2VQJA

Structure of hdac4 catalytic domain bound to a trifluoromethylketone inhbitor
Total Genus 133
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
133
sequence length
402
structure length
402
Chain Sequence
PRFTTGLVYDTLMLKHQCTCGSSSSHPEHAGRIQSIWSRLQETGLRGKCECIRGRKATLEELQTVHSEAHTLLYGTNPLNRQKLDSKKLLGSLASVFVRLPCGGVGVDSDTIWNEVHSAGAARLAVGCVVELVFKVATGELKNGFAVVRPPGHHAEESTPMGFCYFNSVAVAAKLLQQRLSVSKILIVDWDVHHGNGTQQAFYSDPSVLYMSLHRYDDGNFFPGSGAPDEVGTGPGVGFNVNMAFTGGLDPPMGDAEYLAAFRTVVMPIASEFAPDVVLVSSGFDAVEGHPTPLGGYNLSARCFGYLTKQLMGLAGGRIVLALEGGHDLTAICDASEACVSALLGNELDPLPEKVLQQRPNANAVRSMEKVMEIHSKYWRCLQRTTSTAGRSLIEAQTCENE
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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molecule tags Hydrolase
molecule keywords HISTONE DEACETYLASE 4
publication title Structural and Functional Analysis of the Human Hdac4 Catalytic Domain Reveals a Regulatory Zinc-Binding Domain.
pubmed doi rcsb
source organism Homo sapiens
total genus 133
structure length 402
sequence length 402
ec nomenclature ec 3.5.1.98: Histone deacetylase.
pdb deposition date 2008-03-17

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00850 Hist_deacetyl Histone deacetylase domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.800.20 Alpha Beta 3-Layer(aba) Sandwich Arginase; Chain A Histone deacetylase domain 2vqjA00
3RQDA 3MZ6A 4RN1A 4QA6A 1ZZ3A 5A2SA 5G0GA 4BZ6A 5G13A 3Q9CA 5G1BA 5EF7A 1C3SA 5G12A 5G0HA 2VQMA 3SFHA 1C3PA 4ZUNA 5G17A 1ZZ1A 5EFNA 5D1BA 4RN0A 3C0ZA 4BZ5A 1VKGA 3F06A 4RN2A 5DC5A 1C3RA 5EFHA 2GH6A 3EZTA 4QA5A 5EFKB 5D1CA 5BWZA 3EW8A 2VQOA 4ZURA 4QA0A 4LY1A 5G3WA 5EF8A 3MZ4A 3ZNRA 5ICNB 4QA3A 4QA4A 1T67A 3ZNSA 5THSA 3Q9EA 2V5WA 5EFJD 5D1DA 4CQFA 5LI3A 5FUEA 4A69A 3Q9FA 4ZUOA 5G0IA 3C0YA 1W22A 4CBYA 5G10A 3F0RA 5EFGA 1T69A 5G1AA 5G1CA 2VQWG 4LXZA 5EEKA 5THUA 4ZUMA 5FCWA 5THTA 3EWFA 5EEFA 1T64A 4ZUPA 4BZ9A 3F07A 4ZUQA 4QA7A 5EFBD 5G0JA 5DC7A 3MZ7A 5DC6A 5G11A 4BZ8A 5IWGA 5G0XA 5EEIA 3SFFA 3EZPA 3MENA 5JI5A 5DC8A 4BKXB 4CBTA 5IX0A 3C10A 2VCGA 4QA1A 1ZZ0A 5EEMA 5THVA 5G0YA 5EENA 2VQVA 2VQQA 2V5XA 3Q9BA 3MAXA 3MZ3A 4QA2A 4BZ7A 2VQJA
chains in the Genus database with same CATH superfamily
4RHLA 4DZ4A 1HQHA 2AEBA 3RQDA 3MZ6A 4RN1A 4QA6A 1ZZ3A 5A2SA 4G3HA 5G0GA 3THEA 4BZ6A 5G13A 3Q9CA 1P8SA 4GWDA 5EF7A 1P8OA 1GQ6A 3E8QA 5G1BA 1C3SA 5G12A 5G0HA 3TH7A 1TA1A 1D3VA 1RLAA 4HXQA 4MYLA 2VQMA 3SFHA 1C3PA 4ZUNA 5G17A 1ZZ1A 1R1OA 5EFNA 5D1BA 4RN0A 1T4RA 1TBLA 1P8MA 2RLAA 3C0ZA 4Q3RA 1T4PA 4BZ5A 1T5GA 1VKGA 3F06A 4RN2A 5DC5A 1C3RA 5EFHA 4MYNA 2GH6A 5HJ9A 1P8RA 3EZTA 3NIQA 1HQ5A 4MYKA 4QA5A 5EFKB 5D1CA 5BWZA 1P8PA 4Q40A 1T4TA 3EW8A 2VQOA 4ITYA 1WOIA 4QA0A 4LY1A 1T5FA 4ZURA 3F80A 5G3WA 5CEVA 5EF8A 3MZ4A 3KV2A 1TBJA 3ZNRA 3E6VA 5ICNB 3LP4A 3SL0A 2EF5A 4QA3A 4IE1A 3M1RA 4QA4A 2PLLA 1WOHA 3E8ZA 1T67A 3ZNSA 5THSA 4CEVA 2PHOA 3Q9EA 5RLAA 4Q3SA 4FCKA 1PQ3A 3E6KA 2V5WA 4IE3A 4IXVA 3LP7A 4Q41A 5EFJD 1HQGA 5D1DA 4CQFA 5LI3A 5FUEA 3GMZA 4A69A 3Q9FA 4ZUOA 3THHA 2ZAVA 3GN0A 5G0IA 3C0YA 1XFKA 1W22A 4RHMA 4CBYA 5G10A 3F0RA 3MJLA 3CEVA 4Q42A 1P8NA 1GQ7A 1T69A 4RHIA 5EFGA 5G1AA 1ZPGA 2VQWG 2PHAA 3NIOA 5G1CA 3THJA 1WVBA 4LXZA 5EEKA 3PZLA 4RHQA 5THUA 4ZUMA 1ZPEA 4FCIA 5FCWA 1WOGA 5THTA 4IU1A 3EWFA 4I06A 5EEFA 1TBHA 3MFWA 4IU4A 2EIVA 1T64A 4Q3TA 4ZUPA 3F07A 4BZ9A 4ZUQA 4QA7A 3MMRA 3NIPA 5EFBD 4Q3PA 5G0JA 4HZEA 3SL1A 1HQXA 4MXRA 4GSVA 3SJTA 5DC7A 3MZ7A 5DC6A 5G11A 3RLAA 5IWGA 4BZ8A 5G0XA 4Q3VA 5EEIA 3SFFA 2EF4A 1CEVA 4GSZA 1P8QA 3EZPA 1T4SA 3MENA 4IU0A 5JI5A 4HWWA 3E9BA 5DC8A 4BKXB 4RHJA 4CBTA 5IX0A 3TF3A 3C10A 2VCGA 4Q3UA 4QA1A 4IE2A 1ZZ0A 4MYFA 4RLAA 5EEMA 5THVA 5G0YA 5EENA 4Q3QA 1WVAA 5HJAA 3SKKA 4IU5A 4GSMA 2VQVA 3LHLA 2CEVA 2V5XA 2VQQA 1HQFA 4Q3RC 3Q9BA 3MFVA 3MAXA 4GWCA 3MZ3A 4QA2A 4BZ7A 3DJ8A 2A0MA 4IXUA 4RHKA 2VQJA
chains in the Genus database with same CATH topology
3RQDA 3MZ6A 4RN1A 4QA6A 1ZZ3A 5A2SA 5G0GA 4BZ6A 5G13A 3Q9CA 5G1BA 5EF7A 1C3SA 5G12A 5G0HA 2VQMA 3SFHA 1C3PA 4ZUNA 5G17A 1ZZ1A 5EFNA 5D1BA 4RN0A 3C0ZA 4BZ5A 1VKGA 3F06A 4RN2A 5DC5A 1C3RA 5EFHA 2GH6A 3EZTA 4QA5A 5EFKB 5D1CA 5BWZA 3EW8A 2VQOA 4ZURA 4QA0A 4LY1A 5G3WA 5EF8A 3MZ4A 3ZNRA 5ICNB 4QA3A 4QA4A 1T67A 3ZNSA 5THSA 3Q9EA 2V5WA 5EFJD 5D1DA 4CQFA 5LI3A 5FUEA 4A69A 3Q9FA 4ZUOA 5G0IA 3C0YA 1W22A 4CBYA 5G10A 3F0RA 5EFGA 1T69A 5G1AA 5G1CA 2VQWG 4LXZA 5EEKA 5THUA 4ZUMA 5FCWA 5THTA 3EWFA 5EEFA 1T64A 4ZUPA 4BZ9A 3F07A 4ZUQA 4QA7A 5EFBD 5G0JA 5DC7A 3MZ7A 5DC6A 5G11A 4BZ8A 5IWGA 5G0XA 5EEIA 3SFFA 3EZPA 3MENA 5JI5A 5DC8A 4BKXB 4CBTA 5IX0A 3C10A 2VCGA 4QA1A 1ZZ0A 5EEMA 5THVA 5G0YA 5EENA 2VQVA 2VQQA 2V5XA 3Q9BA 3MAXA 3MZ3A 4QA2A 4BZ7A 2VQJA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 3RQD A;  3MZ6 A;  4RN1 A;  4QA6 A;  1ZZ3 A;  5A2S A;  5G0G A;  4BZ6 A;  5G13 A;  3Q9C A;  5G1B A;  5EF7 A;  1C3S A;  5G12 A;  5G0H A;  2VQM A;  3SFH A;  1C3P A;  4ZUN A;  5G17 A;  1ZZ1 A;  5EFN A;  5D1B A;  4RN0 A;  3C0Z A;  4BZ5 A;  1VKG A;  3F06 A;  4RN2 A;  5DC5 A;  1C3R A;  5EFH A;  2GH6 A;  3EZT A;  4QA5 A;  5EFK B;  5D1C A;  5BWZ A;  3EW8 A;  2VQO A;  4ZUR A;  4QA0 A;  4LY1 A;  5G3W A;  5EF8 A;  3MZ4 A;  3ZNR A;  5ICN B;  4QA3 A;  4QA4 A;  1T67 A;  3ZNS A;  5THS A;  3Q9E A;  2V5W A;  5EFJ D;  5D1D A;  4CQF A;  5LI3 A;  5FUE A;  4A69 A;  3Q9F A;  4ZUO A;  5G0I A;  3C0Y A;  1W22 A;  4CBY A;  5G10 A;  3F0R A;  5EFG A;  1T69 A;  5G1A A;  5G1C A;  2VQW G;  4LXZ A;  5EEK A;  5THU A;  4ZUM A;  5FCW A;  5THT A;  3EWF A;  5EEF A;  1T64 A;  4ZUP A;  4BZ9 A;  3F07 A;  4ZUQ A;  4QA7 A;  5EFB D;  5G0J A;  5DC7 A;  3MZ7 A;  5DC6 A;  5G11 A;  4BZ8 A;  5IWG A;  5G0X A;  5EEI A;  3SFF A;  3EZP A;  3MEN A;  5JI5 A;  5DC8 A;  4BKX B;  4CBT A;  5IX0 A;  3C10 A;  2VCG A;  4QA1 A;  1ZZ0 A;  5EEM A;  5THV A;  5G0Y A;  5EEN A;  2VQV A;  2VQQ A;  2V5X A;  3Q9B A;  3MAX A;  3MZ3 A;  4QA2 A;  4BZ7 A;  2VQJ A; 
#chains in the Genus database with same CATH topology
 4RHL A;  4DZ4 A;  1HQH A;  2AEB A;  3RQD A;  3MZ6 A;  4RN1 A;  4QA6 A;  1ZZ3 A;  5A2S A;  4G3H A;  5G0G A;  3THE A;  4BZ6 A;  5G13 A;  3Q9C A;  1P8S A;  4GWD A;  5EF7 A;  1P8O A;  1GQ6 A;  3E8Q A;  5G1B A;  1C3S A;  5G12 A;  5G0H A;  3TH7 A;  1TA1 A;  1D3V A;  1RLA A;  4HXQ A;  4MYL A;  2VQM A;  3SFH A;  1C3P A;  4ZUN A;  5G17 A;  1ZZ1 A;  1R1O A;  5EFN A;  5D1B A;  4RN0 A;  1T4R A;  1TBL A;  1P8M A;  2RLA A;  3C0Z A;  4Q3R A;  1T4P A;  4BZ5 A;  1T5G A;  1VKG A;  3F06 A;  4RN2 A;  5DC5 A;  1C3R A;  5EFH A;  4MYN A;  2GH6 A;  5HJ9 A;  1P8R A;  3EZT A;  3NIQ A;  1HQ5 A;  4MYK A;  4QA5 A;  5EFK B;  5D1C A;  5BWZ A;  1P8P A;  4Q40 A;  1T4T A;  3EW8 A;  2VQO A;  4ITY A;  1WOI A;  4QA0 A;  4LY1 A;  1T5F A;  4ZUR A;  3F80 A;  5G3W A;  5CEV A;  5EF8 A;  3MZ4 A;  3KV2 A;  1TBJ A;  3ZNR A;  3E6V A;  5ICN B;  3LP4 A;  3SL0 A;  2EF5 A;  4QA3 A;  4IE1 A;  3M1R A;  4QA4 A;  2PLL A;  1WOH A;  3E8Z A;  1T67 A;  3ZNS A;  5THS A;  4CEV A;  2PHO A;  3Q9E A;  5RLA A;  4Q3S A;  4FCK A;  1PQ3 A;  3E6K A;  2V5W A;  4IE3 A;  4IXV A;  3LP7 A;  4Q41 A;  5EFJ D;  1HQG A;  5D1D A;  4CQF A;  5LI3 A;  5FUE A;  3GMZ A;  4A69 A;  3Q9F A;  4ZUO A;  3THH A;  2ZAV A;  3GN0 A;  5G0I A;  3C0Y A;  1XFK A;  1W22 A;  4RHM A;  4CBY A;  5G10 A;  3F0R A;  3MJL A;  3CEV A;  4Q42 A;  1P8N A;  1GQ7 A;  1T69 A;  4RHI A;  5EFG A;  5G1A A;  1ZPG A;  2VQW G;  2PHA A;  3NIO A;  5G1C A;  3THJ A;  1WVB A;  4LXZ A;  5EEK A;  3PZL A;  4RHQ A;  5THU A;  4ZUM A;  1ZPE A;  4FCI A;  5FCW A;  1WOG A;  5THT A;  4IU1 A;  3EWF A;  4I06 A;  5EEF A;  1TBH A;  3MFW A;  4IU4 A;  2EIV A;  1T64 A;  4Q3T A;  4ZUP A;  3F07 A;  4BZ9 A;  4ZUQ A;  4QA7 A;  3MMR A;  3NIP A;  5EFB D;  4Q3P A;  5G0J A;  4HZE A;  3SL1 A;  1HQX A;  4MXR A;  4GSV A;  3SJT A;  5DC7 A;  3MZ7 A;  5DC6 A;  5G11 A;  3RLA A;  5IWG A;  4BZ8 A;  5G0X A;  4Q3V A;  5EEI A;  3SFF A;  2EF4 A;  1CEV A;  4GSZ A;  1P8Q A;  3EZP A;  1T4S A;  3MEN A;  4IU0 A;  5JI5 A;  4HWW A;  3E9B A;  5DC8 A;  4BKX B;  4RHJ A;  4CBT A;  5IX0 A;  3TF3 A;  3C10 A;  2VCG A;  4Q3U A;  4QA1 A;  4IE2 A;  1ZZ0 A;  4MYF A;  4RLA A;  5EEM A;  5THV A;  5G0Y A;  5EEN A;  4Q3Q A;  1WVA A;  5HJA A;  3SKK A;  4IU5 A;  4GSM A;  2VQV A;  3LHL A;  2CEV A;  2V5X A;  2VQQ A;  1HQF A;  4Q3R C;  3Q9B A;  3MFV A;  3MAX A;  4GWC A;  3MZ3 A;  4QA2 A;  4BZ7 A;  3DJ8 A;  2A0M A;  4IXU A;  4RHK A;  2VQJ A; 
#chains in the Genus database with same CATH homology
 3RQD A;  3MZ6 A;  4RN1 A;  4QA6 A;  1ZZ3 A;  5A2S A;  5G0G A;  4BZ6 A;  5G13 A;  3Q9C A;  5G1B A;  5EF7 A;  1C3S A;  5G12 A;  5G0H A;  2VQM A;  3SFH A;  1C3P A;  4ZUN A;  5G17 A;  1ZZ1 A;  5EFN A;  5D1B A;  4RN0 A;  3C0Z A;  4BZ5 A;  1VKG A;  3F06 A;  4RN2 A;  5DC5 A;  1C3R A;  5EFH A;  2GH6 A;  3EZT A;  4QA5 A;  5EFK B;  5D1C A;  5BWZ A;  3EW8 A;  2VQO A;  4ZUR A;  4QA0 A;  4LY1 A;  5G3W A;  5EF8 A;  3MZ4 A;  3ZNR A;  5ICN B;  4QA3 A;  4QA4 A;  1T67 A;  3ZNS A;  5THS A;  3Q9E A;  2V5W A;  5EFJ D;  5D1D A;  4CQF A;  5LI3 A;  5FUE A;  4A69 A;  3Q9F A;  4ZUO A;  5G0I A;  3C0Y A;  1W22 A;  4CBY A;  5G10 A;  3F0R A;  5EFG A;  1T69 A;  5G1A A;  5G1C A;  2VQW G;  4LXZ A;  5EEK A;  5THU A;  4ZUM A;  5FCW A;  5THT A;  3EWF A;  5EEF A;  1T64 A;  4ZUP A;  4BZ9 A;  3F07 A;  4ZUQ A;  4QA7 A;  5EFB D;  5G0J A;  5DC7 A;  3MZ7 A;  5DC6 A;  5G11 A;  4BZ8 A;  5IWG A;  5G0X A;  5EEI A;  3SFF A;  3EZP A;  3MEN A;  5JI5 A;  5DC8 A;  4BKX B;  4CBT A;  5IX0 A;  3C10 A;  2VCG A;  4QA1 A;  1ZZ0 A;  5EEM A;  5THV A;  5G0Y A;  5EEN A;  2VQV A;  2VQQ A;  2V5X A;  3Q9B A;  3MAX A;  3MZ3 A;  4QA2 A;  4BZ7 A;  2VQJ A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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