2ETLA

Crystal structure of ubiquitin carboxy-terminal hydrolase l1 (uch-l1)
Total Genus 70
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
70
Knots found
sequence length
223
structure length
223
Chain Sequence
MQLKPMEINPEMLNKVLSRLGVAGQWRFVDVLGLEEESLGSVPAPACALLLLFPLTAQHENFRKKQIEELKGQEVSPKVYFMKQTIGNSCGTIGLIHAVANNQDKLGFEDGSVLKQFLSETEKMSPEDRAKCFEKNEAIQAAHDAVAQEGQCRVDDKVNFHFILFNNVDGHLYELDGRMPFPVNHGASSEDTLLKDAAKVCREFTEREQGEVRFSAVALCKAA
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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molecule tags Hydrolase, ligase
molecule keywords Ubiquitin carboxyl-terminal hydrolase isozyme L1
publication title Structural basis for conformational plasticity of the Parkinson's disease-associated ubiquitin hydrolase UCH-L1.
pubmed doi rcsb
source organism Homo sapiens
total genus 70
structure length 223
sequence length 223
chains with identical sequence B
other databases KnotProt 2.0: K -52 -31 -31
ec nomenclature ec 3.4.19.12: Ubiquitinyl hydrolase 1.
pdb deposition date 2005-10-27

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF01088 Peptidase_C12 Ubiquitin carboxyl-terminal hydrolase, family 1
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.532.10 Alpha Beta 3-Layer(aba) Sandwich Ubiquitin C-terminal Hydrolase UCH-l3 Peptidase C12, ubiquitin carboxyl-terminal hydrolase 2etlA00
3KW5A 1CMXA 3KVFA 1XD3A 3RIIA 4UEMA 3TB3A 3IFWA 1UCHA 2ETLA 4I6NA 3A7SA 3RISA 3IHRA 2LENA 3IRTA 4IG7A 4DM9A 4JKJA 4UELA
chains in the Genus database with same CATH superfamily
3KW5A 1CMXA 3KVFA 1XD3A 3RIIA 4UEMA 3TB3A 3IFWA 1UCHA 2ETLA 4I6NA 3A7SA 3RISA 3IHRA 2LENA 3IRTA 4IG7A 4DM9A 4JKJA 4UELA
chains in the Genus database with same CATH topology
3KW5A 1CMXA 3KVFA 1XD3A 3RIIA 4UEMA 3TB3A 3IFWA 1UCHA 2ETLA 4I6NA 3A7SA 3RISA 3IHRA 2LENA 3IRTA 4IG7A 4DM9A 4JKJA 4UELA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 3KW5 A;  1CMX A;  3KVF A;  1XD3 A;  3RII A;  4UEM A;  3TB3 A;  3IFW A;  1UCH A;  2ETL A;  4I6N A;  3A7S A;  3RIS A;  3IHR A;  2LEN A;  3IRT A;  4IG7 A;  4DM9 A;  4JKJ A;  4UEL A; 
#chains in the Genus database with same CATH topology
 3KW5 A;  1CMX A;  3KVF A;  1XD3 A;  3RII A;  4UEM A;  3TB3 A;  3IFW A;  1UCH A;  2ETL A;  4I6N A;  3A7S A;  3RIS A;  3IHR A;  2LEN A;  3IRT A;  4IG7 A;  4DM9 A;  4JKJ A;  4UEL A; 
#chains in the Genus database with same CATH homology
 3KW5 A;  1CMX A;  3KVF A;  1XD3 A;  3RII A;  4UEM A;  3TB3 A;  3IFW A;  1UCH A;  2ETL A;  4I6N A;  3A7S A;  3RIS A;  3IHR A;  2LEN A;  3IRT A;  4IG7 A;  4DM9 A;  4JKJ A;  4UEL A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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