3BDFA

Crystal structure of metal-free e. coli alkaline phosphatase (t155v)
Total Genus 159
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
159
Knots found
sequence length
449
structure length
434
Chain Sequence
TPEMPVLENRAAQGDITAPGGARRLTGDQTAALRDSLSDKPAKNIILLIGDGMGDSEITAARNYAEGAGGFFKGIDALPLTGQYTHYALNKKTGKPDYVTDSAASATAWSTGVKTYNGALGVDIHEKDHPTILEMAKAAGLATGNVSTAELQDAVPAALVAHVTSRKCYGPSATSEKCPGNALEKGGKGSITEQLLNARADVTLGGGAKTFAETATAGEWQGKTLREQAQARGYQLVSDAASLNSVTEANQQKPLLGLFADGNMPVRWLGPKATYHGNIDKPAVTCTPNPQRNDSVPTLAQMTDKAIELLSKNEKGFFLQVEGASIANPCGQIGETVDLDEAVQRALEFAKKEGNTLVIVTADHAHASQIVAPDTKAPGLTQALNTKDGAVMVMSYGTGSQLRIAAYGPHAANVVGLTDQTDLFYTMKAALGLK
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

molecule keywords Alkaline phosphatase
publication title The Active-Site Trimetallic Cluster of Alkaline Phosphatase is Lost Upon Isosteric Mutation at the Mg2+-Coordinating Residue Threonine-155
rcsb
source organism Escherichia coli
molecule tags Hydrolase
total genus 159
structure length 434
sequence length 449
chains with identical sequence B
other databases KnotProt 2.0: S +31
ec nomenclature ec 3.1.3.1: Alkaline phosphatase.
pdb deposition date 2007-11-14

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00245 Alk_phosphatase Alkaline phosphatase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.720.10 Alpha Beta 3-Layer(aba) Sandwich Alkaline Phosphatase, subunit A Alkaline Phosphatase, subunit A 3bdfA00
5TJ3A 4N7TA 3TWZA 3UN5A 5L0KA 4UOPA 3NKMA 5LRMA 4LRAA 3E2DA 2D1GA 3TX0A 1P49A 1ELZA 1FSUA 4UORA 3WAVA 4UPIA 5L0EA 1EQJA 5DLVA 4NWXA 5GRRA 5L0BA 4KM4A 2RH6A 3NKNA 4NWJA 4MY4A 5IJSA 1O98A 1ANIA 2VQRA 3TG0A 2W8DA 1ELXA 3SZZA 5DLWA 4KJDA 3BDHA 5IJQA 2ANHA 1ALHA 2W8SA 1AJDA 1ZEBA 3WAWA 3IDDA 3M8YA 4UOOA 3M8WA 1HQAA 1AUKA 3NKRA 5KXAA 2ZKTA 3T00A 1ANJA 3A52A 4LQYA 4LR8A 1AJCA 2W5TA 4LREA 2W5SA 3UN2A 4KAVA 1E3CP 1AJBA 2XR9A 3IGYB 1KHJA 3MK0A 2GSNA 1URAA 1B8JA 4CXSA 1ALIA 1EI6A 4ZG9A 5LIAA 1AJAA 1Y7AA 3DYCA 4LR7A 5GOVA 3T02A 4CYRA 1ALKA 4UPHA 1HJKA 2GSUA 3UNYA 5INHA 3M7VA 4LRFA 4CYSA 4KJGA 1ALJA 1EW9A 1HDHA 4LRDA 1EW8A 4UPLA 4GTZA 1URBA 3BDFA 3NKOA 4MIVA 4ZG7A 3B5QA 4FDIA 4GTXA 3ED4A 3DPCA 5DLTA 1ED8A 2GSOA 4CXUA 1EJJA 3BDGA 4GTWA 3OT9A 1ELYA 4B56A 5LRNA 2W5WA 4LRBA 5K4PA 3NVLA 1KHNA 3KD8A 3WAYA 1KHKA 4CXKA 1E2SP 1E33P 3UN3A 3M8ZA 1N2LA 4LR2A 1ED9A 2W5VA 2IFYA 2X98A 3Q3QA 4FDJA 4MHXA 1KH7A 1SHQA 3WBHA 4LR9A 4ZG6A 2W5RA 2G9YA 1SHNA 1Y6VA 1KH5A 3MK2A 1KH9A 3T01A 2IUCA 5LQQA 1KHLA 5C66A 2XRGA 2GA3A 2W5XA 4KAYA 2W5QA 5HRTA 1N2KA 5EGHA 3CMRA 3SZYA 4GTYA 3MK1A 3NKQA 3BDGB 1KH4A 4LRCA 1O99A 4UPKA 4TN0A 1EW2A 3UO0A 1ZEDA 4YR1A 5AJ9A 3NKPA 3LXQA 3IGZB 1E1ZP 1ZEFA 4ZGAA 1K7HA 2GLQA 4QAXA 2IUCB 3WAXA 5EGEA 2QZUA
chains in the Genus database with same CATH superfamily
5TJ3A 4N7TA 3TWZA 3UN5A 5L0KA 4UOPA 3NKMA 5LRMA 4LRAA 3E2DA 2D1GA 3TX0A 1P49A 1ELZA 1FSUA 4UORA 3WAVA 4UPIA 5L0EA 1EQJA 5DLVA 4NWXA 5GRRA 5L0BA 4KM4A 2RH6A 3NKNA 4NWJA 4MY4A 5IJSA 1O98A 1ANIA 2VQRA 3TG0A 2W8DA 1ELXA 3SZZA 5DLWA 4KJDA 3BDHA 5IJQA 2ANHA 1ALHA 2W8SA 1AJDA 1ZEBA 3WAWA 3IDDA 3M8YA 4UOOA 3M8WA 1HQAA 1AUKA 3NKRA 5KXAA 2ZKTA 3T00A 1ANJA 3A52A 4LQYA 4LR8A 1AJCA 2W5TA 4LREA 2W5SA 3UN2A 4KAVA 1E3CP 1AJBA 2XR9A 3IGYB 1KHJA 3MK0A 2GSNA 1URAA 1B8JA 4CXSA 1ALIA 1EI6A 4ZG9A 5LIAA 1AJAA 1Y7AA 3DYCA 4LR7A 5GOVA 3T02A 4CYRA 1ALKA 4UPHA 1HJKA 2GSUA 3UNYA 5INHA 3M7VA 4LRFA 4CYSA 4KJGA 1ALJA 1EW9A 1HDHA 4LRDA 1EW8A 4UPLA 4GTZA 1URBA 3BDFA 3NKOA 4MIVA 4ZG7A 3B5QA 4FDIA 4GTXA 3ED4A 3DPCA 5DLTA 1ED8A 2GSOA 4CXUA 1EJJA 3BDGA 4GTWA 3OT9A 1ELYA 4B56A 5LRNA 2W5WA 4LRBA 5K4PA 3NVLA 1KHNA 3KD8A 3WAYA 1KHKA 4CXKA 1E2SP 1E33P 3UN3A 3M8ZA 1N2LA 4LR2A 1ED9A 2W5VA 2IFYA 2X98A 3Q3QA 4FDJA 4MHXA 1KH7A 1SHQA 3WBHA 4LR9A 4ZG6A 2W5RA 2G9YA 1SHNA 1Y6VA 1KH5A 3MK2A 1KH9A 3T01A 2IUCA 5LQQA 1KHLA 5C66A 2XRGA 2GA3A 2W5XA 4KAYA 2W5QA 5HRTA 1N2KA 5EGHA 3CMRA 3SZYA 4GTYA 3MK1A 3NKQA 3BDGB 1KH4A 4LRCA 1O99A 4UPKA 4TN0A 1EW2A 3UO0A 1ZEDA 4YR1A 5AJ9A 3NKPA 3LXQA 3IGZB 1E1ZP 1ZEFA 4ZGAA 1K7HA 2GLQA 4QAXA 2IUCB 3WAXA 5EGEA 2QZUA
chains in the Genus database with same CATH topology
5TJ3A 4N7TA 3TWZA 3UN5A 5L0KA 4UOPA 3NKMA 5LRMA 4LRAA 3E2DA 2D1GA 3TX0A 1P49A 1ELZA 1FSUA 4UORA 3WAVA 4UPIA 5L0EA 1EQJA 5DLVA 4NWXA 5GRRA 5L0BA 4KM4A 2RH6A 3NKNA 4NWJA 4MY4A 5IJSA 1O98A 1ANIA 2VQRA 3TG0A 2W8DA 1ELXA 3SZZA 5DLWA 4KJDA 3BDHA 5IJQA 2ANHA 1ALHA 2W8SA 1AJDA 1ZEBA 3WAWA 3IDDA 3M8YA 4UOOA 3M8WA 1HQAA 1AUKA 3NKRA 5KXAA 2ZKTA 3T00A 1ANJA 3A52A 4LQYA 4LR8A 1AJCA 2W5TA 4LREA 2W5SA 3UN2A 4KAVA 1E3CP 1AJBA 2XR9A 3IGYB 1KHJA 3MK0A 2GSNA 1URAA 1B8JA 4CXSA 1ALIA 1EI6A 4ZG9A 5LIAA 1AJAA 1Y7AA 3DYCA 4LR7A 5GOVA 3T02A 4CYRA 1ALKA 4UPHA 1HJKA 2GSUA 3UNYA 5INHA 3M7VA 4LRFA 4CYSA 4KJGA 1ALJA 1EW9A 1HDHA 4LRDA 1EW8A 4UPLA 4GTZA 1URBA 3BDFA 3NKOA 4MIVA 4ZG7A 3B5QA 4FDIA 4GTXA 3ED4A 3DPCA 5DLTA 1ED8A 2GSOA 4CXUA 1EJJA 3BDGA 4GTWA 3OT9A 1ELYA 4B56A 5LRNA 2W5WA 4LRBA 5K4PA 3NVLA 1KHNA 3KD8A 3WAYA 1KHKA 4CXKA 1E2SP 1E33P 3UN3A 3M8ZA 1N2LA 4LR2A 1ED9A 2W5VA 2IFYA 2X98A 3Q3QA 4FDJA 4MHXA 1KH7A 1SHQA 3WBHA 4LR9A 4ZG6A 2W5RA 2G9YA 1SHNA 1Y6VA 1KH5A 3MK2A 1KH9A 3T01A 2IUCA 5LQQA 1KHLA 5C66A 2XRGA 2GA3A 2W5XA 4KAYA 2W5QA 5HRTA 1N2KA 5EGHA 3CMRA 3SZYA 4GTYA 3MK1A 3NKQA 3BDGB 1KH4A 4LRCA 1O99A 4UPKA 4TN0A 1EW2A 3UO0A 1ZEDA 4YR1A 5AJ9A 3NKPA 3LXQA 3IGZB 1E1ZP 1ZEFA 4ZGAA 1K7HA 2GLQA 4QAXA 2IUCB 3WAXA 5EGEA 2QZUA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 5TJ3 A;  4N7T A;  3TWZ A;  3UN5 A;  5L0K A;  4UOP A;  3NKM A;  5LRM A;  4LRA A;  3E2D A;  2D1G A;  3TX0 A;  1P49 A;  1ELZ A;  1FSU A;  4UOR A;  3WAV A;  4UPI A;  5L0E A;  1EQJ A;  5DLV A;  4NWX A;  5GRR A;  5L0B A;  4KM4 A;  2RH6 A;  3NKN A;  4NWJ A;  4MY4 A;  5IJS A;  1O98 A;  1ANI A;  2VQR A;  3TG0 A;  2W8D A;  1ELX A;  3SZZ A;  5DLW A;  4KJD A;  3BDH A;  5IJQ A;  2ANH A;  1ALH A;  2W8S A;  1AJD A;  1ZEB A;  3WAW A;  3IDD A;  3M8Y A;  4UOO A;  3M8W A;  1HQA A;  1AUK A;  3NKR A;  5KXA A;  2ZKT A;  3T00 A;  1ANJ A;  3A52 A;  4LQY A;  4LR8 A;  1AJC A;  2W5T A;  4LRE A;  2W5S A;  3UN2 A;  4KAV A;  1E3C P;  1AJB A;  2XR9 A;  3IGY B;  1KHJ A;  3MK0 A;  2GSN A;  1URA A;  1B8J A;  4CXS A;  1ALI A;  1EI6 A;  4ZG9 A;  5LIA A;  1AJA A;  1Y7A A;  3DYC A;  4LR7 A;  5GOV A;  3T02 A;  4CYR A;  1ALK A;  4UPH A;  1HJK A;  2GSU A;  3UNY A;  5INH A;  3M7V A;  4LRF A;  4CYS A;  4KJG A;  1ALJ A;  1EW9 A;  1HDH A;  4LRD A;  1EW8 A;  4UPL A;  4GTZ A;  1URB A;  3BDF A;  3NKO A;  4MIV A;  4ZG7 A;  3B5Q A;  4FDI A;  4GTX A;  3ED4 A;  3DPC A;  5DLT A;  1ED8 A;  2GSO A;  4CXU A;  1EJJ A;  3BDG A;  4GTW A;  3OT9 A;  1ELY A;  4B56 A;  5LRN A;  2W5W A;  4LRB A;  5K4P A;  3NVL A;  1KHN A;  3KD8 A;  3WAY A;  1KHK A;  4CXK A;  1E2S P;  1E33 P;  3UN3 A;  3M8Z A;  1N2L A;  4LR2 A;  1ED9 A;  2W5V A;  2IFY A;  2X98 A;  3Q3Q A;  4FDJ A;  4MHX A;  1KH7 A;  1SHQ A;  3WBH A;  4LR9 A;  4ZG6 A;  2W5R A;  2G9Y A;  1SHN A;  1Y6V A;  1KH5 A;  3MK2 A;  1KH9 A;  3T01 A;  2IUC A;  5LQQ A;  1KHL A;  5C66 A;  2XRG A;  2GA3 A;  2W5X A;  4KAY A;  2W5Q A;  5HRT A;  1N2K A;  5EGH A;  3CMR A;  3SZY A;  4GTY A;  3MK1 A;  3NKQ A;  3BDG B;  1KH4 A;  4LRC A;  1O99 A;  4UPK A;  4TN0 A;  1EW2 A;  3UO0 A;  1ZED A;  4YR1 A;  5AJ9 A;  3NKP A;  3LXQ A;  3IGZ B;  1E1Z P;  1ZEF A;  4ZGA A;  1K7H A;  2GLQ A;  4QAX A;  2IUC B;  3WAX A;  5EGE A;  2QZU A; 
#chains in the Genus database with same CATH topology
 5TJ3 A;  4N7T A;  3TWZ A;  3UN5 A;  5L0K A;  4UOP A;  3NKM A;  5LRM A;  4LRA A;  3E2D A;  2D1G A;  3TX0 A;  1P49 A;  1ELZ A;  1FSU A;  4UOR A;  3WAV A;  4UPI A;  5L0E A;  1EQJ A;  5DLV A;  4NWX A;  5GRR A;  5L0B A;  4KM4 A;  2RH6 A;  3NKN A;  4NWJ A;  4MY4 A;  5IJS A;  1O98 A;  1ANI A;  2VQR A;  3TG0 A;  2W8D A;  1ELX A;  3SZZ A;  5DLW A;  4KJD A;  3BDH A;  5IJQ A;  2ANH A;  1ALH A;  2W8S A;  1AJD A;  1ZEB A;  3WAW A;  3IDD A;  3M8Y A;  4UOO A;  3M8W A;  1HQA A;  1AUK A;  3NKR A;  5KXA A;  2ZKT A;  3T00 A;  1ANJ A;  3A52 A;  4LQY A;  4LR8 A;  1AJC A;  2W5T A;  4LRE A;  2W5S A;  3UN2 A;  4KAV A;  1E3C P;  1AJB A;  2XR9 A;  3IGY B;  1KHJ A;  3MK0 A;  2GSN A;  1URA A;  1B8J A;  4CXS A;  1ALI A;  1EI6 A;  4ZG9 A;  5LIA A;  1AJA A;  1Y7A A;  3DYC A;  4LR7 A;  5GOV A;  3T02 A;  4CYR A;  1ALK A;  4UPH A;  1HJK A;  2GSU A;  3UNY A;  5INH A;  3M7V A;  4LRF A;  4CYS A;  4KJG A;  1ALJ A;  1EW9 A;  1HDH A;  4LRD A;  1EW8 A;  4UPL A;  4GTZ A;  1URB A;  3BDF A;  3NKO A;  4MIV A;  4ZG7 A;  3B5Q A;  4FDI A;  4GTX A;  3ED4 A;  3DPC A;  5DLT A;  1ED8 A;  2GSO A;  4CXU A;  1EJJ A;  3BDG A;  4GTW A;  3OT9 A;  1ELY A;  4B56 A;  5LRN A;  2W5W A;  4LRB A;  5K4P A;  3NVL A;  1KHN A;  3KD8 A;  3WAY A;  1KHK A;  4CXK A;  1E2S P;  1E33 P;  3UN3 A;  3M8Z A;  1N2L A;  4LR2 A;  1ED9 A;  2W5V A;  2IFY A;  2X98 A;  3Q3Q A;  4FDJ A;  4MHX A;  1KH7 A;  1SHQ A;  3WBH A;  4LR9 A;  4ZG6 A;  2W5R A;  2G9Y A;  1SHN A;  1Y6V A;  1KH5 A;  3MK2 A;  1KH9 A;  3T01 A;  2IUC A;  5LQQ A;  1KHL A;  5C66 A;  2XRG A;  2GA3 A;  2W5X A;  4KAY A;  2W5Q A;  5HRT A;  1N2K A;  5EGH A;  3CMR A;  3SZY A;  4GTY A;  3MK1 A;  3NKQ A;  3BDG B;  1KH4 A;  4LRC A;  1O99 A;  4UPK A;  4TN0 A;  1EW2 A;  3UO0 A;  1ZED A;  4YR1 A;  5AJ9 A;  3NKP A;  3LXQ A;  3IGZ B;  1E1Z P;  1ZEF A;  4ZGA A;  1K7H A;  2GLQ A;  4QAX A;  2IUC B;  3WAX A;  5EGE A;  2QZU A; 
#chains in the Genus database with same CATH homology
 5TJ3 A;  4N7T A;  3TWZ A;  3UN5 A;  5L0K A;  4UOP A;  3NKM A;  5LRM A;  4LRA A;  3E2D A;  2D1G A;  3TX0 A;  1P49 A;  1ELZ A;  1FSU A;  4UOR A;  3WAV A;  4UPI A;  5L0E A;  1EQJ A;  5DLV A;  4NWX A;  5GRR A;  5L0B A;  4KM4 A;  2RH6 A;  3NKN A;  4NWJ A;  4MY4 A;  5IJS A;  1O98 A;  1ANI A;  2VQR A;  3TG0 A;  2W8D A;  1ELX A;  3SZZ A;  5DLW A;  4KJD A;  3BDH A;  5IJQ A;  2ANH A;  1ALH A;  2W8S A;  1AJD A;  1ZEB A;  3WAW A;  3IDD A;  3M8Y A;  4UOO A;  3M8W A;  1HQA A;  1AUK A;  3NKR A;  5KXA A;  2ZKT A;  3T00 A;  1ANJ A;  3A52 A;  4LQY A;  4LR8 A;  1AJC A;  2W5T A;  4LRE A;  2W5S A;  3UN2 A;  4KAV A;  1E3C P;  1AJB A;  2XR9 A;  3IGY B;  1KHJ A;  3MK0 A;  2GSN A;  1URA A;  1B8J A;  4CXS A;  1ALI A;  1EI6 A;  4ZG9 A;  5LIA A;  1AJA A;  1Y7A A;  3DYC A;  4LR7 A;  5GOV A;  3T02 A;  4CYR A;  1ALK A;  4UPH A;  1HJK A;  2GSU A;  3UNY A;  5INH A;  3M7V A;  4LRF A;  4CYS A;  4KJG A;  1ALJ A;  1EW9 A;  1HDH A;  4LRD A;  1EW8 A;  4UPL A;  4GTZ A;  1URB A;  3BDF A;  3NKO A;  4MIV A;  4ZG7 A;  3B5Q A;  4FDI A;  4GTX A;  3ED4 A;  3DPC A;  5DLT A;  1ED8 A;  2GSO A;  4CXU A;  1EJJ A;  3BDG A;  4GTW A;  3OT9 A;  1ELY A;  4B56 A;  5LRN A;  2W5W A;  4LRB A;  5K4P A;  3NVL A;  1KHN A;  3KD8 A;  3WAY A;  1KHK A;  4CXK A;  1E2S P;  1E33 P;  3UN3 A;  3M8Z A;  1N2L A;  4LR2 A;  1ED9 A;  2W5V A;  2IFY A;  2X98 A;  3Q3Q A;  4FDJ A;  4MHX A;  1KH7 A;  1SHQ A;  3WBH A;  4LR9 A;  4ZG6 A;  2W5R A;  2G9Y A;  1SHN A;  1Y6V A;  1KH5 A;  3MK2 A;  1KH9 A;  3T01 A;  2IUC A;  5LQQ A;  1KHL A;  5C66 A;  2XRG A;  2GA3 A;  2W5X A;  4KAY A;  2W5Q A;  5HRT A;  1N2K A;  5EGH A;  3CMR A;  3SZY A;  4GTY A;  3MK1 A;  3NKQ A;  3BDG B;  1KH4 A;  4LRC A;  1O99 A;  4UPK A;  4TN0 A;  1EW2 A;  3UO0 A;  1ZED A;  4YR1 A;  5AJ9 A;  3NKP A;  3LXQ A;  3IGZ B;  1E1Z P;  1ZEF A;  4ZGA A;  1K7H A;  2GLQ A;  4QAX A;  2IUC B;  3WAX A;  5EGE A;  2QZU A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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