1KH5A

E. coli alkaline phosphatase mutant (d330n) mimic of the transition states with aluminium fluoride
Total Genus 151
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
151
Knots found
sequence length
444
structure length
444
Chain Sequence
VLENRAAQGNITAPGGARRLTGDQTAALRNSLSDKPAKNIILLIGDGMGDSEITAARNYAEGAGGFFKGIDALPLTGQYTHYALNKKTGKPDYVTDSAASATAWSTGVKTYNGALGVDIHEKDHPTILEMAKAAGLATGNVSTAELQDATPAALVAHVTSRKCYGPSATSQKCPGNALEKGGKGSITEQLLNARADVTLGGGAKTFAETATAGEWQGKTLREEAEARGYQLVSDAASLNSVTEANQQKPLLGLFADGNMPVRWLGPKATYHGNIDKPAVTCTPNPQRNDSVPTLAQMTDKAIELLSKNEKGFFLQVEGASIDKQNHAANPCGQIGETVDLDEAVQRALEFAKKEGNTLVIVTADHAHASQIVAPDTKAPGLTQALNTKDGAVMVMSYGNSEEDSQEHTGSQLRIAAYGPHAANVVGLTDQTDLFYTMKAALGLK
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

molecule keywords ALKALINE PHOSPHATASE
publication title Artificial evolution of an enzyme active site: structural studies of three highly active mutants of Escherichia coli alkaline phosphatase.
pubmed doi rcsb
source organism Escherichia coli
molecule tags Hydrolase
total genus 151
structure length 444
sequence length 444
chains with identical sequence B
other databases KnotProt 2.0: S +31
ec nomenclature ec 3.1.3.1: Alkaline phosphatase.
pdb deposition date 2001-11-29

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00245 Alk_phosphatase Alkaline phosphatase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.720.10 Alpha Beta 3-Layer(aba) Sandwich Alkaline Phosphatase, subunit A Alkaline Phosphatase, subunit A 1kh5A00
1ZEDA 3NKMA 3A52A 2XRGA 4UORA 4ZG6A 3UN2A 1ELYA 1ALHA 4QAXA 4CXSA 5IJQA 2W5VA 1P49A 1EJJA 3BDGB 4UPKA 4CYSA 4UOOA 3IDDA 1ELZA 5KXAA 3T02A 5L0EA 5L0KA 2W5XA 1AJCA 4KJDA 4ZGAA 3BDFA 2W8DA 5GRRA 4LR2A 4GTXA 5TJ3A 1B8JA 4CXUA 2IUCA 5K4PA 3WAWA 5L0BA 1ZEBA 3NKRA 4LR9A 4LRAA 3WAXA 3E2DA 1E1ZP 5EGEA 5DLVA 3KD8A 4LRFA 2W5RA 5GOVA 1EW8A 1ALIA 2W5SA 1KH7A 3WAVA 1EW9A 1KHLA 4UOPA 3SZYA 3M8WA 4NWXA 1AUKA 5LIAA 4LR8A 3M7VA 1ELXA 2W5QA 3BDHA 4ZG9A 4ZG7A 1EQJA 3IGYB 3MK1A 3UNYA 4GTWA 5LQQA 3CMRA 2W5TA 4GTYA 4GTZA 2W8SA 1KH9A 4TN0A 4UPHA 2GSNA 3LXQA 3UO0A 1ALJA 2ANHA 1ALKA 2X98A 3DYCA 1ED8A 1N2LA 1E2SP 4KJGA 2D1GA 3BDGA 3MK0A 5HRTA 3NKNA 5INHA 1ANIA 1O98A 4FDIA 4MIVA 4KAYA 3TWZA 3Q3QA 1KHKA 1SHQA 3B5QA 1FSUA 4LRBA 3T00A 4MY4A 1HJKA 2G9YA 1ANJA 3OT9A 4LQYA 3NVLA 2IUCB 3ED4A 3WAYA 1N2KA 3M8YA 5IJSA 1KH4A 4LR7A 2VQRA 4LRCA 4B56A 1E3CP 2GLQA 5EGHA 1URAA 3UN3A 2RH6A 2XR9A 1SHNA 4YR1A 2IFYA 1HDHA 2GSOA 3DPCA 4CXKA 5LRNA 1EI6A 4LRDA 5LRMA 4LREA 3SZZA 4KAVA 1KH5A 3NKOA 4FDJA 1Y7AA 4UPIA 3TX0A 5C66A 5DLWA 1URBA 1EW2A 2GSUA 1AJAA 2W5WA 2GA3A 3NKQA 2ZKTA 4MHXA 3WBHA 2QZUA 3TG0A 1E33P 1O99A 3M8ZA 1AJBA 4KM4A 1Y6VA 1ZEFA 4N7TA 5AJ9A 3IGZB 5DLTA 1HQAA 4UPLA 3UN5A 3T01A 1AJDA 4CYRA 1KHNA 3NKPA 1K7HA 1ED9A 1KHJA 4NWJA 3MK2A
chains in the Genus database with same CATH superfamily
1ZEDA 3NKMA 3A52A 2XRGA 4UORA 4ZG6A 3UN2A 1ELYA 1ALHA 4QAXA 4CXSA 5IJQA 2W5VA 1P49A 1EJJA 3BDGB 4UPKA 4CYSA 4UOOA 3IDDA 1ELZA 5KXAA 3T02A 5L0EA 5L0KA 2W5XA 1AJCA 4KJDA 4ZGAA 3BDFA 2W8DA 5GRRA 4LR2A 4GTXA 5TJ3A 1B8JA 4CXUA 2IUCA 5K4PA 3WAWA 5L0BA 1ZEBA 3NKRA 4LR9A 4LRAA 3WAXA 3E2DA 1E1ZP 5EGEA 5DLVA 3KD8A 4LRFA 2W5RA 5GOVA 1EW8A 1ALIA 2W5SA 1KH7A 3WAVA 1EW9A 1KHLA 4UOPA 3SZYA 3M8WA 4NWXA 1AUKA 5LIAA 4LR8A 3M7VA 1ELXA 2W5QA 3BDHA 4ZG9A 4ZG7A 1EQJA 3IGYB 3MK1A 3UNYA 4GTWA 5LQQA 3CMRA 2W5TA 4GTYA 4GTZA 2W8SA 1KH9A 4TN0A 4UPHA 2GSNA 3LXQA 3UO0A 1ALJA 2ANHA 1ALKA 2X98A 3DYCA 1ED8A 1N2LA 1E2SP 4KJGA 2D1GA 3BDGA 3MK0A 5HRTA 3NKNA 5INHA 1ANIA 1O98A 4FDIA 4MIVA 4KAYA 3TWZA 3Q3QA 1KHKA 1SHQA 3B5QA 1FSUA 4LRBA 3T00A 4MY4A 1HJKA 2G9YA 1ANJA 3OT9A 4LQYA 3NVLA 2IUCB 3ED4A 3WAYA 1N2KA 3M8YA 5IJSA 1KH4A 4LR7A 2VQRA 4LRCA 4B56A 1E3CP 2GLQA 5EGHA 1URAA 3UN3A 2RH6A 2XR9A 1SHNA 4YR1A 2IFYA 1HDHA 2GSOA 3DPCA 4CXKA 5LRNA 1EI6A 4LRDA 5LRMA 4LREA 3SZZA 4KAVA 1KH5A 3NKOA 4FDJA 1Y7AA 4UPIA 3TX0A 5C66A 5DLWA 1URBA 1EW2A 2GSUA 1AJAA 2W5WA 2GA3A 3NKQA 2ZKTA 4MHXA 3WBHA 2QZUA 3TG0A 1E33P 1O99A 3M8ZA 1AJBA 4KM4A 1Y6VA 1ZEFA 4N7TA 5AJ9A 3IGZB 5DLTA 1HQAA 4UPLA 3UN5A 3T01A 1AJDA 4CYRA 1KHNA 3NKPA 1K7HA 1ED9A 1KHJA 4NWJA 3MK2A
chains in the Genus database with same CATH topology
1ZEDA 3NKMA 3A52A 2XRGA 4UORA 4ZG6A 3UN2A 1ELYA 1ALHA 4QAXA 4CXSA 5IJQA 2W5VA 1P49A 1EJJA 3BDGB 4UPKA 4CYSA 4UOOA 3IDDA 1ELZA 5KXAA 3T02A 5L0EA 5L0KA 2W5XA 1AJCA 4KJDA 4ZGAA 3BDFA 2W8DA 5GRRA 4LR2A 4GTXA 5TJ3A 1B8JA 4CXUA 2IUCA 5K4PA 3WAWA 5L0BA 1ZEBA 3NKRA 4LR9A 4LRAA 3WAXA 3E2DA 1E1ZP 5EGEA 5DLVA 3KD8A 4LRFA 2W5RA 5GOVA 1EW8A 1ALIA 2W5SA 1KH7A 3WAVA 1EW9A 1KHLA 4UOPA 3SZYA 3M8WA 4NWXA 1AUKA 5LIAA 4LR8A 3M7VA 1ELXA 2W5QA 3BDHA 4ZG9A 4ZG7A 1EQJA 3IGYB 3MK1A 3UNYA 4GTWA 5LQQA 3CMRA 2W5TA 4GTYA 4GTZA 2W8SA 1KH9A 4TN0A 4UPHA 2GSNA 3LXQA 3UO0A 1ALJA 2ANHA 1ALKA 2X98A 3DYCA 1ED8A 1N2LA 1E2SP 4KJGA 2D1GA 3BDGA 3MK0A 5HRTA 3NKNA 5INHA 1ANIA 1O98A 4FDIA 4MIVA 4KAYA 3TWZA 3Q3QA 1KHKA 1SHQA 3B5QA 1FSUA 4LRBA 3T00A 4MY4A 1HJKA 2G9YA 1ANJA 3OT9A 4LQYA 3NVLA 2IUCB 3ED4A 3WAYA 1N2KA 3M8YA 5IJSA 1KH4A 4LR7A 2VQRA 4LRCA 4B56A 1E3CP 2GLQA 5EGHA 1URAA 3UN3A 2RH6A 2XR9A 1SHNA 4YR1A 2IFYA 1HDHA 2GSOA 3DPCA 4CXKA 5LRNA 1EI6A 4LRDA 5LRMA 4LREA 3SZZA 4KAVA 1KH5A 3NKOA 4FDJA 1Y7AA 4UPIA 3TX0A 5C66A 5DLWA 1URBA 1EW2A 2GSUA 1AJAA 2W5WA 2GA3A 3NKQA 2ZKTA 4MHXA 3WBHA 2QZUA 3TG0A 1E33P 1O99A 3M8ZA 1AJBA 4KM4A 1Y6VA 1ZEFA 4N7TA 5AJ9A 3IGZB 5DLTA 1HQAA 4UPLA 3UN5A 3T01A 1AJDA 4CYRA 1KHNA 3NKPA 1K7HA 1ED9A 1KHJA 4NWJA 3MK2A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1ZED A;  3NKM A;  3A52 A;  2XRG A;  4UOR A;  4ZG6 A;  3UN2 A;  1ELY A;  1ALH A;  4QAX A;  4CXS A;  5IJQ A;  2W5V A;  1P49 A;  1EJJ A;  3BDG B;  4UPK A;  4CYS A;  4UOO A;  3IDD A;  1ELZ A;  5KXA A;  3T02 A;  5L0E A;  5L0K A;  2W5X A;  1AJC A;  4KJD A;  4ZGA A;  3BDF A;  2W8D A;  5GRR A;  4LR2 A;  4GTX A;  5TJ3 A;  1B8J A;  4CXU A;  2IUC A;  5K4P A;  3WAW A;  5L0B A;  1ZEB A;  3NKR A;  4LR9 A;  4LRA A;  3WAX A;  3E2D A;  1E1Z P;  5EGE A;  5DLV A;  3KD8 A;  4LRF A;  2W5R A;  5GOV A;  1EW8 A;  1ALI A;  2W5S A;  1KH7 A;  3WAV A;  1EW9 A;  1KHL A;  4UOP A;  3SZY A;  3M8W A;  4NWX A;  1AUK A;  5LIA A;  4LR8 A;  3M7V A;  1ELX A;  2W5Q A;  3BDH A;  4ZG9 A;  4ZG7 A;  1EQJ A;  3IGY B;  3MK1 A;  3UNY A;  4GTW A;  5LQQ A;  3CMR A;  2W5T A;  4GTY A;  4GTZ A;  2W8S A;  1KH9 A;  4TN0 A;  4UPH A;  2GSN A;  3LXQ A;  3UO0 A;  1ALJ A;  2ANH A;  1ALK A;  2X98 A;  3DYC A;  1ED8 A;  1N2L A;  1E2S P;  4KJG A;  2D1G A;  3BDG A;  3MK0 A;  5HRT A;  3NKN A;  5INH A;  1ANI A;  1O98 A;  4FDI A;  4MIV A;  4KAY A;  3TWZ A;  3Q3Q A;  1KHK A;  1SHQ A;  3B5Q A;  1FSU A;  4LRB A;  3T00 A;  4MY4 A;  1HJK A;  2G9Y A;  1ANJ A;  3OT9 A;  4LQY A;  3NVL A;  2IUC B;  3ED4 A;  3WAY A;  1N2K A;  3M8Y A;  5IJS A;  1KH4 A;  4LR7 A;  2VQR A;  4LRC A;  4B56 A;  1E3C P;  2GLQ A;  5EGH A;  1URA A;  3UN3 A;  2RH6 A;  2XR9 A;  1SHN A;  4YR1 A;  2IFY A;  1HDH A;  2GSO A;  3DPC A;  4CXK A;  5LRN A;  1EI6 A;  4LRD A;  5LRM A;  4LRE A;  3SZZ A;  4KAV A;  1KH5 A;  3NKO A;  4FDJ A;  1Y7A A;  4UPI A;  3TX0 A;  5C66 A;  5DLW A;  1URB A;  1EW2 A;  2GSU A;  1AJA A;  2W5W A;  2GA3 A;  3NKQ A;  2ZKT A;  4MHX A;  3WBH A;  2QZU A;  3TG0 A;  1E33 P;  1O99 A;  3M8Z A;  1AJB A;  4KM4 A;  1Y6V A;  1ZEF A;  4N7T A;  5AJ9 A;  3IGZ B;  5DLT A;  1HQA A;  4UPL A;  3UN5 A;  3T01 A;  1AJD A;  4CYR A;  1KHN A;  3NKP A;  1K7H A;  1ED9 A;  1KHJ A;  4NWJ A;  3MK2 A; 
#chains in the Genus database with same CATH topology
 1ZED A;  3NKM A;  3A52 A;  2XRG A;  4UOR A;  4ZG6 A;  3UN2 A;  1ELY A;  1ALH A;  4QAX A;  4CXS A;  5IJQ A;  2W5V A;  1P49 A;  1EJJ A;  3BDG B;  4UPK A;  4CYS A;  4UOO A;  3IDD A;  1ELZ A;  5KXA A;  3T02 A;  5L0E A;  5L0K A;  2W5X A;  1AJC A;  4KJD A;  4ZGA A;  3BDF A;  2W8D A;  5GRR A;  4LR2 A;  4GTX A;  5TJ3 A;  1B8J A;  4CXU A;  2IUC A;  5K4P A;  3WAW A;  5L0B A;  1ZEB A;  3NKR A;  4LR9 A;  4LRA A;  3WAX A;  3E2D A;  1E1Z P;  5EGE A;  5DLV A;  3KD8 A;  4LRF A;  2W5R A;  5GOV A;  1EW8 A;  1ALI A;  2W5S A;  1KH7 A;  3WAV A;  1EW9 A;  1KHL A;  4UOP A;  3SZY A;  3M8W A;  4NWX A;  1AUK A;  5LIA A;  4LR8 A;  3M7V A;  1ELX A;  2W5Q A;  3BDH A;  4ZG9 A;  4ZG7 A;  1EQJ A;  3IGY B;  3MK1 A;  3UNY A;  4GTW A;  5LQQ A;  3CMR A;  2W5T A;  4GTY A;  4GTZ A;  2W8S A;  1KH9 A;  4TN0 A;  4UPH A;  2GSN A;  3LXQ A;  3UO0 A;  1ALJ A;  2ANH A;  1ALK A;  2X98 A;  3DYC A;  1ED8 A;  1N2L A;  1E2S P;  4KJG A;  2D1G A;  3BDG A;  3MK0 A;  5HRT A;  3NKN A;  5INH A;  1ANI A;  1O98 A;  4FDI A;  4MIV A;  4KAY A;  3TWZ A;  3Q3Q A;  1KHK A;  1SHQ A;  3B5Q A;  1FSU A;  4LRB A;  3T00 A;  4MY4 A;  1HJK A;  2G9Y A;  1ANJ A;  3OT9 A;  4LQY A;  3NVL A;  2IUC B;  3ED4 A;  3WAY A;  1N2K A;  3M8Y A;  5IJS A;  1KH4 A;  4LR7 A;  2VQR A;  4LRC A;  4B56 A;  1E3C P;  2GLQ A;  5EGH A;  1URA A;  3UN3 A;  2RH6 A;  2XR9 A;  1SHN A;  4YR1 A;  2IFY A;  1HDH A;  2GSO A;  3DPC A;  4CXK A;  5LRN A;  1EI6 A;  4LRD A;  5LRM A;  4LRE A;  3SZZ A;  4KAV A;  1KH5 A;  3NKO A;  4FDJ A;  1Y7A A;  4UPI A;  3TX0 A;  5C66 A;  5DLW A;  1URB A;  1EW2 A;  2GSU A;  1AJA A;  2W5W A;  2GA3 A;  3NKQ A;  2ZKT A;  4MHX A;  3WBH A;  2QZU A;  3TG0 A;  1E33 P;  1O99 A;  3M8Z A;  1AJB A;  4KM4 A;  1Y6V A;  1ZEF A;  4N7T A;  5AJ9 A;  3IGZ B;  5DLT A;  1HQA A;  4UPL A;  3UN5 A;  3T01 A;  1AJD A;  4CYR A;  1KHN A;  3NKP A;  1K7H A;  1ED9 A;  1KHJ A;  4NWJ A;  3MK2 A; 
#chains in the Genus database with same CATH homology
 1ZED A;  3NKM A;  3A52 A;  2XRG A;  4UOR A;  4ZG6 A;  3UN2 A;  1ELY A;  1ALH A;  4QAX A;  4CXS A;  5IJQ A;  2W5V A;  1P49 A;  1EJJ A;  3BDG B;  4UPK A;  4CYS A;  4UOO A;  3IDD A;  1ELZ A;  5KXA A;  3T02 A;  5L0E A;  5L0K A;  2W5X A;  1AJC A;  4KJD A;  4ZGA A;  3BDF A;  2W8D A;  5GRR A;  4LR2 A;  4GTX A;  5TJ3 A;  1B8J A;  4CXU A;  2IUC A;  5K4P A;  3WAW A;  5L0B A;  1ZEB A;  3NKR A;  4LR9 A;  4LRA A;  3WAX A;  3E2D A;  1E1Z P;  5EGE A;  5DLV A;  3KD8 A;  4LRF A;  2W5R A;  5GOV A;  1EW8 A;  1ALI A;  2W5S A;  1KH7 A;  3WAV A;  1EW9 A;  1KHL A;  4UOP A;  3SZY A;  3M8W A;  4NWX A;  1AUK A;  5LIA A;  4LR8 A;  3M7V A;  1ELX A;  2W5Q A;  3BDH A;  4ZG9 A;  4ZG7 A;  1EQJ A;  3IGY B;  3MK1 A;  3UNY A;  4GTW A;  5LQQ A;  3CMR A;  2W5T A;  4GTY A;  4GTZ A;  2W8S A;  1KH9 A;  4TN0 A;  4UPH A;  2GSN A;  3LXQ A;  3UO0 A;  1ALJ A;  2ANH A;  1ALK A;  2X98 A;  3DYC A;  1ED8 A;  1N2L A;  1E2S P;  4KJG A;  2D1G A;  3BDG A;  3MK0 A;  5HRT A;  3NKN A;  5INH A;  1ANI A;  1O98 A;  4FDI A;  4MIV A;  4KAY A;  3TWZ A;  3Q3Q A;  1KHK A;  1SHQ A;  3B5Q A;  1FSU A;  4LRB A;  3T00 A;  4MY4 A;  1HJK A;  2G9Y A;  1ANJ A;  3OT9 A;  4LQY A;  3NVL A;  2IUC B;  3ED4 A;  3WAY A;  1N2K A;  3M8Y A;  5IJS A;  1KH4 A;  4LR7 A;  2VQR A;  4LRC A;  4B56 A;  1E3C P;  2GLQ A;  5EGH A;  1URA A;  3UN3 A;  2RH6 A;  2XR9 A;  1SHN A;  4YR1 A;  2IFY A;  1HDH A;  2GSO A;  3DPC A;  4CXK A;  5LRN A;  1EI6 A;  4LRD A;  5LRM A;  4LRE A;  3SZZ A;  4KAV A;  1KH5 A;  3NKO A;  4FDJ A;  1Y7A A;  4UPI A;  3TX0 A;  5C66 A;  5DLW A;  1URB A;  1EW2 A;  2GSU A;  1AJA A;  2W5W A;  2GA3 A;  3NKQ A;  2ZKT A;  4MHX A;  3WBH A;  2QZU A;  3TG0 A;  1E33 P;  1O99 A;  3M8Z A;  1AJB A;  4KM4 A;  1Y6V A;  1ZEF A;  4N7T A;  5AJ9 A;  3IGZ B;  5DLT A;  1HQA A;  4UPL A;  3UN5 A;  3T01 A;  1AJD A;  4CYR A;  1KHN A;  3NKP A;  1K7H A;  1ED9 A;  1KHJ A;  4NWJ A;  3MK2 A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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