ZA 5IWGA 3MZ3A 1ZZ0A 4A69A 3EZPA 1C3SA 3MZ7A 5THUA 4RN1A 4ZUNA 3EWFA 4QA7A 4BZ7A 5DC6A 5D1BA 4BZ9A 3MENA 5EF8A 5G12A 1T64A 5G0IA 4QA3A 5G1CA 4QA4A 3ZNSA 3Q9EA 4QA5A 4RN0A 4QA0A 5EEKA 2GH6A 3MZ6A 2VQQA 5FCWA 2VQMA 2VQOA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4RN2 A;  5G1B A;  2V5W A;  1ZZ3 A;  3C0Y A;  3SFF A;  5G0X A;  3F06 A;  5DC5 A;  4CQF A;  1T69 A;  3EZT A;  5THV A;  5G11 A;  4QA6 A;  5EF7 A;  5G17 A;  5THT A;  2VCG A;  5G13 A;  5D1C A;  3ZNR A;  3MZ4 A;  5D1D A;  2VQV A;  3F07 A;  3RQD A;  5IX0 A;  3Q9F A;  5THS A;  4CBT A;  1VKG A;  3Q9B A;  5A2S A;  5EEI A;  1W22 A;  4BKX B;  5EFK B;  1C3P A;  4ZUQ A;  5G0J A;  5DC7 A;  5EFG A;  5EFJ D;  4ZUP A;  4QA1 A;  5EEM A;  1C3R A;  4QA2 A;  5EFN A;  4BZ8 A;  2V5X A;  5LI3 A;  2VQJ A;  3C10 A;  4LY1 A;  4ZUO A;  5G0G A;  4BZ6 A;  4BZ5 A;  2VQW G;  3MAX A;  5BWZ A;  5ICN B;  5EEN A;  4CBY A;  1T67 A;  5EFB D;  5JI5 A;  4ZUR A;  5G3W A;  3Q9C A;  5EEF A;  5DC8 A;  3F0R A;  5EFH A;  4LXZ A;  5G0H A;  5G10 A;  3EW8 A;  3SFH A;  1ZZ1 A;  5G0Y A;  5G1A A;  5FUE A;  4ZUM A;  3C0Z A;  5IWG A;  3MZ3 A;  1ZZ0 A;  4A69 A;  3EZP A;  1C3S A;  3MZ7 A;  5THU A;  4RN1 A;  4ZUN A;  3EWF A;  4QA7 A;  4BZ7 A;  5DC6 A;  5D1B A;  4BZ9 A;  3MEN A;  5EF8 A;  5G12 A;  1T64 A;  5G0I A;  4QA3 A;  5G1C A;  4QA4 A;  3ZNS A;  3Q9E A;  4QA5 A;  4RN0 A;  4QA0 A;  5EEK A;  2GH6 A;  3MZ6 A;  2VQQ A;  5FCW A;  2VQM A;  2VQO A; 
#chains in the Genus database with same CATH topology
 4RN2 A;  5G1B A;  1T5G A;  2V5W A;  1P8S A;  4RHK A;  1ZZ3 A;  1TBJ A;  3THJ A;  3E8Z A;  4Q3Q A;  4Q3U A;  3C0Y A;  4G3H A;  3SFF A;  5G0X A;  3F06 A;  4Q3V A;  5DC5 A;  1GQ6 A;  4MYN A;  1T69 A;  3EZT A;  5THV A;  4CQF A;  1WVA A;  5G11 A;  4QA6 A;  5EF7 A;  5G17 A;  5THT A;  2VCG A;  1WOG A;  5G13 A;  3NIP A;  5D1C A;  3ZNR A;  1P8N A;  3MZ4 A;  3TH7 A;  4MYL A;  4Q3S A;  5D1D A;  2VQV A;  2PLL A;  1HQG A;  3F07 A;  1P8Q A;  3RQD A;  4Q41 A;  1P8O A;  5IX0 A;  3MFW A;  3Q9F A;  4IE3 A;  5THS A;  4CBT A;  1VKG A;  3Q9B A;  5A2S A;  3NIQ A;  1CEV A;  3E8Q A;  5EEI A;  1W22 A;  1HQH A;  4Q3T A;  4BKX B;  5EFK B;  1P8M A;  3MMR A;  2PHO A;  1C3P A;  4Q42 A;  1WOH A;  4IU1 A;  4ZUQ A;  5G0J A;  4MYF A;  5DC7 A;  4I06 A;  3PZL A;  5HJA A;  3RLA A;  5EFG A;  5EFJ D;  4ZUP A;  2RLA A;  1HQX A;  2PHA A;  2VQM A;  2EF5 A;  1C3R A;  4QA1 A;  5EEM A;  5CEV A;  1R1O A;  4QA2 A;  5EFN A;  4IU4 A;  3E9B A;  2AEB A;  4BZ8 A;  5RLA A;  2V5X A;  4FCI A;  2VQJ A;  4Q40 A;  5HJ9 A;  5LI3 A;  3LP7 A;  3C10 A;  4IXV A;  4HXQ A;  3THH A;  3THE A;  4LY1 A;  4ZUO A;  3SL0 A;  4RHL A;  3LHL A;  3LP4 A;  4HWW A;  5DC8 A;  4DZ4 A;  1RLA A;  5G0G A;  2CEV A;  1P8P A;  3GN0 A;  4BZ6 A;  4BZ5 A;  2VQW G;  4RHI A;  4RLA A;  3GMZ A;  4GWD A;  3MAX A;  4GWC A;  4IXU A;  1XFK A;  5BWZ A;  2EF4 A;  3SJT A;  5ICN B;  4GSZ A;  4Q3R C;  3DJ8 A;  5EEN A;  4CBY A;  3KV2 A;  1T67 A;  5EFB D;  1P8R A;  1T5F A;  4ZUR A;  3MFV A;  3Q9C A;  4MXR A;  5G3W A;  5JI5 A;  5EEF A;  3F80 A;  3M1R A;  3F0R A;  4IE2 A;  4IU5 A;  1TBL A;  4LXZ A;  4MYK A;  4RHM A;  1HQ5 A;  2EIV A;  3EW8 A;  5EFH A;  5G0H A;  5G10 A;  3SFH A;  1HQF A;  1ZZ1 A;  4HZE A;  5G1A A;  4ITY A;  5G0Y A;  3E6K A;  1WOI A;  5FUE A;  1ZPE A;  4ZUM A;  3C0Z A;  5IWG A;  3E6V A;  2A0M A;  3MJL A;  1ZZ0 A;  3MZ3 A;  4RHJ A;  4RHQ A;  4A69 A;  1GQ7 A;  1T4P A;  3EZP A;  4GSV A;  1C3S A;  3MZ7 A;  1T4R A;  5THU A;  3SL1 A;  4RN1 A;  1T4S A;  1TA1 A;  4ZUN A;  3EWF A;  4GSM A;  4QA7 A;  4IU0 A;  4BZ7 A;  5DC6 A;  5D1B A;  4BZ9 A;  3MEN A;  3CEV A;  5EF8 A;  5G12 A;  1T64 A;  3SKK A;  2ZAV A;  5G0I A;  1TBH A;  4Q3R A;  4QA3 A;  5G1C A;  4QA4 A;  3ZNS A;  3Q9E A;  4QA5 A;  4RN0 A;  4QA0 A;  5EEK A;  2GH6 A;  1WVB A;  1PQ3 A;  3NIO A;  4Q3P A;  4CEV A;  3TF3 A;  3MZ6 A;  2VQQ A;  5FCW A;  1D3V A;  1ZPG A;  1T4T A;  2VQO A;  4IE1 A;  4FCK A; 
#chains in the Genus database with same CATH homology
 4RN2 A;  5G1B A;  2V5W A;  1ZZ3 A;  3C0Y A;  3SFF A;  5G0X A;  3F06 A;  5DC5 A;  4CQF A;  1T69 A;  3EZT A;  5THV A;  5G11 A;  4QA6 A;  5EF7 A;  5G17 A;  5THT A;  2VCG A;  5G13 A;  5D1C A;  3ZNR A;  3MZ4 A;  5D1D A;  2VQV A;  3F07 A;  3RQD A;  5IX0 A;  3Q9F A;  5THS A;  4CBT A;  1VKG A;  3Q9B A;  5A2S A;  5EEI A;  1W22 A;  4BKX B;  5EFK B;  1C3P A;  4ZUQ A;  5G0J A;  5DC7 A;  5EFG A;  5EFJ D;  4ZUP A;  4QA1 A;  5EEM A;  1C3R A;  4QA2 A;  5EFN A;  4BZ8 A;  2V5X A;  5LI3 A;  2VQJ A;  3C10 A;  4LY1 A;  4ZUO A;  5G0G A;  4BZ6 A;  4BZ5 A;  2VQW G;  3MAX A;  5BWZ A;  5ICN B;  5EEN A;  4CBY A;  1T67 A;  5EFB D;  5JI5 A;  4ZUR A;  5G3W A;  3Q9C A;  5EEF A;  5DC8 A;  3F0R A;  5EFH A;  4LXZ A;  5G0H A;  5G10 A;  3EW8 A;  3SFH A;  1ZZ1 A;  5G0Y A;  5G1A A;  5FUE A;  4ZUM A;  3C0Z A;  5IWG A;  3MZ3 A;  1ZZ0 A;  4A69 A;  3EZP A;  1C3S A;  3MZ7 A;  5THU A;  4RN1 A;  4ZUN A;  3EWF A;  4QA7 A;  4BZ7 A;  5DC6 A;  5D1B A;  4BZ9 A;  3MEN A;  5EF8 A;  5G12 A;  1T64 A;  5G0I A;  4QA3 A;  5G1C A;  4QA4 A;  3ZNS A;  3Q9E A;  4QA5 A;  4RN0 A;  4QA0 A;  5EEK A;  2GH6 A;  3MZ6 A;  2VQQ A;  5FCW A;  2VQM A;  2VQO A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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