3EZPA

Crystal structure analysis of human hdac8 d101n variant
Total Genus 123
Loading diagram...

The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
123
sequence length
364
structure length
357
Chain Sequence
LVPVYIYSPEYVSMCDSLAKIPKRASMVHSLIEAYALHKQMRIVKPKVASMEEMATFHTDAYLQHLQKVSQDSIEYGLGYNCPATEGIFDYAAAIGGATITAAQCLIDGMCKVAINWSGGWHHAKKDEASGFCYLNDAVLGILRLRRKFERILYVDLDLHHGDGVEDAFSFTSKVMTVSLHKFSPGFFPGTGDVSDVGLGKGRYYSVNVPIQDGIQDEKYYQICESVLKEVYQAFNPKAVVLQLGADTIAGDPMCSFNMTPVGIGKCLKYILQWQLATLILGGGGYNLANTARCWTYLTGVILGKTLSSEIPDHEFFTAYGPDYVLEITPSCRPDRNEPHRIQQILNYIKGNLKHVV
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
{{ tooltip.sname }} connected with {{ tooltip.tname }} : {{qFormat(tooltip.svalue) }}
molecule tags Hydrolase
molecule keywords Histone deacetylase 8
publication title Structural studies of human histone deacetylase 8 and its site-specific variants complexed with substrate and inhibitors.
pubmed doi rcsb
source organism Homo sapiens
total genus 123
structure length 357
sequence length 364
chains with identical sequence B
ec nomenclature ec 3.5.1.98: Histone deacetylase.
pdb deposition date 2008-10-23

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00850 Hist_deacetyl Histone deacetylase domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.800.20 Alpha Beta 3-Layer(aba) Sandwich Arginase; Chain A Histone deacetylase domain 3ezpA00
2VQWG 4QA0A 5DC6A 4RN2A 5THTA 4ZUPA 4RN0A 1W22A 3EZTA 5G13A 4ZUMA 1VKGA 3MZ6A 3RQDA 2GH6A 5FUEA 4QA1A 5EEKA 4BZ8A 5FCWA 5G1BA 5G10A 5G12A 5G0IA 5G1CA 1C3SA 1C3PA 2V5XA 3C10A 5G1AA 3F06A 3MZ3A 5G0XA 2V5WA 4BKXB 1T67A 5EENA 1T64A 3ZNRA 5EFBD 3MAXA 1ZZ3A 1C3RA 2VQQA 5G0GA 4CQFA 5G0HA 5DC5A 3EW8A 2VQJA 5G17A 2VCGA 5EF8A 4ZURA 2VQVA 3SFHA 4CBYA 3Q9BA 4A69A 3F0RA 3Q9CA 3MZ7A 5BWZA 3F07A 5D1CA 4ZUQA 4BZ5A 4QA4A 4BZ6A 1ZZ0A 5G11A 4ZUOA 5DC7A 4LXZA 4LY1A 4QA3A 3MENA 4QA6A 5EEMA 3ZNSA 3C0YA 4QA2A 5EEFA 4ZUNA 5LI3A 5G0JA 5A2SA 5IX0A 2VQOA 2VQMA 3MZ4A 5ICNB 5THSA 5EFHA 5EFJD 5THVA 3EZPA 3SFFA 5DC8A 1T69A 3Q9EA 4QA5A 4RN1A 3EWFA 5IWGA 5THUA 5JI5A 4BZ7A 5D1DA 5EEIA 5EFNA 5EFGA 5G3WA 5G0YA 1ZZ1A 4CBTA 5D1BA 5EF7A 4BZ9A 4QA7A 3C0ZA 3Q9FA 5EFKB
chains in the Genus database with same CATH superfamily
2VQWG 4QA0A 3E6VA 5DC6A 4RN2A 5THTA 4MYLA 1T4TA 4ZUPA 4I06A 4RHLA 2ZAVA 1W22A 3EZTA 1D3VA 4RN0A 4GWCA 5G13A 4ZUMA 4FCKA 3SKKA 3RLAA 3GN0A 3E9BA 1VKGA 4MYKA 3MZ6A 3RQDA 2GH6A 5FUEA 3DJ8A 4QA1A 2PLLA 5EEKA 4BZ8A 5FCWA 5G1BA 4MYNA 5CEVA 3E8QA 5G10A 1P8PA 1GQ7A 5G12A 5G0IA 1XFKA 2EF4A 4MYFA 1C3SA 5G1CA 1C3PA 4RHIA 2PHAA 2V5XA 3C10A 5G1AA 3F06A 3MZ3A 4IU0A 1WOIA 4IXUA 5G0XA 2V5WA 3CEVA 4BKXB 1T67A 5EENA 1T64A 1P8QA 1TA1A 3ZNRA 4ITYA 5EFBD 3NIQA 3MAXA 1ZZ3A 4HZEA 1C3RA 2VQQA 4Q3RA 4GWDA 1T4RA 4GSMA 5G0GA 3TH7A 5G0HA 5DC5A 4CQFA 3EW8A 2VQJA 4IE2A 1P8SA 4IU1A 1P8MA 4MXRA 5G17A 2VCGA 5EF8A 3MMRA 3F80A 4ZURA 2VQVA 1T5GA 3SFHA 4CBYA 3PZLA 3LP7A 1ZPEA 3Q9BA 3SL0A 1TBJA 3F0RA 3Q9CA 4A69A 3MZ7A 4IU4A 1HQGA 5BWZA 1ZPGA 3F07A 5D1CA 4ZUQA 4Q3SA 4BZ5A 5RLAA 4HXQA 4QA4A 4BZ6A 1ZZ0A 5G11A 1HQFA 4ZUOA 3MFVA 5DC7A 4LXZA 4LY1A 4Q3QA 4IE1A 4QA3A 5HJAA 3MENA 4QA6A 1P8RA 4GSZA 4Q42A 3M1RA 3THJA 5EEMA 3ZNSA 4Q3VA 3C0YA 4Q3TA 1TBLA 1WVBA 3GMZA 4QA2A 3LHLA 5EEFA 4ZUNA 4G3HA 1HQ5A 3MJLA 4FCIA 4Q41A 3THHA 5LI3A 1RLAA 5G0JA 2EIVA 5A2SA 2CEVA 5IX0A 1TBHA 2VQOA 2VQMA 3MZ4A 5ICNB 4IXVA 2PHOA 1GQ6A 4GSVA 4IE3A 4Q3RC 5THSA 1WOGA 5EFHA 5EFJD 5THVA 1PQ3A 3EZPA 4RHKA 3SJTA 2EF5A 3SFFA 5DC8A 1T69A 2RLAA 3LP4A 4RHMA 3E8ZA 3Q9EA 4QA5A 5HJ9A 2A0MA 4RN1A 3EWFA 5IWGA 5THUA 3TF3A 4DZ4A 4IU5A 4RHQA 3SL1A 5JI5A 4BZ7A 5D1DA 1T5FA 3KV2A 3NIPA 1T4PA 4RHJA 1HQXA 5EEIA 1P8OA 3E6KA 3NIOA 4RLAA 5EFNA 1CEVA 5EFGA 1HQHA 5G3WA 4Q40A 5G0YA 3MFWA 1WVAA 1ZZ1A 1T4SA 4Q3PA 5D1BA 3THEA 4CBTA 4HWWA 5EF7A 1WOHA 4BZ9A 4QA7A 1P8NA 3C0ZA 4CEVA 4Q3UA 1R1OA 2AEBA 3Q9FA 5EFKB
chains in the Genus database with same CATH topology
2VQWG 4QA0A 5DC6A 4RN2A 5THTA 4ZUPA 4RN0A 1W22A 3EZTA 5G13A 4ZUMA 1VKGA 3MZ6A 3RQDA 2GH6A 5FUEA 4QA1A 5EEKA 4BZ8A 5FCWA 5G1BA 5G10A 5G12A 5G0IA 5G1CA 1C3SA 1C3PA 2V5XA 3C10A 5G1AA 3F06A 3MZ3A 5G0XA 2V5WA 4BKXB 1T67A 5EENA 1T64A 3ZNRA 5EFBD 3MAXA 1ZZ3A 1C3RA 2VQQA 5G0GA 4CQFA 5G0HA 5DC5A 3EW8A 2VQJA 5G17A 2VCGA 5EF8A 4ZURA 2VQVA 3SFHA 4CBYA 3Q9BA 4A69A 3F0RA 3Q9CA 3MZ7A 5BWZA 3F07A 5D1CA 4ZUQA 4BZ5A 4QA4A 4BZ6A 1ZZ0A 5G11A 4ZUOA 5DC7A 4LXZA 4LY1A 4QA3A 3MENA 4QA6A 5EEMA 3ZNSA 3C0YA 4QA2A 5EEFA 4ZUNA 5LI3A 5G0JA 5A2SA 5IX0A 2VQOA 2VQMA 3MZ4A 5ICNB 5THSA 5EFHA 5EFJD 5THVA 3EZPA 3SFFA 5DC8A 1T69A 3Q9EA 4QA5A 4RN1A 3EWFA 5IWGA 5THUA 5JI5A 4BZ7A 5D1DA 5EEIA 5EFNA 5EFGA 5G3WA 5G0YA 1ZZ1A 4CBTA 5D1BA 5EF7A 4BZ9A 4QA7A 3C0ZA 3Q9FA 5EFKB
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 2VQW G;  4QA0 A;  5DC6 A;  4RN2 A;  5THT A;  4ZUP A;  4RN0 A;  1W22 A;  3EZT A;  5G13 A;  4ZUM A;  1VKG A;  3MZ6 A;  3RQD A;  2GH6 A;  5FUE A;  4QA1 A;  5EEK A;  4BZ8 A;  5FCW A;  5G1B A;  5G10 A;  5G12 A;  5G0I A;  5G1C A;  1C3S A;  1C3P A;  2V5X A;  3C10 A;  5G1A A;  3F06 A;  3MZ3 A;  5G0X A;  2V5W A;  4BKX B;  1T67 A;  5EEN A;  1T64 A;  3ZNR A;  5EFB D;  3MAX A;  1ZZ3 A;  1C3R A;  2VQQ A;  5G0G A;  4CQF A;  5G0H A;  5DC5 A;  3EW8 A;  2VQJ A;  5G17 A;  2VCG A;  5EF8 A;  4ZUR A;  2VQV A;  3SFH A;  4CBY A;  3Q9B A;  4A69 A;  3F0R A;  3Q9C A;  3MZ7 A;  5BWZ A;  3F07 A;  5D1C A;  4ZUQ A;  4BZ5 A;  4QA4 A;  4BZ6 A;  1ZZ0 A;  5G11 A;  4ZUO A;  5DC7 A;  4LXZ A;  4LY1 A;  4QA3 A;  3MEN A;  4QA6 A;  5EEM A;  3ZNS A;  3C0Y A;  4QA2 A;  5EEF A;  4ZUN A;  5LI3 A;  5G0J A;  5A2S A;  5IX0 A;  2VQO A;  2VQM A;  3MZ4 A;  5ICN B;  5THS A;  5EFH A;  5EFJ D;  5THV A;  3EZP A;  3SFF A;  5DC8 A;  1T69 A;  3Q9E A;  4QA5 A;  4RN1 A;  3EWF A;  5IWG A;  5THU A;  5JI5 A;  4BZ7 A;  5D1D A;  5EEI A;  5EFN A;  5EFG A;  5G3W A;  5G0Y A;  1ZZ1 A;  4CBT A;  5D1B A;  5EF7 A;  4BZ9 A;  4QA7 A;  3C0Z A;  3Q9F A;  5EFK B; 
#chains in the Genus database with same CATH topology
 2VQW G;  4QA0 A;  3E6V A;  5DC6 A;  4RN2 A;  5THT A;  4MYL A;  1T4T A;  4ZUP A;  4I06 A;  4RHL A;  2ZAV A;  1W22 A;  3EZT A;  1D3V A;  4RN0 A;  4GWC A;  5G13 A;  4ZUM A;  4FCK A;  3SKK A;  3RLA A;  3GN0 A;  3E9B A;  1VKG A;  4MYK A;  3MZ6 A;  3RQD A;  2GH6 A;  5FUE A;  3DJ8 A;  4QA1 A;  2PLL A;  5EEK A;  4BZ8 A;  5FCW A;  5G1B A;  4MYN A;  5CEV A;  3E8Q A;  5G10 A;  1P8P A;  1GQ7 A;  5G12 A;  5G0I A;  1XFK A;  2EF4 A;  4MYF A;  1C3S A;  5G1C A;  1C3P A;  4RHI A;  2PHA A;  2V5X A;  3C10 A;  5G1A A;  3F06 A;  3MZ3 A;  4IU0 A;  1WOI A;  4IXU A;  5G0X A;  2V5W A;  3CEV A;  4BKX B;  1T67 A;  5EEN A;  1T64 A;  1P8Q A;  1TA1 A;  3ZNR A;  4ITY A;  5EFB D;  3NIQ A;  3MAX A;  1ZZ3 A;  4HZE A;  1C3R A;  2VQQ A;  4Q3R A;  4GWD A;  1T4R A;  4GSM A;  5G0G A;  3TH7 A;  5G0H A;  5DC5 A;  4CQF A;  3EW8 A;  2VQJ A;  4IE2 A;  1P8S A;  4IU1 A;  1P8M A;  4MXR A;  5G17 A;  2VCG A;  5EF8 A;  3MMR A;  3F80 A;  4ZUR A;  2VQV A;  1T5G A;  3SFH A;  4CBY A;  3PZL A;  3LP7 A;  1ZPE A;  3Q9B A;  3SL0 A;  1TBJ A;  3F0R A;  3Q9C A;  4A69 A;  3MZ7 A;  4IU4 A;  1HQG A;  5BWZ A;  1ZPG A;  3F07 A;  5D1C A;  4ZUQ A;  4Q3S A;  4BZ5 A;  5RLA A;  4HXQ A;  4QA4 A;  4BZ6 A;  1ZZ0 A;  5G11 A;  1HQF A;  4ZUO A;  3MFV A;  5DC7 A;  4LXZ A;  4LY1 A;  4Q3Q A;  4IE1 A;  4QA3 A;  5HJA A;  3MEN A;  4QA6 A;  1P8R A;  4GSZ A;  4Q42 A;  3M1R A;  3THJ A;  5EEM A;  3ZNS A;  4Q3V A;  3C0Y A;  4Q3T A;  1TBL A;  1WVB A;  3GMZ A;  4QA2 A;  3LHL A;  5EEF A;  4ZUN A;  4G3H A;  1HQ5 A;  3MJL A;  4FCI A;  4Q41 A;  3THH A;  5LI3 A;  1RLA A;  5G0J A;  2EIV A;  5A2S A;  2CEV A;  5IX0 A;  1TBH A;  2VQO A;  2VQM A;  3MZ4 A;  5ICN B;  4IXV A;  2PHO A;  1GQ6 A;  4GSV A;  4IE3 A;  4Q3R C;  5THS A;  1WOG A;  5EFH A;  5EFJ D;  5THV A;  1PQ3 A;  3EZP A;  4RHK A;  3SJT A;  2EF5 A;  3SFF A;  5DC8 A;  1T69 A;  2RLA A;  3LP4 A;  4RHM A;  3E8Z A;  3Q9E A;  4QA5 A;  5HJ9 A;  2A0M A;  4RN1 A;  3EWF A;  5IWG A;  5THU A;  3TF3 A;  4DZ4 A;  4IU5 A;  4RHQ A;  3SL1 A;  5JI5 A;  4BZ7 A;  5D1D A;  1T5F A;  3KV2 A;  3NIP A;  1T4P A;  4RHJ A;  1HQX A;  5EEI A;  1P8O A;  3E6K A;  3NIO A;  4RLA A;  5EFN A;  1CEV A;  5EFG A;  1HQH A;  5G3W A;  4Q40 A;  5G0Y A;  3MFW A;  1WVA A;  1ZZ1 A;  1T4S A;  4Q3P A;  5D1B A;  3THE A;  4CBT A;  4HWW A;  5EF7 A;  1WOH A;  4BZ9 A;  4QA7 A;  1P8N A;  3C0Z A;  4CEV A;  4Q3U A;  1R1O A;  2AEB A;  3Q9F A;  5EFK B; 
#chains in the Genus database with same CATH homology
 2VQW G;  4QA0 A;  5DC6 A;  4RN2 A;  5THT A;  4ZUP A;  4RN0 A;  1W22 A;  3EZT A;  5G13 A;  4ZUM A;  1VKG A;  3MZ6 A;  3RQD A;  2GH6 A;  5FUE A;  4QA1 A;  5EEK A;  4BZ8 A;  5FCW A;  5G1B A;  5G10 A;  5G12 A;  5G0I A;  5G1C A;  1C3S A;  1C3P A;  2V5X A;  3C10 A;  5G1A A;  3F06 A;  3MZ3 A;  5G0X A;  2V5W A;  4BKX B;  1T67 A;  5EEN A;  1T64 A;  3ZNR A;  5EFB D;  3MAX A;  1ZZ3 A;  1C3R A;  2VQQ A;  5G0G A;  4CQF A;  5G0H A;  5DC5 A;  3EW8 A;  2VQJ A;  5G17 A;  2VCG A;  5EF8 A;  4ZUR A;  2VQV A;  3SFH A;  4CBY A;  3Q9B A;  4A69 A;  3F0R A;  3Q9C A;  3MZ7 A;  5BWZ A;  3F07 A;  5D1C A;  4ZUQ A;  4BZ5 A;  4QA4 A;  4BZ6 A;  1ZZ0 A;  5G11 A;  4ZUO A;  5DC7 A;  4LXZ A;  4LY1 A;  4QA3 A;  3MEN A;  4QA6 A;  5EEM A;  3ZNS A;  3C0Y A;  4QA2 A;  5EEF A;  4ZUN A;  5LI3 A;  5G0J A;  5A2S A;  5IX0 A;  2VQO A;  2VQM A;  3MZ4 A;  5ICN B;  5THS A;  5EFH A;  5EFJ D;  5THV A;  3EZP A;  3SFF A;  5DC8 A;  1T69 A;  3Q9E A;  4QA5 A;  4RN1 A;  3EWF A;  5IWG A;  5THU A;  5JI5 A;  4BZ7 A;  5D1D A;  5EEI A;  5EFN A;  5EFG A;  5G3W A;  5G0Y A;  1ZZ1 A;  4CBT A;  5D1B A;  5EF7 A;  4BZ9 A;  4QA7 A;  3C0Z A;  3Q9F A;  5EFK B; 
...loading similar chains, please wait...
similar chains in the Genus database (?% sequence similarity)
...loading similar chains, please wait...
similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
...loading similar chains, please wait...
#similar chains, but unknotted
...loading similar chains, please wait...
#similar chains in the pdb database (?% sequence similarity)
...loading similar chains, please wait...