1ZEFA

Structure of alkaline phosphatase from human placenta in complex with its uncompetitive inhibitor l-phe
Total Genus 176
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
176
Knots found
sequence length
481
structure length
480
Chain Sequence
IIPVEEENPDFWNREAAEALGAAKKLQPAQTAAKNLIIFLGDGMGVSTVTAARILKGQKKDKLGPEIPLAMDRFPYVALSKTYNVDKHVPDGATATAYLCGVKGNFQTIGLSAAARFNQCNTTRGNEVISVMNRAKKAGKSVGVVTTTRVQHASPAGTYAHTVNRNWYSDADVPASARQEGCQDIATQLISNMDIDVILGGGRKYMFRMGTPDPEYPDDYSQGGTRLDGKNLVQEWLAKRQGARYVWNRTELMQASLDPSVTHLMGLFEPGDMKYEIHRDSTLDPSLMEMTEAALRLLSRNPRGFFLFVEGGRIDHGHHESRAYRALTETIMFDDAIERAGQLTSEEDTLSLVTADHSHVFSFGGYPLRGSSIFGLAPGKARDRKAYTVLLYGNGPGYVLKDGARPDVTESESGSPEYRQQSAVPLDEETHAGEDVAVFARGPQAHLVHGVQEQTFIAHVMAFAACLEPYTACDLAPPAG
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

molecule tags Hydrolase
molecule keywords Alkaline phosphatase
publication title Structural Studies of Human Placental Alkaline Phosphatase in Complex with Functional Ligands.
pubmed doi rcsb
total genus 176
structure length 480
sequence length 481
other databases KnotProt 2.0: S +31
ec nomenclature ec 3.1.3.1: Alkaline phosphatase.
pdb deposition date 2005-04-18

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00245 Alk_phosphatase Alkaline phosphatase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.720.10 Alpha Beta 3-Layer(aba) Sandwich Alkaline Phosphatase, subunit A Alkaline Phosphatase, subunit A 1zefA00
4GTWA 4LRDA 5AJ9A 4ZG6A 1KHLA 1KH7A 3UNYA 3TX0A 1ALJA 1ELYA 4UPKA 3NKNA 4YR1A 4B56A 1ZEFA 2W8DA 3LXQA 2ZKTA 3BDGB 1O98A 4KM4A 2GLQA 1HQAA 2IUCA 3IGYB 3T00A 4NWJA 5GRRA 4KJGA 3NKPA 3NKMA 4LR7A 4LREA 2D1GA 3BDHA 3UN2A 3WAVA 3UO0A 1ANJA 5L0EA 2ANHA 1AJBA 1HJKA 1KH4A 1SHQA 1URBA 3M8YA 3MK2A 1ZEDA 4LRBA 5LRNA 1Y6VA 1E33P 5IJSA 3WBHA 1AUKA 4UPHA 4UOPA 4LRFA 2XR9A 4KAYA 3E2DA 2W5SA 3Q3QA 2W5XA 5DLWA 3NKOA 3T01A 1KHNA 1N2KA 4LRCA 3B5QA 2IUCB 1ALHA 1FSUA 2IFYA 3TWZA 1AJAA 1URAA 1ZEBA 4ZG9A 2W8SA 4MIVA 4CXSA 1EW8A 3NKQA 3KD8A 1E2SP 1ELXA 4MY4A 3NVLA 1EW2A 5C66A 5LQQA 4KAVA 1HDHA 1ALIA 3UN3A 2XRGA 5GOVA 3OT9A 2W5TA 3SZZA 5IJQA 3TG0A 3T02A 5L0KA 3IDDA 1KH5A 1Y7AA 3BDFA 3WAWA 1K7HA 2GSUA 1AJDA 2QZUA 5DLVA 1ALKA 1O99A 3MK1A 1ED9A 4TN0A 3M7VA 3M8ZA 5LIAA 4LQYA 5L0BA 4FDIA 3IGZB 4UOOA 4GTZA 2G9YA 1ELZA 1E3CP 5LRMA 5TJ3A 2W5WA 2RH6A 4UPLA 4UORA 4MHXA 1EQJA 4CXUA 4ZG7A 1P49A 4UPIA 1EW9A 3A52A 5K4PA 2X98A 4CXKA 1B8JA 3UN5A 2W5VA 3DPCA 2W5QA 4LR9A 5KXAA 3ED4A 3WAXA 3CMRA 5EGEA 4CYRA 1EI6A 3DYCA 1N2LA 4KJDA 1SHNA 5DLTA 3BDGA 4LR2A 4CYSA 2GSNA 3NKRA 4FDJA 5INHA 1EJJA 1KHJA 1E1ZP 3M8WA 4LR8A 1ANIA 5HRTA 1AJCA 3SZYA 3WAYA 4ZGAA 2GA3A 3MK0A 4NWXA 5EGHA 4GTXA 4LRAA 1KHKA 4QAXA 2VQRA 1KH9A 4GTYA 1ED8A 2W5RA 2GSOA 4N7TA
chains in the Genus database with same CATH superfamily
4GTWA 4LRDA 5AJ9A 4ZG6A 1KHLA 1KH7A 3UNYA 3TX0A 1ALJA 1ELYA 4UPKA 3NKNA 4YR1A 4B56A 1ZEFA 2W8DA 3LXQA 2ZKTA 3BDGB 1O98A 4KM4A 2GLQA 1HQAA 2IUCA 3IGYB 3T00A 4NWJA 5GRRA 4KJGA 3NKPA 3NKMA 4LR7A 4LREA 2D1GA 3BDHA 3UN2A 3WAVA 3UO0A 1ANJA 5L0EA 2ANHA 1AJBA 1HJKA 1KH4A 1SHQA 1URBA 3M8YA 3MK2A 1ZEDA 4LRBA 5LRNA 1Y6VA 1E33P 5IJSA 3WBHA 1AUKA 4UPHA 4UOPA 4LRFA 2XR9A 4KAYA 3E2DA 2W5SA 3Q3QA 2W5XA 5DLWA 3NKOA 3T01A 1KHNA 1N2KA 4LRCA 3B5QA 2IUCB 1ALHA 1FSUA 2IFYA 3TWZA 1AJAA 1URAA 1ZEBA 4ZG9A 2W8SA 4MIVA 4CXSA 1EW8A 3NKQA 3KD8A 1E2SP 1ELXA 4MY4A 3NVLA 1EW2A 5C66A 5LQQA 4KAVA 1HDHA 1ALIA 3UN3A 2XRGA 5GOVA 3OT9A 2W5TA 3SZZA 5IJQA 3TG0A 3T02A 5L0KA 3IDDA 1KH5A 1Y7AA 3BDFA 3WAWA 1K7HA 2GSUA 1AJDA 2QZUA 5DLVA 1ALKA 1O99A 3MK1A 1ED9A 4TN0A 3M7VA 3M8ZA 5LIAA 4LQYA 5L0BA 4FDIA 3IGZB 4UOOA 4GTZA 2G9YA 1ELZA 1E3CP 5LRMA 5TJ3A 2W5WA 2RH6A 4UPLA 4UORA 4MHXA 1EQJA 4CXUA 4ZG7A 1P49A 4UPIA 1EW9A 3A52A 5K4PA 2X98A 4CXKA 1B8JA 3UN5A 2W5VA 3DPCA 2W5QA 4LR9A 5KXAA 3ED4A 3WAXA 3CMRA 5EGEA 4CYRA 1EI6A 3DYCA 1N2LA 4KJDA 1SHNA 5DLTA 3BDGA 4LR2A 4CYSA 2GSNA 3NKRA 4FDJA 5INHA 1EJJA 1KHJA 1E1ZP 3M8WA 4LR8A 1ANIA 5HRTA 1AJCA 3SZYA 3WAYA 4ZGAA 2GA3A 3MK0A 4NWXA 5EGHA 4GTXA 4LRAA 1KHKA 4QAXA 2VQRA 1KH9A 4GTYA 1ED8A 2W5RA 2GSOA 4N7TA
chains in the Genus database with same CATH topology
4GTWA 4LRDA 5AJ9A 4ZG6A 1KHLA 1KH7A 3UNYA 3TX0A 1ALJA 1ELYA 4UPKA 3NKNA 4YR1A 4B56A 1ZEFA 2W8DA 3LXQA 2ZKTA 3BDGB 1O98A 4KM4A 2GLQA 1HQAA 2IUCA 3IGYB 3T00A 4NWJA 5GRRA 4KJGA 3NKPA 3NKMA 4LR7A 4LREA 2D1GA 3BDHA 3UN2A 3WAVA 3UO0A 1ANJA 5L0EA 2ANHA 1AJBA 1HJKA 1KH4A 1SHQA 1URBA 3M8YA 3MK2A 1ZEDA 4LRBA 5LRNA 1Y6VA 1E33P 5IJSA 3WBHA 1AUKA 4UPHA 4UOPA 4LRFA 2XR9A 4KAYA 3E2DA 2W5SA 3Q3QA 2W5XA 5DLWA 3NKOA 3T01A 1KHNA 1N2KA 4LRCA 3B5QA 2IUCB 1ALHA 1FSUA 2IFYA 3TWZA 1AJAA 1URAA 1ZEBA 4ZG9A 2W8SA 4MIVA 4CXSA 1EW8A 3NKQA 3KD8A 1E2SP 1ELXA 4MY4A 3NVLA 1EW2A 5C66A 5LQQA 4KAVA 1HDHA 1ALIA 3UN3A 2XRGA 5GOVA 3OT9A 2W5TA 3SZZA 5IJQA 3TG0A 3T02A 5L0KA 3IDDA 1KH5A 1Y7AA 3BDFA 3WAWA 1K7HA 2GSUA 1AJDA 2QZUA 5DLVA 1ALKA 1O99A 3MK1A 1ED9A 4TN0A 3M7VA 3M8ZA 5LIAA 4LQYA 5L0BA 4FDIA 3IGZB 4UOOA 4GTZA 2G9YA 1ELZA 1E3CP 5LRMA 5TJ3A 2W5WA 2RH6A 4UPLA 4UORA 4MHXA 1EQJA 4CXUA 4ZG7A 1P49A 4UPIA 1EW9A 3A52A 5K4PA 2X98A 4CXKA 1B8JA 3UN5A 2W5VA 3DPCA 2W5QA 4LR9A 5KXAA 3ED4A 3WAXA 3CMRA 5EGEA 4CYRA 1EI6A 3DYCA 1N2LA 4KJDA 1SHNA 5DLTA 3BDGA 4LR2A 4CYSA 2GSNA 3NKRA 4FDJA 5INHA 1EJJA 1KHJA 1E1ZP 3M8WA 4LR8A 1ANIA 5HRTA 1AJCA 3SZYA 3WAYA 4ZGAA 2GA3A 3MK0A 4NWXA 5EGHA 4GTXA 4LRAA 1KHKA 4QAXA 2VQRA 1KH9A 4GTYA 1ED8A 2W5RA 2GSOA 4N7TA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4GTW A;  4LRD A;  5AJ9 A;  4ZG6 A;  1KHL A;  1KH7 A;  3UNY A;  3TX0 A;  1ALJ A;  1ELY A;  4UPK A;  3NKN A;  4YR1 A;  4B56 A;  1ZEF A;  2W8D A;  3LXQ A;  2ZKT A;  3BDG B;  1O98 A;  4KM4 A;  2GLQ A;  1HQA A;  2IUC A;  3IGY B;  3T00 A;  4NWJ A;  5GRR A;  4KJG A;  3NKP A;  3NKM A;  4LR7 A;  4LRE A;  2D1G A;  3BDH A;  3UN2 A;  3WAV A;  3UO0 A;  1ANJ A;  5L0E A;  2ANH A;  1AJB A;  1HJK A;  1KH4 A;  1SHQ A;  1URB A;  3M8Y A;  3MK2 A;  1ZED A;  4LRB A;  5LRN A;  1Y6V A;  1E33 P;  5IJS A;  3WBH A;  1AUK A;  4UPH A;  4UOP A;  4LRF A;  2XR9 A;  4KAY A;  3E2D A;  2W5S A;  3Q3Q A;  2W5X A;  5DLW A;  3NKO A;  3T01 A;  1KHN A;  1N2K A;  4LRC A;  3B5Q A;  2IUC B;  1ALH A;  1FSU A;  2IFY A;  3TWZ A;  1AJA A;  1URA A;  1ZEB A;  4ZG9 A;  2W8S A;  4MIV A;  4CXS A;  1EW8 A;  3NKQ A;  3KD8 A;  1E2S P;  1ELX A;  4MY4 A;  3NVL A;  1EW2 A;  5C66 A;  5LQQ A;  4KAV A;  1HDH A;  1ALI A;  3UN3 A;  2XRG A;  5GOV A;  3OT9 A;  2W5T A;  3SZZ A;  5IJQ A;  3TG0 A;  3T02 A;  5L0K A;  3IDD A;  1KH5 A;  1Y7A A;  3BDF A;  3WAW A;  1K7H A;  2GSU A;  1AJD A;  2QZU A;  5DLV A;  1ALK A;  1O99 A;  3MK1 A;  1ED9 A;  4TN0 A;  3M7V A;  3M8Z A;  5LIA A;  4LQY A;  5L0B A;  4FDI A;  3IGZ B;  4UOO A;  4GTZ A;  2G9Y A;  1ELZ A;  1E3C P;  5LRM A;  5TJ3 A;  2W5W A;  2RH6 A;  4UPL A;  4UOR A;  4MHX A;  1EQJ A;  4CXU A;  4ZG7 A;  1P49 A;  4UPI A;  1EW9 A;  3A52 A;  5K4P A;  2X98 A;  4CXK A;  1B8J A;  3UN5 A;  2W5V A;  3DPC A;  2W5Q A;  4LR9 A;  5KXA A;  3ED4 A;  3WAX A;  3CMR A;  5EGE A;  4CYR A;  1EI6 A;  3DYC A;  1N2L A;  4KJD A;  1SHN A;  5DLT A;  3BDG A;  4LR2 A;  4CYS A;  2GSN A;  3NKR A;  4FDJ A;  5INH A;  1EJJ A;  1KHJ A;  1E1Z P;  3M8W A;  4LR8 A;  1ANI A;  5HRT A;  1AJC A;  3SZY A;  3WAY A;  4ZGA A;  2GA3 A;  3MK0 A;  4NWX A;  5EGH A;  4GTX A;  4LRA A;  1KHK A;  4QAX A;  2VQR A;  1KH9 A;  4GTY A;  1ED8 A;  2W5R A;  2GSO A;  4N7T A; 
#chains in the Genus database with same CATH topology
 4GTW A;  4LRD A;  5AJ9 A;  4ZG6 A;  1KHL A;  1KH7 A;  3UNY A;  3TX0 A;  1ALJ A;  1ELY A;  4UPK A;  3NKN A;  4YR1 A;  4B56 A;  1ZEF A;  2W8D A;  3LXQ A;  2ZKT A;  3BDG B;  1O98 A;  4KM4 A;  2GLQ A;  1HQA A;  2IUC A;  3IGY B;  3T00 A;  4NWJ A;  5GRR A;  4KJG A;  3NKP A;  3NKM A;  4LR7 A;  4LRE A;  2D1G A;  3BDH A;  3UN2 A;  3WAV A;  3UO0 A;  1ANJ A;  5L0E A;  2ANH A;  1AJB A;  1HJK A;  1KH4 A;  1SHQ A;  1URB A;  3M8Y A;  3MK2 A;  1ZED A;  4LRB A;  5LRN A;  1Y6V A;  1E33 P;  5IJS A;  3WBH A;  1AUK A;  4UPH A;  4UOP A;  4LRF A;  2XR9 A;  4KAY A;  3E2D A;  2W5S A;  3Q3Q A;  2W5X A;  5DLW A;  3NKO A;  3T01 A;  1KHN A;  1N2K A;  4LRC A;  3B5Q A;  2IUC B;  1ALH A;  1FSU A;  2IFY A;  3TWZ A;  1AJA A;  1URA A;  1ZEB A;  4ZG9 A;  2W8S A;  4MIV A;  4CXS A;  1EW8 A;  3NKQ A;  3KD8 A;  1E2S P;  1ELX A;  4MY4 A;  3NVL A;  1EW2 A;  5C66 A;  5LQQ A;  4KAV A;  1HDH A;  1ALI A;  3UN3 A;  2XRG A;  5GOV A;  3OT9 A;  2W5T A;  3SZZ A;  5IJQ A;  3TG0 A;  3T02 A;  5L0K A;  3IDD A;  1KH5 A;  1Y7A A;  3BDF A;  3WAW A;  1K7H A;  2GSU A;  1AJD A;  2QZU A;  5DLV A;  1ALK A;  1O99 A;  3MK1 A;  1ED9 A;  4TN0 A;  3M7V A;  3M8Z A;  5LIA A;  4LQY A;  5L0B A;  4FDI A;  3IGZ B;  4UOO A;  4GTZ A;  2G9Y A;  1ELZ A;  1E3C P;  5LRM A;  5TJ3 A;  2W5W A;  2RH6 A;  4UPL A;  4UOR A;  4MHX A;  1EQJ A;  4CXU A;  4ZG7 A;  1P49 A;  4UPI A;  1EW9 A;  3A52 A;  5K4P A;  2X98 A;  4CXK A;  1B8J A;  3UN5 A;  2W5V A;  3DPC A;  2W5Q A;  4LR9 A;  5KXA A;  3ED4 A;  3WAX A;  3CMR A;  5EGE A;  4CYR A;  1EI6 A;  3DYC A;  1N2L A;  4KJD A;  1SHN A;  5DLT A;  3BDG A;  4LR2 A;  4CYS A;  2GSN A;  3NKR A;  4FDJ A;  5INH A;  1EJJ A;  1KHJ A;  1E1Z P;  3M8W A;  4LR8 A;  1ANI A;  5HRT A;  1AJC A;  3SZY A;  3WAY A;  4ZGA A;  2GA3 A;  3MK0 A;  4NWX A;  5EGH A;  4GTX A;  4LRA A;  1KHK A;  4QAX A;  2VQR A;  1KH9 A;  4GTY A;  1ED8 A;  2W5R A;  2GSO A;  4N7T A; 
#chains in the Genus database with same CATH homology
 4GTW A;  4LRD A;  5AJ9 A;  4ZG6 A;  1KHL A;  1KH7 A;  3UNY A;  3TX0 A;  1ALJ A;  1ELY A;  4UPK A;  3NKN A;  4YR1 A;  4B56 A;  1ZEF A;  2W8D A;  3LXQ A;  2ZKT A;  3BDG B;  1O98 A;  4KM4 A;  2GLQ A;  1HQA A;  2IUC A;  3IGY B;  3T00 A;  4NWJ A;  5GRR A;  4KJG A;  3NKP A;  3NKM A;  4LR7 A;  4LRE A;  2D1G A;  3BDH A;  3UN2 A;  3WAV A;  3UO0 A;  1ANJ A;  5L0E A;  2ANH A;  1AJB A;  1HJK A;  1KH4 A;  1SHQ A;  1URB A;  3M8Y A;  3MK2 A;  1ZED A;  4LRB A;  5LRN A;  1Y6V A;  1E33 P;  5IJS A;  3WBH A;  1AUK A;  4UPH A;  4UOP A;  4LRF A;  2XR9 A;  4KAY A;  3E2D A;  2W5S A;  3Q3Q A;  2W5X A;  5DLW A;  3NKO A;  3T01 A;  1KHN A;  1N2K A;  4LRC A;  3B5Q A;  2IUC B;  1ALH A;  1FSU A;  2IFY A;  3TWZ A;  1AJA A;  1URA A;  1ZEB A;  4ZG9 A;  2W8S A;  4MIV A;  4CXS A;  1EW8 A;  3NKQ A;  3KD8 A;  1E2S P;  1ELX A;  4MY4 A;  3NVL A;  1EW2 A;  5C66 A;  5LQQ A;  4KAV A;  1HDH A;  1ALI A;  3UN3 A;  2XRG A;  5GOV A;  3OT9 A;  2W5T A;  3SZZ A;  5IJQ A;  3TG0 A;  3T02 A;  5L0K A;  3IDD A;  1KH5 A;  1Y7A A;  3BDF A;  3WAW A;  1K7H A;  2GSU A;  1AJD A;  2QZU A;  5DLV A;  1ALK A;  1O99 A;  3MK1 A;  1ED9 A;  4TN0 A;  3M7V A;  3M8Z A;  5LIA A;  4LQY A;  5L0B A;  4FDI A;  3IGZ B;  4UOO A;  4GTZ A;  2G9Y A;  1ELZ A;  1E3C P;  5LRM A;  5TJ3 A;  2W5W A;  2RH6 A;  4UPL A;  4UOR A;  4MHX A;  1EQJ A;  4CXU A;  4ZG7 A;  1P49 A;  4UPI A;  1EW9 A;  3A52 A;  5K4P A;  2X98 A;  4CXK A;  1B8J A;  3UN5 A;  2W5V A;  3DPC A;  2W5Q A;  4LR9 A;  5KXA A;  3ED4 A;  3WAX A;  3CMR A;  5EGE A;  4CYR A;  1EI6 A;  3DYC A;  1N2L A;  4KJD A;  1SHN A;  5DLT A;  3BDG A;  4LR2 A;  4CYS A;  2GSN A;  3NKR A;  4FDJ A;  5INH A;  1EJJ A;  1KHJ A;  1E1Z P;  3M8W A;  4LR8 A;  1ANI A;  5HRT A;  1AJC A;  3SZY A;  3WAY A;  4ZGA A;  2GA3 A;  3MK0 A;  4NWX A;  5EGH A;  4GTX A;  4LRA A;  1KHK A;  4QAX A;  2VQR A;  1KH9 A;  4GTY A;  1ED8 A;  2W5R A;  2GSO A;  4N7T A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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