2IV0A

Thermal stability of isocitrate dehydrogenase from archaeoglobus fulgidus studied by crystal structure analysis and engineering of chimers
Total Genus 136
Loading diagram...

The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
136
sequence length
412
structure length
412
Chain Sequence
MQYEKVKPPENGEKIRYENGKLIVPDNPIIPYFEGDGIGKDVVPAAIRVLDAAADKIGKEVVWFQVYAGEDAYKLYGNYLPDDTLNAIKEFRVALKGPLTTPVGGGYRSLNVTIRQVLDLYANVRPVYYLKGVPSPIKHPEKVNFVIFRENTEDVYAGIEWPRGSEEALKLIRFLKNEFGVTIREDSGIGIKPISEFATKRLVRMAIRYAIENNRKSVTLVHKGNIMKYTEGAFRDWGYEVAKQEFGEYCITEDELWDKYGGKQPEGKIVVKDRIADNMFQQILTRTDEYDVIALPNLNGDYLSDAAAALIGGLGIAPGSNIGDGIGVFEPVHGSAPKYAGQNKVNPTAEILTGALMFEYIGWKDASEMIKKAVEMTISSGIVTYDIHRHMGGTKVGTREFAEAVVENLQSL
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
{{ tooltip.sname }} connected with {{ tooltip.tname }} : {{qFormat(tooltip.svalue) }}
molecule tags Oxidoreductase
molecule keywords ISOCITRATE DEHYDROGENASE
publication title Thermal Stability of Isocitrate Dehydrogenase from Archaeoglobus Fulgidus Studied by Crystal Structure Analysis and Engineering of Chimers
pubmed doi rcsb
source organism Archaeoglobus fulgidus
total genus 136
structure length 412
sequence length 412
chains with identical sequence B
ec nomenclature ec 1.1.1.42: Isocitrate dehydrogenase (NADP(+)).
pdb deposition date 2006-06-08

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00180 Iso_dh Isocitrate/isopropylmalate dehydrogenase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.718.10 Alpha Beta 3-Layer(aba) Sandwich Isopropylmalate Dehydrogenase Isopropylmalate Dehydrogenase 2iv0A00
3UDOA 5K10A 4AJRA 3MAPA 3AH3A 1R8KA 5K11A 5GRFA 4AOYA 5DE1A 5GRHB 6ICDA 9ICDA 3MASA 4XXVA 1HEXA 3TSNA 5GRIA 1XABA 3WZWA 5L57A 2E0CA 1IDCA 2UXQA 1OSJA 2D1CA 3ASJA 3VL2A 2QFVA 1A05A 4L03A 1IDEA 5HN4A 5J34A 4L04A 2QFYA 1TYOA 1SJSA 2ZTWA 1DR8A 1OSIA 1XACA 4UMYA 1PB3A 2AYQA 1DPZA 2IV0A 3FLKA 2UXRA 1ISOA 1YCOA 3MASB 3WZYA 5GREA 3WZXA 4Y1PA 1PS6A 4P69C 5HN3A 5HN6A 1IDFA 1WPWA 1PS7A 7ICDA 2DHTA 2Y40A 1XADA 4XRXA 5I96A 5J32A 5GRLB 2G4OA 3VMJA 1IKAA 5J33A 3VKZA 4WUOA 1PTMA 1WALA 3DMSA 3WZVA 5L58A 1P8FA 3INMA 3MARA 1GROA 3BLXA 1PB1A 3BLVB 4F7IA 5GREB 4HCXA 3TNGA 4XS3A 4I3LA 3UDUA 5GRFB 1CNZA 4ATYA 3FMXX 4AJBA 1T0LA 5GRIB 1CW1A 1U7NA 3LCBC 1HJ6A 4KZOA 3TY4A 4BNPA 3U1HA 1CW4A 1GC9A 1GRPA 1CW7A 1V94A 3BLVA 1T09A 4UMXA 5GRHA 3VL6A 1IDDA 4YB4A 8ICDA 1CM7A 4JQPA 3LXYA 4JA8A 1BL5A 1HQSA 2QFXA 4AJ3A 2Y42A 3U9EA 1IDMA 3VMKA 3VL7A 3VL4A 1AI2A 2D4VA 4L06A 4AJCA 3TY3A 2QFWA 4ICDA 4AOVA 1G2UA 3R8WA 5ICDA 2E5MA 1GC8A 1XKDA 2Y41A 1X0LA 1YXOA 3UF6A 5I95A 1W0DA 1VLCA 3US8A 3ICDA 4AJAA 1XGVA 1V53A 2HI1A 1VI1A 1ZORA 3VMLA 4AJSA 1AI3A 1XAAA 4I3KA 5GRLA 3BLXB 2Y3ZA 1LWDA 1DR0A 4AOUA 3VL3A 5LGEA 4IWHA 1V5BA 1IPDA 5HN5A
chains in the Genus database with same CATH superfamily
3UDOA 5K10A 4AJRA 3MAPA 3AH3A 1R8KA 5K11A 5GRFA 4AOYA 5DE1A 5GRHB 6ICDA 9ICDA 3MASA 4XXVA 1HEXA 3TSNA 5GRIA 1XABA 3WZWA 5L57A 2E0CA 1IDCA 2UXQA 1OSJA 2D1CA 3ASJA 3VL2A 2QFVA 1A05A 4L03A 1IDEA 5HN4A 5J34A 4L04A 2QFYA 1TYOA 1SJSA 2ZTWA 1DR8A 1OSIA 1XACA 4UMYA 1PB3A 2AYQA 1DPZA 2IV0A 3FLKA 2UXRA 1ISOA 1YCOA 3MASB 3WZYA 5GREA 3WZXA 4Y1PA 1PS6A 4P69C 5HN3A 5HN6A 1IDFA 1WPWA 1PS7A 7ICDA 2DHTA 2Y40A 1XADA 4XRXA 5I96A 5J32A 5GRLB 2G4OA 3VMJA 1IKAA 5J33A 3VKZA 4WUOA 1PTMA 1WALA 3DMSA 3WZVA 5L58A 1P8FA 3INMA 3MARA 1GROA 3BLXA 1PB1A 3BLVB 4F7IA 5GREB 4HCXA 3TNGA 4XS3A 4I3LA 3UDUA 5GRFB 1CNZA 4ATYA 3FMXX 4AJBA 1T0LA 5GRIB 1CW1A 1U7NA 3LCBC 1HJ6A 4KZOA 3TY4A 4BNPA 3U1HA 1CW4A 1GC9A 1GRPA 1CW7A 1V94A 3BLVA 1T09A 4UMXA 5GRHA 3VL6A 1IDDA 4YB4A 8ICDA 1CM7A 4JQPA 3LXYA 4JA8A 1BL5A 1HQSA 2QFXA 4AJ3A 2Y42A 3U9EA 1IDMA 3VMKA 3VL7A 3VL4A 1AI2A 2D4VA 4L06A 4AJCA 3TY3A 2QFWA 4ICDA 4AOVA 1G2UA 3R8WA 5ICDA 2E5MA 1GC8A 1XKDA 2Y41A 1X0LA 1YXOA 3UF6A 5I95A 1W0DA 1VLCA 3US8A 3ICDA 4AJAA 1XGVA 1V53A 2HI1A 1VI1A 1ZORA 3VMLA 4AJSA 1AI3A 1XAAA 4I3KA 5GRLA 3BLXB 2Y3ZA 1LWDA 1DR0A 4AOUA 3VL3A 5LGEA 4IWHA 1V5BA 1IPDA 5HN5A
chains in the Genus database with same CATH topology
3UDOA 5K10A 4AJRA 3MAPA 3AH3A 1R8KA 5K11A 5GRFA 4AOYA 5DE1A 5GRHB 6ICDA 9ICDA 3MASA 4XXVA 1HEXA 3TSNA 5GRIA 1XABA 3WZWA 5L57A 2E0CA 1IDCA 2UXQA 1OSJA 2D1CA 3ASJA 3VL2A 2QFVA 1A05A 4L03A 1IDEA 5HN4A 5J34A 4L04A 2QFYA 1TYOA 1SJSA 2ZTWA 1DR8A 1OSIA 1XACA 4UMYA 1PB3A 2AYQA 1DPZA 2IV0A 3FLKA 2UXRA 1ISOA 1YCOA 3MASB 3WZYA 5GREA 3WZXA 4Y1PA 1PS6A 4P69C 5HN3A 5HN6A 1IDFA 1WPWA 1PS7A 7ICDA 2DHTA 2Y40A 1XADA 4XRXA 5I96A 5J32A 5GRLB 2G4OA 3VMJA 1IKAA 5J33A 3VKZA 4WUOA 1PTMA 1WALA 3DMSA 3WZVA 5L58A 1P8FA 3INMA 3MARA 1GROA 3BLXA 1PB1A 3BLVB 4F7IA 5GREB 4HCXA 3TNGA 4XS3A 4I3LA 3UDUA 5GRFB 1CNZA 4ATYA 3FMXX 4AJBA 1T0LA 5GRIB 1CW1A 1U7NA 3LCBC 1HJ6A 4KZOA 3TY4A 4BNPA 3U1HA 1CW4A 1GC9A 1GRPA 1CW7A 1V94A 3BLVA 1T09A 4UMXA 5GRHA 3VL6A 1IDDA 4YB4A 8ICDA 1CM7A 4JQPA 3LXYA 4JA8A 1BL5A 1HQSA 2QFXA 4AJ3A 2Y42A 3U9EA 1IDMA 3VMKA 3VL7A 3VL4A 1AI2A 2D4VA 4L06A 4AJCA 3TY3A 2QFWA 4ICDA 4AOVA 1G2UA 3R8WA 5ICDA 2E5MA 1GC8A 1XKDA 2Y41A 1X0LA 1YXOA 3UF6A 5I95A 1W0DA 1VLCA 3US8A 3ICDA 4AJAA 1XGVA 1V53A 2HI1A 1VI1A 1ZORA 3VMLA 4AJSA 1AI3A 1XAAA 4I3KA 5GRLA 3BLXB 2Y3ZA 1LWDA 1DR0A 4AOUA 3VL3A 5LGEA 4IWHA 1V5BA 1IPDA 5HN5A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 3UDO A;  5K10 A;  4AJR A;  3MAP A;  3AH3 A;  1R8K A;  5K11 A;  5GRF A;  4AOY A;  5DE1 A;  5GRH B;  6ICD A;  9ICD A;  3MAS A;  4XXV A;  1HEX A;  3TSN A;  5GRI A;  1XAB A;  3WZW A;  5L57 A;  2E0C A;  1IDC A;  2UXQ A;  1OSJ A;  2D1C A;  3ASJ A;  3VL2 A;  2QFV A;  1A05 A;  4L03 A;  1IDE A;  5HN4 A;  5J34 A;  4L04 A;  2QFY A;  1TYO A;  1SJS A;  2ZTW A;  1DR8 A;  1OSI A;  1XAC A;  4UMY A;  1PB3 A;  2AYQ A;  1DPZ A;  2IV0 A;  3FLK A;  2UXR A;  1ISO A;  1YCO A;  3MAS B;  3WZY A;  5GRE A;  3WZX A;  4Y1P A;  1PS6 A;  4P69 C;  5HN3 A;  5HN6 A;  1IDF A;  1WPW A;  1PS7 A;  7ICD A;  2DHT A;  2Y40 A;  1XAD A;  4XRX A;  5I96 A;  5J32 A;  5GRL B;  2G4O A;  3VMJ A;  1IKA A;  5J33 A;  3VKZ A;  4WUO A;  1PTM A;  1WAL A;  3DMS A;  3WZV A;  5L58 A;  1P8F A;  3INM A;  3MAR A;  1GRO A;  3BLX A;  1PB1 A;  3BLV B;  4F7I A;  5GRE B;  4HCX A;  3TNG A;  4XS3 A;  4I3L A;  3UDU A;  5GRF B;  1CNZ A;  4ATY A;  3FMX X;  4AJB A;  1T0L A;  5GRI B;  1CW1 A;  1U7N A;  3LCB C;  1HJ6 A;  4KZO A;  3TY4 A;  4BNP A;  3U1H A;  1CW4 A;  1GC9 A;  1GRP A;  1CW7 A;  1V94 A;  3BLV A;  1T09 A;  4UMX A;  5GRH A;  3VL6 A;  1IDD A;  4YB4 A;  8ICD A;  1CM7 A;  4JQP A;  3LXY A;  4JA8 A;  1BL5 A;  1HQS A;  2QFX A;  4AJ3 A;  2Y42 A;  3U9E A;  1IDM A;  3VMK A;  3VL7 A;  3VL4 A;  1AI2 A;  2D4V A;  4L06 A;  4AJC A;  3TY3 A;  2QFW A;  4ICD A;  4AOV A;  1G2U A;  3R8W A;  5ICD A;  2E5M A;  1GC8 A;  1XKD A;  2Y41 A;  1X0L A;  1YXO A;  3UF6 A;  5I95 A;  1W0D A;  1VLC A;  3US8 A;  3ICD A;  4AJA A;  1XGV A;  1V53 A;  2HI1 A;  1VI1 A;  1ZOR A;  3VML A;  4AJS A;  1AI3 A;  1XAA A;  4I3K A;  5GRL A;  3BLX B;  2Y3Z A;  1LWD A;  1DR0 A;  4AOU A;  3VL3 A;  5LGE A;  4IWH A;  1V5B A;  1IPD A;  5HN5 A; 
#chains in the Genus database with same CATH topology
 3UDO A;  5K10 A;  4AJR A;  3MAP A;  3AH3 A;  1R8K A;  5K11 A;  5GRF A;  4AOY A;  5DE1 A;  5GRH B;  6ICD A;  9ICD A;  3MAS A;  4XXV A;  1HEX A;  3TSN A;  5GRI A;  1XAB A;  3WZW A;  5L57 A;  2E0C A;  1IDC A;  2UXQ A;  1OSJ A;  2D1C A;  3ASJ A;  3VL2 A;  2QFV A;  1A05 A;  4L03 A;  1IDE A;  5HN4 A;  5J34 A;  4L04 A;  2QFY A;  1TYO A;  1SJS A;  2ZTW A;  1DR8 A;  1OSI A;  1XAC A;  4UMY A;  1PB3 A;  2AYQ A;  1DPZ A;  2IV0 A;  3FLK A;  2UXR A;  1ISO A;  1YCO A;  3MAS B;  3WZY A;  5GRE A;  3WZX A;  4Y1P A;  1PS6 A;  4P69 C;  5HN3 A;  5HN6 A;  1IDF A;  1WPW A;  1PS7 A;  7ICD A;  2DHT A;  2Y40 A;  1XAD A;  4XRX A;  5I96 A;  5J32 A;  5GRL B;  2G4O A;  3VMJ A;  1IKA A;  5J33 A;  3VKZ A;  4WUO A;  1PTM A;  1WAL A;  3DMS A;  3WZV A;  5L58 A;  1P8F A;  3INM A;  3MAR A;  1GRO A;  3BLX A;  1PB1 A;  3BLV B;  4F7I A;  5GRE B;  4HCX A;  3TNG A;  4XS3 A;  4I3L A;  3UDU A;  5GRF B;  1CNZ A;  4ATY A;  3FMX X;  4AJB A;  1T0L A;  5GRI B;  1CW1 A;  1U7N A;  3LCB C;  1HJ6 A;  4KZO A;  3TY4 A;  4BNP A;  3U1H A;  1CW4 A;  1GC9 A;  1GRP A;  1CW7 A;  1V94 A;  3BLV A;  1T09 A;  4UMX A;  5GRH A;  3VL6 A;  1IDD A;  4YB4 A;  8ICD A;  1CM7 A;  4JQP A;  3LXY A;  4JA8 A;  1BL5 A;  1HQS A;  2QFX A;  4AJ3 A;  2Y42 A;  3U9E A;  1IDM A;  3VMK A;  3VL7 A;  3VL4 A;  1AI2 A;  2D4V A;  4L06 A;  4AJC A;  3TY3 A;  2QFW A;  4ICD A;  4AOV A;  1G2U A;  3R8W A;  5ICD A;  2E5M A;  1GC8 A;  1XKD A;  2Y41 A;  1X0L A;  1YXO A;  3UF6 A;  5I95 A;  1W0D A;  1VLC A;  3US8 A;  3ICD A;  4AJA A;  1XGV A;  1V53 A;  2HI1 A;  1VI1 A;  1ZOR A;  3VML A;  4AJS A;  1AI3 A;  1XAA A;  4I3K A;  5GRL A;  3BLX B;  2Y3Z A;  1LWD A;  1DR0 A;  4AOU A;  3VL3 A;  5LGE A;  4IWH A;  1V5B A;  1IPD A;  5HN5 A; 
#chains in the Genus database with same CATH homology
 3UDO A;  5K10 A;  4AJR A;  3MAP A;  3AH3 A;  1R8K A;  5K11 A;  5GRF A;  4AOY A;  5DE1 A;  5GRH B;  6ICD A;  9ICD A;  3MAS A;  4XXV A;  1HEX A;  3TSN A;  5GRI A;  1XAB A;  3WZW A;  5L57 A;  2E0C A;  1IDC A;  2UXQ A;  1OSJ A;  2D1C A;  3ASJ A;  3VL2 A;  2QFV A;  1A05 A;  4L03 A;  1IDE A;  5HN4 A;  5J34 A;  4L04 A;  2QFY A;  1TYO A;  1SJS A;  2ZTW A;  1DR8 A;  1OSI A;  1XAC A;  4UMY A;  1PB3 A;  2AYQ A;  1DPZ A;  2IV0 A;  3FLK A;  2UXR A;  1ISO A;  1YCO A;  3MAS B;  3WZY A;  5GRE A;  3WZX A;  4Y1P A;  1PS6 A;  4P69 C;  5HN3 A;  5HN6 A;  1IDF A;  1WPW A;  1PS7 A;  7ICD A;  2DHT A;  2Y40 A;  1XAD A;  4XRX A;  5I96 A;  5J32 A;  5GRL B;  2G4O A;  3VMJ A;  1IKA A;  5J33 A;  3VKZ A;  4WUO A;  1PTM A;  1WAL A;  3DMS A;  3WZV A;  5L58 A;  1P8F A;  3INM A;  3MAR A;  1GRO A;  3BLX A;  1PB1 A;  3BLV B;  4F7I A;  5GRE B;  4HCX A;  3TNG A;  4XS3 A;  4I3L A;  3UDU A;  5GRF B;  1CNZ A;  4ATY A;  3FMX X;  4AJB A;  1T0L A;  5GRI B;  1CW1 A;  1U7N A;  3LCB C;  1HJ6 A;  4KZO A;  3TY4 A;  4BNP A;  3U1H A;  1CW4 A;  1GC9 A;  1GRP A;  1CW7 A;  1V94 A;  3BLV A;  1T09 A;  4UMX A;  5GRH A;  3VL6 A;  1IDD A;  4YB4 A;  8ICD A;  1CM7 A;  4JQP A;  3LXY A;  4JA8 A;  1BL5 A;  1HQS A;  2QFX A;  4AJ3 A;  2Y42 A;  3U9E A;  1IDM A;  3VMK A;  3VL7 A;  3VL4 A;  1AI2 A;  2D4V A;  4L06 A;  4AJC A;  3TY3 A;  2QFW A;  4ICD A;  4AOV A;  1G2U A;  3R8W A;  5ICD A;  2E5M A;  1GC8 A;  1XKD A;  2Y41 A;  1X0L A;  1YXO A;  3UF6 A;  5I95 A;  1W0D A;  1VLC A;  3US8 A;  3ICD A;  4AJA A;  1XGV A;  1V53 A;  2HI1 A;  1VI1 A;  1ZOR A;  3VML A;  4AJS A;  1AI3 A;  1XAA A;  4I3K A;  5GRL A;  3BLX B;  2Y3Z A;  1LWD A;  1DR0 A;  4AOU A;  3VL3 A;  5LGE A;  4IWH A;  1V5B A;  1IPD A;  5HN5 A; 
...loading similar chains, please wait...
similar chains in the Genus database (?% sequence similarity)
...loading similar chains, please wait...
similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
...loading similar chains, please wait...
#similar chains, but unknotted
...loading similar chains, please wait...
#similar chains in the pdb database (?% sequence similarity)
...loading similar chains, please wait...