2ANTI

The 2.6 a structure of antithrombin indicates a conformational change at the heparin binding site
Total Genus 112
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
112
sequence length
432
structure length
419
Chain Sequence
HGSPVDICTAKPRDIPMNPMCIYRSPEKKATNRRVWELSKANSRFATTFYQHLADSKNDNDNIFLSPLSISTAFAMTKLGACNDTLQQLMEVFKFDTISEKTSDQIHFFFAKLNCRLYRKANKSSKLVSANRLFGDKSLTFNETYQDISELVYGAKLQPLDFKENAEQSRAAINKWVSNKTEGRITDVIPSEAINELTVLVLVNTIYFKGLWKSKFSPENTRKELFYKADGESCSASMMYQEGKFRYRRVAEGTQVLELPFKGDDITMVLILPKPEKSLAKVEKELTPEVLQEWLDELEEMMLVVHMPRFRIEDGFSLKEQLQDMGLVDLFSPEKSKLPGIVAEGRDDLYVSDAFHKAFLEVNEEGSEAAASTAVVIAGRSLNPNRVTFKANRPFLVFIREVPLNTIIFMGRVANPCVK
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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molecule tags Serpin
molecule keywords ANTITHROMBIN
publication title The 2.6 A structure of antithrombin indicates a conformational change at the heparin binding site.
pubmed doi rcsb
total genus 112
structure length 419
sequence length 432
chains with identical sequence L
ec nomenclature
pdb deposition date 1997-01-28

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
I PF00079 Serpin Serpin (serine protease inhibitor)
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.30.39.10 Mainly Beta Roll Alpha-1-antitrypsin; domain 1 Alpha-1-antitrypsin, domain 1 2antI01
3.30.497.10 Alpha Beta 2-Layer Sandwich Antithrombin; Chain I, domain 2 Antithrombin, subunit I, domain 2 2antI02
1XU8A 3CWMA 2PEEA 2H4QA 2WXWA 4GA7A 1QMNA 4Y3KA 4AU3A 1DZGL 5EI0A 1OPHA 2ANTI 5BRRI 4IC0A 1YXAA 3DRMA 2ARQA 1C5GA 1E04I 4AU3B 2BEHL 1DZHL 4RSQA 1OYHI 4C41A 2WY0C 4G8OA 2ARRA 2WY1A 2R9YA 2RIVA 4PYWA 1AZXI 1HP7A 1OO8A 2ZV6A 3Q02A 3Q03A 2XN6A 1SNGA 3EOXA 2H4PA 2V95A 8APIA 1A7CA 1LJ5A 5INWA 1DVMA 1R1LI 4ROBA 1SEKA 4IF8A 2WXZC 1DVNA 2B4XI 4AU4A 3VVJA 2QUGA 4DTEA 1IMVA 1OVAA 2D26A 3H5CA 4DY7C 7APIA 2WXXA 1E03I 3T1PA 1T1FA 1WZ9A 1QMBA 1PSIA 2XN3A 2VDXA 1BR8I 1IZ2A 1LQ8A 2OAYA 5CE0A 3B9FI 1OVAB 1M93B 3KCGI 1JJOC 3FGQA 3STOA 2VH4A 1UHGA 3NE4A 1ATUA 4EB1I 1DB2A 2B5TI 3PB1I 4ZK0A 1EZXA 4AFXA 3F5NA 3NDFA 4BB2A 2XN7A 1DZHI 4Y40A 3DY0A 1D5SA 3DLWA 1QLPA 4X30A 3R4LA 2ZNHA 4AJTA 1ANTI 2VDYA 1ATTA 2HIJI 4YIAA 1XQJA 1C8OA 3ZHAA 2WXYC 4RO9A 5IO1A 1K9OI 4CAAA 3UT3A 4R9IA 1OVAC 2B4XL 2GD4C 2H4RA 2CEOA 4AQHA 4AJUA 4G8RA 1DZGI 2HI9A 5CDZA 2OL2A 4ROAA 1B3KA 2WXZA 1OYHL 1BY7A 5HGCA 1JVQI 3OZQA 3LE2A 3F1SA 1E05I 2BEHI 9APIA 5CDXA 2ACHA 4ZK3A 4EB1L 1LK6I 1JMJA 2DUTA 3CAAA 2RIWA 3CWLA 3CVMA 9PAIA 1JMOA 5C98A 4P0OA 1MTPA 1SR5A 2XN5A 3PZFA 2PEFA 1AS4A 1JTIA 1NQ9I 1OC0A 1F0CA 3LW2A 1TB6I 3F02A 4C49A 2HIJL 3EVJI 3NDDA 1XQGA 3NDAA 1KCTA 1HLEA 4P0FA 4KDSA 1ATHA 1JRRA 3DRUA 4AU2A 4DY0A
chains in the Genus database with same CATH superfamily
1XU8A 3CWMA 2PEEA 2H4QA 2WXWA 4GA7A 1QMNA 4Y3KA 4AU3A 1DZGL 5EI0A 1OPHA 2ANTI 5BRRI 4IC0A 1YXAA 3DRMA 2ARQA 1C5GA 1E04I 4AU3B 2BEHL 1DZHL 4RSQA 1OYHI 4C41A 2WY0C 4G8OA 2ARRA 2WY1A 2R9YA 2RIVA 4PYWA 1AZXI 1HP7A 1OO8A 2ZV6A 3Q02A 3Q03A 2XN6A 1SNGA 3EOXA 2H4PA 2V95A 8APIA 1A7CA 1LJ5A 5INWA 1DVMA 1R1LI 4ROBA 1SEKA 4IF8A 2WXZC 1DVNA 2B4XI 4AU4A 3VVJA 2QUGA 4DTEA 1IMVA 1OVAA 2D26A 3H5CA 4DY7C 7APIA 2WXXA 1E03I 3T1PA 1T1FA 1WZ9A 1QMBA 1PSIA 2XN3A 2VDXA 1BR8I 1IZ2A 1LQ8A 2OAYA 5CE0A 3B9FI 1OVAB 1M93B 3KCGI 1JJOC 3FGQA 3STOA 2VH4A 1UHGA 3NE4A 1ATUA 4EB1I 1DB2A 2B5TI 3PB1I 4ZK0A 1EZXA 4AFXA 3F5NA 3NDFA 4BB2A 2XN7A 1DZHI 4Y40A 3DY0A 1D5SA 3DLWA 1QLPA 4X30A 3R4LA 2ZNHA 4AJTA 1ANTI 2VDYA 1ATTA 2HIJI 4YIAA 1XQJA 1C8OA 3ZHAA 2WXYC 4RO9A 5IO1A 1K9OI 4CAAA 3UT3A 4R9IA 1OVAC 2B4XL 2GD4C 2H4RA 2CEOA 4AQHA 4AJUA 4G8RA 1DZGI 2HI9A 5CDZA 2OL2A 4ROAA 1B3KA 2WXZA 1OYHL 1BY7A 5HGCA 1JVQI 3OZQA 3LE2A 3F1SA 1E05I 2BEHI 9APIA 5CDXA 2ACHA 4ZK3A 4EB1L 1LK6I 1JMJA 2DUTA 3CAAA 2RIWA 3CWLA 3CVMA 9PAIA 1JMOA 5C98A 4P0OA 1MTPA 1SR5A 2XN5A 3PZFA 2PEFA 1AS4A 1JTIA 1NQ9I 1OC0A 1F0CA 3LW2A 1TB6I 3F02A 4C49A 2HIJL 3EVJI 3NDDA 1XQGA 3NDAA 1KCTA 1HLEA 4P0FA 4KDSA 1ATHA 1JRRA 3DRUA 4AU2A 4DY0A
chains in the Genus database with same CATH topology
1XU8A 3CWMA 2PEEA 2H4QA 2WXWA 4GA7A 1QMNA 4Y3KA 4AU3A 1DZGL 5EI0A 1OPHA 2ANTI 5BRRI 4IC0A 1YXAA 3DRMA 2ARQA 1C5GA 1E04I 4AU3B 2BEHL 1DZHL 4RSQA 1OYHI 4C41A 2WY0C 4G8OA 2ARRA 2WY1A 2R9YA 2RIVA 4PYWA 1AZXI 1HP7A 1OO8A 2ZV6A 3Q02A 3Q03A 2XN6A 1SNGA 3EOXA 2H4PA 2V95A 8APIA 1A7CA 1LJ5A 5INWA 1DVMA 1R1LI 4ROBA 1SEKA 4IF8A 2WXZC 1DVNA 2B4XI 4AU4A 3VVJA 2QUGA 4DTEA 1IMVA 1OVAA 2D26A 3H5CA 4DY7C 7APIA 2WXXA 1E03I 3T1PA 1T1FA 1WZ9A 1QMBA 1PSIA 2XN3A 2VDXA 1BR8I 1IZ2A 1LQ8A 2OAYA 5CE0A 3B9FI 1OVAB 1M93B 3KCGI 1JJOC 3FGQA 3STOA 2VH4A 1UHGA 3NE4A 1ATUA 4EB1I 1DB2A 2B5TI 3PB1I 4ZK0A 1EZXA 4AFXA 3F5NA 3NDFA 4BB2A 2XN7A 1DZHI 4Y40A 3DY0A 1D5SA 3DLWA 1QLPA 4X30A 3R4LA 2ZNHA 4AJTA 1ANTI 2VDYA 1ATTA 2HIJI 4YIAA 1XQJA 1C8OA 3ZHAA 2WXYC 4RO9A 5IO1A 1K9OI 4CAAA 3UT3A 4R9IA 1OVAC 2B4XL 2GD4C 2H4RA 2CEOA 4AQHA 4AJUA 4G8RA 1DZGI 2HI9A 5CDZA 2OL2A 4ROAA 1B3KA 2WXZA 1OYHL 1BY7A 5HGCA 1JVQI 3OZQA 3LE2A 3F1SA 1E05I 2BEHI 9APIA 5CDXA 2ACHA 4ZK3A 4EB1L 1LK6I 1JMJA 2DUTA 3CAAA 2RIWA 3CWLA 3CVMA 9PAIA 1JMOA 5C98A 4P0OA 1MTPA 1SR5A 2XN5A 3PZFA 2PEFA 1AS4A 1JTIA 1NQ9I 1OC0A 1F0CA 3LW2A 1TB6I 3F02A 4C49A 2HIJL 3EVJI 3NDDA 1XQGA 3NDAA 1KCTA 1HLEA 4P0FA 4KDSA 1ATHA 1JRRA 3DRUA 4AU2A 4DY0A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1XU8 A;  3CWM A;  2PEE A;  2H4Q A;  2WXW A;  4GA7 A;  1QMN A;  4Y3K A;  4AU3 A;  1DZG L;  5EI0 A;  1OPH A;  2ANT I;  5BRR I;  4IC0 A;  1YXA A;  3DRM A;  2ARQ A;  1C5G A;  1E04 I;  4AU3 B;  2BEH L;  1DZH L;  4RSQ A;  1OYH I;  4C41 A;  2WY0 C;  4G8O A;  2ARR A;  2WY1 A;  2R9Y A;  2RIV A;  4PYW A;  1AZX I;  1HP7 A;  1OO8 A;  2ZV6 A;  3Q02 A;  3Q03 A;  2XN6 A;  1SNG A;  3EOX A;  2H4P A;  2V95 A;  8API A;  1A7C A;  1LJ5 A;  5INW A;  1DVM A;  1R1L I;  4ROB A;  1SEK A;  4IF8 A;  2WXZ C;  1DVN A;  2B4X I;  4AU4 A;  3VVJ A;  2QUG A;  4DTE A;  1IMV A;  1OVA A;  2D26 A;  3H5C A;  4DY7 C;  7API A;  2WXX A;  1E03 I;  3T1P A;  1T1F A;  1WZ9 A;  1QMB A;  1PSI A;  2XN3 A;  2VDX A;  1BR8 I;  1IZ2 A;  1LQ8 A;  2OAY A;  5CE0 A;  3B9F I;  1OVA B;  1M93 B;  3KCG I;  1JJO C;  3FGQ A;  3STO A;  2VH4 A;  1UHG A;  3NE4 A;  1ATU A;  4EB1 I;  1DB2 A;  2B5T I;  3PB1 I;  4ZK0 A;  1EZX A;  4AFX A;  3F5N A;  3NDF A;  4BB2 A;  2XN7 A;  1DZH I;  4Y40 A;  3DY0 A;  1D5S A;  3DLW A;  1QLP A;  4X30 A;  3R4L A;  2ZNH A;  4AJT A;  1ANT I;  2VDY A;  1ATT A;  2HIJ I;  4YIA A;  1XQJ A;  1C8O A;  3ZHA A;  2WXY C;  4RO9 A;  5IO1 A;  1K9O I;  4CAA A;  3UT3 A;  4R9I A;  1OVA C;  2B4X L;  2GD4 C;  2H4R A;  2CEO A;  4AQH A;  4AJU A;  4G8R A;  1DZG I;  2HI9 A;  5CDZ A;  2OL2 A;  4ROA A;  1B3K A;  2WXZ A;  1OYH L;  1BY7 A;  5HGC A;  1JVQ I;  3OZQ A;  3LE2 A;  3F1S A;  1E05 I;  2BEH I;  9API A;  5CDX A;  2ACH A;  4ZK3 A;  4EB1 L;  1LK6 I;  1JMJ A;  2DUT A;  3CAA A;  2RIW A;  3CWL A;  3CVM A;  9PAI A;  1JMO A;  5C98 A;  4P0O A;  1MTP A;  1SR5 A;  2XN5 A;  3PZF A;  2PEF A;  1AS4 A;  1JTI A;  1NQ9 I;  1OC0 A;  1F0C A;  3LW2 A;  1TB6 I;  3F02 A;  4C49 A;  2HIJ L;  3EVJ I;  3NDD A;  1XQG A;  3NDA A;  1KCT A;  1HLE A;  4P0F A;  4KDS A;  1ATH A;  1JRR A;  3DRU A;  4AU2 A;  4DY0 A; 
#chains in the Genus database with same CATH topology
 1XU8 A;  3CWM A;  2PEE A;  2H4Q A;  2WXW A;  4GA7 A;  1QMN A;  4Y3K A;  4AU3 A;  1DZG L;  5EI0 A;  1OPH A;  2ANT I;  5BRR I;  4IC0 A;  1YXA A;  3DRM A;  2ARQ A;  1C5G A;  1E04 I;  4AU3 B;  2BEH L;  1DZH L;  4RSQ A;  1OYH I;  4C41 A;  2WY0 C;  4G8O A;  2ARR A;  2WY1 A;  2R9Y A;  2RIV A;  4PYW A;  1AZX I;  1HP7 A;  1OO8 A;  2ZV6 A;  3Q02 A;  3Q03 A;  2XN6 A;  1SNG A;  3EOX A;  2H4P A;  2V95 A;  8API A;  1A7C A;  1LJ5 A;  5INW A;  1DVM A;  1R1L I;  4ROB A;  1SEK A;  4IF8 A;  2WXZ C;  1DVN A;  2B4X I;  4AU4 A;  3VVJ A;  2QUG A;  4DTE A;  1IMV A;  1OVA A;  2D26 A;  3H5C A;  4DY7 C;  7API A;  2WXX A;  1E03 I;  3T1P A;  1T1F A;  1WZ9 A;  1QMB A;  1PSI A;  2XN3 A;  2VDX A;  1BR8 I;  1IZ2 A;  1LQ8 A;  2OAY A;  5CE0 A;  3B9F I;  1OVA B;  1M93 B;  3KCG I;  1JJO C;  3FGQ A;  3STO A;  2VH4 A;  1UHG A;  3NE4 A;  1ATU A;  4EB1 I;  1DB2 A;  2B5T I;  3PB1 I;  4ZK0 A;  1EZX A;  4AFX A;  3F5N A;  3NDF A;  4BB2 A;  2XN7 A;  1DZH I;  4Y40 A;  3DY0 A;  1D5S A;  3DLW A;  1QLP A;  4X30 A;  3R4L A;  2ZNH A;  4AJT A;  1ANT I;  2VDY A;  1ATT A;  2HIJ I;  4YIA A;  1XQJ A;  1C8O A;  3ZHA A;  2WXY C;  4RO9 A;  5IO1 A;  1K9O I;  4CAA A;  3UT3 A;  4R9I A;  1OVA C;  2B4X L;  2GD4 C;  2H4R A;  2CEO A;  4AQH A;  4AJU A;  4G8R A;  1DZG I;  2HI9 A;  5CDZ A;  2OL2 A;  4ROA A;  1B3K A;  2WXZ A;  1OYH L;  1BY7 A;  5HGC A;  1JVQ I;  3OZQ A;  3LE2 A;  3F1S A;  1E05 I;  2BEH I;  9API A;  5CDX A;  2ACH A;  4ZK3 A;  4EB1 L;  1LK6 I;  1JMJ A;  2DUT A;  3CAA A;  2RIW A;  3CWL A;  3CVM A;  9PAI A;  1JMO A;  5C98 A;  4P0O A;  1MTP A;  1SR5 A;  2XN5 A;  3PZF A;  2PEF A;  1AS4 A;  1JTI A;  1NQ9 I;  1OC0 A;  1F0C A;  3LW2 A;  1TB6 I;  3F02 A;  4C49 A;  2HIJ L;  3EVJ I;  3NDD A;  1XQG A;  3NDA A;  1KCT A;  1HLE A;  4P0F A;  4KDS A;  1ATH A;  1JRR A;  3DRU A;  4AU2 A;  4DY0 A; 
#chains in the Genus database with same CATH homology
 1XU8 A;  3CWM A;  2PEE A;  2H4Q A;  2WXW A;  4GA7 A;  1QMN A;  4Y3K A;  4AU3 A;  1DZG L;  5EI0 A;  1OPH A;  2ANT I;  5BRR I;  4IC0 A;  1YXA A;  3DRM A;  2ARQ A;  1C5G A;  1E04 I;  4AU3 B;  2BEH L;  1DZH L;  4RSQ A;  1OYH I;  4C41 A;  2WY0 C;  4G8O A;  2ARR A;  2WY1 A;  2R9Y A;  2RIV A;  4PYW A;  1AZX I;  1HP7 A;  1OO8 A;  2ZV6 A;  3Q02 A;  3Q03 A;  2XN6 A;  1SNG A;  3EOX A;  2H4P A;  2V95 A;  8API A;  1A7C A;  1LJ5 A;  5INW A;  1DVM A;  1R1L I;  4ROB A;  1SEK A;  4IF8 A;  2WXZ C;  1DVN A;  2B4X I;  4AU4 A;  3VVJ A;  2QUG A;  4DTE A;  1IMV A;  1OVA A;  2D26 A;  3H5C A;  4DY7 C;  7API A;  2WXX A;  1E03 I;  3T1P A;  1T1F A;  1WZ9 A;  1QMB A;  1PSI A;  2XN3 A;  2VDX A;  1BR8 I;  1IZ2 A;  1LQ8 A;  2OAY A;  5CE0 A;  3B9F I;  1OVA B;  1M93 B;  3KCG I;  1JJO C;  3FGQ A;  3STO A;  2VH4 A;  1UHG A;  3NE4 A;  1ATU A;  4EB1 I;  1DB2 A;  2B5T I;  3PB1 I;  4ZK0 A;  1EZX A;  4AFX A;  3F5N A;  3NDF A;  4BB2 A;  2XN7 A;  1DZH I;  4Y40 A;  3DY0 A;  1D5S A;  3DLW A;  1QLP A;  4X30 A;  3R4L A;  2ZNH A;  4AJT A;  1ANT I;  2VDY A;  1ATT A;  2HIJ I;  4YIA A;  1XQJ A;  1C8O A;  3ZHA A;  2WXY C;  4RO9 A;  5IO1 A;  1K9O I;  4CAA A;  3UT3 A;  4R9I A;  1OVA C;  2B4X L;  2GD4 C;  2H4R A;  2CEO A;  4AQH A;  4AJU A;  4G8R A;  1DZG I;  2HI9 A;  5CDZ A;  2OL2 A;  4ROA A;  1B3K A;  2WXZ A;  1OYH L;  1BY7 A;  5HGC A;  1JVQ I;  3OZQ A;  3LE2 A;  3F1S A;  1E05 I;  2BEH I;  9API A;  5CDX A;  2ACH A;  4ZK3 A;  4EB1 L;  1LK6 I;  1JMJ A;  2DUT A;  3CAA A;  2RIW A;  3CWL A;  3CVM A;  9PAI A;  1JMO A;  5C98 A;  4P0O A;  1MTP A;  1SR5 A;  2XN5 A;  3PZF A;  2PEF A;  1AS4 A;  1JTI A;  1NQ9 I;  1OC0 A;  1F0C A;  3LW2 A;  1TB6 I;  3F02 A;  4C49 A;  2HIJ L;  3EVJ I;  3NDD A;  1XQG A;  3NDA A;  1KCT A;  1HLE A;  4P0F A;  4KDS A;  1ATH A;  1JRR A;  3DRU A;  4AU2 A;  4DY0 A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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