3RISA

Crystal structure of the catalytic domain of uchl5, a proteasome-associated human deubiquitinating enzyme, reveals an unproductive form of the enzyme
Total Genus 69
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
69
Knots found
sequence length
233
structure length
227
Chain Sequence
EWCLMESDPGVFTELIKGFGCRGAQVEEIWSLEPENFEKLKPVHGLIFLFKWQPGEEPAGSVVQDSRLDTIFFAKQVINNACATQAIVSVLLNCTHQDVHLGETLSEFKEFSQSFDAAMKGLALSNSDVIRQVHNSFARQQMFEFDTKDAFHFVSYVPVNGRLYELDGLREGPIDLGACNQDDWISAVRPVIEKRIQKYSEGEIRFNLMAIVSDRKMIYEQKIAELQ
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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molecule tags Hydrolase
molecule keywords Ubiquitin carboxyl-terminal hydrolase isozyme L5
publication title Crystal structure of the catalytic domain of UCHL5, a proteasome-associated human deubiquitinating enzyme, reveals an unproductive form of the enzyme.
pubmed doi rcsb
source organism Homo sapiens
total genus 69
structure length 227
sequence length 233
chains with identical sequence B, C, D
other databases KnotProt 2.0: K -52 -31 -31
ec nomenclature ec 3.4.19.12: Ubiquitinyl hydrolase 1.
pdb deposition date 2011-04-14

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF01088 Peptidase_C12 Ubiquitin carboxyl-terminal hydrolase, family 1
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.532.10 Alpha Beta 3-Layer(aba) Sandwich Ubiquitin C-terminal Hydrolase UCH-l3 Peptidase C12, ubiquitin carboxyl-terminal hydrolase 3risA00
4I6NA 4UELA 3TB3A 4IG7A 3IFWA 3KW5A 4JKJA 4DM9A 1CMXA 1XD3A 3KVFA 2LENA 2ETLA 3RIIA 3A7SA 3IRTA 4UEMA 3IHRA 3RISA 1UCHA
chains in the Genus database with same CATH superfamily
4I6NA 4UELA 3TB3A 4IG7A 3IFWA 3KW5A 4JKJA 4DM9A 1CMXA 1XD3A 3KVFA 2LENA 2ETLA 3RIIA 3A7SA 3IRTA 4UEMA 3IHRA 3RISA 1UCHA
chains in the Genus database with same CATH topology
4I6NA 4UELA 3TB3A 4IG7A 3IFWA 3KW5A 4JKJA 4DM9A 1CMXA 1XD3A 3KVFA 2LENA 2ETLA 3RIIA 3A7SA 3IRTA 4UEMA 3IHRA 3RISA 1UCHA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4I6N A;  4UEL A;  3TB3 A;  4IG7 A;  3IFW A;  3KW5 A;  4JKJ A;  4DM9 A;  1CMX A;  1XD3 A;  3KVF A;  2LEN A;  2ETL A;  3RII A;  3A7S A;  3IRT A;  4UEM A;  3IHR A;  3RIS A;  1UCH A; 
#chains in the Genus database with same CATH topology
 4I6N A;  4UEL A;  3TB3 A;  4IG7 A;  3IFW A;  3KW5 A;  4JKJ A;  4DM9 A;  1CMX A;  1XD3 A;  3KVF A;  2LEN A;  2ETL A;  3RII A;  3A7S A;  3IRT A;  4UEM A;  3IHR A;  3RIS A;  1UCH A; 
#chains in the Genus database with same CATH homology
 4I6N A;  4UEL A;  3TB3 A;  4IG7 A;  3IFW A;  3KW5 A;  4JKJ A;  4DM9 A;  1CMX A;  1XD3 A;  3KVF A;  2LEN A;  2ETL A;  3RII A;  3A7S A;  3IRT A;  4UEM A;  3IHR A;  3RIS A;  1UCH A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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