1IDFA

Isocitrate dehydrogenase k230m mutant apo enzyme
Total Genus 125
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
125
sequence length
414
structure length
414
Chain Sequence
SKVVVPAQGKKITLQNGKLNVPENPIIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPAETLDLIREYRVAIKGPLTTPVGGGIRSLNVALRQELDLYICLRPVRYYQGTPSPVKHPELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCSEEGTKRLVRAAIEYAIANDRDSVTLVHMGNIMKFTEGAFKDWGYQLAREEFGGELIDGGPWLKVKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMNLNGDYISDALAAQVGGIGIAPGANIGDECALFEATHGTAPKYAGQDKVNPGSIILSAEMMLRHMGWTEAADLIVKGMEGAINAKTVTYDFERLMDGAKLLKCSEFGDAIIENM
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Mutagenesis and Laue structures of enzyme intermediates: isocitrate dehydrogenase.
pubmed rcsb
molecule tags Oxidoreductase (nad(a)-choh(d))
source organism Escherichia coli
molecule keywords ISOCITRATE DEHYDROGENASE
total genus 125
structure length 414
sequence length 414
ec nomenclature ec 1.1.1.42: Isocitrate dehydrogenase (NADP(+)).
pdb deposition date 1995-01-18

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00180 Iso_dh Isocitrate/isopropylmalate dehydrogenase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.718.10 Alpha Beta 3-Layer(aba) Sandwich Isopropylmalate Dehydrogenase Isopropylmalate Dehydrogenase 1idfA00
1WPWA 4L03A 1HEXA 1WALA 3AH3A 3WZWA 2D4VA 1IPDA 5DE1A 9ICDA 1XABA 1CNZA 1AI2A 1IDEA 2Y41A 1CW1A 3UF6A 1DR0A 3FLKA 3UDUA 4F7IA 1PB3A 4JQPA 4AJRA 3WZYA 1CM7A 1P8FA 3BLVA 3TSNA 2QFVA 1VI1A 3TY4A 1CW4A 1XAAA 5GRHB 3MASA 4KZOA 2QFYA 5GREB 1PTMA 5GRLA 4AJSA 4AOYA 4UMXA 2QFXA 4BNPA 4AJ3A 1OSJA 3VL2A 5HN4A 3VL4A 4IWHA 2HI1A 2Y42A 3LXYA 1A05A 1YCOA 3VL3A 1PS6A 6ICDA 5ICDA 2UXQA 1XADA 1R8KA 4Y1PA 5K10A 4ICDA 3U1HA 1IDCA 2D1CA 1GROA 5J33A 4AJAA 5HN6A 1G2UA 1YXOA 1V94A 7ICDA 3VMLA 5J32A 5HN3A 3VMKA 1GC9A 5GRIA 5GRFA 1PS7A 1HQSA 3BLXA 3WZXA 4YB4A 1T0LA 3MARA 3DMSA 4WUOA 1XGVA 1AI3A 1V5BA 3BLVB 2QFWA 4L04A 3VMJA 2UXRA 1PB1A 1DR8A 1OSIA 4I3LA 2G4OA 4AOVA 4XS3A 2DHTA 4JA8A 4XRXA 3MASB 1HJ6A 4XXVA 5LGEA 5GRLB 1V53A 1W0DA 3MAPA 1BL5A 4ATYA 3UDOA 1XKDA 1DPZA 3R8WA 8ICDA 2E0CA 1ZORA 1TYOA 4UMYA 5K11A 5L57A 1SJSA 5HN5A 1IDMA 3VL7A 3ASJA 3WZVA 4AJCA 1VLCA 5GRHA 3TNGA 5I96A 5GREA 2E5MA 1GC8A 3TY3A 3VL6A 5I95A 1LWDA 3LCBC 3U9EA 3FMXX 1ISOA 1IDDA 5GRIB 5GRFB 4I3KA 3BLXB 3ICDA 1CW7A 1XACA 4L06A 5J34A 5L58A 1GRPA 3INMA 1IKAA 2ZTWA 2Y3ZA 3US8A 3VKZA 1X0LA 1IDFA 2IV0A 4AJBA 2AYQA 4AOUA 4P69C 2Y40A 1U7NA 4HCXA 1T09A
chains in the Genus database with same CATH superfamily
1WPWA 4L03A 1HEXA 1WALA 3AH3A 3WZWA 2D4VA 1IPDA 5DE1A 9ICDA 1XABA 1CNZA 1AI2A 1IDEA 2Y41A 1CW1A 3UF6A 1DR0A 3FLKA 3UDUA 4F7IA 1PB3A 4JQPA 4AJRA 3WZYA 1CM7A 1P8FA 3BLVA 3TSNA 2QFVA 1VI1A 3TY4A 1CW4A 1XAAA 5GRHB 3MASA 4KZOA 2QFYA 5GREB 1PTMA 5GRLA 4AJSA 4AOYA 4UMXA 2QFXA 4BNPA 4AJ3A 1OSJA 3VL2A 5HN4A 3VL4A 4IWHA 2HI1A 2Y42A 3LXYA 1A05A 1YCOA 3VL3A 1PS6A 6ICDA 5ICDA 2UXQA 1XADA 1R8KA 4Y1PA 5K10A 4ICDA 3U1HA 1IDCA 2D1CA 1GROA 5J33A 4AJAA 5HN6A 1G2UA 1YXOA 1V94A 7ICDA 3VMLA 5J32A 5HN3A 3VMKA 1GC9A 5GRIA 5GRFA 1PS7A 1HQSA 3BLXA 3WZXA 4YB4A 1T0LA 3MARA 3DMSA 4WUOA 1XGVA 1AI3A 1V5BA 3BLVB 2QFWA 4L04A 3VMJA 2UXRA 1PB1A 1DR8A 1OSIA 4I3LA 2G4OA 4AOVA 4XS3A 2DHTA 4JA8A 4XRXA 3MASB 1HJ6A 4XXVA 5LGEA 5GRLB 1V53A 1W0DA 3MAPA 1BL5A 4ATYA 3UDOA 1XKDA 1DPZA 3R8WA 8ICDA 2E0CA 1ZORA 1TYOA 4UMYA 5K11A 5L57A 1SJSA 5HN5A 1IDMA 3VL7A 3ASJA 3WZVA 4AJCA 1VLCA 5GRHA 3TNGA 5I96A 5GREA 2E5MA 1GC8A 3TY3A 3VL6A 5I95A 1LWDA 3LCBC 3U9EA 3FMXX 1ISOA 1IDDA 5GRIB 5GRFB 4I3KA 3BLXB 3ICDA 1CW7A 1XACA 4L06A 5J34A 5L58A 1GRPA 3INMA 1IKAA 2ZTWA 2Y3ZA 3US8A 3VKZA 1X0LA 1IDFA 2IV0A 4AJBA 2AYQA 4AOUA 4P69C 2Y40A 1U7NA 4HCXA 1T09A
chains in the Genus database with same CATH topology
1WPWA 4L03A 1HEXA 1WALA 3AH3A 3WZWA 2D4VA 1IPDA 5DE1A 9ICDA 1XABA 1CNZA 1AI2A 1IDEA 2Y41A 1CW1A 3UF6A 1DR0A 3FLKA 3UDUA 4F7IA 1PB3A 4JQPA 4AJRA 3WZYA 1CM7A 1P8FA 3BLVA 3TSNA 2QFVA 1VI1A 3TY4A 1CW4A 1XAAA 5GRHB 3MASA 4KZOA 2QFYA 5GREB 1PTMA 5GRLA 4AJSA 4AOYA 4UMXA 2QFXA 4BNPA 4AJ3A 1OSJA 3VL2A 5HN4A 3VL4A 4IWHA 2HI1A 2Y42A 3LXYA 1A05A 1YCOA 3VL3A 1PS6A 6ICDA 5ICDA 2UXQA 1XADA 1R8KA 4Y1PA 5K10A 4ICDA 3U1HA 1IDCA 2D1CA 1GROA 5J33A 4AJAA 5HN6A 1G2UA 1YXOA 1V94A 7ICDA 3VMLA 5J32A 5HN3A 3VMKA 1GC9A 5GRIA 5GRFA 1PS7A 1HQSA 3BLXA 3WZXA 4YB4A 1T0LA 3MARA 3DMSA 4WUOA 1XGVA 1AI3A 1V5BA 3BLVB 2QFWA 4L04A 3VMJA 2UXRA 1PB1A 1DR8A 1OSIA 4I3LA 2G4OA 4AOVA 4XS3A 2DHTA 4JA8A 4XRXA 3MASB 1HJ6A 4XXVA 5LGEA 5GRLB 1V53A 1W0DA 3MAPA 1BL5A 4ATYA 3UDOA 1XKDA 1DPZA 3R8WA 8ICDA 2E0CA 1ZORA 1TYOA 4UMYA 5K11A 5L57A 1SJSA 5HN5A 1IDMA 3VL7A 3ASJA 3WZVA 4AJCA 1VLCA 5GRHA 3TNGA 5I96A 5GREA 2E5MA 1GC8A 3TY3A 3VL6A 5I95A 1LWDA 3LCBC 3U9EA 3FMXX 1ISOA 1IDDA 5GRIB 5GRFB 4I3KA 3BLXB 3ICDA 1CW7A 1XACA 4L06A 5J34A 5L58A 1GRPA 3INMA 1IKAA 2ZTWA 2Y3ZA 3US8A 3VKZA 1X0LA 1IDFA 2IV0A 4AJBA 2AYQA 4AOUA 4P69C 2Y40A 1U7NA 4HCXA 1T09A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1WPW A;  4L03 A;  1HEX A;  1WAL A;  3AH3 A;  3WZW A;  2D4V A;  1IPD A;  5DE1 A;  9ICD A;  1XAB A;  1CNZ A;  1AI2 A;  1IDE A;  2Y41 A;  1CW1 A;  3UF6 A;  1DR0 A;  3FLK A;  3UDU A;  4F7I A;  1PB3 A;  4JQP A;  4AJR A;  3WZY A;  1CM7 A;  1P8F A;  3BLV A;  3TSN A;  2QFV A;  1VI1 A;  3TY4 A;  1CW4 A;  1XAA A;  5GRH B;  3MAS A;  4KZO A;  2QFY A;  5GRE B;  1PTM A;  5GRL A;  4AJS A;  4AOY A;  4UMX A;  2QFX A;  4BNP A;  4AJ3 A;  1OSJ A;  3VL2 A;  5HN4 A;  3VL4 A;  4IWH A;  2HI1 A;  2Y42 A;  3LXY A;  1A05 A;  1YCO A;  3VL3 A;  1PS6 A;  6ICD A;  5ICD A;  2UXQ A;  1XAD A;  1R8K A;  4Y1P A;  5K10 A;  4ICD A;  3U1H A;  1IDC A;  2D1C A;  1GRO A;  5J33 A;  4AJA A;  5HN6 A;  1G2U A;  1YXO A;  1V94 A;  7ICD A;  3VML A;  5J32 A;  5HN3 A;  3VMK A;  1GC9 A;  5GRI A;  5GRF A;  1PS7 A;  1HQS A;  3BLX A;  3WZX A;  4YB4 A;  1T0L A;  3MAR A;  3DMS A;  4WUO A;  1XGV A;  1AI3 A;  1V5B A;  3BLV B;  2QFW A;  4L04 A;  3VMJ A;  2UXR A;  1PB1 A;  1DR8 A;  1OSI A;  4I3L A;  2G4O A;  4AOV A;  4XS3 A;  2DHT A;  4JA8 A;  4XRX A;  3MAS B;  1HJ6 A;  4XXV A;  5LGE A;  5GRL B;  1V53 A;  1W0D A;  3MAP A;  1BL5 A;  4ATY A;  3UDO A;  1XKD A;  1DPZ A;  3R8W A;  8ICD A;  2E0C A;  1ZOR A;  1TYO A;  4UMY A;  5K11 A;  5L57 A;  1SJS A;  5HN5 A;  1IDM A;  3VL7 A;  3ASJ A;  3WZV A;  4AJC A;  1VLC A;  5GRH A;  3TNG A;  5I96 A;  5GRE A;  2E5M A;  1GC8 A;  3TY3 A;  3VL6 A;  5I95 A;  1LWD A;  3LCB C;  3U9E A;  3FMX X;  1ISO A;  1IDD A;  5GRI B;  5GRF B;  4I3K A;  3BLX B;  3ICD A;  1CW7 A;  1XAC A;  4L06 A;  5J34 A;  5L58 A;  1GRP A;  3INM A;  1IKA A;  2ZTW A;  2Y3Z A;  3US8 A;  3VKZ A;  1X0L A;  1IDF A;  2IV0 A;  4AJB A;  2AYQ A;  4AOU A;  4P69 C;  2Y40 A;  1U7N A;  4HCX A;  1T09 A; 
#chains in the Genus database with same CATH topology
 1WPW A;  4L03 A;  1HEX A;  1WAL A;  3AH3 A;  3WZW A;  2D4V A;  1IPD A;  5DE1 A;  9ICD A;  1XAB A;  1CNZ A;  1AI2 A;  1IDE A;  2Y41 A;  1CW1 A;  3UF6 A;  1DR0 A;  3FLK A;  3UDU A;  4F7I A;  1PB3 A;  4JQP A;  4AJR A;  3WZY A;  1CM7 A;  1P8F A;  3BLV A;  3TSN A;  2QFV A;  1VI1 A;  3TY4 A;  1CW4 A;  1XAA A;  5GRH B;  3MAS A;  4KZO A;  2QFY A;  5GRE B;  1PTM A;  5GRL A;  4AJS A;  4AOY A;  4UMX A;  2QFX A;  4BNP A;  4AJ3 A;  1OSJ A;  3VL2 A;  5HN4 A;  3VL4 A;  4IWH A;  2HI1 A;  2Y42 A;  3LXY A;  1A05 A;  1YCO A;  3VL3 A;  1PS6 A;  6ICD A;  5ICD A;  2UXQ A;  1XAD A;  1R8K A;  4Y1P A;  5K10 A;  4ICD A;  3U1H A;  1IDC A;  2D1C A;  1GRO A;  5J33 A;  4AJA A;  5HN6 A;  1G2U A;  1YXO A;  1V94 A;  7ICD A;  3VML A;  5J32 A;  5HN3 A;  3VMK A;  1GC9 A;  5GRI A;  5GRF A;  1PS7 A;  1HQS A;  3BLX A;  3WZX A;  4YB4 A;  1T0L A;  3MAR A;  3DMS A;  4WUO A;  1XGV A;  1AI3 A;  1V5B A;  3BLV B;  2QFW A;  4L04 A;  3VMJ A;  2UXR A;  1PB1 A;  1DR8 A;  1OSI A;  4I3L A;  2G4O A;  4AOV A;  4XS3 A;  2DHT A;  4JA8 A;  4XRX A;  3MAS B;  1HJ6 A;  4XXV A;  5LGE A;  5GRL B;  1V53 A;  1W0D A;  3MAP A;  1BL5 A;  4ATY A;  3UDO A;  1XKD A;  1DPZ A;  3R8W A;  8ICD A;  2E0C A;  1ZOR A;  1TYO A;  4UMY A;  5K11 A;  5L57 A;  1SJS A;  5HN5 A;  1IDM A;  3VL7 A;  3ASJ A;  3WZV A;  4AJC A;  1VLC A;  5GRH A;  3TNG A;  5I96 A;  5GRE A;  2E5M A;  1GC8 A;  3TY3 A;  3VL6 A;  5I95 A;  1LWD A;  3LCB C;  3U9E A;  3FMX X;  1ISO A;  1IDD A;  5GRI B;  5GRF B;  4I3K A;  3BLX B;  3ICD A;  1CW7 A;  1XAC A;  4L06 A;  5J34 A;  5L58 A;  1GRP A;  3INM A;  1IKA A;  2ZTW A;  2Y3Z A;  3US8 A;  3VKZ A;  1X0L A;  1IDF A;  2IV0 A;  4AJB A;  2AYQ A;  4AOU A;  4P69 C;  2Y40 A;  1U7N A;  4HCX A;  1T09 A; 
#chains in the Genus database with same CATH homology
 1WPW A;  4L03 A;  1HEX A;  1WAL A;  3AH3 A;  3WZW A;  2D4V A;  1IPD A;  5DE1 A;  9ICD A;  1XAB A;  1CNZ A;  1AI2 A;  1IDE A;  2Y41 A;  1CW1 A;  3UF6 A;  1DR0 A;  3FLK A;  3UDU A;  4F7I A;  1PB3 A;  4JQP A;  4AJR A;  3WZY A;  1CM7 A;  1P8F A;  3BLV A;  3TSN A;  2QFV A;  1VI1 A;  3TY4 A;  1CW4 A;  1XAA A;  5GRH B;  3MAS A;  4KZO A;  2QFY A;  5GRE B;  1PTM A;  5GRL A;  4AJS A;  4AOY A;  4UMX A;  2QFX A;  4BNP A;  4AJ3 A;  1OSJ A;  3VL2 A;  5HN4 A;  3VL4 A;  4IWH A;  2HI1 A;  2Y42 A;  3LXY A;  1A05 A;  1YCO A;  3VL3 A;  1PS6 A;  6ICD A;  5ICD A;  2UXQ A;  1XAD A;  1R8K A;  4Y1P A;  5K10 A;  4ICD A;  3U1H A;  1IDC A;  2D1C A;  1GRO A;  5J33 A;  4AJA A;  5HN6 A;  1G2U A;  1YXO A;  1V94 A;  7ICD A;  3VML A;  5J32 A;  5HN3 A;  3VMK A;  1GC9 A;  5GRI A;  5GRF A;  1PS7 A;  1HQS A;  3BLX A;  3WZX A;  4YB4 A;  1T0L A;  3MAR A;  3DMS A;  4WUO A;  1XGV A;  1AI3 A;  1V5B A;  3BLV B;  2QFW A;  4L04 A;  3VMJ A;  2UXR A;  1PB1 A;  1DR8 A;  1OSI A;  4I3L A;  2G4O A;  4AOV A;  4XS3 A;  2DHT A;  4JA8 A;  4XRX A;  3MAS B;  1HJ6 A;  4XXV A;  5LGE A;  5GRL B;  1V53 A;  1W0D A;  3MAP A;  1BL5 A;  4ATY A;  3UDO A;  1XKD A;  1DPZ A;  3R8W A;  8ICD A;  2E0C A;  1ZOR A;  1TYO A;  4UMY A;  5K11 A;  5L57 A;  1SJS A;  5HN5 A;  1IDM A;  3VL7 A;  3ASJ A;  3WZV A;  4AJC A;  1VLC A;  5GRH A;  3TNG A;  5I96 A;  5GRE A;  2E5M A;  1GC8 A;  3TY3 A;  3VL6 A;  5I95 A;  1LWD A;  3LCB C;  3U9E A;  3FMX X;  1ISO A;  1IDD A;  5GRI B;  5GRF B;  4I3K A;  3BLX B;  3ICD A;  1CW7 A;  1XAC A;  4L06 A;  5J34 A;  5L58 A;  1GRP A;  3INM A;  1IKA A;  2ZTW A;  2Y3Z A;  3US8 A;  3VKZ A;  1X0L A;  1IDF A;  2IV0 A;  4AJB A;  2AYQ A;  4AOU A;  4P69 C;  2Y40 A;  1U7N A;  4HCX A;  1T09 A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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