1BY7A

Human plasminogen activator inhibitor-2. loop (66-98) deletion mutant
Total Genus 114
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
114
Knots found
sequence length
381
structure length
354
Chain Sequence
EDLCVANTLFALNLFKHLAKASPTQNLFLSPWSISSTMAMVYMGSRGSTEDQMAKVLQFNEVGAADKIHSSFRSLSSAINLLESVNKLFGEKSASFREEYIRLCQKYYSSEPQAVDFLECAEEARKKINSWVKTQTKGKIPNLLPEGSVDGDTRMVLVNAVYFKGKWKTPFEKKLYPFRVNSAQRTPVQMMYLREKLNIGYIEDLKAQILELPYAGDVSMFLLLPDEIADVSTGLELLESEITYDKLNKWTSKDKMAEDEVEVYIPQFKLEEHYELRSILRSMGMEDAFNKGRANFSGMSERNDLFLSEVFHQAMVDVNEEGTGPQFVADHPFLFLIMHKITNCILFFGRFSSP
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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molecule keywords PROTEIN (PLASMINOGEN ACTIVATOR INHIBITOR-2)
publication title The crystal structure of plasminogen activator inhibitor 2 at 2.0 A resolution: implications for serpin function.
pubmed doi rcsb
source organism Homo sapiens
molecule tags Protein binding
total genus 114
structure length 354
sequence length 381
other databases KnotProt 2.0: K +31
ec nomenclature
pdb deposition date 1998-10-27

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00079 Serpin Serpin (serine protease inhibitor)
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.30.39.10 Mainly Beta Roll Alpha-1-antitrypsin; domain 1 Alpha-1-antitrypsin, domain 1 1by7A01
3.30.497.10 Alpha Beta 2-Layer Sandwich Antithrombin; Chain I, domain 2 Antithrombin, subunit I, domain 2 1by7A02
1YXAA 2WXZC 4IF8A 2ZV6A 1SNGA 2H4PA 4AJTA 2HI9A 4EB1L 4AU3B 1DZHI 3CWMA 4KDSA 5C98A 1DZGI 1M93B 4Y40A 4G8RA 3PZFA 3H5CA 4AQHA 4CAAA 2H4RA 4C49A 5IO1A 1OYHL 5CDXA 3OZQA 2ARQA 3Q02A 1E04I 2RIWA 1NQ9I 4P0OA 1JVQI 2QUGA 1HP7A 1JMOA 3DRUA 2DUTA 1QLPA 1DZGL 3DLWA 1C8OA 4ROBA 2VH4A 3F1SA 2PEFA 2CEOA 1PSIA 1K9OI 1BY7A 2XN6A 4X30A 3PB1I 1OVAA 4RO9A 8APIA 1XQGA 4Y3KA 3F5NA 3STOA 1D5SA 3FGQA 2ZNHA 2XN7A 1MTPA 4RSQA 3VVJA 4BB2A 2BEHL 3NDAA 3EVJI 2WXZA 4PYWA 1T1FA 3DRMA 1IZ2A 4AFXA 1C5GA 2RIVA 2ACHA 1DVMA 3NE4A 3CAAA 1HLEA 2R9YA 4ZK0A 1ATUA 1BR8I 3F02A 4ZK3A 1F0CA 3LE2A 5CE0A 5INWA 1ATHA 3B9FI 4G8OA 1SEKA 2XN3A 3ZHAA 4DY0A 2B5TI 1XU8A 5EI0A 2B4XL 2OAYA 2WY0C 3KCGI 1AS4A 4EB1I 1B3KA 1QMBA 4AJUA 2WXWA 1JJOC 1OVAB 4R9IA 7APIA 1OC0A 1IMVA 1OPHA 1E03I 3DY0A 1LK6I 1SR5A 5CDZA 5HGCA 2ARRA 1DZHL 3CVMA 1DVNA 1E05I 3T1PA 1TB6I 1LQ8A 1WZ9A 2D26A 2OL2A 3R4LA 4DTEA 1XQJA 4C41A 1R1LI 1DB2A 1JRRA 2HIJL 3CWLA 4DY7C 2VDYA 2WY1A 2B4XI 2XN5A 4YIAA 4AU3A 2PEEA 9APIA 1JTIA 1EZXA 2WXXA 1LJ5A 3NDDA 3Q03A 4AU2A 2VDXA 1KCTA 2V95A 4IC0A 5BRRI 2ANTI 1AZXI 3UT3A 2WXYC 1OVAC 4GA7A 3EOXA 4ROAA 1ATTA 1JMJA 2BEHI 1UHGA 4P0FA 1ANTI 2HIJI 2H4QA 1OYHI 1OO8A 9PAIA 1QMNA 3LW2A 3NDFA 4AU4A 1A7CA 2GD4C
chains in the Genus database with same CATH superfamily
1YXAA 2WXZC 4IF8A 2ZV6A 1SNGA 2H4PA 4AJTA 2HI9A 4EB1L 4AU3B 1DZHI 3CWMA 4KDSA 5C98A 1DZGI 1M93B 4Y40A 4G8RA 3PZFA 3H5CA 4AQHA 4CAAA 2H4RA 4C49A 5IO1A 1OYHL 5CDXA 3OZQA 2ARQA 3Q02A 1E04I 2RIWA 1NQ9I 4P0OA 1JVQI 2QUGA 1HP7A 1JMOA 3DRUA 2DUTA 1QLPA 1DZGL 3DLWA 1C8OA 4ROBA 2VH4A 3F1SA 2PEFA 2CEOA 1PSIA 1K9OI 1BY7A 2XN6A 4X30A 3PB1I 1OVAA 4RO9A 8APIA 1XQGA 4Y3KA 3F5NA 3STOA 1D5SA 3FGQA 2ZNHA 2XN7A 1MTPA 4RSQA 3VVJA 4BB2A 2BEHL 3NDAA 3EVJI 2WXZA 4PYWA 1T1FA 3DRMA 1IZ2A 4AFXA 1C5GA 2RIVA 2ACHA 1DVMA 3NE4A 3CAAA 1HLEA 2R9YA 4ZK0A 1ATUA 1BR8I 3F02A 4ZK3A 1F0CA 3LE2A 5CE0A 5INWA 1ATHA 3B9FI 4G8OA 1SEKA 2XN3A 3ZHAA 4DY0A 2B5TI 1XU8A 5EI0A 2B4XL 2OAYA 2WY0C 3KCGI 1AS4A 4EB1I 1B3KA 1QMBA 4AJUA 2WXWA 1JJOC 1OVAB 4R9IA 7APIA 1OC0A 1IMVA 1OPHA 1E03I 3DY0A 1LK6I 1SR5A 5CDZA 5HGCA 2ARRA 1DZHL 3CVMA 1DVNA 1E05I 3T1PA 1TB6I 1LQ8A 1WZ9A 2D26A 2OL2A 3R4LA 4DTEA 1XQJA 4C41A 1R1LI 1DB2A 1JRRA 2HIJL 3CWLA 4DY7C 2VDYA 2WY1A 2B4XI 2XN5A 4YIAA 4AU3A 2PEEA 9APIA 1JTIA 1EZXA 2WXXA 1LJ5A 3NDDA 3Q03A 4AU2A 2VDXA 1KCTA 2V95A 4IC0A 5BRRI 2ANTI 1AZXI 3UT3A 2WXYC 1OVAC 4GA7A 3EOXA 4ROAA 1ATTA 1JMJA 2BEHI 1UHGA 4P0FA 1ANTI 2HIJI 2H4QA 1OYHI 1OO8A 9PAIA 1QMNA 3LW2A 3NDFA 4AU4A 1A7CA 2GD4C
chains in the Genus database with same CATH topology
1YXAA 2WXZC 4IF8A 2ZV6A 1SNGA 2H4PA 4AJTA 2HI9A 4EB1L 4AU3B 1DZHI 3CWMA 4KDSA 5C98A 1DZGI 1M93B 4Y40A 4G8RA 3PZFA 3H5CA 4AQHA 4CAAA 2H4RA 4C49A 5IO1A 1OYHL 5CDXA 3OZQA 2ARQA 3Q02A 1E04I 2RIWA 1NQ9I 4P0OA 1JVQI 2QUGA 1HP7A 1JMOA 3DRUA 2DUTA 1QLPA 1DZGL 3DLWA 1C8OA 4ROBA 2VH4A 3F1SA 2PEFA 2CEOA 1PSIA 1K9OI 1BY7A 2XN6A 4X30A 3PB1I 1OVAA 4RO9A 8APIA 1XQGA 4Y3KA 3F5NA 3STOA 1D5SA 3FGQA 2ZNHA 2XN7A 1MTPA 4RSQA 3VVJA 4BB2A 2BEHL 3NDAA 3EVJI 2WXZA 4PYWA 1T1FA 3DRMA 1IZ2A 4AFXA 1C5GA 2RIVA 2ACHA 1DVMA 3NE4A 3CAAA 1HLEA 2R9YA 4ZK0A 1ATUA 1BR8I 3F02A 4ZK3A 1F0CA 3LE2A 5CE0A 5INWA 1ATHA 3B9FI 4G8OA 1SEKA 2XN3A 3ZHAA 4DY0A 2B5TI 1XU8A 5EI0A 2B4XL 2OAYA 2WY0C 3KCGI 1AS4A 4EB1I 1B3KA 1QMBA 4AJUA 2WXWA 1JJOC 1OVAB 4R9IA 7APIA 1OC0A 1IMVA 1OPHA 1E03I 3DY0A 1LK6I 1SR5A 5CDZA 5HGCA 2ARRA 1DZHL 3CVMA 1DVNA 1E05I 3T1PA 1TB6I 1LQ8A 1WZ9A 2D26A 2OL2A 3R4LA 4DTEA 1XQJA 4C41A 1R1LI 1DB2A 1JRRA 2HIJL 3CWLA 4DY7C 2VDYA 2WY1A 2B4XI 2XN5A 4YIAA 4AU3A 2PEEA 9APIA 1JTIA 1EZXA 2WXXA 1LJ5A 3NDDA 3Q03A 4AU2A 2VDXA 1KCTA 2V95A 4IC0A 5BRRI 2ANTI 1AZXI 3UT3A 2WXYC 1OVAC 4GA7A 3EOXA 4ROAA 1ATTA 1JMJA 2BEHI 1UHGA 4P0FA 1ANTI 2HIJI 2H4QA 1OYHI 1OO8A 9PAIA 1QMNA 3LW2A 3NDFA 4AU4A 1A7CA 2GD4C
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1YXA A;  2WXZ C;  4IF8 A;  2ZV6 A;  1SNG A;  2H4P A;  4AJT A;  2HI9 A;  4EB1 L;  4AU3 B;  1DZH I;  3CWM A;  4KDS A;  5C98 A;  1DZG I;  1M93 B;  4Y40 A;  4G8R A;  3PZF A;  3H5C A;  4AQH A;  4CAA A;  2H4R A;  4C49 A;  5IO1 A;  1OYH L;  5CDX A;  3OZQ A;  2ARQ A;  3Q02 A;  1E04 I;  2RIW A;  1NQ9 I;  4P0O A;  1JVQ I;  2QUG A;  1HP7 A;  1JMO A;  3DRU A;  2DUT A;  1QLP A;  1DZG L;  3DLW A;  1C8O A;  4ROB A;  2VH4 A;  3F1S A;  2PEF A;  2CEO A;  1PSI A;  1K9O I;  1BY7 A;  2XN6 A;  4X30 A;  3PB1 I;  1OVA A;  4RO9 A;  8API A;  1XQG A;  4Y3K A;  3F5N A;  3STO A;  1D5S A;  3FGQ A;  2ZNH A;  2XN7 A;  1MTP A;  4RSQ A;  3VVJ A;  4BB2 A;  2BEH L;  3NDA A;  3EVJ I;  2WXZ A;  4PYW A;  1T1F A;  3DRM A;  1IZ2 A;  4AFX A;  1C5G A;  2RIV A;  2ACH A;  1DVM A;  3NE4 A;  3CAA A;  1HLE A;  2R9Y A;  4ZK0 A;  1ATU A;  1BR8 I;  3F02 A;  4ZK3 A;  1F0C A;  3LE2 A;  5CE0 A;  5INW A;  1ATH A;  3B9F I;  4G8O A;  1SEK A;  2XN3 A;  3ZHA A;  4DY0 A;  2B5T I;  1XU8 A;  5EI0 A;  2B4X L;  2OAY A;  2WY0 C;  3KCG I;  1AS4 A;  4EB1 I;  1B3K A;  1QMB A;  4AJU A;  2WXW A;  1JJO C;  1OVA B;  4R9I A;  7API A;  1OC0 A;  1IMV A;  1OPH A;  1E03 I;  3DY0 A;  1LK6 I;  1SR5 A;  5CDZ A;  5HGC A;  2ARR A;  1DZH L;  3CVM A;  1DVN A;  1E05 I;  3T1P A;  1TB6 I;  1LQ8 A;  1WZ9 A;  2D26 A;  2OL2 A;  3R4L A;  4DTE A;  1XQJ A;  4C41 A;  1R1L I;  1DB2 A;  1JRR A;  2HIJ L;  3CWL A;  4DY7 C;  2VDY A;  2WY1 A;  2B4X I;  2XN5 A;  4YIA A;  4AU3 A;  2PEE A;  9API A;  1JTI A;  1EZX A;  2WXX A;  1LJ5 A;  3NDD A;  3Q03 A;  4AU2 A;  2VDX A;  1KCT A;  2V95 A;  4IC0 A;  5BRR I;  2ANT I;  1AZX I;  3UT3 A;  2WXY C;  1OVA C;  4GA7 A;  3EOX A;  4ROA A;  1ATT A;  1JMJ A;  2BEH I;  1UHG A;  4P0F A;  1ANT I;  2HIJ I;  2H4Q A;  1OYH I;  1OO8 A;  9PAI A;  1QMN A;  3LW2 A;  3NDF A;  4AU4 A;  1A7C A;  2GD4 C; 
#chains in the Genus database with same CATH topology
 1YXA A;  2WXZ C;  4IF8 A;  2ZV6 A;  1SNG A;  2H4P A;  4AJT A;  2HI9 A;  4EB1 L;  4AU3 B;  1DZH I;  3CWM A;  4KDS A;  5C98 A;  1DZG I;  1M93 B;  4Y40 A;  4G8R A;  3PZF A;  3H5C A;  4AQH A;  4CAA A;  2H4R A;  4C49 A;  5IO1 A;  1OYH L;  5CDX A;  3OZQ A;  2ARQ A;  3Q02 A;  1E04 I;  2RIW A;  1NQ9 I;  4P0O A;  1JVQ I;  2QUG A;  1HP7 A;  1JMO A;  3DRU A;  2DUT A;  1QLP A;  1DZG L;  3DLW A;  1C8O A;  4ROB A;  2VH4 A;  3F1S A;  2PEF A;  2CEO A;  1PSI A;  1K9O I;  1BY7 A;  2XN6 A;  4X30 A;  3PB1 I;  1OVA A;  4RO9 A;  8API A;  1XQG A;  4Y3K A;  3F5N A;  3STO A;  1D5S A;  3FGQ A;  2ZNH A;  2XN7 A;  1MTP A;  4RSQ A;  3VVJ A;  4BB2 A;  2BEH L;  3NDA A;  3EVJ I;  2WXZ A;  4PYW A;  1T1F A;  3DRM A;  1IZ2 A;  4AFX A;  1C5G A;  2RIV A;  2ACH A;  1DVM A;  3NE4 A;  3CAA A;  1HLE A;  2R9Y A;  4ZK0 A;  1ATU A;  1BR8 I;  3F02 A;  4ZK3 A;  1F0C A;  3LE2 A;  5CE0 A;  5INW A;  1ATH A;  3B9F I;  4G8O A;  1SEK A;  2XN3 A;  3ZHA A;  4DY0 A;  2B5T I;  1XU8 A;  5EI0 A;  2B4X L;  2OAY A;  2WY0 C;  3KCG I;  1AS4 A;  4EB1 I;  1B3K A;  1QMB A;  4AJU A;  2WXW A;  1JJO C;  1OVA B;  4R9I A;  7API A;  1OC0 A;  1IMV A;  1OPH A;  1E03 I;  3DY0 A;  1LK6 I;  1SR5 A;  5CDZ A;  5HGC A;  2ARR A;  1DZH L;  3CVM A;  1DVN A;  1E05 I;  3T1P A;  1TB6 I;  1LQ8 A;  1WZ9 A;  2D26 A;  2OL2 A;  3R4L A;  4DTE A;  1XQJ A;  4C41 A;  1R1L I;  1DB2 A;  1JRR A;  2HIJ L;  3CWL A;  4DY7 C;  2VDY A;  2WY1 A;  2B4X I;  2XN5 A;  4YIA A;  4AU3 A;  2PEE A;  9API A;  1JTI A;  1EZX A;  2WXX A;  1LJ5 A;  3NDD A;  3Q03 A;  4AU2 A;  2VDX A;  1KCT A;  2V95 A;  4IC0 A;  5BRR I;  2ANT I;  1AZX I;  3UT3 A;  2WXY C;  1OVA C;  4GA7 A;  3EOX A;  4ROA A;  1ATT A;  1JMJ A;  2BEH I;  1UHG A;  4P0F A;  1ANT I;  2HIJ I;  2H4Q A;  1OYH I;  1OO8 A;  9PAI A;  1QMN A;  3LW2 A;  3NDF A;  4AU4 A;  1A7C A;  2GD4 C; 
#chains in the Genus database with same CATH homology
 1YXA A;  2WXZ C;  4IF8 A;  2ZV6 A;  1SNG A;  2H4P A;  4AJT A;  2HI9 A;  4EB1 L;  4AU3 B;  1DZH I;  3CWM A;  4KDS A;  5C98 A;  1DZG I;  1M93 B;  4Y40 A;  4G8R A;  3PZF A;  3H5C A;  4AQH A;  4CAA A;  2H4R A;  4C49 A;  5IO1 A;  1OYH L;  5CDX A;  3OZQ A;  2ARQ A;  3Q02 A;  1E04 I;  2RIW A;  1NQ9 I;  4P0O A;  1JVQ I;  2QUG A;  1HP7 A;  1JMO A;  3DRU A;  2DUT A;  1QLP A;  1DZG L;  3DLW A;  1C8O A;  4ROB A;  2VH4 A;  3F1S A;  2PEF A;  2CEO A;  1PSI A;  1K9O I;  1BY7 A;  2XN6 A;  4X30 A;  3PB1 I;  1OVA A;  4RO9 A;  8API A;  1XQG A;  4Y3K A;  3F5N A;  3STO A;  1D5S A;  3FGQ A;  2ZNH A;  2XN7 A;  1MTP A;  4RSQ A;  3VVJ A;  4BB2 A;  2BEH L;  3NDA A;  3EVJ I;  2WXZ A;  4PYW A;  1T1F A;  3DRM A;  1IZ2 A;  4AFX A;  1C5G A;  2RIV A;  2ACH A;  1DVM A;  3NE4 A;  3CAA A;  1HLE A;  2R9Y A;  4ZK0 A;  1ATU A;  1BR8 I;  3F02 A;  4ZK3 A;  1F0C A;  3LE2 A;  5CE0 A;  5INW A;  1ATH A;  3B9F I;  4G8O A;  1SEK A;  2XN3 A;  3ZHA A;  4DY0 A;  2B5T I;  1XU8 A;  5EI0 A;  2B4X L;  2OAY A;  2WY0 C;  3KCG I;  1AS4 A;  4EB1 I;  1B3K A;  1QMB A;  4AJU A;  2WXW A;  1JJO C;  1OVA B;  4R9I A;  7API A;  1OC0 A;  1IMV A;  1OPH A;  1E03 I;  3DY0 A;  1LK6 I;  1SR5 A;  5CDZ A;  5HGC A;  2ARR A;  1DZH L;  3CVM A;  1DVN A;  1E05 I;  3T1P A;  1TB6 I;  1LQ8 A;  1WZ9 A;  2D26 A;  2OL2 A;  3R4L A;  4DTE A;  1XQJ A;  4C41 A;  1R1L I;  1DB2 A;  1JRR A;  2HIJ L;  3CWL A;  4DY7 C;  2VDY A;  2WY1 A;  2B4X I;  2XN5 A;  4YIA A;  4AU3 A;  2PEE A;  9API A;  1JTI A;  1EZX A;  2WXX A;  1LJ5 A;  3NDD A;  3Q03 A;  4AU2 A;  2VDX A;  1KCT A;  2V95 A;  4IC0 A;  5BRR I;  2ANT I;  1AZX I;  3UT3 A;  2WXY C;  1OVA C;  4GA7 A;  3EOX A;  4ROA A;  1ATT A;  1JMJ A;  2BEH I;  1UHG A;  4P0F A;  1ANT I;  2HIJ I;  2H4Q A;  1OYH I;  1OO8 A;  9PAI A;  1QMN A;  3LW2 A;  3NDF A;  4AU4 A;  1A7C A;  2GD4 C; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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