1AI3A

Orbital steering in the catalytic power of enzymes: small structural changes with large catalytic consequences
Total Genus 132
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
132
sequence length
414
structure length
414
Chain Sequence
SKVVVPAQGKKITLQNGKLNVPENPIIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPAETLDLIREYRVAIKGPLTTPVGGGIRSLNVALRQELDLYICLRPVRYYQGTPSPVKHPELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCSEEGTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFGGELIDGGPWLKVKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMNLNGDYISDALAAQVGGIGIAPGANIGDECALFEATHGTAPKYAGQDKVNPGSIILSAEMMLRHMGWTEAADLIVKGMEGAINAKTVTYDFERLMDGAKLLKCSEFGDAIIENM
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Orbital steering in the catalytic power of enzymes: small structural changes with large catalytic consequences.
pubmed doi rcsb
molecule tags Oxidoreductase
source organism Escherichia coli
molecule keywords ISOCITRATE DEHYDROGENASE
total genus 132
structure length 414
sequence length 414
ec nomenclature ec 1.1.1.42: Isocitrate dehydrogenase (NADP(+)).
pdb deposition date 1997-04-30

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00180 Iso_dh Isocitrate/isopropylmalate dehydrogenase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.718.10 Alpha Beta 3-Layer(aba) Sandwich Isopropylmalate Dehydrogenase Isopropylmalate Dehydrogenase 1ai3A00
3TNGA 5K11A 1R8KA 1GC8A 1IDCA 4UMXA 2Y42A 5LGEA 1V53A 5GRHA 4ATYA 5HN3A 5HN5A 1PB3A 1XABA 1DR8A 2QFWA 5K10A 5GRIA 5L57A 2QFXA 1CNZA 5GREA 4L06A 1LWDA 4P69C 4UMYA 1IDMA 1AI3A 4AJBA 1IPDA 3U1HA 1CW7A 1AI2A 3LCBC 1WALA 2E0CA 4JA8A 2ZTWA 3ASJA 3VL4A 3BLXA 1OSIA 1A05A 5GRHB 3BLVA 1XKDA 1DR0A 1W0DA 5GRIB 3TSNA 3UDUA 5HN6A 5GREB 5L58A 3WZWA 1P8FA 4JQPA 1OSJA 7ICDA 3LXYA 1PS7A 3DMSA 9ICDA 5J33A 3TY3A 6ICDA 3VL2A 4AJCA 2D4VA 3ICDA 3BLXB 5HN4A 3MARA 4AJSA 3FLKA 1VLCA 1IDFA 1TYOA 4I3LA 3AH3A 4AJ3A 1X0LA 3US8A 1V5BA 1G2UA 3VL7A 1BL5A 1ZORA 1PTMA 3WZYA 5I95A 3U9EA 3MAPA 4AJRA 1XGVA 2QFVA 5GRFA 5GRLA 8ICDA 1WPWA 4HCXA 3TY4A 1IDEA 3MASA 3R8WA 1XADA 2Y40A 1U7NA 2UXRA 4WUOA 4XXVA 2HI1A 5ICDA 1SJSA 2Y3ZA 2D1CA 3VL3A 3BLVB 3UDOA 2Y41A 3INMA 1T09A 3VMLA 1YXOA 1PB1A 2UXQA 1GROA 4ICDA 5GRLB 4L04A 5GRFB 2AYQA 2QFYA 3WZVA 4AOVA 1GRPA 1YCOA 3MASB 3VL6A 4BNPA 4F7IA 4AOUA 1XAAA 1CW1A 3VMJA 2E5MA 4AJAA 1T0LA 3WZXA 3UF6A 1IDDA 1PS6A 2DHTA 4XS3A 1HJ6A 4IWHA 1IKAA 1CM7A 4L03A 1GC9A 4I3KA 5J34A 3VMKA 3VKZA 4AOYA 4Y1PA 2IV0A 2G4OA 1VI1A 4XRXA 4YB4A 1ISOA 1XACA 1V94A 5DE1A 1CW4A 1HQSA 1DPZA 3FMXX 4KZOA 1HEXA 5I96A 5J32A
chains in the Genus database with same CATH superfamily
3TNGA 5K11A 1R8KA 1GC8A 1IDCA 4UMXA 2Y42A 5LGEA 1V53A 5GRHA 4ATYA 5HN3A 5HN5A 1PB3A 1XABA 1DR8A 2QFWA 5K10A 5GRIA 5L57A 2QFXA 1CNZA 5GREA 4L06A 1LWDA 4P69C 4UMYA 1IDMA 1AI3A 4AJBA 1IPDA 3U1HA 1CW7A 1AI2A 3LCBC 1WALA 2E0CA 4JA8A 2ZTWA 3ASJA 3VL4A 3BLXA 1OSIA 1A05A 5GRHB 3BLVA 1XKDA 1DR0A 1W0DA 5GRIB 3TSNA 3UDUA 5HN6A 5GREB 5L58A 3WZWA 1P8FA 4JQPA 1OSJA 7ICDA 3LXYA 1PS7A 3DMSA 9ICDA 5J33A 3TY3A 6ICDA 3VL2A 4AJCA 2D4VA 3ICDA 3BLXB 5HN4A 3MARA 4AJSA 3FLKA 1VLCA 1IDFA 1TYOA 4I3LA 3AH3A 4AJ3A 1X0LA 3US8A 1V5BA 1G2UA 3VL7A 1BL5A 1ZORA 1PTMA 3WZYA 5I95A 3U9EA 3MAPA 4AJRA 1XGVA 2QFVA 5GRFA 5GRLA 8ICDA 1WPWA 4HCXA 3TY4A 1IDEA 3MASA 3R8WA 1XADA 2Y40A 1U7NA 2UXRA 4WUOA 4XXVA 2HI1A 5ICDA 1SJSA 2Y3ZA 2D1CA 3VL3A 3BLVB 3UDOA 2Y41A 3INMA 1T09A 3VMLA 1YXOA 1PB1A 2UXQA 1GROA 4ICDA 5GRLB 4L04A 5GRFB 2AYQA 2QFYA 3WZVA 4AOVA 1GRPA 1YCOA 3MASB 3VL6A 4BNPA 4F7IA 4AOUA 1XAAA 1CW1A 3VMJA 2E5MA 4AJAA 1T0LA 3WZXA 3UF6A 1IDDA 1PS6A 2DHTA 4XS3A 1HJ6A 4IWHA 1IKAA 1CM7A 4L03A 1GC9A 4I3KA 5J34A 3VMKA 3VKZA 4AOYA 4Y1PA 2IV0A 2G4OA 1VI1A 4XRXA 4YB4A 1ISOA 1XACA 1V94A 5DE1A 1CW4A 1HQSA 1DPZA 3FMXX 4KZOA 1HEXA 5I96A 5J32A
chains in the Genus database with same CATH topology
3TNGA 5K11A 1R8KA 1GC8A 1IDCA 4UMXA 2Y42A 5LGEA 1V53A 5GRHA 4ATYA 5HN3A 5HN5A 1PB3A 1XABA 1DR8A 2QFWA 5K10A 5GRIA 5L57A 2QFXA 1CNZA 5GREA 4L06A 1LWDA 4P69C 4UMYA 1IDMA 1AI3A 4AJBA 1IPDA 3U1HA 1CW7A 1AI2A 3LCBC 1WALA 2E0CA 4JA8A 2ZTWA 3ASJA 3VL4A 3BLXA 1OSIA 1A05A 5GRHB 3BLVA 1XKDA 1DR0A 1W0DA 5GRIB 3TSNA 3UDUA 5HN6A 5GREB 5L58A 3WZWA 1P8FA 4JQPA 1OSJA 7ICDA 3LXYA 1PS7A 3DMSA 9ICDA 5J33A 3TY3A 6ICDA 3VL2A 4AJCA 2D4VA 3ICDA 3BLXB 5HN4A 3MARA 4AJSA 3FLKA 1VLCA 1IDFA 1TYOA 4I3LA 3AH3A 4AJ3A 1X0LA 3US8A 1V5BA 1G2UA 3VL7A 1BL5A 1ZORA 1PTMA 3WZYA 5I95A 3U9EA 3MAPA 4AJRA 1XGVA 2QFVA 5GRFA 5GRLA 8ICDA 1WPWA 4HCXA 3TY4A 1IDEA 3MASA 3R8WA 1XADA 2Y40A 1U7NA 2UXRA 4WUOA 4XXVA 2HI1A 5ICDA 1SJSA 2Y3ZA 2D1CA 3VL3A 3BLVB 3UDOA 2Y41A 3INMA 1T09A 3VMLA 1YXOA 1PB1A 2UXQA 1GROA 4ICDA 5GRLB 4L04A 5GRFB 2AYQA 2QFYA 3WZVA 4AOVA 1GRPA 1YCOA 3MASB 3VL6A 4BNPA 4F7IA 4AOUA 1XAAA 1CW1A 3VMJA 2E5MA 4AJAA 1T0LA 3WZXA 3UF6A 1IDDA 1PS6A 2DHTA 4XS3A 1HJ6A 4IWHA 1IKAA 1CM7A 4L03A 1GC9A 4I3KA 5J34A 3VMKA 3VKZA 4AOYA 4Y1PA 2IV0A 2G4OA 1VI1A 4XRXA 4YB4A 1ISOA 1XACA 1V94A 5DE1A 1CW4A 1HQSA 1DPZA 3FMXX 4KZOA 1HEXA 5I96A 5J32A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 3TNG A;  5K11 A;  1R8K A;  1GC8 A;  1IDC A;  4UMX A;  2Y42 A;  5LGE A;  1V53 A;  5GRH A;  4ATY A;  5HN3 A;  5HN5 A;  1PB3 A;  1XAB A;  1DR8 A;  2QFW A;  5K10 A;  5GRI A;  5L57 A;  2QFX A;  1CNZ A;  5GRE A;  4L06 A;  1LWD A;  4P69 C;  4UMY A;  1IDM A;  1AI3 A;  4AJB A;  1IPD A;  3U1H A;  1CW7 A;  1AI2 A;  3LCB C;  1WAL A;  2E0C A;  4JA8 A;  2ZTW A;  3ASJ A;  3VL4 A;  3BLX A;  1OSI A;  1A05 A;  5GRH B;  3BLV A;  1XKD A;  1DR0 A;  1W0D A;  5GRI B;  3TSN A;  3UDU A;  5HN6 A;  5GRE B;  5L58 A;  3WZW A;  1P8F A;  4JQP A;  1OSJ A;  7ICD A;  3LXY A;  1PS7 A;  3DMS A;  9ICD A;  5J33 A;  3TY3 A;  6ICD A;  3VL2 A;  4AJC A;  2D4V A;  3ICD A;  3BLX B;  5HN4 A;  3MAR A;  4AJS A;  3FLK A;  1VLC A;  1IDF A;  1TYO A;  4I3L A;  3AH3 A;  4AJ3 A;  1X0L A;  3US8 A;  1V5B A;  1G2U A;  3VL7 A;  1BL5 A;  1ZOR A;  1PTM A;  3WZY A;  5I95 A;  3U9E A;  3MAP A;  4AJR A;  1XGV A;  2QFV A;  5GRF A;  5GRL A;  8ICD A;  1WPW A;  4HCX A;  3TY4 A;  1IDE A;  3MAS A;  3R8W A;  1XAD A;  2Y40 A;  1U7N A;  2UXR A;  4WUO A;  4XXV A;  2HI1 A;  5ICD A;  1SJS A;  2Y3Z A;  2D1C A;  3VL3 A;  3BLV B;  3UDO A;  2Y41 A;  3INM A;  1T09 A;  3VML A;  1YXO A;  1PB1 A;  2UXQ A;  1GRO A;  4ICD A;  5GRL B;  4L04 A;  5GRF B;  2AYQ A;  2QFY A;  3WZV A;  4AOV A;  1GRP A;  1YCO A;  3MAS B;  3VL6 A;  4BNP A;  4F7I A;  4AOU A;  1XAA A;  1CW1 A;  3VMJ A;  2E5M A;  4AJA A;  1T0L A;  3WZX A;  3UF6 A;  1IDD A;  1PS6 A;  2DHT A;  4XS3 A;  1HJ6 A;  4IWH A;  1IKA A;  1CM7 A;  4L03 A;  1GC9 A;  4I3K A;  5J34 A;  3VMK A;  3VKZ A;  4AOY A;  4Y1P A;  2IV0 A;  2G4O A;  1VI1 A;  4XRX A;  4YB4 A;  1ISO A;  1XAC A;  1V94 A;  5DE1 A;  1CW4 A;  1HQS A;  1DPZ A;  3FMX X;  4KZO A;  1HEX A;  5I96 A;  5J32 A; 
#chains in the Genus database with same CATH topology
 3TNG A;  5K11 A;  1R8K A;  1GC8 A;  1IDC A;  4UMX A;  2Y42 A;  5LGE A;  1V53 A;  5GRH A;  4ATY A;  5HN3 A;  5HN5 A;  1PB3 A;  1XAB A;  1DR8 A;  2QFW A;  5K10 A;  5GRI A;  5L57 A;  2QFX A;  1CNZ A;  5GRE A;  4L06 A;  1LWD A;  4P69 C;  4UMY A;  1IDM A;  1AI3 A;  4AJB A;  1IPD A;  3U1H A;  1CW7 A;  1AI2 A;  3LCB C;  1WAL A;  2E0C A;  4JA8 A;  2ZTW A;  3ASJ A;  3VL4 A;  3BLX A;  1OSI A;  1A05 A;  5GRH B;  3BLV A;  1XKD A;  1DR0 A;  1W0D A;  5GRI B;  3TSN A;  3UDU A;  5HN6 A;  5GRE B;  5L58 A;  3WZW A;  1P8F A;  4JQP A;  1OSJ A;  7ICD A;  3LXY A;  1PS7 A;  3DMS A;  9ICD A;  5J33 A;  3TY3 A;  6ICD A;  3VL2 A;  4AJC A;  2D4V A;  3ICD A;  3BLX B;  5HN4 A;  3MAR A;  4AJS A;  3FLK A;  1VLC A;  1IDF A;  1TYO A;  4I3L A;  3AH3 A;  4AJ3 A;  1X0L A;  3US8 A;  1V5B A;  1G2U A;  3VL7 A;  1BL5 A;  1ZOR A;  1PTM A;  3WZY A;  5I95 A;  3U9E A;  3MAP A;  4AJR A;  1XGV A;  2QFV A;  5GRF A;  5GRL A;  8ICD A;  1WPW A;  4HCX A;  3TY4 A;  1IDE A;  3MAS A;  3R8W A;  1XAD A;  2Y40 A;  1U7N A;  2UXR A;  4WUO A;  4XXV A;  2HI1 A;  5ICD A;  1SJS A;  2Y3Z A;  2D1C A;  3VL3 A;  3BLV B;  3UDO A;  2Y41 A;  3INM A;  1T09 A;  3VML A;  1YXO A;  1PB1 A;  2UXQ A;  1GRO A;  4ICD A;  5GRL B;  4L04 A;  5GRF B;  2AYQ A;  2QFY A;  3WZV A;  4AOV A;  1GRP A;  1YCO A;  3MAS B;  3VL6 A;  4BNP A;  4F7I A;  4AOU A;  1XAA A;  1CW1 A;  3VMJ A;  2E5M A;  4AJA A;  1T0L A;  3WZX A;  3UF6 A;  1IDD A;  1PS6 A;  2DHT A;  4XS3 A;  1HJ6 A;  4IWH A;  1IKA A;  1CM7 A;  4L03 A;  1GC9 A;  4I3K A;  5J34 A;  3VMK A;  3VKZ A;  4AOY A;  4Y1P A;  2IV0 A;  2G4O A;  1VI1 A;  4XRX A;  4YB4 A;  1ISO A;  1XAC A;  1V94 A;  5DE1 A;  1CW4 A;  1HQS A;  1DPZ A;  3FMX X;  4KZO A;  1HEX A;  5I96 A;  5J32 A; 
#chains in the Genus database with same CATH homology
 3TNG A;  5K11 A;  1R8K A;  1GC8 A;  1IDC A;  4UMX A;  2Y42 A;  5LGE A;  1V53 A;  5GRH A;  4ATY A;  5HN3 A;  5HN5 A;  1PB3 A;  1XAB A;  1DR8 A;  2QFW A;  5K10 A;  5GRI A;  5L57 A;  2QFX A;  1CNZ A;  5GRE A;  4L06 A;  1LWD A;  4P69 C;  4UMY A;  1IDM A;  1AI3 A;  4AJB A;  1IPD A;  3U1H A;  1CW7 A;  1AI2 A;  3LCB C;  1WAL A;  2E0C A;  4JA8 A;  2ZTW A;  3ASJ A;  3VL4 A;  3BLX A;  1OSI A;  1A05 A;  5GRH B;  3BLV A;  1XKD A;  1DR0 A;  1W0D A;  5GRI B;  3TSN A;  3UDU A;  5HN6 A;  5GRE B;  5L58 A;  3WZW A;  1P8F A;  4JQP A;  1OSJ A;  7ICD A;  3LXY A;  1PS7 A;  3DMS A;  9ICD A;  5J33 A;  3TY3 A;  6ICD A;  3VL2 A;  4AJC A;  2D4V A;  3ICD A;  3BLX B;  5HN4 A;  3MAR A;  4AJS A;  3FLK A;  1VLC A;  1IDF A;  1TYO A;  4I3L A;  3AH3 A;  4AJ3 A;  1X0L A;  3US8 A;  1V5B A;  1G2U A;  3VL7 A;  1BL5 A;  1ZOR A;  1PTM A;  3WZY A;  5I95 A;  3U9E A;  3MAP A;  4AJR A;  1XGV A;  2QFV A;  5GRF A;  5GRL A;  8ICD A;  1WPW A;  4HCX A;  3TY4 A;  1IDE A;  3MAS A;  3R8W A;  1XAD A;  2Y40 A;  1U7N A;  2UXR A;  4WUO A;  4XXV A;  2HI1 A;  5ICD A;  1SJS A;  2Y3Z A;  2D1C A;  3VL3 A;  3BLV B;  3UDO A;  2Y41 A;  3INM A;  1T09 A;  3VML A;  1YXO A;  1PB1 A;  2UXQ A;  1GRO A;  4ICD A;  5GRL B;  4L04 A;  5GRF B;  2AYQ A;  2QFY A;  3WZV A;  4AOV A;  1GRP A;  1YCO A;  3MAS B;  3VL6 A;  4BNP A;  4F7I A;  4AOU A;  1XAA A;  1CW1 A;  3VMJ A;  2E5M A;  4AJA A;  1T0L A;  3WZX A;  3UF6 A;  1IDD A;  1PS6 A;  2DHT A;  4XS3 A;  1HJ6 A;  4IWH A;  1IKA A;  1CM7 A;  4L03 A;  1GC9 A;  4I3K A;  5J34 A;  3VMK A;  3VKZ A;  4AOY A;  4Y1P A;  2IV0 A;  2G4O A;  1VI1 A;  4XRX A;  4YB4 A;  1ISO A;  1XAC A;  1V94 A;  5DE1 A;  1CW4 A;  1HQS A;  1DPZ A;  3FMX X;  4KZO A;  1HEX A;  5I96 A;  5J32 A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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