3EZTA

Crystal structure analysis of human hdac8 d101e variant
Total Genus 121
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
121
sequence length
364
structure length
357
Chain Sequence
LVPVYIYSPEYVSMCDSLAKIPKRASMVHSLIEAYALHKQMRIVKPKVASMEEMATFHTDAYLQHLQKVSQDSIEYGLGYECPATEGIFDYAAAIGGATITAAQCLIDGMCKVAINWSGGWHHAKKDEASGFCYLNDAVLGILRLRRKFERILYVDLDLHHGDGVEDAFSFTSKVMTVSLHKFSPGFFPGTGDVSDVGLGKGRYYSVNVPIQDGIQDEKYYQICESVLKEVYQAFNPKAVVLQLGADTIAGDPMCSFNMTPVGIGKCLKYILQWQLATLILGGGGYNLANTARCWTYLTGVILGKTLSSEIPDHEFFTAYGPDYVLEITPSCRPDRNEPHRIQQILNYIKGNLKHVV
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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molecule tags Hydrolase
molecule keywords Histone deacetylase 8
publication title Structural studies of human histone deacetylase 8 and its site-specific variants complexed with substrate and inhibitors.
pubmed doi rcsb
source organism Homo sapiens
total genus 121
structure length 357
sequence length 364
chains with identical sequence B
ec nomenclature ec 3.5.1.98: Histone deacetylase.
pdb deposition date 2008-10-23

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00850 Hist_deacetyl Histone deacetylase domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.800.20 Alpha Beta 3-Layer(aba) Sandwich Arginase; Chain A Histone deacetylase domain 3eztA00
5IWGA 5THTA 5A2SA 1ZZ1A 4LY1A 5IX0A 5EFJD 3EZTA 3MENA 5EFGA 5JI5A 5EFHA 4ZUNA 5BWZA 4QA1A 2VCGA 2VQMA 5G1AA 3SFHA 3MZ4A 4BZ6A 3F06A 5EENA 5G0HA 4RN2A 3F0RA 3Q9FA 3Q9EA 1C3SA 4QA4A 5FUEA 2GH6A 4ZUPA 2VQQA 3MZ3A 5G13A 4ZUQA 2V5WA 4LXZA 3C10A 5DC8A 5G1BA 5ICNB 1C3PA 3MZ7A 4CQFA 5EEKA 4QA5A 4ZUMA 1T69A 5EF8A 2VQWG 3MAXA 4ZURA 4RN0A 3Q9BA 4QA7A 3F07A 4ZUOA 5G11A 3Q9CA 3SFFA 4QA0A 5G3WA 5D1BA 4BKXB 1T64A 5G12A 4QA3A 5EFKB 4QA6A 4CBTA 4CBYA 3ZNRA 5G17A 5G0YA 5G10A 5EEMA 4BZ5A 1W22A 5EEFA 5DC5A 4BZ7A 3C0YA 5EEIA 4BZ9A 5EF7A 1VKGA 5D1DA 3ZNSA 3EZPA 1ZZ3A 5DC6A 3EW8A 3MZ6A 5THUA 5THSA 1C3RA 2V5XA 5G0GA 5G0IA 5DC7A 1T67A 5THVA 5G1CA 4QA2A 3EWFA 2VQOA 2VQVA 5D1CA 5FCWA 4BZ8A 3C0ZA 4A69A 2VQJA 1ZZ0A 4RN1A 5EFNA 3RQDA 5G0XA 5G0JA 5EFBD 5LI3A
chains in the Genus database with same CATH superfamily
5IWGA 3LP4A 1TBHA 3E6VA 3E6KA 4IE1A 5THTA 5A2SA 4ITYA 1ZZ1A 4LY1A 5IX0A 4RHMA 1TA1A 3EZTA 1HQGA 5EFJD 1WVAA 3MENA 4Q40A 5EFGA 3RLAA 5EFHA 4ZUNA 3SL1A 4DZ4A 5BWZA 4MYKA 4QA1A 2VCGA 2VQMA 1TBLA 1XFKA 5G1AA 3SFHA 3MZ4A 4G3HA 4IU4A 4Q3TA 4BZ6A 3F80A 3F06A 2CEVA 1TBJA 3MFVA 5EENA 5G0HA 5JI5A 1PQ3A 5EFBD 1CEVA 4RN2A 3F0RA 2EF5A 3Q9FA 4Q3VA 1T4TA 3MFWA 4RHKA 3Q9EA 1C3SA 1P8RA 3GMZA 1P8MA 4MXRA 3SL0A 4QA4A 5FUEA 1WOHA 4CEVA 2GH6A 4IE3A 1RLAA 3CEVA 2PHAA 4ZUPA 4I06A 1T5FA 1T5GA 3MJLA 2VQQA 3MZ3A 5G13A 4IU5A 4ZUQA 2V5WA 4LXZA 5HJ9A 3C10A 5DC8A 5G1BA 3SKKA 3PZLA 3THEA 1C3PA 4Q3PA 5ICNB 3DJ8A 3MZ7A 4CQFA 5EEKA 4QA5A 4ZUMA 1GQ7A 4GWDA 1T69A 1R1OA 3M1RA 3MMRA 2PHOA 1P8OA 4Q3SA 4MYNA 4Q3RC 5EF8A 2VQWG 5CEVA 3MAXA 4ZURA 5HJAA 4RN0A 4RHQA 3Q9BA 4QA7A 3THJA 3F07A 4ZUOA 5G11A 3Q9CA 3SFFA 4QA0A 1D3VA 1GQ6A 2EF4A 2ZAVA 5G3WA 5D1BA 4IU0A 4BKXB 5G12A 4QA3A 5EFKB 4QA6A 1HQ5A 4IXUA 4RHJA 4CBTA 1P8PA 4CBYA 3ZNRA 4Q3QA 5G17A 5G0YA 5G10A 4GWCA 4RHIA 4HZEA 5EEMA 3E8ZA 3GN0A 4BZ5A 1W22A 5EEFA 5DC5A 3TH7A 4BZ7A 3NIOA 4FCKA 3C0YA 5EEIA 4IU1A 2AEBA 4BZ9A 5EF7A 1VKGA 1T4SA 4Q3UA 5D1DA 4GSMA 3LHLA 3ZNSA 1T4PA 1HQFA 3KV2A 4Q41A 1T4RA 5RLAA 4IE2A 3EZPA 1ZZ3A 1ZPEA 3NIQA 2A0MA 5DC6A 4FCIA 3EW8A 4Q3RA 3THHA 3NIPA 3MZ6A 4GSVA 5THUA 3E9BA 3SJTA 1P8SA 5THSA 1C3RA 2V5XA 1WOGA 5G0GA 3E8QA 5G0IA 4RHLA 4RLAA 5DC7A 4HWWA 1WOIA 1P8QA 1T67A 2RLAA 5THVA 4MYFA 5G1CA 4QA2A 3EWFA 2VQOA 1WVBA 2VQVA 3LP7A 4MYLA 5D1CA 4GSZA 1P8NA 5FCWA 4BZ8A 2EIVA 3C0ZA 4A69A 2PLLA 2VQJA 1ZZ0A 4RN1A 4HXQA 5EFNA 3RQDA 1ZPGA 1HQHA 1HQXA 4IXVA 4Q42A 5G0XA 5G0JA 3TF3A 1T64A 5LI3A
chains in the Genus database with same CATH topology
5IWGA 5THTA 5A2SA 1ZZ1A 4LY1A 5IX0A 5EFJD 3EZTA 3MENA 5EFGA 5JI5A 5EFHA 4ZUNA 5BWZA 4QA1A 2VCGA 2VQMA 5G1AA 3SFHA 3MZ4A 4BZ6A 3F06A 5EENA 5G0HA 4RN2A 3F0RA 3Q9FA 3Q9EA 1C3SA 4QA4A 5FUEA 2GH6A 4ZUPA 2VQQA 3MZ3A 5G13A 4ZUQA 2V5WA 4LXZA 3C10A 5DC8A 5G1BA 5ICNB 1C3PA 3MZ7A 4CQFA 5EEKA 4QA5A 4ZUMA 1T69A 5EF8A 2VQWG 3MAXA 4ZURA 4RN0A 3Q9BA 4QA7A 3F07A 4ZUOA 5G11A 3Q9CA 3SFFA 4QA0A 5G3WA 5D1BA 4BKXB 1T64A 5G12A 4QA3A 5EFKB 4QA6A 4CBTA 4CBYA 3ZNRA 5G17A 5G0YA 5G10A 5EEMA 4BZ5A 1W22A 5EEFA 5DC5A 4BZ7A 3C0YA 5EEIA 4BZ9A 5EF7A 1VKGA 5D1DA 3ZNSA 3EZPA 1ZZ3A 5DC6A 3EW8A 3MZ6A 5THUA 5THSA 1C3RA 2V5XA 5G0GA 5G0IA 5DC7A 1T67A 5THVA 5G1CA 4QA2A 3EWFA 2VQOA 2VQVA 5D1CA 5FCWA 4BZ8A 3C0ZA 4A69A 2VQJA 1ZZ0A 4RN1A 5EFNA 3RQDA 5G0XA 5G0JA 5EFBD 5LI3A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 5IWG A;  5THT A;  5A2S A;  1ZZ1 A;  4LY1 A;  5IX0 A;  5EFJ D;  3EZT A;  3MEN A;  5EFG A;  5JI5 A;  5EFH A;  4ZUN A;  5BWZ A;  4QA1 A;  2VCG A;  2VQM A;  5G1A A;  3SFH A;  3MZ4 A;  4BZ6 A;  3F06 A;  5EEN A;  5G0H A;  4RN2 A;  3F0R A;  3Q9F A;  3Q9E A;  1C3S A;  4QA4 A;  5FUE A;  2GH6 A;  4ZUP A;  2VQQ A;  3MZ3 A;  5G13 A;  4ZUQ A;  2V5W A;  4LXZ A;  3C10 A;  5DC8 A;  5G1B A;  5ICN B;  1C3P A;  3MZ7 A;  4CQF A;  5EEK A;  4QA5 A;  4ZUM A;  1T69 A;  5EF8 A;  2VQW G;  3MAX A;  4ZUR A;  4RN0 A;  3Q9B A;  4QA7 A;  3F07 A;  4ZUO A;  5G11 A;  3Q9C A;  3SFF A;  4QA0 A;  5G3W A;  5D1B A;  4BKX B;  1T64 A;  5G12 A;  4QA3 A;  5EFK B;  4QA6 A;  4CBT A;  4CBY A;  3ZNR A;  5G17 A;  5G0Y A;  5G10 A;  5EEM A;  4BZ5 A;  1W22 A;  5EEF A;  5DC5 A;  4BZ7 A;  3C0Y A;  5EEI A;  4BZ9 A;  5EF7 A;  1VKG A;  5D1D A;  3ZNS A;  3EZP A;  1ZZ3 A;  5DC6 A;  3EW8 A;  3MZ6 A;  5THU A;  5THS A;  1C3R A;  2V5X A;  5G0G A;  5G0I A;  5DC7 A;  1T67 A;  5THV A;  5G1C A;  4QA2 A;  3EWF A;  2VQO A;  2VQV A;  5D1C A;  5FCW A;  4BZ8 A;  3C0Z A;  4A69 A;  2VQJ A;  1ZZ0 A;  4RN1 A;  5EFN A;  3RQD A;  5G0X A;  5G0J A;  5EFB D;  5LI3 A; 
#chains in the Genus database with same CATH topology
 5IWG A;  3LP4 A;  1TBH A;  3E6V A;  3E6K A;  4IE1 A;  5THT A;  5A2S A;  4ITY A;  1ZZ1 A;  4LY1 A;  5IX0 A;  4RHM A;  1TA1 A;  3EZT A;  1HQG A;  5EFJ D;  1WVA A;  3MEN A;  4Q40 A;  5EFG A;  3RLA A;  5EFH A;  4ZUN A;  3SL1 A;  4DZ4 A;  5BWZ A;  4MYK A;  4QA1 A;  2VCG A;  2VQM A;  1TBL A;  1XFK A;  5G1A A;  3SFH A;  3MZ4 A;  4G3H A;  4IU4 A;  4Q3T A;  4BZ6 A;  3F80 A;  3F06 A;  2CEV A;  1TBJ A;  3MFV A;  5EEN A;  5G0H A;  5JI5 A;  1PQ3 A;  5EFB D;  1CEV A;  4RN2 A;  3F0R A;  2EF5 A;  3Q9F A;  4Q3V A;  1T4T A;  3MFW A;  4RHK A;  3Q9E A;  1C3S A;  1P8R A;  3GMZ A;  1P8M A;  4MXR A;  3SL0 A;  4QA4 A;  5FUE A;  1WOH A;  4CEV A;  2GH6 A;  4IE3 A;  1RLA A;  3CEV A;  2PHA A;  4ZUP A;  4I06 A;  1T5F A;  1T5G A;  3MJL A;  2VQQ A;  3MZ3 A;  5G13 A;  4IU5 A;  4ZUQ A;  2V5W A;  4LXZ A;  5HJ9 A;  3C10 A;  5DC8 A;  5G1B A;  3SKK A;  3PZL A;  3THE A;  1C3P A;  4Q3P A;  5ICN B;  3DJ8 A;  3MZ7 A;  4CQF A;  5EEK A;  4QA5 A;  4ZUM A;  1GQ7 A;  4GWD A;  1T69 A;  1R1O A;  3M1R A;  3MMR A;  2PHO A;  1P8O A;  4Q3S A;  4MYN A;  4Q3R C;  5EF8 A;  2VQW G;  5CEV A;  3MAX A;  4ZUR A;  5HJA A;  4RN0 A;  4RHQ A;  3Q9B A;  4QA7 A;  3THJ A;  3F07 A;  4ZUO A;  5G11 A;  3Q9C A;  3SFF A;  4QA0 A;  1D3V A;  1GQ6 A;  2EF4 A;  2ZAV A;  5G3W A;  5D1B A;  4IU0 A;  4BKX B;  5G12 A;  4QA3 A;  5EFK B;  4QA6 A;  1HQ5 A;  4IXU A;  4RHJ A;  4CBT A;  1P8P A;  4CBY A;  3ZNR A;  4Q3Q A;  5G17 A;  5G0Y A;  5G10 A;  4GWC A;  4RHI A;  4HZE A;  5EEM A;  3E8Z A;  3GN0 A;  4BZ5 A;  1W22 A;  5EEF A;  5DC5 A;  3TH7 A;  4BZ7 A;  3NIO A;  4FCK A;  3C0Y A;  5EEI A;  4IU1 A;  2AEB A;  4BZ9 A;  5EF7 A;  1VKG A;  1T4S A;  4Q3U A;  5D1D A;  4GSM A;  3LHL A;  3ZNS A;  1T4P A;  1HQF A;  3KV2 A;  4Q41 A;  1T4R A;  5RLA A;  4IE2 A;  3EZP A;  1ZZ3 A;  1ZPE A;  3NIQ A;  2A0M A;  5DC6 A;  4FCI A;  3EW8 A;  4Q3R A;  3THH A;  3NIP A;  3MZ6 A;  4GSV A;  5THU A;  3E9B A;  3SJT A;  1P8S A;  5THS A;  1C3R A;  2V5X A;  1WOG A;  5G0G A;  3E8Q A;  5G0I A;  4RHL A;  4RLA A;  5DC7 A;  4HWW A;  1WOI A;  1P8Q A;  1T67 A;  2RLA A;  5THV A;  4MYF A;  5G1C A;  4QA2 A;  3EWF A;  2VQO A;  1WVB A;  2VQV A;  3LP7 A;  4MYL A;  5D1C A;  4GSZ A;  1P8N A;  5FCW A;  4BZ8 A;  2EIV A;  3C0Z A;  4A69 A;  2PLL A;  2VQJ A;  1ZZ0 A;  4RN1 A;  4HXQ A;  5EFN A;  3RQD A;  1ZPG A;  1HQH A;  1HQX A;  4IXV A;  4Q42 A;  5G0X A;  5G0J A;  3TF3 A;  1T64 A;  5LI3 A; 
#chains in the Genus database with same CATH homology
 5IWG A;  5THT A;  5A2S A;  1ZZ1 A;  4LY1 A;  5IX0 A;  5EFJ D;  3EZT A;  3MEN A;  5EFG A;  5JI5 A;  5EFH A;  4ZUN A;  5BWZ A;  4QA1 A;  2VCG A;  2VQM A;  5G1A A;  3SFH A;  3MZ4 A;  4BZ6 A;  3F06 A;  5EEN A;  5G0H A;  4RN2 A;  3F0R A;  3Q9F A;  3Q9E A;  1C3S A;  4QA4 A;  5FUE A;  2GH6 A;  4ZUP A;  2VQQ A;  3MZ3 A;  5G13 A;  4ZUQ A;  2V5W A;  4LXZ A;  3C10 A;  5DC8 A;  5G1B A;  5ICN B;  1C3P A;  3MZ7 A;  4CQF A;  5EEK A;  4QA5 A;  4ZUM A;  1T69 A;  5EF8 A;  2VQW G;  3MAX A;  4ZUR A;  4RN0 A;  3Q9B A;  4QA7 A;  3F07 A;  4ZUO A;  5G11 A;  3Q9C A;  3SFF A;  4QA0 A;  5G3W A;  5D1B A;  4BKX B;  1T64 A;  5G12 A;  4QA3 A;  5EFK B;  4QA6 A;  4CBT A;  4CBY A;  3ZNR A;  5G17 A;  5G0Y A;  5G10 A;  5EEM A;  4BZ5 A;  1W22 A;  5EEF A;  5DC5 A;  4BZ7 A;  3C0Y A;  5EEI A;  4BZ9 A;  5EF7 A;  1VKG A;  5D1D A;  3ZNS A;  3EZP A;  1ZZ3 A;  5DC6 A;  3EW8 A;  3MZ6 A;  5THU A;  5THS A;  1C3R A;  2V5X A;  5G0G A;  5G0I A;  5DC7 A;  1T67 A;  5THV A;  5G1C A;  4QA2 A;  3EWF A;  2VQO A;  2VQV A;  5D1C A;  5FCW A;  4BZ8 A;  3C0Z A;  4A69 A;  2VQJ A;  1ZZ0 A;  4RN1 A;  5EFN A;  3RQD A;  5G0X A;  5G0J A;  5EFB D;  5LI3 A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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