1HQSA

Crystal structure of isocitrate dehydrogenase from bacillus subtilis
Total Genus 152
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
152
sequence length
423
structure length
422
Chain Sequence
MAQGEKITVSNGVLNVPNNPIIPFIEGDGTGPDIWNAASKVLEAAVEKAYKGEKKITWKEVYAGEKAYNKTGEWLPAETLDVIREYFIAIKGPLTTPVGGGIRSLNVALRQELDLFVLRPVRYFTGVPSPVKRPEDTDMVIFRENTEDIYAGIEYAKGSEEVQKLISFLQNELNVNKIRFPETSGIGIKPVSEEGTSRLVRAAIDYAIEHGRKSVTLVHKGNIMKFTEGAFKNWGYELAEKEYGDKVFTWAQYDRIAEEQGKDAANKAQSEAEAAGKIIIKDSIADIFLQQILTRPNEFDVVATMNLNGDYISDALAAQVGGIGIAPGANINYETGHAIFEATHGTAPKYAGLDKVNPSSVILSGVLLLEHLGWNEAADLVIKSMEKTIASKVVTYDFARLMDGATEVKCSEFGEELIKNMD
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Crystal structure of Bacillus subtilis isocitrate dehydrogenase at 1.55 A. Insights into the nature of substrate specificity exhibited by Escherichia coli isocitrate dehydrogenase kinase/phosphatase.
pubmed doi rcsb
molecule tags Oxidoreductase
source organism Bacillus subtilis
molecule keywords ISOCITRATE DEHYDROGENASE
total genus 152
structure length 422
sequence length 423
chains with identical sequence B
ec nomenclature ec 1.1.1.42: Isocitrate dehydrogenase (NADP(+)).
pdb deposition date 2000-12-19

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00180 Iso_dh Isocitrate/isopropylmalate dehydrogenase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.718.10 Alpha Beta 3-Layer(aba) Sandwich Isopropylmalate Dehydrogenase Isopropylmalate Dehydrogenase 1hqsA00
4Y1PA 1CW4A 4AJSA 5GREA 9ICDA 1IDFA 1HQSA 1DR8A 1PTMA 5J32A 1AI3A 1XACA 4ICDA 2QFYA 3R8WA 2G4OA 5ICDA 3TSNA 1CM7A 1WPWA 2Y42A 3VL6A 1W0DA 3WZWA 1U7NA 1CW1A 4UMXA 3FMXX 5L58A 4L03A 3VMLA 1IDMA 1P8FA 1PS6A 4AJ3A 1HEXA 5HN6A 1GROA 1V53A 1IDCA 3MASB 3INMA 1XADA 2QFVA 5DE1A 5GRHB 5LGEA 4AJCA 1YCOA 1HJ6A 5K10A 5J33A 3TY4A 3BLVA 1GRPA 1OSIA 5GRIB 2D4VA 3VL2A 3VMJA 6ICDA 2UXQA 4JA8A 3UDUA 1WALA 1OSJA 3MARA 4AJRA 5GRLA 3BLXA 1PB1A 1XKDA 3LXYA 5I96A 5GRHA 4I3KA 3WZYA 1VI1A 1GC8A 4BNPA 2ZTWA 3WZXA 4HCXA 5HN5A 1CW7A 1XAAA 1BL5A 5GRFB 5GRIA 1V94A 4P69C 2AYQA 1CNZA 2UXRA 1IDDA 1V5BA 5L57A 1T0LA 5GREB 3TNGA 4ATYA 4I3LA 1TYOA 1IDEA 3FLKA 4XRXA 3TY3A 1X0LA 1DR0A 3ICDA 2Y41A 1YXOA 3MASA 1G2UA 1T09A 4XS3A 5HN4A 3VL4A 3VL7A 2E5MA 5K11A 3AH3A 8ICDA 4UMYA 3U1HA 3UDOA 1AI2A 2DHTA 2IV0A 3ASJA 4XXVA 1PS7A 1GC9A 4L06A 1ISOA 1LWDA 2QFXA 4WUOA 4AOUA 7ICDA 2Y3ZA 3VL3A 1SJSA 4F7IA 1IPDA 1XABA 2E0CA 1VLCA 5I95A 1XGVA 3DMSA 5HN3A 4IWHA 3BLVB 3VKZA 4AJBA 5J34A 2QFWA 4KZOA 3U9EA 4YB4A 1IKAA 1ZORA 3UF6A 4AOVA 4L04A 3BLXB 5GRLB 4AJAA 2D1CA 3WZVA 5GRFA 1PB3A 3LCBC 2Y40A 1DPZA 3MAPA 1R8KA 2HI1A 3US8A 4AOYA 4JQPA 3VMKA 1A05A
chains in the Genus database with same CATH superfamily
4Y1PA 1CW4A 4AJSA 5GREA 9ICDA 1IDFA 1HQSA 1DR8A 1PTMA 5J32A 1AI3A 1XACA 4ICDA 2QFYA 3R8WA 2G4OA 5ICDA 3TSNA 1CM7A 1WPWA 2Y42A 3VL6A 1W0DA 3WZWA 1U7NA 1CW1A 4UMXA 3FMXX 5L58A 4L03A 3VMLA 1IDMA 1P8FA 1PS6A 4AJ3A 1HEXA 5HN6A 1GROA 1V53A 1IDCA 3MASB 3INMA 1XADA 2QFVA 5DE1A 5GRHB 5LGEA 4AJCA 1YCOA 1HJ6A 5K10A 5J33A 3TY4A 3BLVA 1GRPA 1OSIA 5GRIB 2D4VA 3VL2A 3VMJA 6ICDA 2UXQA 4JA8A 3UDUA 1WALA 1OSJA 3MARA 4AJRA 5GRLA 3BLXA 1PB1A 1XKDA 3LXYA 5I96A 5GRHA 4I3KA 3WZYA 1VI1A 1GC8A 4BNPA 2ZTWA 3WZXA 4HCXA 5HN5A 1CW7A 1XAAA 1BL5A 5GRFB 5GRIA 1V94A 4P69C 2AYQA 1CNZA 2UXRA 1IDDA 1V5BA 5L57A 1T0LA 5GREB 3TNGA 4ATYA 4I3LA 1TYOA 1IDEA 3FLKA 4XRXA 3TY3A 1X0LA 1DR0A 3ICDA 2Y41A 1YXOA 3MASA 1G2UA 1T09A 4XS3A 5HN4A 3VL4A 3VL7A 2E5MA 5K11A 3AH3A 8ICDA 4UMYA 3U1HA 3UDOA 1AI2A 2DHTA 2IV0A 3ASJA 4XXVA 1PS7A 1GC9A 4L06A 1ISOA 1LWDA 2QFXA 4WUOA 4AOUA 7ICDA 2Y3ZA 3VL3A 1SJSA 4F7IA 1IPDA 1XABA 2E0CA 1VLCA 5I95A 1XGVA 3DMSA 5HN3A 4IWHA 3BLVB 3VKZA 4AJBA 5J34A 2QFWA 4KZOA 3U9EA 4YB4A 1IKAA 1ZORA 3UF6A 4AOVA 4L04A 3BLXB 5GRLB 4AJAA 2D1CA 3WZVA 5GRFA 1PB3A 3LCBC 2Y40A 1DPZA 3MAPA 1R8KA 2HI1A 3US8A 4AOYA 4JQPA 3VMKA 1A05A
chains in the Genus database with same CATH topology
4Y1PA 1CW4A 4AJSA 5GREA 9ICDA 1IDFA 1HQSA 1DR8A 1PTMA 5J32A 1AI3A 1XACA 4ICDA 2QFYA 3R8WA 2G4OA 5ICDA 3TSNA 1CM7A 1WPWA 2Y42A 3VL6A 1W0DA 3WZWA 1U7NA 1CW1A 4UMXA 3FMXX 5L58A 4L03A 3VMLA 1IDMA 1P8FA 1PS6A 4AJ3A 1HEXA 5HN6A 1GROA 1V53A 1IDCA 3MASB 3INMA 1XADA 2QFVA 5DE1A 5GRHB 5LGEA 4AJCA 1YCOA 1HJ6A 5K10A 5J33A 3TY4A 3BLVA 1GRPA 1OSIA 5GRIB 2D4VA 3VL2A 3VMJA 6ICDA 2UXQA 4JA8A 3UDUA 1WALA 1OSJA 3MARA 4AJRA 5GRLA 3BLXA 1PB1A 1XKDA 3LXYA 5I96A 5GRHA 4I3KA 3WZYA 1VI1A 1GC8A 4BNPA 2ZTWA 3WZXA 4HCXA 5HN5A 1CW7A 1XAAA 1BL5A 5GRFB 5GRIA 1V94A 4P69C 2AYQA 1CNZA 2UXRA 1IDDA 1V5BA 5L57A 1T0LA 5GREB 3TNGA 4ATYA 4I3LA 1TYOA 1IDEA 3FLKA 4XRXA 3TY3A 1X0LA 1DR0A 3ICDA 2Y41A 1YXOA 3MASA 1G2UA 1T09A 4XS3A 5HN4A 3VL4A 3VL7A 2E5MA 5K11A 3AH3A 8ICDA 4UMYA 3U1HA 3UDOA 1AI2A 2DHTA 2IV0A 3ASJA 4XXVA 1PS7A 1GC9A 4L06A 1ISOA 1LWDA 2QFXA 4WUOA 4AOUA 7ICDA 2Y3ZA 3VL3A 1SJSA 4F7IA 1IPDA 1XABA 2E0CA 1VLCA 5I95A 1XGVA 3DMSA 5HN3A 4IWHA 3BLVB 3VKZA 4AJBA 5J34A 2QFWA 4KZOA 3U9EA 4YB4A 1IKAA 1ZORA 3UF6A 4AOVA 4L04A 3BLXB 5GRLB 4AJAA 2D1CA 3WZVA 5GRFA 1PB3A 3LCBC 2Y40A 1DPZA 3MAPA 1R8KA 2HI1A 3US8A 4AOYA 4JQPA 3VMKA 1A05A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4Y1P A;  1CW4 A;  4AJS A;  5GRE A;  9ICD A;  1IDF A;  1HQS A;  1DR8 A;  1PTM A;  5J32 A;  1AI3 A;  1XAC A;  4ICD A;  2QFY A;  3R8W A;  2G4O A;  5ICD A;  3TSN A;  1CM7 A;  1WPW A;  2Y42 A;  3VL6 A;  1W0D A;  3WZW A;  1U7N A;  1CW1 A;  4UMX A;  3FMX X;  5L58 A;  4L03 A;  3VML A;  1IDM A;  1P8F A;  1PS6 A;  4AJ3 A;  1HEX A;  5HN6 A;  1GRO A;  1V53 A;  1IDC A;  3MAS B;  3INM A;  1XAD A;  2QFV A;  5DE1 A;  5GRH B;  5LGE A;  4AJC A;  1YCO A;  1HJ6 A;  5K10 A;  5J33 A;  3TY4 A;  3BLV A;  1GRP A;  1OSI A;  5GRI B;  2D4V A;  3VL2 A;  3VMJ A;  6ICD A;  2UXQ A;  4JA8 A;  3UDU A;  1WAL A;  1OSJ A;  3MAR A;  4AJR A;  5GRL A;  3BLX A;  1PB1 A;  1XKD A;  3LXY A;  5I96 A;  5GRH A;  4I3K A;  3WZY A;  1VI1 A;  1GC8 A;  4BNP A;  2ZTW A;  3WZX A;  4HCX A;  5HN5 A;  1CW7 A;  1XAA A;  1BL5 A;  5GRF B;  5GRI A;  1V94 A;  4P69 C;  2AYQ A;  1CNZ A;  2UXR A;  1IDD A;  1V5B A;  5L57 A;  1T0L A;  5GRE B;  3TNG A;  4ATY A;  4I3L A;  1TYO A;  1IDE A;  3FLK A;  4XRX A;  3TY3 A;  1X0L A;  1DR0 A;  3ICD A;  2Y41 A;  1YXO A;  3MAS A;  1G2U A;  1T09 A;  4XS3 A;  5HN4 A;  3VL4 A;  3VL7 A;  2E5M A;  5K11 A;  3AH3 A;  8ICD A;  4UMY A;  3U1H A;  3UDO A;  1AI2 A;  2DHT A;  2IV0 A;  3ASJ A;  4XXV A;  1PS7 A;  1GC9 A;  4L06 A;  1ISO A;  1LWD A;  2QFX A;  4WUO A;  4AOU A;  7ICD A;  2Y3Z A;  3VL3 A;  1SJS A;  4F7I A;  1IPD A;  1XAB A;  2E0C A;  1VLC A;  5I95 A;  1XGV A;  3DMS A;  5HN3 A;  4IWH A;  3BLV B;  3VKZ A;  4AJB A;  5J34 A;  2QFW A;  4KZO A;  3U9E A;  4YB4 A;  1IKA A;  1ZOR A;  3UF6 A;  4AOV A;  4L04 A;  3BLX B;  5GRL B;  4AJA A;  2D1C A;  3WZV A;  5GRF A;  1PB3 A;  3LCB C;  2Y40 A;  1DPZ A;  3MAP A;  1R8K A;  2HI1 A;  3US8 A;  4AOY A;  4JQP A;  3VMK A;  1A05 A; 
#chains in the Genus database with same CATH topology
 4Y1P A;  1CW4 A;  4AJS A;  5GRE A;  9ICD A;  1IDF A;  1HQS A;  1DR8 A;  1PTM A;  5J32 A;  1AI3 A;  1XAC A;  4ICD A;  2QFY A;  3R8W A;  2G4O A;  5ICD A;  3TSN A;  1CM7 A;  1WPW A;  2Y42 A;  3VL6 A;  1W0D A;  3WZW A;  1U7N A;  1CW1 A;  4UMX A;  3FMX X;  5L58 A;  4L03 A;  3VML A;  1IDM A;  1P8F A;  1PS6 A;  4AJ3 A;  1HEX A;  5HN6 A;  1GRO A;  1V53 A;  1IDC A;  3MAS B;  3INM A;  1XAD A;  2QFV A;  5DE1 A;  5GRH B;  5LGE A;  4AJC A;  1YCO A;  1HJ6 A;  5K10 A;  5J33 A;  3TY4 A;  3BLV A;  1GRP A;  1OSI A;  5GRI B;  2D4V A;  3VL2 A;  3VMJ A;  6ICD A;  2UXQ A;  4JA8 A;  3UDU A;  1WAL A;  1OSJ A;  3MAR A;  4AJR A;  5GRL A;  3BLX A;  1PB1 A;  1XKD A;  3LXY A;  5I96 A;  5GRH A;  4I3K A;  3WZY A;  1VI1 A;  1GC8 A;  4BNP A;  2ZTW A;  3WZX A;  4HCX A;  5HN5 A;  1CW7 A;  1XAA A;  1BL5 A;  5GRF B;  5GRI A;  1V94 A;  4P69 C;  2AYQ A;  1CNZ A;  2UXR A;  1IDD A;  1V5B A;  5L57 A;  1T0L A;  5GRE B;  3TNG A;  4ATY A;  4I3L A;  1TYO A;  1IDE A;  3FLK A;  4XRX A;  3TY3 A;  1X0L A;  1DR0 A;  3ICD A;  2Y41 A;  1YXO A;  3MAS A;  1G2U A;  1T09 A;  4XS3 A;  5HN4 A;  3VL4 A;  3VL7 A;  2E5M A;  5K11 A;  3AH3 A;  8ICD A;  4UMY A;  3U1H A;  3UDO A;  1AI2 A;  2DHT A;  2IV0 A;  3ASJ A;  4XXV A;  1PS7 A;  1GC9 A;  4L06 A;  1ISO A;  1LWD A;  2QFX A;  4WUO A;  4AOU A;  7ICD A;  2Y3Z A;  3VL3 A;  1SJS A;  4F7I A;  1IPD A;  1XAB A;  2E0C A;  1VLC A;  5I95 A;  1XGV A;  3DMS A;  5HN3 A;  4IWH A;  3BLV B;  3VKZ A;  4AJB A;  5J34 A;  2QFW A;  4KZO A;  3U9E A;  4YB4 A;  1IKA A;  1ZOR A;  3UF6 A;  4AOV A;  4L04 A;  3BLX B;  5GRL B;  4AJA A;  2D1C A;  3WZV A;  5GRF A;  1PB3 A;  3LCB C;  2Y40 A;  1DPZ A;  3MAP A;  1R8K A;  2HI1 A;  3US8 A;  4AOY A;  4JQP A;  3VMK A;  1A05 A; 
#chains in the Genus database with same CATH homology
 4Y1P A;  1CW4 A;  4AJS A;  5GRE A;  9ICD A;  1IDF A;  1HQS A;  1DR8 A;  1PTM A;  5J32 A;  1AI3 A;  1XAC A;  4ICD A;  2QFY A;  3R8W A;  2G4O A;  5ICD A;  3TSN A;  1CM7 A;  1WPW A;  2Y42 A;  3VL6 A;  1W0D A;  3WZW A;  1U7N A;  1CW1 A;  4UMX A;  3FMX X;  5L58 A;  4L03 A;  3VML A;  1IDM A;  1P8F A;  1PS6 A;  4AJ3 A;  1HEX A;  5HN6 A;  1GRO A;  1V53 A;  1IDC A;  3MAS B;  3INM A;  1XAD A;  2QFV A;  5DE1 A;  5GRH B;  5LGE A;  4AJC A;  1YCO A;  1HJ6 A;  5K10 A;  5J33 A;  3TY4 A;  3BLV A;  1GRP A;  1OSI A;  5GRI B;  2D4V A;  3VL2 A;  3VMJ A;  6ICD A;  2UXQ A;  4JA8 A;  3UDU A;  1WAL A;  1OSJ A;  3MAR A;  4AJR A;  5GRL A;  3BLX A;  1PB1 A;  1XKD A;  3LXY A;  5I96 A;  5GRH A;  4I3K A;  3WZY A;  1VI1 A;  1GC8 A;  4BNP A;  2ZTW A;  3WZX A;  4HCX A;  5HN5 A;  1CW7 A;  1XAA A;  1BL5 A;  5GRF B;  5GRI A;  1V94 A;  4P69 C;  2AYQ A;  1CNZ A;  2UXR A;  1IDD A;  1V5B A;  5L57 A;  1T0L A;  5GRE B;  3TNG A;  4ATY A;  4I3L A;  1TYO A;  1IDE A;  3FLK A;  4XRX A;  3TY3 A;  1X0L A;  1DR0 A;  3ICD A;  2Y41 A;  1YXO A;  3MAS A;  1G2U A;  1T09 A;  4XS3 A;  5HN4 A;  3VL4 A;  3VL7 A;  2E5M A;  5K11 A;  3AH3 A;  8ICD A;  4UMY A;  3U1H A;  3UDO A;  1AI2 A;  2DHT A;  2IV0 A;  3ASJ A;  4XXV A;  1PS7 A;  1GC9 A;  4L06 A;  1ISO A;  1LWD A;  2QFX A;  4WUO A;  4AOU A;  7ICD A;  2Y3Z A;  3VL3 A;  1SJS A;  4F7I A;  1IPD A;  1XAB A;  2E0C A;  1VLC A;  5I95 A;  1XGV A;  3DMS A;  5HN3 A;  4IWH A;  3BLV B;  3VKZ A;  4AJB A;  5J34 A;  2QFW A;  4KZO A;  3U9E A;  4YB4 A;  1IKA A;  1ZOR A;  3UF6 A;  4AOV A;  4L04 A;  3BLX B;  5GRL B;  4AJA A;  2D1C A;  3WZV A;  5GRF A;  1PB3 A;  3LCB C;  2Y40 A;  1DPZ A;  3MAP A;  1R8K A;  2HI1 A;  3US8 A;  4AOY A;  4JQP A;  3VMK A;  1A05 A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
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#similar chains, but unknotted
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