1IDCA

Isocitrate dehydrogenase from e.coli (mutant k230m), steady-state intermediate complex determined by laue crystallography
Total Genus 138
Loading diagram...

The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
138
sequence length
414
structure length
414
Chain Sequence
SKVVVPAQGKKITLQNGKLNVPENPIIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPAETLDLIREYRVAIKGPLTTPVGGGIRSLNVALRQELDLYICLRPVRYYQGTPSPVKHPELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCSEEGTKRLVRAAIEYAIANDRDSVTLVHMGNIMKFTEGAFKDWGYQLAREEFGGELIDGGPWLKVKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMNLNGDYISDALAAQVGGIGIAPGANIGDECALFEATHGTAPKYAGQDKVNPGSIILSAEMMLRHMGWTEAADLIVKGMEGAINAKTVTYDFERLMDGAKLLKCSEFGDAIIENM
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
{{ tooltip.sname }} connected with {{ tooltip.tname }} : {{qFormat(tooltip.svalue) }}
publication title Mutagenesis and Laue structures of enzyme intermediates: isocitrate dehydrogenase.
pubmed rcsb
molecule tags Oxidoreductase (nad(a)-choh(d))
source organism Escherichia coli
molecule keywords ISOCITRATE DEHYDROGENASE
total genus 138
structure length 414
sequence length 414
ec nomenclature ec 1.1.1.42: Isocitrate dehydrogenase (NADP(+)).
pdb deposition date 1995-01-18

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00180 Iso_dh Isocitrate/isopropylmalate dehydrogenase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.718.10 Alpha Beta 3-Layer(aba) Sandwich Isopropylmalate Dehydrogenase Isopropylmalate Dehydrogenase 1idcA00
3U1HA 1VLCA 5L58A 4IWHA 1IPDA 5I96A 3VL4A 1TYOA 1V53A 4HCXA 5J32A 1WALA 9ICDA 1A05A 4JA8A 4XS3A 3VL7A 1GROA 3LXYA 3VMKA 1DR0A 5GRFA 1ZORA 2AYQA 4AJAA 1DPZA 3VMJA 3ICDA 5GRLA 3UF6A 1ISOA 3BLXB 3MAPA 4AJBA 3R8WA 4AOVA 4KZOA 1IDEA 3BLVA 2D4VA 2Y41A 3MARA 4L04A 4L06A 4XXVA 3WZXA 1XABA 1IKAA 2E5MA 2UXQA 1HEXA 1PS6A 5ICDA 4XRXA 2IV0A 5HN5A 4AOYA 2D1CA 1HJ6A 1WPWA 3US8A 3U9EA 3MASA 5K10A 3UDOA 1XGVA 2E0CA 1GC9A 1AI3A 1XAAA 3INMA 4Y1PA 2Y42A 5GRHA 3WZVA 1U7NA 4YB4A 5K11A 1CM7A 1XKDA 2ZTWA 4I3KA 4JQPA 5GRIA 1CW7A 1YXOA 2QFWA 1W0DA 4AOUA 4AJ3A 5HN4A 1T0LA 1YCOA 2Y40A 3TY4A 5GREB 1V94A 1R8KA 2Y3ZA 3BLVB 1SJSA 2UXRA 4ICDA 1CNZA 1IDMA 4WUOA 3TY3A 1V5BA 3BLXA 2QFYA 1PB1A 1XACA 1XADA 1HQSA 1P8FA 4AJRA 4AJCA 2DHTA 4ATYA 1BL5A 5DE1A 4BNPA 3VL2A 3AH3A 3WZWA 2QFXA 1X0LA 3VKZA 5I95A 1PB3A 3LCBC 4I3LA 3DMSA 3ASJA 5HN6A 1IDCA 5GRHB 5GRFB 5GRLB 1VI1A 5GRIB 3TNGA 3WZYA 1PTMA 1DR8A 1IDFA 1PS7A 3FMXX 4L03A 3VL6A 4UMXA 6ICDA 4F7IA 3UDUA 3FLKA 5HN3A 2QFVA 4P69C 2G4OA 1CW1A 7ICDA 1CW4A 1GRPA 1OSIA 3TSNA 1AI2A 1OSJA 1T09A 1GC8A 1IDDA 5J33A 8ICDA 5GREA 4UMYA 4AJSA 1LWDA 3MASB 1G2UA 5L57A 3VL3A 5LGEA 5J34A 2HI1A 3VMLA
chains in the Genus database with same CATH superfamily
3U1HA 1VLCA 5L58A 4IWHA 1IPDA 5I96A 3VL4A 1TYOA 1V53A 4HCXA 5J32A 1WALA 9ICDA 1A05A 4JA8A 4XS3A 3VL7A 1GROA 3LXYA 3VMKA 1DR0A 5GRFA 1ZORA 2AYQA 4AJAA 1DPZA 3VMJA 3ICDA 5GRLA 3UF6A 1ISOA 3BLXB 3MAPA 4AJBA 3R8WA 4AOVA 4KZOA 1IDEA 3BLVA 2D4VA 2Y41A 3MARA 4L04A 4L06A 4XXVA 3WZXA 1XABA 1IKAA 2E5MA 2UXQA 1HEXA 1PS6A 5ICDA 4XRXA 2IV0A 5HN5A 4AOYA 2D1CA 1HJ6A 1WPWA 3US8A 3U9EA 3MASA 5K10A 3UDOA 1XGVA 2E0CA 1GC9A 1AI3A 1XAAA 3INMA 4Y1PA 2Y42A 5GRHA 3WZVA 1U7NA 4YB4A 5K11A 1CM7A 1XKDA 2ZTWA 4I3KA 4JQPA 5GRIA 1CW7A 1YXOA 2QFWA 1W0DA 4AOUA 4AJ3A 5HN4A 1T0LA 1YCOA 2Y40A 3TY4A 5GREB 1V94A 1R8KA 2Y3ZA 3BLVB 1SJSA 2UXRA 4ICDA 1CNZA 1IDMA 4WUOA 3TY3A 1V5BA 3BLXA 2QFYA 1PB1A 1XACA 1XADA 1HQSA 1P8FA 4AJRA 4AJCA 2DHTA 4ATYA 1BL5A 5DE1A 4BNPA 3VL2A 3AH3A 3WZWA 2QFXA 1X0LA 3VKZA 5I95A 1PB3A 3LCBC 4I3LA 3DMSA 3ASJA 5HN6A 1IDCA 5GRHB 5GRFB 5GRLB 1VI1A 5GRIB 3TNGA 3WZYA 1PTMA 1DR8A 1IDFA 1PS7A 3FMXX 4L03A 3VL6A 4UMXA 6ICDA 4F7IA 3UDUA 3FLKA 5HN3A 2QFVA 4P69C 2G4OA 1CW1A 7ICDA 1CW4A 1GRPA 1OSIA 3TSNA 1AI2A 1OSJA 1T09A 1GC8A 1IDDA 5J33A 8ICDA 5GREA 4UMYA 4AJSA 1LWDA 3MASB 1G2UA 5L57A 3VL3A 5LGEA 5J34A 2HI1A 3VMLA
chains in the Genus database with same CATH topology
3U1HA 1VLCA 5L58A 4IWHA 1IPDA 5I96A 3VL4A 1TYOA 1V53A 4HCXA 5J32A 1WALA 9ICDA 1A05A 4JA8A 4XS3A 3VL7A 1GROA 3LXYA 3VMKA 1DR0A 5GRFA 1ZORA 2AYQA 4AJAA 1DPZA 3VMJA 3ICDA 5GRLA 3UF6A 1ISOA 3BLXB 3MAPA 4AJBA 3R8WA 4AOVA 4KZOA 1IDEA 3BLVA 2D4VA 2Y41A 3MARA 4L04A 4L06A 4XXVA 3WZXA 1XABA 1IKAA 2E5MA 2UXQA 1HEXA 1PS6A 5ICDA 4XRXA 2IV0A 5HN5A 4AOYA 2D1CA 1HJ6A 1WPWA 3US8A 3U9EA 3MASA 5K10A 3UDOA 1XGVA 2E0CA 1GC9A 1AI3A 1XAAA 3INMA 4Y1PA 2Y42A 5GRHA 3WZVA 1U7NA 4YB4A 5K11A 1CM7A 1XKDA 2ZTWA 4I3KA 4JQPA 5GRIA 1CW7A 1YXOA 2QFWA 1W0DA 4AOUA 4AJ3A 5HN4A 1T0LA 1YCOA 2Y40A 3TY4A 5GREB 1V94A 1R8KA 2Y3ZA 3BLVB 1SJSA 2UXRA 4ICDA 1CNZA 1IDMA 4WUOA 3TY3A 1V5BA 3BLXA 2QFYA 1PB1A 1XACA 1XADA 1HQSA 1P8FA 4AJRA 4AJCA 2DHTA 4ATYA 1BL5A 5DE1A 4BNPA 3VL2A 3AH3A 3WZWA 2QFXA 1X0LA 3VKZA 5I95A 1PB3A 3LCBC 4I3LA 3DMSA 3ASJA 5HN6A 1IDCA 5GRHB 5GRFB 5GRLB 1VI1A 5GRIB 3TNGA 3WZYA 1PTMA 1DR8A 1IDFA 1PS7A 3FMXX 4L03A 3VL6A 4UMXA 6ICDA 4F7IA 3UDUA 3FLKA 5HN3A 2QFVA 4P69C 2G4OA 1CW1A 7ICDA 1CW4A 1GRPA 1OSIA 3TSNA 1AI2A 1OSJA 1T09A 1GC8A 1IDDA 5J33A 8ICDA 5GREA 4UMYA 4AJSA 1LWDA 3MASB 1G2UA 5L57A 3VL3A 5LGEA 5J34A 2HI1A 3VMLA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 3U1H A;  1VLC A;  5L58 A;  4IWH A;  1IPD A;  5I96 A;  3VL4 A;  1TYO A;  1V53 A;  4HCX A;  5J32 A;  1WAL A;  9ICD A;  1A05 A;  4JA8 A;  4XS3 A;  3VL7 A;  1GRO A;  3LXY A;  3VMK A;  1DR0 A;  5GRF A;  1ZOR A;  2AYQ A;  4AJA A;  1DPZ A;  3VMJ A;  3ICD A;  5GRL A;  3UF6 A;  1ISO A;  3BLX B;  3MAP A;  4AJB A;  3R8W A;  4AOV A;  4KZO A;  1IDE A;  3BLV A;  2D4V A;  2Y41 A;  3MAR A;  4L04 A;  4L06 A;  4XXV A;  3WZX A;  1XAB A;  1IKA A;  2E5M A;  2UXQ A;  1HEX A;  1PS6 A;  5ICD A;  4XRX A;  2IV0 A;  5HN5 A;  4AOY A;  2D1C A;  1HJ6 A;  1WPW A;  3US8 A;  3U9E A;  3MAS A;  5K10 A;  3UDO A;  1XGV A;  2E0C A;  1GC9 A;  1AI3 A;  1XAA A;  3INM A;  4Y1P A;  2Y42 A;  5GRH A;  3WZV A;  1U7N A;  4YB4 A;  5K11 A;  1CM7 A;  1XKD A;  2ZTW A;  4I3K A;  4JQP A;  5GRI A;  1CW7 A;  1YXO A;  2QFW A;  1W0D A;  4AOU A;  4AJ3 A;  5HN4 A;  1T0L A;  1YCO A;  2Y40 A;  3TY4 A;  5GRE B;  1V94 A;  1R8K A;  2Y3Z A;  3BLV B;  1SJS A;  2UXR A;  4ICD A;  1CNZ A;  1IDM A;  4WUO A;  3TY3 A;  1V5B A;  3BLX A;  2QFY A;  1PB1 A;  1XAC A;  1XAD A;  1HQS A;  1P8F A;  4AJR A;  4AJC A;  2DHT A;  4ATY A;  1BL5 A;  5DE1 A;  4BNP A;  3VL2 A;  3AH3 A;  3WZW A;  2QFX A;  1X0L A;  3VKZ A;  5I95 A;  1PB3 A;  3LCB C;  4I3L A;  3DMS A;  3ASJ A;  5HN6 A;  1IDC A;  5GRH B;  5GRF B;  5GRL B;  1VI1 A;  5GRI B;  3TNG A;  3WZY A;  1PTM A;  1DR8 A;  1IDF A;  1PS7 A;  3FMX X;  4L03 A;  3VL6 A;  4UMX A;  6ICD A;  4F7I A;  3UDU A;  3FLK A;  5HN3 A;  2QFV A;  4P69 C;  2G4O A;  1CW1 A;  7ICD A;  1CW4 A;  1GRP A;  1OSI A;  3TSN A;  1AI2 A;  1OSJ A;  1T09 A;  1GC8 A;  1IDD A;  5J33 A;  8ICD A;  5GRE A;  4UMY A;  4AJS A;  1LWD A;  3MAS B;  1G2U A;  5L57 A;  3VL3 A;  5LGE A;  5J34 A;  2HI1 A;  3VML A; 
#chains in the Genus database with same CATH topology
 3U1H A;  1VLC A;  5L58 A;  4IWH A;  1IPD A;  5I96 A;  3VL4 A;  1TYO A;  1V53 A;  4HCX A;  5J32 A;  1WAL A;  9ICD A;  1A05 A;  4JA8 A;  4XS3 A;  3VL7 A;  1GRO A;  3LXY A;  3VMK A;  1DR0 A;  5GRF A;  1ZOR A;  2AYQ A;  4AJA A;  1DPZ A;  3VMJ A;  3ICD A;  5GRL A;  3UF6 A;  1ISO A;  3BLX B;  3MAP A;  4AJB A;  3R8W A;  4AOV A;  4KZO A;  1IDE A;  3BLV A;  2D4V A;  2Y41 A;  3MAR A;  4L04 A;  4L06 A;  4XXV A;  3WZX A;  1XAB A;  1IKA A;  2E5M A;  2UXQ A;  1HEX A;  1PS6 A;  5ICD A;  4XRX A;  2IV0 A;  5HN5 A;  4AOY A;  2D1C A;  1HJ6 A;  1WPW A;  3US8 A;  3U9E A;  3MAS A;  5K10 A;  3UDO A;  1XGV A;  2E0C A;  1GC9 A;  1AI3 A;  1XAA A;  3INM A;  4Y1P A;  2Y42 A;  5GRH A;  3WZV A;  1U7N A;  4YB4 A;  5K11 A;  1CM7 A;  1XKD A;  2ZTW A;  4I3K A;  4JQP A;  5GRI A;  1CW7 A;  1YXO A;  2QFW A;  1W0D A;  4AOU A;  4AJ3 A;  5HN4 A;  1T0L A;  1YCO A;  2Y40 A;  3TY4 A;  5GRE B;  1V94 A;  1R8K A;  2Y3Z A;  3BLV B;  1SJS A;  2UXR A;  4ICD A;  1CNZ A;  1IDM A;  4WUO A;  3TY3 A;  1V5B A;  3BLX A;  2QFY A;  1PB1 A;  1XAC A;  1XAD A;  1HQS A;  1P8F A;  4AJR A;  4AJC A;  2DHT A;  4ATY A;  1BL5 A;  5DE1 A;  4BNP A;  3VL2 A;  3AH3 A;  3WZW A;  2QFX A;  1X0L A;  3VKZ A;  5I95 A;  1PB3 A;  3LCB C;  4I3L A;  3DMS A;  3ASJ A;  5HN6 A;  1IDC A;  5GRH B;  5GRF B;  5GRL B;  1VI1 A;  5GRI B;  3TNG A;  3WZY A;  1PTM A;  1DR8 A;  1IDF A;  1PS7 A;  3FMX X;  4L03 A;  3VL6 A;  4UMX A;  6ICD A;  4F7I A;  3UDU A;  3FLK A;  5HN3 A;  2QFV A;  4P69 C;  2G4O A;  1CW1 A;  7ICD A;  1CW4 A;  1GRP A;  1OSI A;  3TSN A;  1AI2 A;  1OSJ A;  1T09 A;  1GC8 A;  1IDD A;  5J33 A;  8ICD A;  5GRE A;  4UMY A;  4AJS A;  1LWD A;  3MAS B;  1G2U A;  5L57 A;  3VL3 A;  5LGE A;  5J34 A;  2HI1 A;  3VML A; 
#chains in the Genus database with same CATH homology
 3U1H A;  1VLC A;  5L58 A;  4IWH A;  1IPD A;  5I96 A;  3VL4 A;  1TYO A;  1V53 A;  4HCX A;  5J32 A;  1WAL A;  9ICD A;  1A05 A;  4JA8 A;  4XS3 A;  3VL7 A;  1GRO A;  3LXY A;  3VMK A;  1DR0 A;  5GRF A;  1ZOR A;  2AYQ A;  4AJA A;  1DPZ A;  3VMJ A;  3ICD A;  5GRL A;  3UF6 A;  1ISO A;  3BLX B;  3MAP A;  4AJB A;  3R8W A;  4AOV A;  4KZO A;  1IDE A;  3BLV A;  2D4V A;  2Y41 A;  3MAR A;  4L04 A;  4L06 A;  4XXV A;  3WZX A;  1XAB A;  1IKA A;  2E5M A;  2UXQ A;  1HEX A;  1PS6 A;  5ICD A;  4XRX A;  2IV0 A;  5HN5 A;  4AOY A;  2D1C A;  1HJ6 A;  1WPW A;  3US8 A;  3U9E A;  3MAS A;  5K10 A;  3UDO A;  1XGV A;  2E0C A;  1GC9 A;  1AI3 A;  1XAA A;  3INM A;  4Y1P A;  2Y42 A;  5GRH A;  3WZV A;  1U7N A;  4YB4 A;  5K11 A;  1CM7 A;  1XKD A;  2ZTW A;  4I3K A;  4JQP A;  5GRI A;  1CW7 A;  1YXO A;  2QFW A;  1W0D A;  4AOU A;  4AJ3 A;  5HN4 A;  1T0L A;  1YCO A;  2Y40 A;  3TY4 A;  5GRE B;  1V94 A;  1R8K A;  2Y3Z A;  3BLV B;  1SJS A;  2UXR A;  4ICD A;  1CNZ A;  1IDM A;  4WUO A;  3TY3 A;  1V5B A;  3BLX A;  2QFY A;  1PB1 A;  1XAC A;  1XAD A;  1HQS A;  1P8F A;  4AJR A;  4AJC A;  2DHT A;  4ATY A;  1BL5 A;  5DE1 A;  4BNP A;  3VL2 A;  3AH3 A;  3WZW A;  2QFX A;  1X0L A;  3VKZ A;  5I95 A;  1PB3 A;  3LCB C;  4I3L A;  3DMS A;  3ASJ A;  5HN6 A;  1IDC A;  5GRH B;  5GRF B;  5GRL B;  1VI1 A;  5GRI B;  3TNG A;  3WZY A;  1PTM A;  1DR8 A;  1IDF A;  1PS7 A;  3FMX X;  4L03 A;  3VL6 A;  4UMX A;  6ICD A;  4F7I A;  3UDU A;  3FLK A;  5HN3 A;  2QFV A;  4P69 C;  2G4O A;  1CW1 A;  7ICD A;  1CW4 A;  1GRP A;  1OSI A;  3TSN A;  1AI2 A;  1OSJ A;  1T09 A;  1GC8 A;  1IDD A;  5J33 A;  8ICD A;  5GRE A;  4UMY A;  4AJS A;  1LWD A;  3MAS B;  1G2U A;  5L57 A;  3VL3 A;  5LGE A;  5J34 A;  2HI1 A;  3VML A; 
...loading similar chains, please wait...
similar chains in the Genus database (?% sequence similarity)
...loading similar chains, please wait...
similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
...loading similar chains, please wait...
#similar chains, but unknotted
...loading similar chains, please wait...
#similar chains in the pdb database (?% sequence similarity)
...loading similar chains, please wait...