1EW2A

Crystal structure of a human phosphatase
Total Genus 172
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
172
Knots found
sequence length
479
structure length
479
Chain Sequence
IIPVEEENPDFWNREAAEALGAAKKLQPAQTAAKNLIIFLGDGMGVSTVTAARILKGQKKDKLGPEIPLAMDRFPYVALSKTYNVDKHVPDSGATATAYLCGVKGNFQTIGLSAAARFNQCNTTRGNEVISVMNRAKKAGKSVGVVTTTRVQHASPAGTYAHTVNRNWYSDADVPASARQEGCQDIATQLISNMDIDVILGGGRKYMFRMGTPDPEYPDDYSQGGTRLDGKNLVQEWLAKRQGARYVWNRTELMQASLDPSVTHLMGLFEPGDMKYEIHRDSTLDPSLMEMTEAALRLLSRNPRGFFLFVEGGRIDHGHHESRAYRALTETIMFDDAIERAGQLTSEEDTLSLVTADHSHVFSFGGYPLRGSSIFGLAPGKARDRKAYTVLLYGNGPGYVLKDGARPDVTESESGSPEYRQQSAVPLDEETHAGEDVAVFARGPQAHLVHGVQEQTFIAHVMAFAACLEPYTACDLAPP
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

molecule keywords PHOSPHATASE
publication title Crystal structure of alkaline phosphatase from human placenta at 1.8 A resolution. Implication for a substrate specificity.
pubmed doi rcsb
molecule tags Hydrolase
total genus 172
structure length 479
sequence length 479
other databases KnotProt 2.0: S +31
ec nomenclature ec 3.1.3.1: Alkaline phosphatase.
pdb deposition date 2000-04-21

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00245 Alk_phosphatase Alkaline phosphatase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.720.10 Alpha Beta 3-Layer(aba) Sandwich Alkaline Phosphatase, subunit A Alkaline Phosphatase, subunit A 1ew2A00
4KAVA 3ED4A 4MY4A 4KJDA 3WAYA 4LQYA 1KHLA 5LIAA 2IFYA 4QAXA 4UPIA 1ANIA 1N2KA 3WBHA 1ALJA 1ZEFA 2W8SA 4GTYA 3UN2A 2ZKTA 5IJSA 3BDHA 4NWXA 3UN3A 2ANHA 2IUCA 2D1GA 3IDDA 2W5XA 5DLTA 2RH6A 5L0BA 1KH9A 1ELZA 4UOPA 1KHNA 3SZZA 1KH4A 3Q3QA 5K4PA 3T01A 1B8JA 1EI6A 5TJ3A 3DYCA 4MHXA 3MK2A 4LRFA 1ALIA 2W5SA 4ZG7A 1ALHA 3NKMA 1E1ZP 5INHA 4NWJA 1ED9A 1Y7AA 3KD8A 2W5RA 2W5WA 1AJDA 3NKRA 1KHKA 1O99A 3TWZA 1ED8A 1P49A 3IGZB 4KM4A 5C66A 4GTXA 5EGEA 3LXQA 3CMRA 3DPCA 2G9YA 3NKNA 4N7TA 4ZG6A 4ZGAA 2GSNA 1KHJA 1ANJA 4KJGA 3UN5A 1E2SP 3BDFA 3OT9A 5KXAA 1ALKA 1AJBA 1HQAA 2VQRA 3MK0A 4UORA 3SZYA 5LQQA 5LRNA 4CXSA 4MIVA 1AJCA 1EW8A 1EW2A 3WAXA 2QZUA 4LRCA 3UNYA 1N2LA 1Y6VA 2W5VA 3BDGA 4LREA 3M8WA 3WAWA 4UPLA 2W5TA 3M7VA 1URAA 1HJKA 1SHQA 4LRBA 2W5QA 3T00A 3WAVA 3T02A 5L0EA 1HDHA 3TX0A 5IJQA 1EQJA 4UOOA 5DLWA 5AJ9A 1E3CP 2GLQA 3NKOA 5GOVA 1ZEDA 3NVLA 4LR8A 5L0KA 2IUCB 1AJAA 3NKPA 4B56A 3UO0A 1EJJA 2XR9A 4FDJA 3B5QA 1ELYA 3A52A 4LR2A 4UPKA 4CXKA 3M8ZA 1E33P 1FSUA 4KAYA 5GRRA 5LRMA 1KH7A 4GTWA 3MK1A 2GSOA 4LR7A 1URBA 3E2DA 2GA3A 3IGYB 1K7HA 2X98A 4LRAA 1ZEBA 4GTZA 1KH5A 3NKQA 1EW9A 3BDGB 4CXUA 1ELXA 2W8DA 1SHNA 4LRDA 5EGHA 2GSUA 4ZG9A 1AUKA 1O98A 3M8YA 5HRTA 4YR1A 5DLVA 4LR9A 2XRGA 4FDIA 4UPHA 4CYSA 4CYRA 3TG0A 4TN0A
chains in the Genus database with same CATH superfamily
4KAVA 3ED4A 4MY4A 4KJDA 3WAYA 4LQYA 1KHLA 5LIAA 2IFYA 4QAXA 4UPIA 1ANIA 1N2KA 3WBHA 1ALJA 1ZEFA 2W8SA 4GTYA 3UN2A 2ZKTA 5IJSA 3BDHA 4NWXA 3UN3A 2ANHA 2IUCA 2D1GA 3IDDA 2W5XA 5DLTA 2RH6A 5L0BA 1KH9A 1ELZA 4UOPA 1KHNA 3SZZA 1KH4A 3Q3QA 5K4PA 3T01A 1B8JA 1EI6A 5TJ3A 3DYCA 4MHXA 3MK2A 4LRFA 1ALIA 2W5SA 4ZG7A 1ALHA 3NKMA 1E1ZP 5INHA 4NWJA 1ED9A 1Y7AA 3KD8A 2W5RA 2W5WA 1AJDA 3NKRA 1KHKA 1O99A 3TWZA 1ED8A 1P49A 3IGZB 4KM4A 5C66A 4GTXA 5EGEA 3LXQA 3CMRA 3DPCA 2G9YA 3NKNA 4N7TA 4ZG6A 4ZGAA 2GSNA 1KHJA 1ANJA 4KJGA 3UN5A 1E2SP 3BDFA 3OT9A 5KXAA 1ALKA 1AJBA 1HQAA 2VQRA 3MK0A 4UORA 3SZYA 5LQQA 5LRNA 4CXSA 4MIVA 1AJCA 1EW8A 1EW2A 3WAXA 2QZUA 4LRCA 3UNYA 1N2LA 1Y6VA 2W5VA 3BDGA 4LREA 3M8WA 3WAWA 4UPLA 2W5TA 3M7VA 1URAA 1HJKA 1SHQA 4LRBA 2W5QA 3T00A 3WAVA 3T02A 5L0EA 1HDHA 3TX0A 5IJQA 1EQJA 4UOOA 5DLWA 5AJ9A 1E3CP 2GLQA 3NKOA 5GOVA 1ZEDA 3NVLA 4LR8A 5L0KA 2IUCB 1AJAA 3NKPA 4B56A 3UO0A 1EJJA 2XR9A 4FDJA 3B5QA 1ELYA 3A52A 4LR2A 4UPKA 4CXKA 3M8ZA 1E33P 1FSUA 4KAYA 5GRRA 5LRMA 1KH7A 4GTWA 3MK1A 2GSOA 4LR7A 1URBA 3E2DA 2GA3A 3IGYB 1K7HA 2X98A 4LRAA 1ZEBA 4GTZA 1KH5A 3NKQA 1EW9A 3BDGB 4CXUA 1ELXA 2W8DA 1SHNA 4LRDA 5EGHA 2GSUA 4ZG9A 1AUKA 1O98A 3M8YA 5HRTA 4YR1A 5DLVA 4LR9A 2XRGA 4FDIA 4UPHA 4CYSA 4CYRA 3TG0A 4TN0A
chains in the Genus database with same CATH topology
4KAVA 3ED4A 4MY4A 4KJDA 3WAYA 4LQYA 1KHLA 5LIAA 2IFYA 4QAXA 4UPIA 1ANIA 1N2KA 3WBHA 1ALJA 1ZEFA 2W8SA 4GTYA 3UN2A 2ZKTA 5IJSA 3BDHA 4NWXA 3UN3A 2ANHA 2IUCA 2D1GA 3IDDA 2W5XA 5DLTA 2RH6A 5L0BA 1KH9A 1ELZA 4UOPA 1KHNA 3SZZA 1KH4A 3Q3QA 5K4PA 3T01A 1B8JA 1EI6A 5TJ3A 3DYCA 4MHXA 3MK2A 4LRFA 1ALIA 2W5SA 4ZG7A 1ALHA 3NKMA 1E1ZP 5INHA 4NWJA 1ED9A 1Y7AA 3KD8A 2W5RA 2W5WA 1AJDA 3NKRA 1KHKA 1O99A 3TWZA 1ED8A 1P49A 3IGZB 4KM4A 5C66A 4GTXA 5EGEA 3LXQA 3CMRA 3DPCA 2G9YA 3NKNA 4N7TA 4ZG6A 4ZGAA 2GSNA 1KHJA 1ANJA 4KJGA 3UN5A 1E2SP 3BDFA 3OT9A 5KXAA 1ALKA 1AJBA 1HQAA 2VQRA 3MK0A 4UORA 3SZYA 5LQQA 5LRNA 4CXSA 4MIVA 1AJCA 1EW8A 1EW2A 3WAXA 2QZUA 4LRCA 3UNYA 1N2LA 1Y6VA 2W5VA 3BDGA 4LREA 3M8WA 3WAWA 4UPLA 2W5TA 3M7VA 1URAA 1HJKA 1SHQA 4LRBA 2W5QA 3T00A 3WAVA 3T02A 5L0EA 1HDHA 3TX0A 5IJQA 1EQJA 4UOOA 5DLWA 5AJ9A 1E3CP 2GLQA 3NKOA 5GOVA 1ZEDA 3NVLA 4LR8A 5L0KA 2IUCB 1AJAA 3NKPA 4B56A 3UO0A 1EJJA 2XR9A 4FDJA 3B5QA 1ELYA 3A52A 4LR2A 4UPKA 4CXKA 3M8ZA 1E33P 1FSUA 4KAYA 5GRRA 5LRMA 1KH7A 4GTWA 3MK1A 2GSOA 4LR7A 1URBA 3E2DA 2GA3A 3IGYB 1K7HA 2X98A 4LRAA 1ZEBA 4GTZA 1KH5A 3NKQA 1EW9A 3BDGB 4CXUA 1ELXA 2W8DA 1SHNA 4LRDA 5EGHA 2GSUA 4ZG9A 1AUKA 1O98A 3M8YA 5HRTA 4YR1A 5DLVA 4LR9A 2XRGA 4FDIA 4UPHA 4CYSA 4CYRA 3TG0A 4TN0A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4KAV A;  3ED4 A;  4MY4 A;  4KJD A;  3WAY A;  4LQY A;  1KHL A;  5LIA A;  2IFY A;  4QAX A;  4UPI A;  1ANI A;  1N2K A;  3WBH A;  1ALJ A;  1ZEF A;  2W8S A;  4GTY A;  3UN2 A;  2ZKT A;  5IJS A;  3BDH A;  4NWX A;  3UN3 A;  2ANH A;  2IUC A;  2D1G A;  3IDD A;  2W5X A;  5DLT A;  2RH6 A;  5L0B A;  1KH9 A;  1ELZ A;  4UOP A;  1KHN A;  3SZZ A;  1KH4 A;  3Q3Q A;  5K4P A;  3T01 A;  1B8J A;  1EI6 A;  5TJ3 A;  3DYC A;  4MHX A;  3MK2 A;  4LRF A;  1ALI A;  2W5S A;  4ZG7 A;  1ALH A;  3NKM A;  1E1Z P;  5INH A;  4NWJ A;  1ED9 A;  1Y7A A;  3KD8 A;  2W5R A;  2W5W A;  1AJD A;  3NKR A;  1KHK A;  1O99 A;  3TWZ A;  1ED8 A;  1P49 A;  3IGZ B;  4KM4 A;  5C66 A;  4GTX A;  5EGE A;  3LXQ A;  3CMR A;  3DPC A;  2G9Y A;  3NKN A;  4N7T A;  4ZG6 A;  4ZGA A;  2GSN A;  1KHJ A;  1ANJ A;  4KJG A;  3UN5 A;  1E2S P;  3BDF A;  3OT9 A;  5KXA A;  1ALK A;  1AJB A;  1HQA A;  2VQR A;  3MK0 A;  4UOR A;  3SZY A;  5LQQ A;  5LRN A;  4CXS A;  4MIV A;  1AJC A;  1EW8 A;  1EW2 A;  3WAX A;  2QZU A;  4LRC A;  3UNY A;  1N2L A;  1Y6V A;  2W5V A;  3BDG A;  4LRE A;  3M8W A;  3WAW A;  4UPL A;  2W5T A;  3M7V A;  1URA A;  1HJK A;  1SHQ A;  4LRB A;  2W5Q A;  3T00 A;  3WAV A;  3T02 A;  5L0E A;  1HDH A;  3TX0 A;  5IJQ A;  1EQJ A;  4UOO A;  5DLW A;  5AJ9 A;  1E3C P;  2GLQ A;  3NKO A;  5GOV A;  1ZED A;  3NVL A;  4LR8 A;  5L0K A;  2IUC B;  1AJA A;  3NKP A;  4B56 A;  3UO0 A;  1EJJ A;  2XR9 A;  4FDJ A;  3B5Q A;  1ELY A;  3A52 A;  4LR2 A;  4UPK A;  4CXK A;  3M8Z A;  1E33 P;  1FSU A;  4KAY A;  5GRR A;  5LRM A;  1KH7 A;  4GTW A;  3MK1 A;  2GSO A;  4LR7 A;  1URB A;  3E2D A;  2GA3 A;  3IGY B;  1K7H A;  2X98 A;  4LRA A;  1ZEB A;  4GTZ A;  1KH5 A;  3NKQ A;  1EW9 A;  3BDG B;  4CXU A;  1ELX A;  2W8D A;  1SHN A;  4LRD A;  5EGH A;  2GSU A;  4ZG9 A;  1AUK A;  1O98 A;  3M8Y A;  5HRT A;  4YR1 A;  5DLV A;  4LR9 A;  2XRG A;  4FDI A;  4UPH A;  4CYS A;  4CYR A;  3TG0 A;  4TN0 A; 
#chains in the Genus database with same CATH topology
 4KAV A;  3ED4 A;  4MY4 A;  4KJD A;  3WAY A;  4LQY A;  1KHL A;  5LIA A;  2IFY A;  4QAX A;  4UPI A;  1ANI A;  1N2K A;  3WBH A;  1ALJ A;  1ZEF A;  2W8S A;  4GTY A;  3UN2 A;  2ZKT A;  5IJS A;  3BDH A;  4NWX A;  3UN3 A;  2ANH A;  2IUC A;  2D1G A;  3IDD A;  2W5X A;  5DLT A;  2RH6 A;  5L0B A;  1KH9 A;  1ELZ A;  4UOP A;  1KHN A;  3SZZ A;  1KH4 A;  3Q3Q A;  5K4P A;  3T01 A;  1B8J A;  1EI6 A;  5TJ3 A;  3DYC A;  4MHX A;  3MK2 A;  4LRF A;  1ALI A;  2W5S A;  4ZG7 A;  1ALH A;  3NKM A;  1E1Z P;  5INH A;  4NWJ A;  1ED9 A;  1Y7A A;  3KD8 A;  2W5R A;  2W5W A;  1AJD A;  3NKR A;  1KHK A;  1O99 A;  3TWZ A;  1ED8 A;  1P49 A;  3IGZ B;  4KM4 A;  5C66 A;  4GTX A;  5EGE A;  3LXQ A;  3CMR A;  3DPC A;  2G9Y A;  3NKN A;  4N7T A;  4ZG6 A;  4ZGA A;  2GSN A;  1KHJ A;  1ANJ A;  4KJG A;  3UN5 A;  1E2S P;  3BDF A;  3OT9 A;  5KXA A;  1ALK A;  1AJB A;  1HQA A;  2VQR A;  3MK0 A;  4UOR A;  3SZY A;  5LQQ A;  5LRN A;  4CXS A;  4MIV A;  1AJC A;  1EW8 A;  1EW2 A;  3WAX A;  2QZU A;  4LRC A;  3UNY A;  1N2L A;  1Y6V A;  2W5V A;  3BDG A;  4LRE A;  3M8W A;  3WAW A;  4UPL A;  2W5T A;  3M7V A;  1URA A;  1HJK A;  1SHQ A;  4LRB A;  2W5Q A;  3T00 A;  3WAV A;  3T02 A;  5L0E A;  1HDH A;  3TX0 A;  5IJQ A;  1EQJ A;  4UOO A;  5DLW A;  5AJ9 A;  1E3C P;  2GLQ A;  3NKO A;  5GOV A;  1ZED A;  3NVL A;  4LR8 A;  5L0K A;  2IUC B;  1AJA A;  3NKP A;  4B56 A;  3UO0 A;  1EJJ A;  2XR9 A;  4FDJ A;  3B5Q A;  1ELY A;  3A52 A;  4LR2 A;  4UPK A;  4CXK A;  3M8Z A;  1E33 P;  1FSU A;  4KAY A;  5GRR A;  5LRM A;  1KH7 A;  4GTW A;  3MK1 A;  2GSO A;  4LR7 A;  1URB A;  3E2D A;  2GA3 A;  3IGY B;  1K7H A;  2X98 A;  4LRA A;  1ZEB A;  4GTZ A;  1KH5 A;  3NKQ A;  1EW9 A;  3BDG B;  4CXU A;  1ELX A;  2W8D A;  1SHN A;  4LRD A;  5EGH A;  2GSU A;  4ZG9 A;  1AUK A;  1O98 A;  3M8Y A;  5HRT A;  4YR1 A;  5DLV A;  4LR9 A;  2XRG A;  4FDI A;  4UPH A;  4CYS A;  4CYR A;  3TG0 A;  4TN0 A; 
#chains in the Genus database with same CATH homology
 4KAV A;  3ED4 A;  4MY4 A;  4KJD A;  3WAY A;  4LQY A;  1KHL A;  5LIA A;  2IFY A;  4QAX A;  4UPI A;  1ANI A;  1N2K A;  3WBH A;  1ALJ A;  1ZEF A;  2W8S A;  4GTY A;  3UN2 A;  2ZKT A;  5IJS A;  3BDH A;  4NWX A;  3UN3 A;  2ANH A;  2IUC A;  2D1G A;  3IDD A;  2W5X A;  5DLT A;  2RH6 A;  5L0B A;  1KH9 A;  1ELZ A;  4UOP A;  1KHN A;  3SZZ A;  1KH4 A;  3Q3Q A;  5K4P A;  3T01 A;  1B8J A;  1EI6 A;  5TJ3 A;  3DYC A;  4MHX A;  3MK2 A;  4LRF A;  1ALI A;  2W5S A;  4ZG7 A;  1ALH A;  3NKM A;  1E1Z P;  5INH A;  4NWJ A;  1ED9 A;  1Y7A A;  3KD8 A;  2W5R A;  2W5W A;  1AJD A;  3NKR A;  1KHK A;  1O99 A;  3TWZ A;  1ED8 A;  1P49 A;  3IGZ B;  4KM4 A;  5C66 A;  4GTX A;  5EGE A;  3LXQ A;  3CMR A;  3DPC A;  2G9Y A;  3NKN A;  4N7T A;  4ZG6 A;  4ZGA A;  2GSN A;  1KHJ A;  1ANJ A;  4KJG A;  3UN5 A;  1E2S P;  3BDF A;  3OT9 A;  5KXA A;  1ALK A;  1AJB A;  1HQA A;  2VQR A;  3MK0 A;  4UOR A;  3SZY A;  5LQQ A;  5LRN A;  4CXS A;  4MIV A;  1AJC A;  1EW8 A;  1EW2 A;  3WAX A;  2QZU A;  4LRC A;  3UNY A;  1N2L A;  1Y6V A;  2W5V A;  3BDG A;  4LRE A;  3M8W A;  3WAW A;  4UPL A;  2W5T A;  3M7V A;  1URA A;  1HJK A;  1SHQ A;  4LRB A;  2W5Q A;  3T00 A;  3WAV A;  3T02 A;  5L0E A;  1HDH A;  3TX0 A;  5IJQ A;  1EQJ A;  4UOO A;  5DLW A;  5AJ9 A;  1E3C P;  2GLQ A;  3NKO A;  5GOV A;  1ZED A;  3NVL A;  4LR8 A;  5L0K A;  2IUC B;  1AJA A;  3NKP A;  4B56 A;  3UO0 A;  1EJJ A;  2XR9 A;  4FDJ A;  3B5Q A;  1ELY A;  3A52 A;  4LR2 A;  4UPK A;  4CXK A;  3M8Z A;  1E33 P;  1FSU A;  4KAY A;  5GRR A;  5LRM A;  1KH7 A;  4GTW A;  3MK1 A;  2GSO A;  4LR7 A;  1URB A;  3E2D A;  2GA3 A;  3IGY B;  1K7H A;  2X98 A;  4LRA A;  1ZEB A;  4GTZ A;  1KH5 A;  3NKQ A;  1EW9 A;  3BDG B;  4CXU A;  1ELX A;  2W8D A;  1SHN A;  4LRD A;  5EGH A;  2GSU A;  4ZG9 A;  1AUK A;  1O98 A;  3M8Y A;  5HRT A;  4YR1 A;  5DLV A;  4LR9 A;  2XRG A;  4FDI A;  4UPH A;  4CYS A;  4CYR A;  3TG0 A;  4TN0 A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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