2FY5A

Structures of ligand bound human choline acetyltransferase provide insight into regulation of acetylcholine synthesis
Total Genus 218
Loading diagram...

The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
218
Knots found
sequence length
594
structure length
577
Chain Sequence
SGLPKLPVPPLQQTLATYLQCMRHLVSEEQFRKSQAIVQQFGAPGGLGETLQQKLLERQEKTANWVSEYWLNDMYLNNRLALPVNSSPAVIFARQHFPGTDDQLRFAASLISGVLSYKALLDSHSIPTDCAKGQLSGQPLCMKQYYGLFSSYRLPGHTQDTLVMPEPEHVIVACCNQFFVLDVVINFRRLSEGDLFTQLRKIVKMASNAAARLPPIGLLTSDGRSEWAEARTVLVKDSTNRDSLDMIERCICLVCLDAPGGVELSDTHRALQLLHGGGYSKNGANRWYDKSLQFVVGRDGTCGVVCEHSPFDGIVLVQCTEHLLKHMPLPAPRRLRWKCSPEIQGHLASSAEKLQRIVKNLDFIVYKFDNYGKTFIKKQKCSPDAFIQVALQLAFYRLHRRLVPTYESASIRRFQEGRVDNIRSATPEALAFVRAVTDHKAAVPASEKLLLLKDAIRAQTAYTVMAITGMAIDNHLLALRELARAMCAALPEMFMDETYLMSNRFVLSTSQVPTTTEMFCCYGPVVPNGYGACYNPQPETILFCISSFHSCAATSSSKFAKAVEESLIDMRDLCSLL
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

molecule keywords Choline O-acetyltransferase
publication title Substrate binding and catalytic mechanism of human choline acetyltransferase.
pubmed doi rcsb
source organism Homo sapiens
molecule tags Transferase
total genus 218
structure length 577
sequence length 594
other databases KnotProt 2.0: Artifct K -31 -31 -
ec nomenclature ec 2.3.1.6: Choline O-acetyltransferase.
pdb deposition date 2006-02-07

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00755 Carn_acyltransf Choline/Carnitine o-acyltransferase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.30.559.40 Alpha Beta 2-Layer Sandwich Chloramphenicol Acetyltransferase Chloramphenicol Acetyltransferase 2fy5A01
3.30.559.70 Alpha Beta 2-Layer Sandwich Chloramphenicol Acetyltransferase Chloramphenicol Acetyltransferase 2fy5A02
1T7NA 2H4TA 2RCUA 2H3WA 2DEBA 2FY5A 1T7QA 2H3UA 2H3PA 1NDFA 2FY4A 2FY3A 4EP9A 2FW3A 1NM8A 1T7OA 4EPHA 2FYOA 1NDIA 1T1UA 4EYWA 1Q6XA 1NDBA 2FY2A 1S5OA
chains in the Genus database with same CATH superfamily
4G0BA 2RKTA 2BGHA 1DPBA 1T7QA 5FALA 1DPDA 2FY3A 2IHWA 1EACA 3MAEA 4EP9A 2ZBAA 5KJUA 3CLAA 3B30A 3U9BA 1T1UA 5FANA 4EYWA 1EAFA 5KJVA 2H4TA 1PD5A 2H3WA 2RCUA 2VSQA 4CLAA 4N72A 1Q9JA 1XL7A 2II4A 2H3PA 1EABA 2II3A 1C4TA 4EPHA 2FYOA 2CLAA 4G2MA 2XHGA 1Q6XA 2JGPA 3U9FA 2FY2A 1Q23A 1SCZA 4G22A 1E2OA 2DEBA 1QCAA 1L5AA 2FY5A 2H3UA 2E1VA 1XMDA 2FY4A 5KJSA 1EAEA 4KECA 4JN5A 1NM8A 1T7OA 5KJTA 2E1TA 1EADA 3L60A 1NDIA 2E1UA 3B2SA 4HVMA 1EAAA 1S5OA 1XL8A 5DUAA 1T7NA 1NOCB 2I9DA 2XR7A 1NDFA 1CLAA 1CIAA 5T3EA 3FP0A 2FW3A 1XMCA 4KE4A 1DPCA 2RKVA 2II5A 5DU9A 5KJWA 1NDBA 3FOTA 4JN3A
chains in the Genus database with same CATH topology
5DUAA 1T7NA 2H4TA 2RCUA 2H3WA 2VSQA 2DEBA 1L5AA 1Q9JA 2FY5A 1T7QA 2H3UA 2H3PA 1NDFA 2FY4A 2FY3A 5T3EA 3FP0A 4EP9A 2FW3A 1NM8A 1T7OA 4JN5A 4EPHA 2FYOA 1NDIA 5DU9A 1T1UA 2XHGA 1Q6XA 4EYWA 2JGPA 1NDBA 3FOTA 4JN3A 4HVMA 2FY2A 1S5OA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1T7N A;  2H4T A;  2RCU A;  2H3W A;  2DEB A;  2FY5 A;  1T7Q A;  2H3U A;  2H3P A;  1NDF A;  2FY4 A;  2FY3 A;  4EP9 A;  2FW3 A;  1NM8 A;  1T7O A;  4EPH A;  2FYO A;  1NDI A;  1T1U A;  4EYW A;  1Q6X A;  1NDB A;  2FY2 A;  1S5O A; 
#chains in the Genus database with same CATH topology
 4G0B A;  2RKT A;  2BGH A;  1DPB A;  1T7Q A;  5FAL A;  1DPD A;  2FY3 A;  2IHW A;  1EAC A;  3MAE A;  4EP9 A;  2ZBA A;  5KJU A;  3CLA A;  3B30 A;  3U9B A;  1T1U A;  5FAN A;  4EYW A;  1EAF A;  5KJV A;  2H4T A;  1PD5 A;  2H3W A;  2RCU A;  2VSQ A;  4CLA A;  4N72 A;  1Q9J A;  1XL7 A;  2II4 A;  2H3P A;  1EAB A;  2II3 A;  1C4T A;  4EPH A;  2FYO A;  2CLA A;  4G2M A;  2XHG A;  1Q6X A;  2JGP A;  3U9F A;  2FY2 A;  1Q23 A;  1SCZ A;  4G22 A;  1E2O A;  2DEB A;  1QCA A;  1L5A A;  2FY5 A;  2H3U A;  2E1V A;  1XMD A;  2FY4 A;  5KJS A;  1EAE A;  4KEC A;  4JN5 A;  1NM8 A;  1T7O A;  5KJT A;  2E1T A;  1EAD A;  3L60 A;  1NDI A;  2E1U A;  3B2S A;  4HVM A;  1EAA A;  1S5O A;  1XL8 A;  5DUA A;  1T7N A;  1NOC B;  2I9D A;  2XR7 A;  1NDF A;  1CLA A;  1CIA A;  5T3E A;  3FP0 A;  2FW3 A;  1XMC A;  4KE4 A;  1DPC A;  2RKV A;  2II5 A;  5DU9 A;  5KJW A;  1NDB A;  3FOT A;  4JN3 A; 
#chains in the Genus database with same CATH homology
 5DUA A;  1T7N A;  2H4T A;  2RCU A;  2H3W A;  2VSQ A;  2DEB A;  1L5A A;  1Q9J A;  2FY5 A;  1T7Q A;  2H3U A;  2H3P A;  1NDF A;  2FY4 A;  2FY3 A;  5T3E A;  3FP0 A;  4EP9 A;  2FW3 A;  1NM8 A;  1T7O A;  4JN5 A;  4EPH A;  2FYO A;  1NDI A;  5DU9 A;  1T1U A;  2XHG A;  1Q6X A;  4EYW A;  2JGP A;  1NDB A;  3FOT A;  4JN3 A;  4HVM A;  2FY2 A;  1S5O A; 
...loading similar chains, please wait...
similar chains in the Genus database (?% sequence similarity)
...loading similar chains, please wait...
similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
...loading similar chains, please wait...
#similar chains, but unknotted
...loading similar chains, please wait...
#similar chains in the pdb database (?% sequence similarity)
...loading similar chains, please wait...