2D26A

Active site distortion is sufficient for proteinase inhibit second crystal structure of covalent serpin-proteinase complex
Total Genus 58
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
58
sequence length
336
structure length
336
Chain Sequence
FNKITPNLAEFAFSLYRQLAHQSNSTNILFSPVSIAAAFAMLSLGAKGDTHDEILEGLNFNLTEIPEAQIHEGFQELLHTLNQPDSQLQLTTGNGLFLSEGLKLVDKFLEDVKKLYHSEAFTVNFGDTEEAKKQINDYVEKGTQGKIVDLVKELDRDTVFALVNYIFFKGKWERPFEVKDTEEEDFHVDQVTTVKVPMMKRLGMFNIQHSKKLSSWVLLMKYLGNATAIFFLPDEGKLQHLENELTHDIITKFLENEDRRSASLHLPKLSITGTYDLKSVLGQLGITKVFSNGADLSGVTEEAPLKLSKAVHKAVLTIDEKGTEAAGAMFLEAIPM
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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molecule tags Hydrolase/hydrolase inhibitor
molecule keywords Alpha-1-antitrypsin
publication title Active Site Distortion Is Sufficient for Proteinase Inhibition by Serpins: Structure of the covalent complex of alpha 1-proteinase inhibitor with porcine pancreatic elastase
pubmed doi rcsb
source organism Homo sapiens
total genus 58
structure length 336
sequence length 336
ec nomenclature
pdb deposition date 2005-09-03
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.30.39.10 Mainly Beta Roll Alpha-1-antitrypsin; domain 1 Alpha-1-antitrypsin, domain 1 2d26A02
3.30.497.10 Alpha Beta 2-Layer Sandwich Antithrombin; Chain I, domain 2 Antithrombin, subunit I, domain 2 2d26A01
1XQGA 4G8OA 1DVNA 2V95A 1B3KA 1F0CA 1UHGA 3ZHAA 1ATTA 4C49A 4R9IA 3PB1I 4DY0A 4AU3A 4AU3B 3T1PA 3DY0A 1JRRA 3DRUA 4AFXA 3F02A 3CWLA 3CVMA 1OVAA 2R9YA 2WXZC 2H4RA 5BRRI 1LQ8A 1QMBA 2RIVA 3OZQA 1JMOA 1IMVA 3FGQA 7APIA 1D5SA 1AZXI 1SEKA 1NQ9I 4G8RA 2OAYA 4YIAA 2GD4C 1DVMA 2D26A 2ACHA 2WXXA 3Q02A 2VDXA 1JVQI 1R1LI 2PEFA 1C5GA 2B4XL 8APIA 1YXAA 1EZXA 1DZGI 1HP7A 2B4XI 1ATUA 4C41A 3CWMA 2WY0C 4P0OA 1XQJA 1BY7A 4CAAA 3F1SA 2OL2A 3STOA 1HLEA 2PEEA 3NDAA 4KDSA 4Y3KA 3LW2A 5HGCA 5C98A 2WXWA 2XN5A 2XN6A 1M93B 3LE2A 2BEHL 2HI9A 3DLWA 2BEHI 5IO1A 2DUTA 1SNGA 2ZNHA 3EOXA 4AQHA 1A7CA 1WZ9A 3Q03A 4EB1L 1DZGL 1QLPA 4BB2A 1LK6I 3EVJI 4EB1I 4RO9A 1OVAC 5CE0A 2B5TI 9APIA 2XN3A 1K9OI 1JMJA 2ARRA 3KCGI 4PYWA 4DTEA 1ATHA 1DB2A 3DRMA 1JJOC 1KCTA 3H5CA 5CDZA 2ARQA 1SR5A 2H4QA 3R4LA 4ROAA 1OYHL 3NDFA 1OYHI 4IC0A 3NE4A 4Y40A 1MTPA 1C8OA 2CEOA 1JTIA 1E05I 1ANTI 1E04I 4AJUA 5INWA 1T1FA 2WXZA 3F5NA 1IZ2A 1XU8A 4P0FA 1DZHL 1QMNA 1DZHI 4ZK0A 1PSIA 2WY1A 1OO8A 2ANTI 1OC0A 1TB6I 3B9FI 4RSQA 3UT3A 4AJTA 3VVJA 1LJ5A 4IF8A 4AU4A 1AS4A 1BR8I 1OVAB 2QUGA 9PAIA 4X30A 2VDYA 2XN7A 4ZK3A 3CAAA 2RIWA 2ZV6A 2HIJL 4GA7A 4ROBA 5CDXA 2HIJI 4AU2A 2H4PA 1E03I 2VH4A 3NDDA 3PZFA 1OPHA 4DY7C 5EI0A 2WXYC
chains in the Genus database with same CATH superfamily
1XQGA 4G8OA 1DVNA 2V95A 1B3KA 1F0CA 1UHGA 3ZHAA 1ATTA 4C49A 4R9IA 3PB1I 4DY0A 4AU3A 4AU3B 3T1PA 3DY0A 1JRRA 3DRUA 4AFXA 3F02A 3CWLA 3CVMA 1OVAA 2R9YA 2WXZC 2H4RA 5BRRI 1LQ8A 1QMBA 2RIVA 3OZQA 1JMOA 1IMVA 3FGQA 7APIA 1D5SA 1AZXI 1SEKA 1NQ9I 4G8RA 2OAYA 4YIAA 2GD4C 1DVMA 2D26A 2ACHA 2WXXA 3Q02A 2VDXA 1JVQI 1R1LI 2PEFA 1C5GA 2B4XL 8APIA 1YXAA 1EZXA 1DZGI 1HP7A 2B4XI 1ATUA 4C41A 3CWMA 2WY0C 4P0OA 1XQJA 1BY7A 4CAAA 3F1SA 2OL2A 3STOA 1HLEA 2PEEA 3NDAA 4KDSA 4Y3KA 3LW2A 5HGCA 5C98A 2WXWA 2XN5A 2XN6A 1M93B 3LE2A 2BEHL 2HI9A 3DLWA 2BEHI 5IO1A 2DUTA 1SNGA 2ZNHA 3EOXA 4AQHA 1A7CA 1WZ9A 3Q03A 4EB1L 1DZGL 1QLPA 4BB2A 1LK6I 3EVJI 4EB1I 4RO9A 1OVAC 5CE0A 2B5TI 9APIA 2XN3A 1K9OI 1JMJA 2ARRA 3KCGI 4PYWA 4DTEA 1ATHA 1DB2A 3DRMA 1JJOC 1KCTA 3H5CA 5CDZA 2ARQA 1SR5A 2H4QA 3R4LA 4ROAA 1OYHL 3NDFA 1OYHI 4IC0A 3NE4A 4Y40A 1MTPA 1C8OA 2CEOA 1JTIA 1E05I 1ANTI 1E04I 4AJUA 5INWA 1T1FA 2WXZA 3F5NA 1IZ2A 1XU8A 4P0FA 1DZHL 1QMNA 1DZHI 4ZK0A 1PSIA 2WY1A 1OO8A 2ANTI 1OC0A 1TB6I 3B9FI 4RSQA 3UT3A 4AJTA 3VVJA 1LJ5A 4IF8A 4AU4A 1AS4A 1BR8I 1OVAB 2QUGA 9PAIA 4X30A 2VDYA 2XN7A 4ZK3A 3CAAA 2RIWA 2ZV6A 2HIJL 4GA7A 4ROBA 5CDXA 2HIJI 4AU2A 2H4PA 1E03I 2VH4A 3NDDA 3PZFA 1OPHA 4DY7C 5EI0A 2WXYC
chains in the Genus database with same CATH topology
1XQGA 4G8OA 1DVNA 2V95A 1B3KA 1F0CA 1UHGA 3ZHAA 1ATTA 4C49A 4R9IA 3PB1I 4DY0A 4AU3A 4AU3B 3T1PA 3DY0A 1JRRA 3DRUA 4AFXA 3F02A 3CWLA 3CVMA 1OVAA 2R9YA 2WXZC 2H4RA 5BRRI 1LQ8A 1QMBA 2RIVA 3OZQA 1JMOA 1IMVA 3FGQA 7APIA 1D5SA 1AZXI 1SEKA 1NQ9I 4G8RA 2OAYA 4YIAA 2GD4C 1DVMA 2D26A 2ACHA 2WXXA 3Q02A 2VDXA 1JVQI 1R1LI 2PEFA 1C5GA 2B4XL 8APIA 1YXAA 1EZXA 1DZGI 1HP7A 2B4XI 1ATUA 4C41A 3CWMA 2WY0C 4P0OA 1XQJA 1BY7A 4CAAA 3F1SA 2OL2A 3STOA 1HLEA 2PEEA 3NDAA 4KDSA 4Y3KA 3LW2A 5HGCA 5C98A 2WXWA 2XN5A 2XN6A 1M93B 3LE2A 2BEHL 2HI9A 3DLWA 2BEHI 5IO1A 2DUTA 1SNGA 2ZNHA 3EOXA 4AQHA 1A7CA 1WZ9A 3Q03A 4EB1L 1DZGL 1QLPA 4BB2A 1LK6I 3EVJI 4EB1I 4RO9A 1OVAC 5CE0A 2B5TI 9APIA 2XN3A 1K9OI 1JMJA 2ARRA 3KCGI 4PYWA 4DTEA 1ATHA 1DB2A 3DRMA 1JJOC 1KCTA 3H5CA 5CDZA 2ARQA 1SR5A 2H4QA 3R4LA 4ROAA 1OYHL 3NDFA 1OYHI 4IC0A 3NE4A 4Y40A 1MTPA 1C8OA 2CEOA 1JTIA 1E05I 1ANTI 1E04I 4AJUA 5INWA 1T1FA 2WXZA 3F5NA 1IZ2A 1XU8A 4P0FA 1DZHL 1QMNA 1DZHI 4ZK0A 1PSIA 2WY1A 1OO8A 2ANTI 1OC0A 1TB6I 3B9FI 4RSQA 3UT3A 4AJTA 3VVJA 1LJ5A 4IF8A 4AU4A 1AS4A 1BR8I 1OVAB 2QUGA 9PAIA 4X30A 2VDYA 2XN7A 4ZK3A 3CAAA 2RIWA 2ZV6A 2HIJL 4GA7A 4ROBA 5CDXA 2HIJI 4AU2A 2H4PA 1E03I 2VH4A 3NDDA 3PZFA 1OPHA 4DY7C 5EI0A 2WXYC
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1XQG A;  4G8O A;  1DVN A;  2V95 A;  1B3K A;  1F0C A;  1UHG A;  3ZHA A;  1ATT A;  4C49 A;  4R9I A;  3PB1 I;  4DY0 A;  4AU3 A;  4AU3 B;  3T1P A;  3DY0 A;  1JRR A;  3DRU A;  4AFX A;  3F02 A;  3CWL A;  3CVM A;  1OVA A;  2R9Y A;  2WXZ C;  2H4R A;  5BRR I;  1LQ8 A;  1QMB A;  2RIV A;  3OZQ A;  1JMO A;  1IMV A;  3FGQ A;  7API A;  1D5S A;  1AZX I;  1SEK A;  1NQ9 I;  4G8R A;  2OAY A;  4YIA A;  2GD4 C;  1DVM A;  2D26 A;  2ACH A;  2WXX A;  3Q02 A;  2VDX A;  1JVQ I;  1R1L I;  2PEF A;  1C5G A;  2B4X L;  8API A;  1YXA A;  1EZX A;  1DZG I;  1HP7 A;  2B4X I;  1ATU A;  4C41 A;  3CWM A;  2WY0 C;  4P0O A;  1XQJ A;  1BY7 A;  4CAA A;  3F1S A;  2OL2 A;  3STO A;  1HLE A;  2PEE A;  3NDA A;  4KDS A;  4Y3K A;  3LW2 A;  5HGC A;  5C98 A;  2WXW A;  2XN5 A;  2XN6 A;  1M93 B;  3LE2 A;  2BEH L;  2HI9 A;  3DLW A;  2BEH I;  5IO1 A;  2DUT A;  1SNG A;  2ZNH A;  3EOX A;  4AQH A;  1A7C A;  1WZ9 A;  3Q03 A;  4EB1 L;  1DZG L;  1QLP A;  4BB2 A;  1LK6 I;  3EVJ I;  4EB1 I;  4RO9 A;  1OVA C;  5CE0 A;  2B5T I;  9API A;  2XN3 A;  1K9O I;  1JMJ A;  2ARR A;  3KCG I;  4PYW A;  4DTE A;  1ATH A;  1DB2 A;  3DRM A;  1JJO C;  1KCT A;  3H5C A;  5CDZ A;  2ARQ A;  1SR5 A;  2H4Q A;  3R4L A;  4ROA A;  1OYH L;  3NDF A;  1OYH I;  4IC0 A;  3NE4 A;  4Y40 A;  1MTP A;  1C8O A;  2CEO A;  1JTI A;  1E05 I;  1ANT I;  1E04 I;  4AJU A;  5INW A;  1T1F A;  2WXZ A;  3F5N A;  1IZ2 A;  1XU8 A;  4P0F A;  1DZH L;  1QMN A;  1DZH I;  4ZK0 A;  1PSI A;  2WY1 A;  1OO8 A;  2ANT I;  1OC0 A;  1TB6 I;  3B9F I;  4RSQ A;  3UT3 A;  4AJT A;  3VVJ A;  1LJ5 A;  4IF8 A;  4AU4 A;  1AS4 A;  1BR8 I;  1OVA B;  2QUG A;  9PAI A;  4X30 A;  2VDY A;  2XN7 A;  4ZK3 A;  3CAA A;  2RIW A;  2ZV6 A;  2HIJ L;  4GA7 A;  4ROB A;  5CDX A;  2HIJ I;  4AU2 A;  2H4P A;  1E03 I;  2VH4 A;  3NDD A;  3PZF A;  1OPH A;  4DY7 C;  5EI0 A;  2WXY C; 
#chains in the Genus database with same CATH topology
 1XQG A;  4G8O A;  1DVN A;  2V95 A;  1B3K A;  1F0C A;  1UHG A;  3ZHA A;  1ATT A;  4C49 A;  4R9I A;  3PB1 I;  4DY0 A;  4AU3 A;  4AU3 B;  3T1P A;  3DY0 A;  1JRR A;  3DRU A;  4AFX A;  3F02 A;  3CWL A;  3CVM A;  1OVA A;  2R9Y A;  2WXZ C;  2H4R A;  5BRR I;  1LQ8 A;  1QMB A;  2RIV A;  3OZQ A;  1JMO A;  1IMV A;  3FGQ A;  7API A;  1D5S A;  1AZX I;  1SEK A;  1NQ9 I;  4G8R A;  2OAY A;  4YIA A;  2GD4 C;  1DVM A;  2D26 A;  2ACH A;  2WXX A;  3Q02 A;  2VDX A;  1JVQ I;  1R1L I;  2PEF A;  1C5G A;  2B4X L;  8API A;  1YXA A;  1EZX A;  1DZG I;  1HP7 A;  2B4X I;  1ATU A;  4C41 A;  3CWM A;  2WY0 C;  4P0O A;  1XQJ A;  1BY7 A;  4CAA A;  3F1S A;  2OL2 A;  3STO A;  1HLE A;  2PEE A;  3NDA A;  4KDS A;  4Y3K A;  3LW2 A;  5HGC A;  5C98 A;  2WXW A;  2XN5 A;  2XN6 A;  1M93 B;  3LE2 A;  2BEH L;  2HI9 A;  3DLW A;  2BEH I;  5IO1 A;  2DUT A;  1SNG A;  2ZNH A;  3EOX A;  4AQH A;  1A7C A;  1WZ9 A;  3Q03 A;  4EB1 L;  1DZG L;  1QLP A;  4BB2 A;  1LK6 I;  3EVJ I;  4EB1 I;  4RO9 A;  1OVA C;  5CE0 A;  2B5T I;  9API A;  2XN3 A;  1K9O I;  1JMJ A;  2ARR A;  3KCG I;  4PYW A;  4DTE A;  1ATH A;  1DB2 A;  3DRM A;  1JJO C;  1KCT A;  3H5C A;  5CDZ A;  2ARQ A;  1SR5 A;  2H4Q A;  3R4L A;  4ROA A;  1OYH L;  3NDF A;  1OYH I;  4IC0 A;  3NE4 A;  4Y40 A;  1MTP A;  1C8O A;  2CEO A;  1JTI A;  1E05 I;  1ANT I;  1E04 I;  4AJU A;  5INW A;  1T1F A;  2WXZ A;  3F5N A;  1IZ2 A;  1XU8 A;  4P0F A;  1DZH L;  1QMN A;  1DZH I;  4ZK0 A;  1PSI A;  2WY1 A;  1OO8 A;  2ANT I;  1OC0 A;  1TB6 I;  3B9F I;  4RSQ A;  3UT3 A;  4AJT A;  3VVJ A;  1LJ5 A;  4IF8 A;  4AU4 A;  1AS4 A;  1BR8 I;  1OVA B;  2QUG A;  9PAI A;  4X30 A;  2VDY A;  2XN7 A;  4ZK3 A;  3CAA A;  2RIW A;  2ZV6 A;  2HIJ L;  4GA7 A;  4ROB A;  5CDX A;  2HIJ I;  4AU2 A;  2H4P A;  1E03 I;  2VH4 A;  3NDD A;  3PZF A;  1OPH A;  4DY7 C;  5EI0 A;  2WXY C; 
#chains in the Genus database with same CATH homology
 1XQG A;  4G8O A;  1DVN A;  2V95 A;  1B3K A;  1F0C A;  1UHG A;  3ZHA A;  1ATT A;  4C49 A;  4R9I A;  3PB1 I;  4DY0 A;  4AU3 A;  4AU3 B;  3T1P A;  3DY0 A;  1JRR A;  3DRU A;  4AFX A;  3F02 A;  3CWL A;  3CVM A;  1OVA A;  2R9Y A;  2WXZ C;  2H4R A;  5BRR I;  1LQ8 A;  1QMB A;  2RIV A;  3OZQ A;  1JMO A;  1IMV A;  3FGQ A;  7API A;  1D5S A;  1AZX I;  1SEK A;  1NQ9 I;  4G8R A;  2OAY A;  4YIA A;  2GD4 C;  1DVM A;  2D26 A;  2ACH A;  2WXX A;  3Q02 A;  2VDX A;  1JVQ I;  1R1L I;  2PEF A;  1C5G A;  2B4X L;  8API A;  1YXA A;  1EZX A;  1DZG I;  1HP7 A;  2B4X I;  1ATU A;  4C41 A;  3CWM A;  2WY0 C;  4P0O A;  1XQJ A;  1BY7 A;  4CAA A;  3F1S A;  2OL2 A;  3STO A;  1HLE A;  2PEE A;  3NDA A;  4KDS A;  4Y3K A;  3LW2 A;  5HGC A;  5C98 A;  2WXW A;  2XN5 A;  2XN6 A;  1M93 B;  3LE2 A;  2BEH L;  2HI9 A;  3DLW A;  2BEH I;  5IO1 A;  2DUT A;  1SNG A;  2ZNH A;  3EOX A;  4AQH A;  1A7C A;  1WZ9 A;  3Q03 A;  4EB1 L;  1DZG L;  1QLP A;  4BB2 A;  1LK6 I;  3EVJ I;  4EB1 I;  4RO9 A;  1OVA C;  5CE0 A;  2B5T I;  9API A;  2XN3 A;  1K9O I;  1JMJ A;  2ARR A;  3KCG I;  4PYW A;  4DTE A;  1ATH A;  1DB2 A;  3DRM A;  1JJO C;  1KCT A;  3H5C A;  5CDZ A;  2ARQ A;  1SR5 A;  2H4Q A;  3R4L A;  4ROA A;  1OYH L;  3NDF A;  1OYH I;  4IC0 A;  3NE4 A;  4Y40 A;  1MTP A;  1C8O A;  2CEO A;  1JTI A;  1E05 I;  1ANT I;  1E04 I;  4AJU A;  5INW A;  1T1F A;  2WXZ A;  3F5N A;  1IZ2 A;  1XU8 A;  4P0F A;  1DZH L;  1QMN A;  1DZH I;  4ZK0 A;  1PSI A;  2WY1 A;  1OO8 A;  2ANT I;  1OC0 A;  1TB6 I;  3B9F I;  4RSQ A;  3UT3 A;  4AJT A;  3VVJ A;  1LJ5 A;  4IF8 A;  4AU4 A;  1AS4 A;  1BR8 I;  1OVA B;  2QUG A;  9PAI A;  4X30 A;  2VDY A;  2XN7 A;  4ZK3 A;  3CAA A;  2RIW A;  2ZV6 A;  2HIJ L;  4GA7 A;  4ROB A;  5CDX A;  2HIJ I;  4AU2 A;  2H4P A;  1E03 I;  2VH4 A;  3NDD A;  3PZF A;  1OPH A;  4DY7 C;  5EI0 A;  2WXY C; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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