3BDGA

Crystal structure of wild-type/t155v mixed dimer of e. coli alkaline phosphatase
Total Genus 159
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
159
Knots found
sequence length
448
structure length
434
Chain Sequence
PEMPVLENRAAQGDITAPGGARRLTGDQTAALRDSLSDKPAKNIILLIGDGMGDSEITAARNYAEGAGGFFKGIDALPLTGQYTHYALNKKTGKPDYVTDSAASATAWSTGVKTYNGALGVDIHEKDHPTILEMAKAAGLATGNVSTAELQDAVPAALVAHVTSRKCYGPSATSEKCPGNALEKGGKGSITEQLLNARADVTLGGGAKTFAETATAGEWQGKTLREQAQARGYQLVSDAASLNSVTEANQQKPLLGLFADGNMPVRWLGPKATYHGNIDKPAVTCTPNPQRNDSVPTLAQMTDKAIELLSKNEKGFFLQVEGASIANPCGQIGETVDLDEAVQRALEFAKKEGNTLVIVTADHAHASQIVAPDTKAPGLTQALNTKDGAVMVMSYGHTGSQLRIAAYGPHAANVVGLTDQTDLFYTMKAALGLK
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

molecule keywords Alkaline phosphatase
publication title The Active-Site Trimetallic Cluster of Alkaline Phosphatase is Lost Upon Isosteric Mutation at the Mg2+-Coordinating Residue Threonine-155
rcsb
source organism Escherichia coli
molecule tags Hydrolase
total genus 159
structure length 434
sequence length 448
other databases KnotProt 2.0: S +31
ec nomenclature ec 3.1.3.1: Alkaline phosphatase.
pdb deposition date 2007-11-14

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00245 Alk_phosphatase Alkaline phosphatase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.720.10 Alpha Beta 3-Layer(aba) Sandwich Alkaline Phosphatase, subunit A Alkaline Phosphatase, subunit A 3bdgA00
1ANJA 2W5XA 1ELYA 2GA3A 5L0BA 5LRMA 4LRAA 4LRFA 1HQAA 5L0KA 5KXAA 4CYSA 1KH7A 3NKRA 4UPKA 4LRCA 1KH9A 4LR7A 3DPCA 3M8YA 3WAVA 4CYRA 3TG0A 4LR2A 1HDHA 4KAVA 2IFYA 2W5TA 5EGHA 3NKNA 4GTXA 3UNYA 4MY4A 4UPIA 3T02A 3BDHA 4KM4A 1FSUA 1EW8A 3BDGB 4B56A 1ALJA 4ZGAA 3NVLA 4YR1A 2GSNA 2X98A 4MHXA 5L0EA 1P49A 1HJKA 1KHLA 1EW2A 1EI6A 4KJGA 1KHJA 4LREA 3MK1A 3KD8A 3UO0A 3CMRA 2D1GA 3M8ZA 5DLTA 5AJ9A 1KHNA 1ZEBA 3NKMA 3WBHA 4GTWA 4CXKA 1EQJA 2GSUA 3DYCA 3TWZA 1ELZA 4CXSA 3BDGA 3IDDA 3ED4A 3M8WA 2VQRA 4FDIA 1N2LA 1K7HA 2G9YA 3UN3A 2XRGA 4KAYA 5INHA 5LRNA 3B5QA 3MK0A 3LXQA 2ANHA 3NKPA 1URAA 3T00A 3SZZA 3NKOA 3UN2A 1E2SP 2RH6A 1AJCA 5LQQA 4UPHA 4ZG9A 1ANIA 3WAWA 3BDFA 3OT9A 1EW9A 1Y7AA 4N7TA 3Q3QA 2W5RA 4UOOA 4UOPA 1ELXA 4ZG6A 4MIVA 2GLQA 5LIAA 4GTZA 1N2KA 1AJBA 1KH4A 3WAYA 3A52A 2IUCA 1E3CP 2W8SA 4UORA 3TX0A 5DLVA 1ED8A 4LR9A 1E33P 3E2DA 4LQYA 2QZUA 3T01A 5DLWA 1ALIA 2W5QA 4LRBA 1O98A 5EGEA 4LRDA 3UN5A 1URBA 2IUCB 1E1ZP 5GRRA 2W5VA 1B8JA 5GOVA 4NWJA 2W8DA 1SHQA 4TN0A 2GSOA 2W5WA 1ED9A 4QAXA 5K4PA 1EJJA 1ALHA 2W5SA 1SHNA 1ALKA 3IGZB 1AUKA 1Y6VA 4GTYA 3SZYA 1AJDA 5C66A 4UPLA 1KH5A 1ZEDA 5TJ3A 4CXUA 1KHKA 3MK2A 4FDJA 5IJSA 1ZEFA 2ZKTA 3M7VA 4NWXA 5HRTA 2XR9A 1AJAA 1O99A 4KJDA 4LR8A 3WAXA 4ZG7A 3IGYB 5IJQA 3NKQA
chains in the Genus database with same CATH superfamily
1ANJA 2W5XA 1ELYA 2GA3A 5L0BA 5LRMA 4LRAA 4LRFA 1HQAA 5L0KA 5KXAA 4CYSA 1KH7A 3NKRA 4UPKA 4LRCA 1KH9A 4LR7A 3DPCA 3M8YA 3WAVA 4CYRA 3TG0A 4LR2A 1HDHA 4KAVA 2IFYA 2W5TA 5EGHA 3NKNA 4GTXA 3UNYA 4MY4A 4UPIA 3T02A 3BDHA 4KM4A 1FSUA 1EW8A 3BDGB 4B56A 1ALJA 4ZGAA 3NVLA 4YR1A 2GSNA 2X98A 4MHXA 5L0EA 1P49A 1HJKA 1KHLA 1EW2A 1EI6A 4KJGA 1KHJA 4LREA 3MK1A 3KD8A 3UO0A 3CMRA 2D1GA 3M8ZA 5DLTA 5AJ9A 1KHNA 1ZEBA 3NKMA 3WBHA 4GTWA 4CXKA 1EQJA 2GSUA 3DYCA 3TWZA 1ELZA 4CXSA 3BDGA 3IDDA 3ED4A 3M8WA 2VQRA 4FDIA 1N2LA 1K7HA 2G9YA 3UN3A 2XRGA 4KAYA 5INHA 5LRNA 3B5QA 3MK0A 3LXQA 2ANHA 3NKPA 1URAA 3T00A 3SZZA 3NKOA 3UN2A 1E2SP 2RH6A 1AJCA 5LQQA 4UPHA 4ZG9A 1ANIA 3WAWA 3BDFA 3OT9A 1EW9A 1Y7AA 4N7TA 3Q3QA 2W5RA 4UOOA 4UOPA 1ELXA 4ZG6A 4MIVA 2GLQA 5LIAA 4GTZA 1N2KA 1AJBA 1KH4A 3WAYA 3A52A 2IUCA 1E3CP 2W8SA 4UORA 3TX0A 5DLVA 1ED8A 4LR9A 1E33P 3E2DA 4LQYA 2QZUA 3T01A 5DLWA 1ALIA 2W5QA 4LRBA 1O98A 5EGEA 4LRDA 3UN5A 1URBA 2IUCB 1E1ZP 5GRRA 2W5VA 1B8JA 5GOVA 4NWJA 2W8DA 1SHQA 4TN0A 2GSOA 2W5WA 1ED9A 4QAXA 5K4PA 1EJJA 1ALHA 2W5SA 1SHNA 1ALKA 3IGZB 1AUKA 1Y6VA 4GTYA 3SZYA 1AJDA 5C66A 4UPLA 1KH5A 1ZEDA 5TJ3A 4CXUA 1KHKA 3MK2A 4FDJA 5IJSA 1ZEFA 2ZKTA 3M7VA 4NWXA 5HRTA 2XR9A 1AJAA 1O99A 4KJDA 4LR8A 3WAXA 4ZG7A 3IGYB 5IJQA 3NKQA
chains in the Genus database with same CATH topology
1ANJA 2W5XA 1ELYA 2GA3A 5L0BA 5LRMA 4LRAA 4LRFA 1HQAA 5L0KA 5KXAA 4CYSA 1KH7A 3NKRA 4UPKA 4LRCA 1KH9A 4LR7A 3DPCA 3M8YA 3WAVA 4CYRA 3TG0A 4LR2A 1HDHA 4KAVA 2IFYA 2W5TA 5EGHA 3NKNA 4GTXA 3UNYA 4MY4A 4UPIA 3T02A 3BDHA 4KM4A 1FSUA 1EW8A 3BDGB 4B56A 1ALJA 4ZGAA 3NVLA 4YR1A 2GSNA 2X98A 4MHXA 5L0EA 1P49A 1HJKA 1KHLA 1EW2A 1EI6A 4KJGA 1KHJA 4LREA 3MK1A 3KD8A 3UO0A 3CMRA 2D1GA 3M8ZA 5DLTA 5AJ9A 1KHNA 1ZEBA 3NKMA 3WBHA 4GTWA 4CXKA 1EQJA 2GSUA 3DYCA 3TWZA 1ELZA 4CXSA 3BDGA 3IDDA 3ED4A 3M8WA 2VQRA 4FDIA 1N2LA 1K7HA 2G9YA 3UN3A 2XRGA 4KAYA 5INHA 5LRNA 3B5QA 3MK0A 3LXQA 2ANHA 3NKPA 1URAA 3T00A 3SZZA 3NKOA 3UN2A 1E2SP 2RH6A 1AJCA 5LQQA 4UPHA 4ZG9A 1ANIA 3WAWA 3BDFA 3OT9A 1EW9A 1Y7AA 4N7TA 3Q3QA 2W5RA 4UOOA 4UOPA 1ELXA 4ZG6A 4MIVA 2GLQA 5LIAA 4GTZA 1N2KA 1AJBA 1KH4A 3WAYA 3A52A 2IUCA 1E3CP 2W8SA 4UORA 3TX0A 5DLVA 1ED8A 4LR9A 1E33P 3E2DA 4LQYA 2QZUA 3T01A 5DLWA 1ALIA 2W5QA 4LRBA 1O98A 5EGEA 4LRDA 3UN5A 1URBA 2IUCB 1E1ZP 5GRRA 2W5VA 1B8JA 5GOVA 4NWJA 2W8DA 1SHQA 4TN0A 2GSOA 2W5WA 1ED9A 4QAXA 5K4PA 1EJJA 1ALHA 2W5SA 1SHNA 1ALKA 3IGZB 1AUKA 1Y6VA 4GTYA 3SZYA 1AJDA 5C66A 4UPLA 1KH5A 1ZEDA 5TJ3A 4CXUA 1KHKA 3MK2A 4FDJA 5IJSA 1ZEFA 2ZKTA 3M7VA 4NWXA 5HRTA 2XR9A 1AJAA 1O99A 4KJDA 4LR8A 3WAXA 4ZG7A 3IGYB 5IJQA 3NKQA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1ANJ A;  2W5X A;  1ELY A;  2GA3 A;  5L0B A;  5LRM A;  4LRA A;  4LRF A;  1HQA A;  5L0K A;  5KXA A;  4CYS A;  1KH7 A;  3NKR A;  4UPK A;  4LRC A;  1KH9 A;  4LR7 A;  3DPC A;  3M8Y A;  3WAV A;  4CYR A;  3TG0 A;  4LR2 A;  1HDH A;  4KAV A;  2IFY A;  2W5T A;  5EGH A;  3NKN A;  4GTX A;  3UNY A;  4MY4 A;  4UPI A;  3T02 A;  3BDH A;  4KM4 A;  1FSU A;  1EW8 A;  3BDG B;  4B56 A;  1ALJ A;  4ZGA A;  3NVL A;  4YR1 A;  2GSN A;  2X98 A;  4MHX A;  5L0E A;  1P49 A;  1HJK A;  1KHL A;  1EW2 A;  1EI6 A;  4KJG A;  1KHJ A;  4LRE A;  3MK1 A;  3KD8 A;  3UO0 A;  3CMR A;  2D1G A;  3M8Z A;  5DLT A;  5AJ9 A;  1KHN A;  1ZEB A;  3NKM A;  3WBH A;  4GTW A;  4CXK A;  1EQJ A;  2GSU A;  3DYC A;  3TWZ A;  1ELZ A;  4CXS A;  3BDG A;  3IDD A;  3ED4 A;  3M8W A;  2VQR A;  4FDI A;  1N2L A;  1K7H A;  2G9Y A;  3UN3 A;  2XRG A;  4KAY A;  5INH A;  5LRN A;  3B5Q A;  3MK0 A;  3LXQ A;  2ANH A;  3NKP A;  1URA A;  3T00 A;  3SZZ A;  3NKO A;  3UN2 A;  1E2S P;  2RH6 A;  1AJC A;  5LQQ A;  4UPH A;  4ZG9 A;  1ANI A;  3WAW A;  3BDF A;  3OT9 A;  1EW9 A;  1Y7A A;  4N7T A;  3Q3Q A;  2W5R A;  4UOO A;  4UOP A;  1ELX A;  4ZG6 A;  4MIV A;  2GLQ A;  5LIA A;  4GTZ A;  1N2K A;  1AJB A;  1KH4 A;  3WAY A;  3A52 A;  2IUC A;  1E3C P;  2W8S A;  4UOR A;  3TX0 A;  5DLV A;  1ED8 A;  4LR9 A;  1E33 P;  3E2D A;  4LQY A;  2QZU A;  3T01 A;  5DLW A;  1ALI A;  2W5Q A;  4LRB A;  1O98 A;  5EGE A;  4LRD A;  3UN5 A;  1URB A;  2IUC B;  1E1Z P;  5GRR A;  2W5V A;  1B8J A;  5GOV A;  4NWJ A;  2W8D A;  1SHQ A;  4TN0 A;  2GSO A;  2W5W A;  1ED9 A;  4QAX A;  5K4P A;  1EJJ A;  1ALH A;  2W5S A;  1SHN A;  1ALK A;  3IGZ B;  1AUK A;  1Y6V A;  4GTY A;  3SZY A;  1AJD A;  5C66 A;  4UPL A;  1KH5 A;  1ZED A;  5TJ3 A;  4CXU A;  1KHK A;  3MK2 A;  4FDJ A;  5IJS A;  1ZEF A;  2ZKT A;  3M7V A;  4NWX A;  5HRT A;  2XR9 A;  1AJA A;  1O99 A;  4KJD A;  4LR8 A;  3WAX A;  4ZG7 A;  3IGY B;  5IJQ A;  3NKQ A; 
#chains in the Genus database with same CATH topology
 1ANJ A;  2W5X A;  1ELY A;  2GA3 A;  5L0B A;  5LRM A;  4LRA A;  4LRF A;  1HQA A;  5L0K A;  5KXA A;  4CYS A;  1KH7 A;  3NKR A;  4UPK A;  4LRC A;  1KH9 A;  4LR7 A;  3DPC A;  3M8Y A;  3WAV A;  4CYR A;  3TG0 A;  4LR2 A;  1HDH A;  4KAV A;  2IFY A;  2W5T A;  5EGH A;  3NKN A;  4GTX A;  3UNY A;  4MY4 A;  4UPI A;  3T02 A;  3BDH A;  4KM4 A;  1FSU A;  1EW8 A;  3BDG B;  4B56 A;  1ALJ A;  4ZGA A;  3NVL A;  4YR1 A;  2GSN A;  2X98 A;  4MHX A;  5L0E A;  1P49 A;  1HJK A;  1KHL A;  1EW2 A;  1EI6 A;  4KJG A;  1KHJ A;  4LRE A;  3MK1 A;  3KD8 A;  3UO0 A;  3CMR A;  2D1G A;  3M8Z A;  5DLT A;  5AJ9 A;  1KHN A;  1ZEB A;  3NKM A;  3WBH A;  4GTW A;  4CXK A;  1EQJ A;  2GSU A;  3DYC A;  3TWZ A;  1ELZ A;  4CXS A;  3BDG A;  3IDD A;  3ED4 A;  3M8W A;  2VQR A;  4FDI A;  1N2L A;  1K7H A;  2G9Y A;  3UN3 A;  2XRG A;  4KAY A;  5INH A;  5LRN A;  3B5Q A;  3MK0 A;  3LXQ A;  2ANH A;  3NKP A;  1URA A;  3T00 A;  3SZZ A;  3NKO A;  3UN2 A;  1E2S P;  2RH6 A;  1AJC A;  5LQQ A;  4UPH A;  4ZG9 A;  1ANI A;  3WAW A;  3BDF A;  3OT9 A;  1EW9 A;  1Y7A A;  4N7T A;  3Q3Q A;  2W5R A;  4UOO A;  4UOP A;  1ELX A;  4ZG6 A;  4MIV A;  2GLQ A;  5LIA A;  4GTZ A;  1N2K A;  1AJB A;  1KH4 A;  3WAY A;  3A52 A;  2IUC A;  1E3C P;  2W8S A;  4UOR A;  3TX0 A;  5DLV A;  1ED8 A;  4LR9 A;  1E33 P;  3E2D A;  4LQY A;  2QZU A;  3T01 A;  5DLW A;  1ALI A;  2W5Q A;  4LRB A;  1O98 A;  5EGE A;  4LRD A;  3UN5 A;  1URB A;  2IUC B;  1E1Z P;  5GRR A;  2W5V A;  1B8J A;  5GOV A;  4NWJ A;  2W8D A;  1SHQ A;  4TN0 A;  2GSO A;  2W5W A;  1ED9 A;  4QAX A;  5K4P A;  1EJJ A;  1ALH A;  2W5S A;  1SHN A;  1ALK A;  3IGZ B;  1AUK A;  1Y6V A;  4GTY A;  3SZY A;  1AJD A;  5C66 A;  4UPL A;  1KH5 A;  1ZED A;  5TJ3 A;  4CXU A;  1KHK A;  3MK2 A;  4FDJ A;  5IJS A;  1ZEF A;  2ZKT A;  3M7V A;  4NWX A;  5HRT A;  2XR9 A;  1AJA A;  1O99 A;  4KJD A;  4LR8 A;  3WAX A;  4ZG7 A;  3IGY B;  5IJQ A;  3NKQ A; 
#chains in the Genus database with same CATH homology
 1ANJ A;  2W5X A;  1ELY A;  2GA3 A;  5L0B A;  5LRM A;  4LRA A;  4LRF A;  1HQA A;  5L0K A;  5KXA A;  4CYS A;  1KH7 A;  3NKR A;  4UPK A;  4LRC A;  1KH9 A;  4LR7 A;  3DPC A;  3M8Y A;  3WAV A;  4CYR A;  3TG0 A;  4LR2 A;  1HDH A;  4KAV A;  2IFY A;  2W5T A;  5EGH A;  3NKN A;  4GTX A;  3UNY A;  4MY4 A;  4UPI A;  3T02 A;  3BDH A;  4KM4 A;  1FSU A;  1EW8 A;  3BDG B;  4B56 A;  1ALJ A;  4ZGA A;  3NVL A;  4YR1 A;  2GSN A;  2X98 A;  4MHX A;  5L0E A;  1P49 A;  1HJK A;  1KHL A;  1EW2 A;  1EI6 A;  4KJG A;  1KHJ A;  4LRE A;  3MK1 A;  3KD8 A;  3UO0 A;  3CMR A;  2D1G A;  3M8Z A;  5DLT A;  5AJ9 A;  1KHN A;  1ZEB A;  3NKM A;  3WBH A;  4GTW A;  4CXK A;  1EQJ A;  2GSU A;  3DYC A;  3TWZ A;  1ELZ A;  4CXS A;  3BDG A;  3IDD A;  3ED4 A;  3M8W A;  2VQR A;  4FDI A;  1N2L A;  1K7H A;  2G9Y A;  3UN3 A;  2XRG A;  4KAY A;  5INH A;  5LRN A;  3B5Q A;  3MK0 A;  3LXQ A;  2ANH A;  3NKP A;  1URA A;  3T00 A;  3SZZ A;  3NKO A;  3UN2 A;  1E2S P;  2RH6 A;  1AJC A;  5LQQ A;  4UPH A;  4ZG9 A;  1ANI A;  3WAW A;  3BDF A;  3OT9 A;  1EW9 A;  1Y7A A;  4N7T A;  3Q3Q A;  2W5R A;  4UOO A;  4UOP A;  1ELX A;  4ZG6 A;  4MIV A;  2GLQ A;  5LIA A;  4GTZ A;  1N2K A;  1AJB A;  1KH4 A;  3WAY A;  3A52 A;  2IUC A;  1E3C P;  2W8S A;  4UOR A;  3TX0 A;  5DLV A;  1ED8 A;  4LR9 A;  1E33 P;  3E2D A;  4LQY A;  2QZU A;  3T01 A;  5DLW A;  1ALI A;  2W5Q A;  4LRB A;  1O98 A;  5EGE A;  4LRD A;  3UN5 A;  1URB A;  2IUC B;  1E1Z P;  5GRR A;  2W5V A;  1B8J A;  5GOV A;  4NWJ A;  2W8D A;  1SHQ A;  4TN0 A;  2GSO A;  2W5W A;  1ED9 A;  4QAX A;  5K4P A;  1EJJ A;  1ALH A;  2W5S A;  1SHN A;  1ALK A;  3IGZ B;  1AUK A;  1Y6V A;  4GTY A;  3SZY A;  1AJD A;  5C66 A;  4UPL A;  1KH5 A;  1ZED A;  5TJ3 A;  4CXU A;  1KHK A;  3MK2 A;  4FDJ A;  5IJS A;  1ZEF A;  2ZKT A;  3M7V A;  4NWX A;  5HRT A;  2XR9 A;  1AJA A;  1O99 A;  4KJD A;  4LR8 A;  3WAX A;  4ZG7 A;  3IGY B;  5IJQ A;  3NKQ A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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