3MZ7A

Crystal structure of d101l co2+ hdac8 complexed with m344
Total Genus 127
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
127
sequence length
365
structure length
356
Chain Sequence
LVPVYIYSPEYVSMCDSLAKIPKRASMVHSLIEAYALHKQMRIVKPKVASMEEMATFHTDAYLQHLQKVSQEEYGLGYLCPATEGIFDYAAAIGGATITAAQCLIDGMCKVAINWSGGWHHAKKDEASGFCYLNDAVLGILRLRRKFERILYVDLDLHHGDGVEDAFSFTSKVMTVSLHKFSPGFFPGTGDVSDVGLGKGRYYSVNVPIQDGIQDEKYYQICESVLKEVYQAFNPKAVVLQLGADTIAGDPMCSFNMTPVGIGKCLKYILQWQLATLILGGGGYNLANTARCWTYLTGVILGKTLSSEIPDHEFFTAYGPDYVLEITPSCRPDRNEPHRIQQILNYIKGNLKHVVI
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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molecule tags Hydrolase
molecule keywords Histone deacetylase 8
publication title Structures of metal-substituted human histone deacetylase 8 provide mechanistic inferences on biological function.
pubmed doi rcsb
source organism Homo sapiens
total genus 127
structure length 356
sequence length 365
ec nomenclature ec 3.5.1.98: Histone deacetylase.
pdb deposition date 2010-05-11

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00850 Hist_deacetyl Histone deacetylase domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.800.20 Alpha Beta 3-Layer(aba) Sandwich Arginase; Chain A Histone deacetylase domain 3mz7A00
5G0JA 5BWZA 2VQMA 2V5XA 5G0GA 5EENA 3MZ4A 1ZZ3A 1VKGA 3Q9FA 4QA2A 4BZ8A 5THTA 5JI5A 4BZ9A 5EFNA 5THVA 5EEFA 5THUA 3SFFA 1T64A 4QA1A 1W22A 3F06A 5EF7A 5G0HA 4QA0A 5G13A 3F07A 3Q9EA 4RN1A 5G0XA 4QA3A 5EEKA 4ZUNA 4ZURA 5G0IA 4QA7A 4CBTA 5EEMA 3EWFA 4LY1A 1C3PA 3Q9BA 3Q9CA 5EFBD 5IWGA 5G1AA 1T67A 4ZUPA 5THSA 5G1CA 5DC8A 4CBYA 4QA6A 5A2SA 5EFKB 3MENA 4A69A 1C3RA 2VQOA 3MZ3A 5DC5A 5G11A 4RN0A 1ZZ0A 5EFJD 5G12A 3MZ7A 1C3SA 3F0RA 2VQJA 4ZUQA 5G3WA 3EZPA 5EFGA 5G0YA 4BZ5A 3C10A 4ZUMA 3EZTA 4BZ6A 3C0ZA 5DC6A 5FUEA 3ZNRA 4RN2A 2GH6A 5IX0A 4BZ7A 5ICNB 4QA5A 5D1BA 2VQWG 3MZ6A 3C0YA 3RQDA 5LI3A 2VCGA 4CQFA 2V5WA 5EFHA 5EEIA 5D1CA 5G17A 3SFHA 5G1BA 5DC7A 5D1DA 4QA4A 4ZUOA 3MAXA 4LXZA 3ZNSA 1T69A 5G10A 2VQQA 5EF8A 2VQVA 4BKXB 1ZZ1A 5FCWA 3EW8A
chains in the Genus database with same CATH superfamily
5G0JA 5BWZA 2VQMA 2V5XA 3TF3A 5G0GA 4Q41A 4IXUA 4DZ4A 5EENA 3MZ4A 3NIQA 3E8ZA 4RLAA 1ZZ3A 3SKKA 1VKGA 3Q9FA 4QA2A 4BZ8A 1WVBA 1TBHA 4IU0A 4Q3TA 5THTA 5EFNA 4MXRA 4RHQA 5EEFA 5THVA 4BZ9A 5CEVA 4IU4A 5THUA 1T64A 3SFFA 4Q3PA 2PHAA 4QA1A 3MMRA 4IE1A 1W22A 3F06A 3GN0A 5EF7A 4HXQA 2RLAA 3E6VA 4GSZA 3CEVA 5G0HA 4QA0A 1HQXA 5G13A 3F07A 3M1RA 3Q9EA 4Q3SA 4RN1A 1RLAA 4Q3QA 5G0XA 2ZAVA 1HQFA 3GMZA 4G3HA 2PLLA 4I06A 4IE3A 4QA3A 5EEKA 4ZUNA 4QA7A 4ZURA 5G0IA 4CBTA 3LHLA 5EEMA 5HJAA 2EF4A 1HQ5A 2PHOA 3EWFA 4RHMA 4RHJA 4LY1A 4IXVA 1C3PA 3KV2A 3Q9BA 3Q9CA 5EFBD 5IWGA 4GSVA 3E9BA 1T67A 3E8QA 4ZUPA 5G1AA 1P8QA 3LP4A 5G1CA 5THSA 5DC8A 1T4PA 4CBYA 4IE2A 4QA6A 1P8OA 4FCIA 5A2SA 5EFKB 2A0MA 3MENA 1C3RA 4A69A 3NIOA 4RHIA 2VQOA 3MZ3A 5DC5A 4HWWA 5G11A 3F80A 3SL1A 4RN0A 4HZEA 1ZPGA 3SL0A 1ZZ0A 5EFJD 5G12A 4GWDA 1HQHA 3MZ7A 1C3SA 4Q3RA 3F0RA 3THHA 4Q3VA 3LP7A 2VQJA 4ZUQA 1T5FA 5G3WA 3EZPA 4GSMA 5EFGA 5G0YA 4BZ5A 3C10A 4MYNA 4MYKA 4ZUMA 3EZTA 4ITYA 5RLAA 4BZ6A 3SJTA 3C0ZA 1P8RA 1WVAA 1PQ3A 5DC6A 5FUEA 3THEA 1CEVA 1D3VA 4RN2A 2GH6A 5IX0A 2EIVA 4Q3UA 3ZNRA 4BZ7A 1P8SA 4Q42A 5FCWA 1P8PA 4QA5A 5D1BA 2VQWG 3MZ6A 2CEVA 3PZLA 1WOIA 5ICNB 3C0YA 1HQGA 4MYFA 3RQDA 4GWCA 3THJA 2VCGA 5LI3A 1GQ7A 4RHKA 4CQFA 1TBLA 2EF5A 3E6KA 2V5WA 1T4SA 1TA1A 5JI5A 4IU5A 2AEBA 5EFHA 3DJ8A 3MFWA 5EEIA 4CEVA 5HJ9A 5D1CA 4Q3RC 5G17A 1TBJA 1WOHA 5G1BA 3SFHA 4IU1A 5DC7A 5D1DA 1T4RA 4FCKA 4QA4A 4ZUOA 3MAXA 4LXZA 1T4TA 3TH7A 4MYLA 3ZNSA 1R1OA 1T69A 3MFVA 4RHLA 5G10A 3RLAA 1WOGA 4Q40A 2VQQA 5EF8A 2VQVA 4BKXB 1T5GA 3NIPA 1ZZ1A 1P8MA 1GQ6A 3MJLA 1ZPEA 1XFKA 3EW8A 1P8NA
chains in the Genus database with same CATH topology
5G0JA 5BWZA 2VQMA 2V5XA 5G0GA 5EENA 3MZ4A 1ZZ3A 1VKGA 3Q9FA 4QA2A 4BZ8A 5THTA 5JI5A 4BZ9A 5EFNA 5THVA 5EEFA 5THUA 3SFFA 1T64A 4QA1A 1W22A 3F06A 5EF7A 5G0HA 4QA0A 5G13A 3F07A 3Q9EA 4RN1A 5G0XA 4QA3A 5EEKA 4ZUNA 4ZURA 5G0IA 4QA7A 4CBTA 5EEMA 3EWFA 4LY1A 1C3PA 3Q9BA 3Q9CA 5EFBD 5IWGA 5G1AA 1T67A 4ZUPA 5THSA 5G1CA 5DC8A 4CBYA 4QA6A 5A2SA 5EFKB 3MENA 4A69A 1C3RA 2VQOA 3MZ3A 5DC5A 5G11A 4RN0A 1ZZ0A 5EFJD 5G12A 3MZ7A 1C3SA 3F0RA 2VQJA 4ZUQA 5G3WA 3EZPA 5EFGA 5G0YA 4BZ5A 3C10A 4ZUMA 3EZTA 4BZ6A 3C0ZA 5DC6A 5FUEA 3ZNRA 4RN2A 2GH6A 5IX0A 4BZ7A 5ICNB 4QA5A 5D1BA 2VQWG 3MZ6A 3C0YA 3RQDA 5LI3A 2VCGA 4CQFA 2V5WA 5EFHA 5EEIA 5D1CA 5G17A 3SFHA 5G1BA 5DC7A 5D1DA 4QA4A 4ZUOA 3MAXA 4LXZA 3ZNSA 1T69A 5G10A 2VQQA 5EF8A 2VQVA 4BKXB 1ZZ1A 5FCWA 3EW8A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 5G0J A;  5BWZ A;  2VQM A;  2V5X A;  5G0G A;  5EEN A;  3MZ4 A;  1ZZ3 A;  1VKG A;  3Q9F A;  4QA2 A;  4BZ8 A;  5THT A;  5JI5 A;  4BZ9 A;  5EFN A;  5THV A;  5EEF A;  5THU A;  3SFF A;  1T64 A;  4QA1 A;  1W22 A;  3F06 A;  5EF7 A;  5G0H A;  4QA0 A;  5G13 A;  3F07 A;  3Q9E A;  4RN1 A;  5G0X A;  4QA3 A;  5EEK A;  4ZUN A;  4ZUR A;  5G0I A;  4QA7 A;  4CBT A;  5EEM A;  3EWF A;  4LY1 A;  1C3P A;  3Q9B A;  3Q9C A;  5EFB D;  5IWG A;  5G1A A;  1T67 A;  4ZUP A;  5THS A;  5G1C A;  5DC8 A;  4CBY A;  4QA6 A;  5A2S A;  5EFK B;  3MEN A;  4A69 A;  1C3R A;  2VQO A;  3MZ3 A;  5DC5 A;  5G11 A;  4RN0 A;  1ZZ0 A;  5EFJ D;  5G12 A;  3MZ7 A;  1C3S A;  3F0R A;  2VQJ A;  4ZUQ A;  5G3W A;  3EZP A;  5EFG A;  5G0Y A;  4BZ5 A;  3C10 A;  4ZUM A;  3EZT A;  4BZ6 A;  3C0Z A;  5DC6 A;  5FUE A;  3ZNR A;  4RN2 A;  2GH6 A;  5IX0 A;  4BZ7 A;  5ICN B;  4QA5 A;  5D1B A;  2VQW G;  3MZ6 A;  3C0Y A;  3RQD A;  5LI3 A;  2VCG A;  4CQF A;  2V5W A;  5EFH A;  5EEI A;  5D1C A;  5G17 A;  3SFH A;  5G1B A;  5DC7 A;  5D1D A;  4QA4 A;  4ZUO A;  3MAX A;  4LXZ A;  3ZNS A;  1T69 A;  5G10 A;  2VQQ A;  5EF8 A;  2VQV A;  4BKX B;  1ZZ1 A;  5FCW A;  3EW8 A; 
#chains in the Genus database with same CATH topology
 5G0J A;  5BWZ A;  2VQM A;  2V5X A;  3TF3 A;  5G0G A;  4Q41 A;  4IXU A;  4DZ4 A;  5EEN A;  3MZ4 A;  3NIQ A;  3E8Z A;  4RLA A;  1ZZ3 A;  3SKK A;  1VKG A;  3Q9F A;  4QA2 A;  4BZ8 A;  1WVB A;  1TBH A;  4IU0 A;  4Q3T A;  5THT A;  5EFN A;  4MXR A;  4RHQ A;  5EEF A;  5THV A;  4BZ9 A;  5CEV A;  4IU4 A;  5THU A;  1T64 A;  3SFF A;  4Q3P A;  2PHA A;  4QA1 A;  3MMR A;  4IE1 A;  1W22 A;  3F06 A;  3GN0 A;  5EF7 A;  4HXQ A;  2RLA A;  3E6V A;  4GSZ A;  3CEV A;  5G0H A;  4QA0 A;  1HQX A;  5G13 A;  3F07 A;  3M1R A;  3Q9E A;  4Q3S A;  4RN1 A;  1RLA A;  4Q3Q A;  5G0X A;  2ZAV A;  1HQF A;  3GMZ A;  4G3H A;  2PLL A;  4I06 A;  4IE3 A;  4QA3 A;  5EEK A;  4ZUN A;  4QA7 A;  4ZUR A;  5G0I A;  4CBT A;  3LHL A;  5EEM A;  5HJA A;  2EF4 A;  1HQ5 A;  2PHO A;  3EWF A;  4RHM A;  4RHJ A;  4LY1 A;  4IXV A;  1C3P A;  3KV2 A;  3Q9B A;  3Q9C A;  5EFB D;  5IWG A;  4GSV A;  3E9B A;  1T67 A;  3E8Q A;  4ZUP A;  5G1A A;  1P8Q A;  3LP4 A;  5G1C A;  5THS A;  5DC8 A;  1T4P A;  4CBY A;  4IE2 A;  4QA6 A;  1P8O A;  4FCI A;  5A2S A;  5EFK B;  2A0M A;  3MEN A;  1C3R A;  4A69 A;  3NIO A;  4RHI A;  2VQO A;  3MZ3 A;  5DC5 A;  4HWW A;  5G11 A;  3F80 A;  3SL1 A;  4RN0 A;  4HZE A;  1ZPG A;  3SL0 A;  1ZZ0 A;  5EFJ D;  5G12 A;  4GWD A;  1HQH A;  3MZ7 A;  1C3S A;  4Q3R A;  3F0R A;  3THH A;  4Q3V A;  3LP7 A;  2VQJ A;  4ZUQ A;  1T5F A;  5G3W A;  3EZP A;  4GSM A;  5EFG A;  5G0Y A;  4BZ5 A;  3C10 A;  4MYN A;  4MYK A;  4ZUM A;  3EZT A;  4ITY A;  5RLA A;  4BZ6 A;  3SJT A;  3C0Z A;  1P8R A;  1WVA A;  1PQ3 A;  5DC6 A;  5FUE A;  3THE A;  1CEV A;  1D3V A;  4RN2 A;  2GH6 A;  5IX0 A;  2EIV A;  4Q3U A;  3ZNR A;  4BZ7 A;  1P8S A;  4Q42 A;  5FCW A;  1P8P A;  4QA5 A;  5D1B A;  2VQW G;  3MZ6 A;  2CEV A;  3PZL A;  1WOI A;  5ICN B;  3C0Y A;  1HQG A;  4MYF A;  3RQD A;  4GWC A;  3THJ A;  2VCG A;  5LI3 A;  1GQ7 A;  4RHK A;  4CQF A;  1TBL A;  2EF5 A;  3E6K A;  2V5W A;  1T4S A;  1TA1 A;  5JI5 A;  4IU5 A;  2AEB A;  5EFH A;  3DJ8 A;  3MFW A;  5EEI A;  4CEV A;  5HJ9 A;  5D1C A;  4Q3R C;  5G17 A;  1TBJ A;  1WOH A;  5G1B A;  3SFH A;  4IU1 A;  5DC7 A;  5D1D A;  1T4R A;  4FCK A;  4QA4 A;  4ZUO A;  3MAX A;  4LXZ A;  1T4T A;  3TH7 A;  4MYL A;  3ZNS A;  1R1O A;  1T69 A;  3MFV A;  4RHL A;  5G10 A;  3RLA A;  1WOG A;  4Q40 A;  2VQQ A;  5EF8 A;  2VQV A;  4BKX B;  1T5G A;  3NIP A;  1ZZ1 A;  1P8M A;  1GQ6 A;  3MJL A;  1ZPE A;  1XFK A;  3EW8 A;  1P8N A; 
#chains in the Genus database with same CATH homology
 5G0J A;  5BWZ A;  2VQM A;  2V5X A;  5G0G A;  5EEN A;  3MZ4 A;  1ZZ3 A;  1VKG A;  3Q9F A;  4QA2 A;  4BZ8 A;  5THT A;  5JI5 A;  4BZ9 A;  5EFN A;  5THV A;  5EEF A;  5THU A;  3SFF A;  1T64 A;  4QA1 A;  1W22 A;  3F06 A;  5EF7 A;  5G0H A;  4QA0 A;  5G13 A;  3F07 A;  3Q9E A;  4RN1 A;  5G0X A;  4QA3 A;  5EEK A;  4ZUN A;  4ZUR A;  5G0I A;  4QA7 A;  4CBT A;  5EEM A;  3EWF A;  4LY1 A;  1C3P A;  3Q9B A;  3Q9C A;  5EFB D;  5IWG A;  5G1A A;  1T67 A;  4ZUP A;  5THS A;  5G1C A;  5DC8 A;  4CBY A;  4QA6 A;  5A2S A;  5EFK B;  3MEN A;  4A69 A;  1C3R A;  2VQO A;  3MZ3 A;  5DC5 A;  5G11 A;  4RN0 A;  1ZZ0 A;  5EFJ D;  5G12 A;  3MZ7 A;  1C3S A;  3F0R A;  2VQJ A;  4ZUQ A;  5G3W A;  3EZP A;  5EFG A;  5G0Y A;  4BZ5 A;  3C10 A;  4ZUM A;  3EZT A;  4BZ6 A;  3C0Z A;  5DC6 A;  5FUE A;  3ZNR A;  4RN2 A;  2GH6 A;  5IX0 A;  4BZ7 A;  5ICN B;  4QA5 A;  5D1B A;  2VQW G;  3MZ6 A;  3C0Y A;  3RQD A;  5LI3 A;  2VCG A;  4CQF A;  2V5W A;  5EFH A;  5EEI A;  5D1C A;  5G17 A;  3SFH A;  5G1B A;  5DC7 A;  5D1D A;  4QA4 A;  4ZUO A;  3MAX A;  4LXZ A;  3ZNS A;  1T69 A;  5G10 A;  2VQQ A;  5EF8 A;  2VQV A;  4BKX B;  1ZZ1 A;  5FCW A;  3EW8 A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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