3CWLA

Crystal structure of alpha-1-antitrypsin, crystal form b
Total Genus 109
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
109
sequence length
372
structure length
371
Chain Sequence
FNKITPNLAEFAFSLYRQLAHQSNSTNIFFSPVSIATAFAMLSLGTKADTHDEILEGLNFNLTEIPEAQIHEGFQELLRTLNQPDSQLQLTTGNGLFLSEGLKLVDKFLEDVKKLYHSEAFTVNFGDTEEAKKQINDYVEKGTQGKIVDLVKELDRDTVFALVNYIFFKGKWERPFEVKDTEEEDFHVDQVTTVKVPMMKRLGMFNIQHKKLSSWVLLMKYLGNATAIFFLPDEGKLQHLENELTHDIITKFLENEDRRSASLHLPKLSITGTYDLKSVLGQLGITKVFSNGADLSGVTEEAPLKLSKAVHKAVLTIDEKGTEAAGAMFLEAIPMSIPPEVKFNKPFVFLMIEQNTKSPLFMGKVVNPTQK
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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molecule tags Protease inhibitor
molecule keywords Alpha-1-antitrypsin
publication title Preventing serpin aggregation: The molecular mechanism of citrate action upon antitrypsin unfolding.
pubmed doi rcsb
source organism Homo sapiens
total genus 109
structure length 371
sequence length 372
ec nomenclature
pdb deposition date 2008-04-22

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00079 Serpin Serpin (serine protease inhibitor)
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.30.39.10 Mainly Beta Roll Alpha-1-antitrypsin; domain 1 Alpha-1-antitrypsin, domain 1 3cwlA02
3.30.497.10 Alpha Beta 2-Layer Sandwich Antithrombin; Chain I, domain 2 Antithrombin, subunit I, domain 2 3cwlA01
2WXZC 1E05I 2VDXA 1DVNA 2GD4C 1LK6I 2RIWA 1LJ5A 1UHGA 1OC0A 1OYHL 5IO1A 1DB2A 2ARRA 3EOXA 4IC0A 3H5CA 1JTIA 1OYHI 3DLWA 1AZXI 5CDZA 3VVJA 3KCGI 2R9YA 1HP7A 2ARQA 4ROBA 4RO9A 3PB1I 4AJTA 1OVAA 1ATTA 4IF8A 4DY7C 1E04I 1LQ8A 5C98A 2OL2A 2WXWA 1IZ2A 4DY0A 1R1LI 4AU3A 4X30A 3F1SA 4Y3KA 3STOA 1M93B 2OAYA 1QMBA 2WXYC 2B5TI 4G8RA 3NDAA 1KCTA 1XQJA 3ZHAA 3R4LA 1QLPA 4YIAA 2ANTI 2WY0C 2B4XI 1WZ9A 3CWLA 1D5SA 3CVMA 1F0CA 4AU3B 4R9IA 4AU4A 3CWMA 2XN6A 4BB2A 2RIVA 3CAAA 3F02A 1DZHI 4GA7A 3NDDA 1C8OA 5INWA 4AQHA 1OVAC 3FGQA 2PEFA 3EVJI 1JRRA 2VH4A 2PEEA 1ATUA 2ACHA 1SEKA 9APIA 4ZK3A 2VDYA 2H4RA 1MTPA 3LE2A 1K9OI 2H4PA 3PZFA 3DY0A 3NDFA 4AU2A 1JMOA 4RSQA 1OVAB 3B9FI 3Q03A 3DRMA 2B4XL 8APIA 4ZK0A 4EB1I 5BRRI 1IMVA 2CEOA 1DZHL 1XQGA 5HGCA 1C5GA 1T1FA 4PYWA 5EI0A 2BEHL 1TB6I 3OZQA 1BR8I 1XU8A 1JVQI 4AJUA 2BEHI 4C49A 2WY1A 5CE0A 2HI9A 4DTEA 1A7CA 1JMJA 3DRUA 2ZNHA 2WXZA 2WXXA 3NE4A 1ANTI 3LW2A 4ROAA 1QMNA 2XN5A 4P0OA 4EB1L 1SR5A 4C41A 1BY7A 3UT3A 1B3KA 1YXAA 1NQ9I 3T1PA 1PSIA 4G8OA 2D26A 2XN7A 1AS4A 2XN3A 1DZGL 5CDXA 7APIA 1OO8A 1ATHA 1DZGI 1HLEA 1E03I 2DUTA 2H4QA 2ZV6A 4Y40A 1DVMA 4P0FA 2V95A 4CAAA 2HIJL 1OPHA 3F5NA 4KDSA 9PAIA 1EZXA 1SNGA 2QUGA 3Q02A 4AFXA 1JJOC 2HIJI
chains in the Genus database with same CATH superfamily
2WXZC 1E05I 2VDXA 1DVNA 2GD4C 1LK6I 2RIWA 1LJ5A 1UHGA 1OC0A 1OYHL 5IO1A 1DB2A 2ARRA 3EOXA 4IC0A 3H5CA 1JTIA 1OYHI 3DLWA 1AZXI 5CDZA 3VVJA 3KCGI 2R9YA 1HP7A 2ARQA 4ROBA 4RO9A 3PB1I 4AJTA 1OVAA 1ATTA 4IF8A 4DY7C 1E04I 1LQ8A 5C98A 2OL2A 2WXWA 1IZ2A 4DY0A 1R1LI 4AU3A 4X30A 3F1SA 4Y3KA 3STOA 1M93B 2OAYA 1QMBA 2WXYC 2B5TI 4G8RA 3NDAA 1KCTA 1XQJA 3ZHAA 3R4LA 1QLPA 4YIAA 2ANTI 2WY0C 2B4XI 1WZ9A 3CWLA 1D5SA 3CVMA 1F0CA 4AU3B 4R9IA 4AU4A 3CWMA 2XN6A 4BB2A 2RIVA 3CAAA 3F02A 1DZHI 4GA7A 3NDDA 1C8OA 5INWA 4AQHA 1OVAC 3FGQA 2PEFA 3EVJI 1JRRA 2VH4A 2PEEA 1ATUA 2ACHA 1SEKA 9APIA 4ZK3A 2VDYA 2H4RA 1MTPA 3LE2A 1K9OI 2H4PA 3PZFA 3DY0A 3NDFA 4AU2A 1JMOA 4RSQA 1OVAB 3B9FI 3Q03A 3DRMA 2B4XL 8APIA 4ZK0A 4EB1I 5BRRI 1IMVA 2CEOA 1DZHL 1XQGA 5HGCA 1C5GA 1T1FA 4PYWA 5EI0A 2BEHL 1TB6I 3OZQA 1BR8I 1XU8A 1JVQI 4AJUA 2BEHI 4C49A 2WY1A 5CE0A 2HI9A 4DTEA 1A7CA 1JMJA 3DRUA 2ZNHA 2WXZA 2WXXA 3NE4A 1ANTI 3LW2A 4ROAA 1QMNA 2XN5A 4P0OA 4EB1L 1SR5A 4C41A 1BY7A 3UT3A 1B3KA 1YXAA 1NQ9I 3T1PA 1PSIA 4G8OA 2D26A 2XN7A 1AS4A 2XN3A 1DZGL 5CDXA 7APIA 1OO8A 1ATHA 1DZGI 1HLEA 1E03I 2DUTA 2H4QA 2ZV6A 4Y40A 1DVMA 4P0FA 2V95A 4CAAA 2HIJL 1OPHA 3F5NA 4KDSA 9PAIA 1EZXA 1SNGA 2QUGA 3Q02A 4AFXA 1JJOC 2HIJI
chains in the Genus database with same CATH topology
2WXZC 1E05I 2VDXA 1DVNA 2GD4C 1LK6I 2RIWA 1LJ5A 1UHGA 1OC0A 1OYHL 5IO1A 1DB2A 2ARRA 3EOXA 4IC0A 3H5CA 1JTIA 1OYHI 3DLWA 1AZXI 5CDZA 3VVJA 3KCGI 2R9YA 1HP7A 2ARQA 4ROBA 4RO9A 3PB1I 4AJTA 1OVAA 1ATTA 4IF8A 4DY7C 1E04I 1LQ8A 5C98A 2OL2A 2WXWA 1IZ2A 4DY0A 1R1LI 4AU3A 4X30A 3F1SA 4Y3KA 3STOA 1M93B 2OAYA 1QMBA 2WXYC 2B5TI 4G8RA 3NDAA 1KCTA 1XQJA 3ZHAA 3R4LA 1QLPA 4YIAA 2ANTI 2WY0C 2B4XI 1WZ9A 3CWLA 1D5SA 3CVMA 1F0CA 4AU3B 4R9IA 4AU4A 3CWMA 2XN6A 4BB2A 2RIVA 3CAAA 3F02A 1DZHI 4GA7A 3NDDA 1C8OA 5INWA 4AQHA 1OVAC 3FGQA 2PEFA 3EVJI 1JRRA 2VH4A 2PEEA 1ATUA 2ACHA 1SEKA 9APIA 4ZK3A 2VDYA 2H4RA 1MTPA 3LE2A 1K9OI 2H4PA 3PZFA 3DY0A 3NDFA 4AU2A 1JMOA 4RSQA 1OVAB 3B9FI 3Q03A 3DRMA 2B4XL 8APIA 4ZK0A 4EB1I 5BRRI 1IMVA 2CEOA 1DZHL 1XQGA 5HGCA 1C5GA 1T1FA 4PYWA 5EI0A 2BEHL 1TB6I 3OZQA 1BR8I 1XU8A 1JVQI 4AJUA 2BEHI 4C49A 2WY1A 5CE0A 2HI9A 4DTEA 1A7CA 1JMJA 3DRUA 2ZNHA 2WXZA 2WXXA 3NE4A 1ANTI 3LW2A 4ROAA 1QMNA 2XN5A 4P0OA 4EB1L 1SR5A 4C41A 1BY7A 3UT3A 1B3KA 1YXAA 1NQ9I 3T1PA 1PSIA 4G8OA 2D26A 2XN7A 1AS4A 2XN3A 1DZGL 5CDXA 7APIA 1OO8A 1ATHA 1DZGI 1HLEA 1E03I 2DUTA 2H4QA 2ZV6A 4Y40A 1DVMA 4P0FA 2V95A 4CAAA 2HIJL 1OPHA 3F5NA 4KDSA 9PAIA 1EZXA 1SNGA 2QUGA 3Q02A 4AFXA 1JJOC 2HIJI
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 2WXZ C;  1E05 I;  2VDX A;  1DVN A;  2GD4 C;  1LK6 I;  2RIW A;  1LJ5 A;  1UHG A;  1OC0 A;  1OYH L;  5IO1 A;  1DB2 A;  2ARR A;  3EOX A;  4IC0 A;  3H5C A;  1JTI A;  1OYH I;  3DLW A;  1AZX I;  5CDZ A;  3VVJ A;  3KCG I;  2R9Y A;  1HP7 A;  2ARQ A;  4ROB A;  4RO9 A;  3PB1 I;  4AJT A;  1OVA A;  1ATT A;  4IF8 A;  4DY7 C;  1E04 I;  1LQ8 A;  5C98 A;  2OL2 A;  2WXW A;  1IZ2 A;  4DY0 A;  1R1L I;  4AU3 A;  4X30 A;  3F1S A;  4Y3K A;  3STO A;  1M93 B;  2OAY A;  1QMB A;  2WXY C;  2B5T I;  4G8R A;  3NDA A;  1KCT A;  1XQJ A;  3ZHA A;  3R4L A;  1QLP A;  4YIA A;  2ANT I;  2WY0 C;  2B4X I;  1WZ9 A;  3CWL A;  1D5S A;  3CVM A;  1F0C A;  4AU3 B;  4R9I A;  4AU4 A;  3CWM A;  2XN6 A;  4BB2 A;  2RIV A;  3CAA A;  3F02 A;  1DZH I;  4GA7 A;  3NDD A;  1C8O A;  5INW A;  4AQH A;  1OVA C;  3FGQ A;  2PEF A;  3EVJ I;  1JRR A;  2VH4 A;  2PEE A;  1ATU A;  2ACH A;  1SEK A;  9API A;  4ZK3 A;  2VDY A;  2H4R A;  1MTP A;  3LE2 A;  1K9O I;  2H4P A;  3PZF A;  3DY0 A;  3NDF A;  4AU2 A;  1JMO A;  4RSQ A;  1OVA B;  3B9F I;  3Q03 A;  3DRM A;  2B4X L;  8API A;  4ZK0 A;  4EB1 I;  5BRR I;  1IMV A;  2CEO A;  1DZH L;  1XQG A;  5HGC A;  1C5G A;  1T1F A;  4PYW A;  5EI0 A;  2BEH L;  1TB6 I;  3OZQ A;  1BR8 I;  1XU8 A;  1JVQ I;  4AJU A;  2BEH I;  4C49 A;  2WY1 A;  5CE0 A;  2HI9 A;  4DTE A;  1A7C A;  1JMJ A;  3DRU A;  2ZNH A;  2WXZ A;  2WXX A;  3NE4 A;  1ANT I;  3LW2 A;  4ROA A;  1QMN A;  2XN5 A;  4P0O A;  4EB1 L;  1SR5 A;  4C41 A;  1BY7 A;  3UT3 A;  1B3K A;  1YXA A;  1NQ9 I;  3T1P A;  1PSI A;  4G8O A;  2D26 A;  2XN7 A;  1AS4 A;  2XN3 A;  1DZG L;  5CDX A;  7API A;  1OO8 A;  1ATH A;  1DZG I;  1HLE A;  1E03 I;  2DUT A;  2H4Q A;  2ZV6 A;  4Y40 A;  1DVM A;  4P0F A;  2V95 A;  4CAA A;  2HIJ L;  1OPH A;  3F5N A;  4KDS A;  9PAI A;  1EZX A;  1SNG A;  2QUG A;  3Q02 A;  4AFX A;  1JJO C;  2HIJ I; 
#chains in the Genus database with same CATH topology
 2WXZ C;  1E05 I;  2VDX A;  1DVN A;  2GD4 C;  1LK6 I;  2RIW A;  1LJ5 A;  1UHG A;  1OC0 A;  1OYH L;  5IO1 A;  1DB2 A;  2ARR A;  3EOX A;  4IC0 A;  3H5C A;  1JTI A;  1OYH I;  3DLW A;  1AZX I;  5CDZ A;  3VVJ A;  3KCG I;  2R9Y A;  1HP7 A;  2ARQ A;  4ROB A;  4RO9 A;  3PB1 I;  4AJT A;  1OVA A;  1ATT A;  4IF8 A;  4DY7 C;  1E04 I;  1LQ8 A;  5C98 A;  2OL2 A;  2WXW A;  1IZ2 A;  4DY0 A;  1R1L I;  4AU3 A;  4X30 A;  3F1S A;  4Y3K A;  3STO A;  1M93 B;  2OAY A;  1QMB A;  2WXY C;  2B5T I;  4G8R A;  3NDA A;  1KCT A;  1XQJ A;  3ZHA A;  3R4L A;  1QLP A;  4YIA A;  2ANT I;  2WY0 C;  2B4X I;  1WZ9 A;  3CWL A;  1D5S A;  3CVM A;  1F0C A;  4AU3 B;  4R9I A;  4AU4 A;  3CWM A;  2XN6 A;  4BB2 A;  2RIV A;  3CAA A;  3F02 A;  1DZH I;  4GA7 A;  3NDD A;  1C8O A;  5INW A;  4AQH A;  1OVA C;  3FGQ A;  2PEF A;  3EVJ I;  1JRR A;  2VH4 A;  2PEE A;  1ATU A;  2ACH A;  1SEK A;  9API A;  4ZK3 A;  2VDY A;  2H4R A;  1MTP A;  3LE2 A;  1K9O I;  2H4P A;  3PZF A;  3DY0 A;  3NDF A;  4AU2 A;  1JMO A;  4RSQ A;  1OVA B;  3B9F I;  3Q03 A;  3DRM A;  2B4X L;  8API A;  4ZK0 A;  4EB1 I;  5BRR I;  1IMV A;  2CEO A;  1DZH L;  1XQG A;  5HGC A;  1C5G A;  1T1F A;  4PYW A;  5EI0 A;  2BEH L;  1TB6 I;  3OZQ A;  1BR8 I;  1XU8 A;  1JVQ I;  4AJU A;  2BEH I;  4C49 A;  2WY1 A;  5CE0 A;  2HI9 A;  4DTE A;  1A7C A;  1JMJ A;  3DRU A;  2ZNH A;  2WXZ A;  2WXX A;  3NE4 A;  1ANT I;  3LW2 A;  4ROA A;  1QMN A;  2XN5 A;  4P0O A;  4EB1 L;  1SR5 A;  4C41 A;  1BY7 A;  3UT3 A;  1B3K A;  1YXA A;  1NQ9 I;  3T1P A;  1PSI A;  4G8O A;  2D26 A;  2XN7 A;  1AS4 A;  2XN3 A;  1DZG L;  5CDX A;  7API A;  1OO8 A;  1ATH A;  1DZG I;  1HLE A;  1E03 I;  2DUT A;  2H4Q A;  2ZV6 A;  4Y40 A;  1DVM A;  4P0F A;  2V95 A;  4CAA A;  2HIJ L;  1OPH A;  3F5N A;  4KDS A;  9PAI A;  1EZX A;  1SNG A;  2QUG A;  3Q02 A;  4AFX A;  1JJO C;  2HIJ I; 
#chains in the Genus database with same CATH homology
 2WXZ C;  1E05 I;  2VDX A;  1DVN A;  2GD4 C;  1LK6 I;  2RIW A;  1LJ5 A;  1UHG A;  1OC0 A;  1OYH L;  5IO1 A;  1DB2 A;  2ARR A;  3EOX A;  4IC0 A;  3H5C A;  1JTI A;  1OYH I;  3DLW A;  1AZX I;  5CDZ A;  3VVJ A;  3KCG I;  2R9Y A;  1HP7 A;  2ARQ A;  4ROB A;  4RO9 A;  3PB1 I;  4AJT A;  1OVA A;  1ATT A;  4IF8 A;  4DY7 C;  1E04 I;  1LQ8 A;  5C98 A;  2OL2 A;  2WXW A;  1IZ2 A;  4DY0 A;  1R1L I;  4AU3 A;  4X30 A;  3F1S A;  4Y3K A;  3STO A;  1M93 B;  2OAY A;  1QMB A;  2WXY C;  2B5T I;  4G8R A;  3NDA A;  1KCT A;  1XQJ A;  3ZHA A;  3R4L A;  1QLP A;  4YIA A;  2ANT I;  2WY0 C;  2B4X I;  1WZ9 A;  3CWL A;  1D5S A;  3CVM A;  1F0C A;  4AU3 B;  4R9I A;  4AU4 A;  3CWM A;  2XN6 A;  4BB2 A;  2RIV A;  3CAA A;  3F02 A;  1DZH I;  4GA7 A;  3NDD A;  1C8O A;  5INW A;  4AQH A;  1OVA C;  3FGQ A;  2PEF A;  3EVJ I;  1JRR A;  2VH4 A;  2PEE A;  1ATU A;  2ACH A;  1SEK A;  9API A;  4ZK3 A;  2VDY A;  2H4R A;  1MTP A;  3LE2 A;  1K9O I;  2H4P A;  3PZF A;  3DY0 A;  3NDF A;  4AU2 A;  1JMO A;  4RSQ A;  1OVA B;  3B9F I;  3Q03 A;  3DRM A;  2B4X L;  8API A;  4ZK0 A;  4EB1 I;  5BRR I;  1IMV A;  2CEO A;  1DZH L;  1XQG A;  5HGC A;  1C5G A;  1T1F A;  4PYW A;  5EI0 A;  2BEH L;  1TB6 I;  3OZQ A;  1BR8 I;  1XU8 A;  1JVQ I;  4AJU A;  2BEH I;  4C49 A;  2WY1 A;  5CE0 A;  2HI9 A;  4DTE A;  1A7C A;  1JMJ A;  3DRU A;  2ZNH A;  2WXZ A;  2WXX A;  3NE4 A;  1ANT I;  3LW2 A;  4ROA A;  1QMN A;  2XN5 A;  4P0O A;  4EB1 L;  1SR5 A;  4C41 A;  1BY7 A;  3UT3 A;  1B3K A;  1YXA A;  1NQ9 I;  3T1P A;  1PSI A;  4G8O A;  2D26 A;  2XN7 A;  1AS4 A;  2XN3 A;  1DZG L;  5CDX A;  7API A;  1OO8 A;  1ATH A;  1DZG I;  1HLE A;  1E03 I;  2DUT A;  2H4Q A;  2ZV6 A;  4Y40 A;  1DVM A;  4P0F A;  2V95 A;  4CAA A;  2HIJ L;  1OPH A;  3F5N A;  4KDS A;  9PAI A;  1EZX A;  1SNG A;  2QUG A;  3Q02 A;  4AFX A;  1JJO C;  2HIJ I; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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