2ANHA

Alkaline phosphatase (d153h)
Total Genus 164
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
164
Knots found
sequence length
446
structure length
446
Chain Sequence
MPVLENRAAQGDITAPGGARRLTGDQTAALRDSLSDKPAKNIILLIGDGMGDSEITAARNYAEGAGGFFKGIDALPLTGQYTHYALNKKTGKPDYVTDSAASATAWSTGVKTYNGALGVDIHEKDHPTILEMAKAAGLATGNVSTAELQHATPAALVAHVTSRKCYGPSATSEKCPGNALEKGGKGSITEQLLNARADVTLGGGAKTFAETATAGEWQGKTLREQAQARGYQLVSDAASLNSVTEANQQKPLLGLFADGNMPVRWLGPKATYHGNIDKPAVTCTPNPQRNDSVPTLAQMTDKAIELLSKNEKGFFLQVEGASIDKQDHAANPCGQIGETVDLDEAVQRALEFAKKEGNTLVIVTADHAHASQIVAPDTKAPGLTQALNTKDGAVMVMSYGNSEEDSQEHTGSQLRIAAYGPHAANVVGLTDQTDLFYTMKAALGLK
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

molecule keywords ALKALINE PHOSPHATASE
publication title Mutations at positions 153 and 328 in Escherichia coli alkaline phosphatase provide insight towards the structure and function of mammalian and yeast alkaline phosphatases.
pubmed doi rcsb
source organism Escherichia coli
molecule tags Alkaline phosphatase
total genus 164
structure length 446
sequence length 446
chains with identical sequence B
other databases KnotProt 2.0: S +31
ec nomenclature ec 3.1.3.1: Alkaline phosphatase.
pdb deposition date 1995-09-06

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00245 Alk_phosphatase Alkaline phosphatase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.720.10 Alpha Beta 3-Layer(aba) Sandwich Alkaline Phosphatase, subunit A Alkaline Phosphatase, subunit A 2anhA00
4KJGA 5GRRA 1AJAA 1AJDA 3T02A 1ALKA 1E1ZP 5L0EA 2IUCA 3Q3QA 3OT9A 4UORA 1URAA 5L0KA 4UOOA 1HJKA 3SZZA 1KH4A 4CXUA 1AJCA 3NKOA 4ZG6A 4LREA 2ANHA 1FSUA 1KHKA 5DLTA 3MK0A 3IGZB 4ZGAA 1EI6A 3WAVA 4MHXA 1URBA 2D1GA 3NKNA 3KD8A 4KAYA 2W5XA 4GTZA 5GOVA 3M8YA 3MK2A 2W8DA 3UN5A 1HDHA 1KHLA 1ANJA 4GTWA 3IGYB 1E3CP 3NKQA 1KH5A 2VQRA 3TX0A 1KHJA 1SHNA 4FDIA 1B8JA 1Y6VA 2W8SA 3NVLA 4YR1A 5LRMA 3BDGB 2X98A 1E33P 1ALJA 4QAXA 2GSNA 5C66A 1O99A 1ZEFA 4KAVA 5L0BA 1ZEDA 4N7TA 3M7VA 1KH7A 3IDDA 3DYCA 4MY4A 4LQYA 4UPLA 3TWZA 3A52A 4FDJA 1AUKA 2W5TA 3WBHA 3WAYA 4CXKA 5LRNA 1EQJA 4LRFA 1ZEBA 5IJSA 1ED9A 3LXQA 5DLVA 3UO0A 2W5SA 4LRAA 4UPKA 1O98A 2GLQA 1EW8A 4UPIA 5AJ9A 5TJ3A 1EW2A 3B5QA 3UNYA 1N2LA 3DPCA 1ALIA 2W5VA 4LR7A 2XRGA 5LIAA 4B56A 3ED4A 1EJJA 1ED8A 4LRCA 2W5WA 1ANIA 3T00A 3UN2A 3BDHA 1SHQA 1HQAA 1P49A 2G9YA 2W5QA 1ALHA 2GA3A 4NWXA 2XR9A 3WAXA 3M8WA 4LR2A 4GTXA 3T01A 3NKRA 1Y7AA 3NKPA 4KJDA 4LRBA 4LR9A 1KH9A 5HRTA 1KHNA 3WAWA 2IUCB 2ZKTA 3MK1A 5EGHA 4CYSA 1E2SP 1K7HA 2GSOA 4ZG7A 2IFYA 4KM4A 4UOPA 1ELZA 2RH6A 2W5RA 3E2DA 3NKMA 4LR8A 5INHA 2GSUA 3M8ZA 4LRDA 4UPHA 3BDFA 1N2KA 4GTYA 4NWJA 4MIVA 3CMRA 3UN3A 4ZG9A 5DLWA 5IJQA 5LQQA 1AJBA 4TN0A 1ELXA 1ELYA 4CYRA 1EW9A 5EGEA 3SZYA 5KXAA 2QZUA 3TG0A 3BDGA 5K4PA 4CXSA
chains in the Genus database with same CATH superfamily
4KJGA 5GRRA 1AJAA 1AJDA 3T02A 1ALKA 1E1ZP 5L0EA 2IUCA 3Q3QA 3OT9A 4UORA 1URAA 5L0KA 4UOOA 1HJKA 3SZZA 1KH4A 4CXUA 1AJCA 3NKOA 4ZG6A 4LREA 2ANHA 1FSUA 1KHKA 5DLTA 3MK0A 3IGZB 4ZGAA 1EI6A 3WAVA 4MHXA 1URBA 2D1GA 3NKNA 3KD8A 4KAYA 2W5XA 4GTZA 5GOVA 3M8YA 3MK2A 2W8DA 3UN5A 1HDHA 1KHLA 1ANJA 4GTWA 3IGYB 1E3CP 3NKQA 1KH5A 2VQRA 3TX0A 1KHJA 1SHNA 4FDIA 1B8JA 1Y6VA 2W8SA 3NVLA 4YR1A 5LRMA 3BDGB 2X98A 1E33P 1ALJA 4QAXA 2GSNA 5C66A 1O99A 1ZEFA 4KAVA 5L0BA 1ZEDA 4N7TA 3M7VA 1KH7A 3IDDA 3DYCA 4MY4A 4LQYA 4UPLA 3TWZA 3A52A 4FDJA 1AUKA 2W5TA 3WBHA 3WAYA 4CXKA 5LRNA 1EQJA 4LRFA 1ZEBA 5IJSA 1ED9A 3LXQA 5DLVA 3UO0A 2W5SA 4LRAA 4UPKA 1O98A 2GLQA 1EW8A 4UPIA 5AJ9A 5TJ3A 1EW2A 3B5QA 3UNYA 1N2LA 3DPCA 1ALIA 2W5VA 4LR7A 2XRGA 5LIAA 4B56A 3ED4A 1EJJA 1ED8A 4LRCA 2W5WA 1ANIA 3T00A 3UN2A 3BDHA 1SHQA 1HQAA 1P49A 2G9YA 2W5QA 1ALHA 2GA3A 4NWXA 2XR9A 3WAXA 3M8WA 4LR2A 4GTXA 3T01A 3NKRA 1Y7AA 3NKPA 4KJDA 4LRBA 4LR9A 1KH9A 5HRTA 1KHNA 3WAWA 2IUCB 2ZKTA 3MK1A 5EGHA 4CYSA 1E2SP 1K7HA 2GSOA 4ZG7A 2IFYA 4KM4A 4UOPA 1ELZA 2RH6A 2W5RA 3E2DA 3NKMA 4LR8A 5INHA 2GSUA 3M8ZA 4LRDA 4UPHA 3BDFA 1N2KA 4GTYA 4NWJA 4MIVA 3CMRA 3UN3A 4ZG9A 5DLWA 5IJQA 5LQQA 1AJBA 4TN0A 1ELXA 1ELYA 4CYRA 1EW9A 5EGEA 3SZYA 5KXAA 2QZUA 3TG0A 3BDGA 5K4PA 4CXSA
chains in the Genus database with same CATH topology
4KJGA 5GRRA 1AJAA 1AJDA 3T02A 1ALKA 1E1ZP 5L0EA 2IUCA 3Q3QA 3OT9A 4UORA 1URAA 5L0KA 4UOOA 1HJKA 3SZZA 1KH4A 4CXUA 1AJCA 3NKOA 4ZG6A 4LREA 2ANHA 1FSUA 1KHKA 5DLTA 3MK0A 3IGZB 4ZGAA 1EI6A 3WAVA 4MHXA 1URBA 2D1GA 3NKNA 3KD8A 4KAYA 2W5XA 4GTZA 5GOVA 3M8YA 3MK2A 2W8DA 3UN5A 1HDHA 1KHLA 1ANJA 4GTWA 3IGYB 1E3CP 3NKQA 1KH5A 2VQRA 3TX0A 1KHJA 1SHNA 4FDIA 1B8JA 1Y6VA 2W8SA 3NVLA 4YR1A 5LRMA 3BDGB 2X98A 1E33P 1ALJA 4QAXA 2GSNA 5C66A 1O99A 1ZEFA 4KAVA 5L0BA 1ZEDA 4N7TA 3M7VA 1KH7A 3IDDA 3DYCA 4MY4A 4LQYA 4UPLA 3TWZA 3A52A 4FDJA 1AUKA 2W5TA 3WBHA 3WAYA 4CXKA 5LRNA 1EQJA 4LRFA 1ZEBA 5IJSA 1ED9A 3LXQA 5DLVA 3UO0A 2W5SA 4LRAA 4UPKA 1O98A 2GLQA 1EW8A 4UPIA 5AJ9A 5TJ3A 1EW2A 3B5QA 3UNYA 1N2LA 3DPCA 1ALIA 2W5VA 4LR7A 2XRGA 5LIAA 4B56A 3ED4A 1EJJA 1ED8A 4LRCA 2W5WA 1ANIA 3T00A 3UN2A 3BDHA 1SHQA 1HQAA 1P49A 2G9YA 2W5QA 1ALHA 2GA3A 4NWXA 2XR9A 3WAXA 3M8WA 4LR2A 4GTXA 3T01A 3NKRA 1Y7AA 3NKPA 4KJDA 4LRBA 4LR9A 1KH9A 5HRTA 1KHNA 3WAWA 2IUCB 2ZKTA 3MK1A 5EGHA 4CYSA 1E2SP 1K7HA 2GSOA 4ZG7A 2IFYA 4KM4A 4UOPA 1ELZA 2RH6A 2W5RA 3E2DA 3NKMA 4LR8A 5INHA 2GSUA 3M8ZA 4LRDA 4UPHA 3BDFA 1N2KA 4GTYA 4NWJA 4MIVA 3CMRA 3UN3A 4ZG9A 5DLWA 5IJQA 5LQQA 1AJBA 4TN0A 1ELXA 1ELYA 4CYRA 1EW9A 5EGEA 3SZYA 5KXAA 2QZUA 3TG0A 3BDGA 5K4PA 4CXSA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4KJG A;  5GRR A;  1AJA A;  1AJD A;  3T02 A;  1ALK A;  1E1Z P;  5L0E A;  2IUC A;  3Q3Q A;  3OT9 A;  4UOR A;  1URA A;  5L0K A;  4UOO A;  1HJK A;  3SZZ A;  1KH4 A;  4CXU A;  1AJC A;  3NKO A;  4ZG6 A;  4LRE A;  2ANH A;  1FSU A;  1KHK A;  5DLT A;  3MK0 A;  3IGZ B;  4ZGA A;  1EI6 A;  3WAV A;  4MHX A;  1URB A;  2D1G A;  3NKN A;  3KD8 A;  4KAY A;  2W5X A;  4GTZ A;  5GOV A;  3M8Y A;  3MK2 A;  2W8D A;  3UN5 A;  1HDH A;  1KHL A;  1ANJ A;  4GTW A;  3IGY B;  1E3C P;  3NKQ A;  1KH5 A;  2VQR A;  3TX0 A;  1KHJ A;  1SHN A;  4FDI A;  1B8J A;  1Y6V A;  2W8S A;  3NVL A;  4YR1 A;  5LRM A;  3BDG B;  2X98 A;  1E33 P;  1ALJ A;  4QAX A;  2GSN A;  5C66 A;  1O99 A;  1ZEF A;  4KAV A;  5L0B A;  1ZED A;  4N7T A;  3M7V A;  1KH7 A;  3IDD A;  3DYC A;  4MY4 A;  4LQY A;  4UPL A;  3TWZ A;  3A52 A;  4FDJ A;  1AUK A;  2W5T A;  3WBH A;  3WAY A;  4CXK A;  5LRN A;  1EQJ A;  4LRF A;  1ZEB A;  5IJS A;  1ED9 A;  3LXQ A;  5DLV A;  3UO0 A;  2W5S A;  4LRA A;  4UPK A;  1O98 A;  2GLQ A;  1EW8 A;  4UPI A;  5AJ9 A;  5TJ3 A;  1EW2 A;  3B5Q A;  3UNY A;  1N2L A;  3DPC A;  1ALI A;  2W5V A;  4LR7 A;  2XRG A;  5LIA A;  4B56 A;  3ED4 A;  1EJJ A;  1ED8 A;  4LRC A;  2W5W A;  1ANI A;  3T00 A;  3UN2 A;  3BDH A;  1SHQ A;  1HQA A;  1P49 A;  2G9Y A;  2W5Q A;  1ALH A;  2GA3 A;  4NWX A;  2XR9 A;  3WAX A;  3M8W A;  4LR2 A;  4GTX A;  3T01 A;  3NKR A;  1Y7A A;  3NKP A;  4KJD A;  4LRB A;  4LR9 A;  1KH9 A;  5HRT A;  1KHN A;  3WAW A;  2IUC B;  2ZKT A;  3MK1 A;  5EGH A;  4CYS A;  1E2S P;  1K7H A;  2GSO A;  4ZG7 A;  2IFY A;  4KM4 A;  4UOP A;  1ELZ A;  2RH6 A;  2W5R A;  3E2D A;  3NKM A;  4LR8 A;  5INH A;  2GSU A;  3M8Z A;  4LRD A;  4UPH A;  3BDF A;  1N2K A;  4GTY A;  4NWJ A;  4MIV A;  3CMR A;  3UN3 A;  4ZG9 A;  5DLW A;  5IJQ A;  5LQQ A;  1AJB A;  4TN0 A;  1ELX A;  1ELY A;  4CYR A;  1EW9 A;  5EGE A;  3SZY A;  5KXA A;  2QZU A;  3TG0 A;  3BDG A;  5K4P A;  4CXS A; 
#chains in the Genus database with same CATH topology
 4KJG A;  5GRR A;  1AJA A;  1AJD A;  3T02 A;  1ALK A;  1E1Z P;  5L0E A;  2IUC A;  3Q3Q A;  3OT9 A;  4UOR A;  1URA A;  5L0K A;  4UOO A;  1HJK A;  3SZZ A;  1KH4 A;  4CXU A;  1AJC A;  3NKO A;  4ZG6 A;  4LRE A;  2ANH A;  1FSU A;  1KHK A;  5DLT A;  3MK0 A;  3IGZ B;  4ZGA A;  1EI6 A;  3WAV A;  4MHX A;  1URB A;  2D1G A;  3NKN A;  3KD8 A;  4KAY A;  2W5X A;  4GTZ A;  5GOV A;  3M8Y A;  3MK2 A;  2W8D A;  3UN5 A;  1HDH A;  1KHL A;  1ANJ A;  4GTW A;  3IGY B;  1E3C P;  3NKQ A;  1KH5 A;  2VQR A;  3TX0 A;  1KHJ A;  1SHN A;  4FDI A;  1B8J A;  1Y6V A;  2W8S A;  3NVL A;  4YR1 A;  5LRM A;  3BDG B;  2X98 A;  1E33 P;  1ALJ A;  4QAX A;  2GSN A;  5C66 A;  1O99 A;  1ZEF A;  4KAV A;  5L0B A;  1ZED A;  4N7T A;  3M7V A;  1KH7 A;  3IDD A;  3DYC A;  4MY4 A;  4LQY A;  4UPL A;  3TWZ A;  3A52 A;  4FDJ A;  1AUK A;  2W5T A;  3WBH A;  3WAY A;  4CXK A;  5LRN A;  1EQJ A;  4LRF A;  1ZEB A;  5IJS A;  1ED9 A;  3LXQ A;  5DLV A;  3UO0 A;  2W5S A;  4LRA A;  4UPK A;  1O98 A;  2GLQ A;  1EW8 A;  4UPI A;  5AJ9 A;  5TJ3 A;  1EW2 A;  3B5Q A;  3UNY A;  1N2L A;  3DPC A;  1ALI A;  2W5V A;  4LR7 A;  2XRG A;  5LIA A;  4B56 A;  3ED4 A;  1EJJ A;  1ED8 A;  4LRC A;  2W5W A;  1ANI A;  3T00 A;  3UN2 A;  3BDH A;  1SHQ A;  1HQA A;  1P49 A;  2G9Y A;  2W5Q A;  1ALH A;  2GA3 A;  4NWX A;  2XR9 A;  3WAX A;  3M8W A;  4LR2 A;  4GTX A;  3T01 A;  3NKR A;  1Y7A A;  3NKP A;  4KJD A;  4LRB A;  4LR9 A;  1KH9 A;  5HRT A;  1KHN A;  3WAW A;  2IUC B;  2ZKT A;  3MK1 A;  5EGH A;  4CYS A;  1E2S P;  1K7H A;  2GSO A;  4ZG7 A;  2IFY A;  4KM4 A;  4UOP A;  1ELZ A;  2RH6 A;  2W5R A;  3E2D A;  3NKM A;  4LR8 A;  5INH A;  2GSU A;  3M8Z A;  4LRD A;  4UPH A;  3BDF A;  1N2K A;  4GTY A;  4NWJ A;  4MIV A;  3CMR A;  3UN3 A;  4ZG9 A;  5DLW A;  5IJQ A;  5LQQ A;  1AJB A;  4TN0 A;  1ELX A;  1ELY A;  4CYR A;  1EW9 A;  5EGE A;  3SZY A;  5KXA A;  2QZU A;  3TG0 A;  3BDG A;  5K4P A;  4CXS A; 
#chains in the Genus database with same CATH homology
 4KJG A;  5GRR A;  1AJA A;  1AJD A;  3T02 A;  1ALK A;  1E1Z P;  5L0E A;  2IUC A;  3Q3Q A;  3OT9 A;  4UOR A;  1URA A;  5L0K A;  4UOO A;  1HJK A;  3SZZ A;  1KH4 A;  4CXU A;  1AJC A;  3NKO A;  4ZG6 A;  4LRE A;  2ANH A;  1FSU A;  1KHK A;  5DLT A;  3MK0 A;  3IGZ B;  4ZGA A;  1EI6 A;  3WAV A;  4MHX A;  1URB A;  2D1G A;  3NKN A;  3KD8 A;  4KAY A;  2W5X A;  4GTZ A;  5GOV A;  3M8Y A;  3MK2 A;  2W8D A;  3UN5 A;  1HDH A;  1KHL A;  1ANJ A;  4GTW A;  3IGY B;  1E3C P;  3NKQ A;  1KH5 A;  2VQR A;  3TX0 A;  1KHJ A;  1SHN A;  4FDI A;  1B8J A;  1Y6V A;  2W8S A;  3NVL A;  4YR1 A;  5LRM A;  3BDG B;  2X98 A;  1E33 P;  1ALJ A;  4QAX A;  2GSN A;  5C66 A;  1O99 A;  1ZEF A;  4KAV A;  5L0B A;  1ZED A;  4N7T A;  3M7V A;  1KH7 A;  3IDD A;  3DYC A;  4MY4 A;  4LQY A;  4UPL A;  3TWZ A;  3A52 A;  4FDJ A;  1AUK A;  2W5T A;  3WBH A;  3WAY A;  4CXK A;  5LRN A;  1EQJ A;  4LRF A;  1ZEB A;  5IJS A;  1ED9 A;  3LXQ A;  5DLV A;  3UO0 A;  2W5S A;  4LRA A;  4UPK A;  1O98 A;  2GLQ A;  1EW8 A;  4UPI A;  5AJ9 A;  5TJ3 A;  1EW2 A;  3B5Q A;  3UNY A;  1N2L A;  3DPC A;  1ALI A;  2W5V A;  4LR7 A;  2XRG A;  5LIA A;  4B56 A;  3ED4 A;  1EJJ A;  1ED8 A;  4LRC A;  2W5W A;  1ANI A;  3T00 A;  3UN2 A;  3BDH A;  1SHQ A;  1HQA A;  1P49 A;  2G9Y A;  2W5Q A;  1ALH A;  2GA3 A;  4NWX A;  2XR9 A;  3WAX A;  3M8W A;  4LR2 A;  4GTX A;  3T01 A;  3NKR A;  1Y7A A;  3NKP A;  4KJD A;  4LRB A;  4LR9 A;  1KH9 A;  5HRT A;  1KHN A;  3WAW A;  2IUC B;  2ZKT A;  3MK1 A;  5EGH A;  4CYS A;  1E2S P;  1K7H A;  2GSO A;  4ZG7 A;  2IFY A;  4KM4 A;  4UOP A;  1ELZ A;  2RH6 A;  2W5R A;  3E2D A;  3NKM A;  4LR8 A;  5INH A;  2GSU A;  3M8Z A;  4LRD A;  4UPH A;  3BDF A;  1N2K A;  4GTY A;  4NWJ A;  4MIV A;  3CMR A;  3UN3 A;  4ZG9 A;  5DLW A;  5IJQ A;  5LQQ A;  1AJB A;  4TN0 A;  1ELX A;  1ELY A;  4CYR A;  1EW9 A;  5EGE A;  3SZY A;  5KXA A;  2QZU A;  3TG0 A;  3BDG A;  5K4P A;  4CXS A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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