3HQWA

Discovery of novel inhibitors of pde10a
Total Genus 130
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
130
sequence length
303
structure length
303
Chain Sequence
PARICRDIELFHFDIGPFENMWPGIFVYMIHRSCGTSCFELEKLCRFIMSVKKNYRRVPYHNWKHAVTVAHCMYAILQNNNGLFTDLERKGLLIACLCHDLDHRGFSNSYLQKFDHPLAALYSTSTMEQHHFSQTVSILQLEGHNIFSTLSSSEYEQVLEIIRKAIIATDLALYFGNRKQLEEMYQTGSLNLHNQSHRDRVIGLMMTACDLCSVTKLWPVTKLTANDIYAEFWAEGDEMKKLGIQPIPMMDRDKRDEVPQGQLGFYNAVAIPCYTTLTQILPPTEPLLKACRDNLNQWEKVIR
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

publication title Discovery of a Novel Class of Phosphodiesterase 10A Inhibitors and Identification of Clinical Candidate 2-[4-(1-Methyl-4-pyridin-4-yl-1H-pyrazol-3-yl)-phenoxymethyl]-quinoline (PF-2545920) for the Treatment of Schizophrenia
pubmed doi rcsb
molecule tags Hydrolase/hydrolase inhibitor
source organism Rattus norvegicus
molecule keywords cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase
total genus 130
structure length 303
sequence length 303
ec nomenclature ec 3.1.4.17: 3',5'-cyclic-nucleotide phosphodiesterase.
pdb deposition date 2009-06-08

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00233 PDEase_I 3'5'-cyclic nucleotide phosphodiesterase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.10.1300.10 Mainly Alpha Orthogonal Bundle Catalytic domain of cyclic nucleotide phosphodiesterase 4b2b 3'5'-cyclic nucleotide phosphodiesterase, catalytic domain 3hqwA00
4JIBA 1RO6A 3SL4A 2OUUA 4NPWA 5AXPA 3W5EA 3LXGA 3QI3A 3G4LA 3ECNA 2OUVA 3DYQA 3K4SA 4MVHA 5DH4A 3G4GA 3SIEA 4C1IA 4HTXA 4Y8CA 3G3NA 1SOJA 4P0NA 3B2RA 3UI7A 2OUPA 4Y2BA 2OUNA 4BBXA 1MKDA 5EDEA 3JWQA 4Y87A 1XORA 3HDZA 4G2JA 1XOMA 3JWRA 3WYMA 1F0JA 1TB5A 2WEYA 4GH6A 1RKPA 1XOQA 3JSWA 3O56A 5EDIB 3V93A 4DDLA 2OVYA 3HC8A 1Y2JA 5C2HA 3D3PA 5C29A 1XMYB 3DYLA 1TBBA 3IADA 4LM1A 5K9RA 4D08A 5EDGB 1XM6A 3SNLA 4YS7A 4MS0A 4LKQA 4IA0A 4OEWA 1OYNA 1Y2HA 2FM0A 2H40A 3WYLA 2O8HA 3O57A 3V9BA 1XMUB 4PM0A 1TBFA 2H44A 2OVVA 2HD1A 3G4IA 3K3EA 3O0JA 3QPOA 3HMVA 4PHWA 4AJFA 5K1IA 3G58A 1XLZA 4DFFA 4MD6A 1ZKNA 1XM4B 1XLXA 4QGEA 4TPPA 3FRGA 2FM5A 4AJGA 4AJMA 1Y2CA 3SL5A 4LM2A 5K32A 3DY8A 3HQWA 3JSIA 3TGEA 3BJCA 4KP6A 3WI2A 3WS8A 4G2WA 3I8VA 3UUOA 5EDIA 1XOSA 4YQHA 1Y2BA 3G4KA 5C1WA 1XMYA 4MYQA 4NW7A 3WYKA 4E90A 3ITUA 2CHMA 5EDGA 4LLJA 3WD9A 4AJDA 4TPMA 1Q9MA 4MSEA 2QYKA 1ZKLA 5C28A 2OUQA 2OUYA 5B25A 1XMUA 3SL3A 3G45A 2OURA 1XOTA 3HR1A 3HQZA 5DH5A 1UHOA 3SNIA 4MRZA 3SL8A 1XM4A 3IBJA 1XP0A 1Y2EA 5I2RA 3DYSA 1UDTA 3HQYA 4LLKA 1RORA 4PHLA 5EDHA 1XOZA 3SHYA 3SHZA 4MSAA 3IAKA 4WZIA 5B4LA 5AXQA 3LY2A 4FCBA 4I9ZA 4Y86A 1RO9A 4LM3A 3V94A 5B4KA 1Y2KA 4X0FA 3ECMA 4G2LA 3ITMA 4HF4A 2QYMA 1UDUA 4MSNA 3N3ZA 4XY2A 4MRWA 2H42A 3SN7A 4LM0A 4OGBA 4W1OA 1T9SA 3TVXA 3GWTA 4LLPA 1TB7A 4MSHA 2QYLA 1PTWA 1XONA 1Y2DA 1Z1LA 4MUWA 5C2EA 4P1RA 4ZO5A 3SL6A 4HTZA 3QI4A 5EDEB 1T9RA 3KKTA 2PW3A 3QPPA 3QPNA 4MSCA 2QYNA 4AELA 4D09A 1TAZA 2Y0JA 4LLXA 4HEUA 1XN0A 3DYNA 4OEXA 3WS9A 3K3HA 5C2AA 3TGGA 4FCDA 2YY2A 4LM4A 4WCUA 2R8QA 2OUSA 4NPVA 1SO2A 4WN1A 4I15A 4G2YA
chains in the Genus database with same CATH superfamily
4JIBA 1RO6A 3SL4A 2OUUA 4NPWA 5AXPA 3W5EA 3LXGA 3QI3A 3G4LA 3ECNA 2OUVA 3DYQA 3K4SA 4MVHA 5DH4A 3G4GA 3SIEA 4C1IA 4HTXA 4Y8CA 3G3NA 1SOJA 4P0NA 3B2RA 3UI7A 2OUPA 4Y2BA 2OUNA 4BBXA 1MKDA 5EDEA 3JWQA 4Y87A 1XORA 3HDZA 4G2JA 1XOMA 3JWRA 3WYMA 1F0JA 1TB5A 2WEYA 4GH6A 1RKPA 1XOQA 3JSWA 3O56A 5EDIB 3V93A 4DDLA 2OVYA 3HC8A 1Y2JA 5C2HA 3D3PA 5C29A 1XMYB 3DYLA 1TBBA 3IADA 4LM1A 5K9RA 4D08A 5EDGB 1XM6A 3SNLA 4YS7A 4MS0A 4LKQA 4IA0A 4OEWA 1OYNA 1Y2HA 2FM0A 2H40A 3WYLA 2O8HA 3O57A 3V9BA 1XMUB 4PM0A 1TBFA 2H44A 2OVVA 2HD1A 3G4IA 3K3EA 3O0JA 3QPOA 3HMVA 4PHWA 4AJFA 5K1IA 3G58A 1XLZA 4DFFA 4MD6A 1ZKNA 1XM4B 1XLXA 4QGEA 4TPPA 3FRGA 2FM5A 4AJGA 4AJMA 1Y2CA 3SL5A 4LM2A 5K32A 3DY8A 3HQWA 3JSIA 3TGEA 3BJCA 4KP6A 3WI2A 3WS8A 4G2WA 3I8VA 3UUOA 5EDIA 1XOSA 4YQHA 1Y2BA 3G4KA 5C1WA 1XMYA 4MYQA 4NW7A 3WYKA 4E90A 3ITUA 2CHMA 5EDGA 4LLJA 3WD9A 4AJDA 4TPMA 1Q9MA 4MSEA 2QYKA 1ZKLA 5C28A 2OUQA 2OUYA 5B25A 1XMUA 3SL3A 3G45A 2OURA 1XOTA 3HR1A 3HQZA 5DH5A 1UHOA 3SNIA 4MRZA 3SL8A 1XM4A 3IBJA 1XP0A 1Y2EA 5I2RA 3DYSA 1UDTA 3HQYA 4LLKA 1RORA 4PHLA 5EDHA 1XOZA 3SHYA 3SHZA 4MSAA 3IAKA 4WZIA 5B4LA 5AXQA 3LY2A 4FCBA 4I9ZA 4Y86A 1RO9A 4LM3A 3V94A 5B4KA 1Y2KA 4X0FA 3ECMA 4G2LA 3ITMA 4HF4A 2QYMA 1UDUA 4MSNA 3N3ZA 4XY2A 4MRWA 2H42A 3SN7A 4LM0A 4OGBA 4W1OA 1T9SA 3TVXA 3GWTA 4LLPA 1TB7A 4MSHA 2QYLA 1PTWA 1XONA 1Y2DA 1Z1LA 4MUWA 5C2EA 4P1RA 4ZO5A 3SL6A 4HTZA 3QI4A 5EDEB 1T9RA 3KKTA 2PW3A 3QPPA 3QPNA 4MSCA 2QYNA 4AELA 4D09A 1TAZA 2Y0JA 4LLXA 4HEUA 1XN0A 3DYNA 4OEXA 3WS9A 3K3HA 5C2AA 3TGGA 4FCDA 2YY2A 4LM4A 4WCUA 2R8QA 2OUSA 4NPVA 1SO2A 4WN1A 4I15A 4G2YA
chains in the Genus database with same CATH topology
4JIBA 1RO6A 3SL4A 2OUUA 4NPWA 5AXPA 3W5EA 3LXGA 3QI3A 3G4LA 3ECNA 2OUVA 3DYQA 3K4SA 4MVHA 5DH4A 3G4GA 3SIEA 4C1IA 4HTXA 4Y8CA 3G3NA 1SOJA 4P0NA 3B2RA 3UI7A 2OUPA 4Y2BA 2OUNA 4BBXA 1MKDA 5EDEA 3JWQA 4Y87A 1XORA 3HDZA 4G2JA 1XOMA 3JWRA 3WYMA 1F0JA 1TB5A 2WEYA 4GH6A 1RKPA 1XOQA 3JSWA 3O56A 5EDIB 3V93A 4DDLA 2OVYA 3HC8A 1Y2JA 5C2HA 3D3PA 5C29A 1XMYB 3DYLA 1TBBA 3IADA 4LM1A 5K9RA 4D08A 5EDGB 1XM6A 3SNLA 4YS7A 4MS0A 4LKQA 4IA0A 4OEWA 1OYNA 1Y2HA 2FM0A 2H40A 3WYLA 2O8HA 3O57A 3V9BA 1XMUB 4PM0A 1TBFA 2H44A 2OVVA 2HD1A 3G4IA 3K3EA 3O0JA 3QPOA 3HMVA 4PHWA 4AJFA 5K1IA 3G58A 1XLZA 4DFFA 4MD6A 1ZKNA 1XM4B 1XLXA 4QGEA 4TPPA 3FRGA 2FM5A 4AJGA 4AJMA 1Y2CA 3SL5A 4LM2A 5K32A 3DY8A 3HQWA 3JSIA 3TGEA 3BJCA 4KP6A 3WI2A 3WS8A 4G2WA 3I8VA 3UUOA 5EDIA 1XOSA 4YQHA 1Y2BA 3G4KA 5C1WA 1XMYA 4MYQA 4NW7A 3WYKA 4E90A 3ITUA 2CHMA 5EDGA 4LLJA 3WD9A 4AJDA 4TPMA 1Q9MA 4MSEA 2QYKA 1ZKLA 5C28A 2OUQA 2OUYA 5B25A 1XMUA 3SL3A 3G45A 2OURA 1XOTA 3HR1A 3HQZA 5DH5A 1UHOA 3SNIA 4MRZA 3SL8A 1XM4A 3IBJA 1XP0A 1Y2EA 5I2RA 3DYSA 1UDTA 3HQYA 4LLKA 1RORA 4PHLA 5EDHA 1XOZA 3SHYA 3SHZA 4MSAA 3IAKA 4WZIA 5B4LA 5AXQA 3LY2A 4FCBA 4I9ZA 4Y86A 1RO9A 4LM3A 3V94A 5B4KA 1Y2KA 4X0FA 3ECMA 4G2LA 3ITMA 4HF4A 2QYMA 1UDUA 4MSNA 3N3ZA 4XY2A 4MRWA 2H42A 3SN7A 4LM0A 4OGBA 4W1OA 1T9SA 3TVXA 3GWTA 4LLPA 1TB7A 4MSHA 2QYLA 1PTWA 1XONA 1Y2DA 1Z1LA 4MUWA 5C2EA 4P1RA 4ZO5A 3SL6A 4HTZA 3QI4A 5EDEB 1T9RA 3KKTA 2PW3A 3QPPA 3QPNA 4MSCA 2QYNA 4AELA 4D09A 1TAZA 2Y0JA 4LLXA 4HEUA 1XN0A 3DYNA 4OEXA 3WS9A 3K3HA 5C2AA 3TGGA 4FCDA 2YY2A 4LM4A 4WCUA 2R8QA 2OUSA 4NPVA 1SO2A 4WN1A 4I15A 4G2YA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4JIB A;  1RO6 A;  3SL4 A;  2OUU A;  4NPW A;  5AXP A;  3W5E A;  3LXG A;  3QI3 A;  3G4L A;  3ECN A;  2OUV A;  3DYQ A;  3K4S A;  4MVH A;  5DH4 A;  3G4G A;  3SIE A;  4C1I A;  4HTX A;  4Y8C A;  3G3N A;  1SOJ A;  4P0N A;  3B2R A;  3UI7 A;  2OUP A;  4Y2B A;  2OUN A;  4BBX A;  1MKD A;  5EDE A;  3JWQ A;  4Y87 A;  1XOR A;  3HDZ A;  4G2J A;  1XOM A;  3JWR A;  3WYM A;  1F0J A;  1TB5 A;  2WEY A;  4GH6 A;  1RKP A;  1XOQ A;  3JSW A;  3O56 A;  5EDI B;  3V93 A;  4DDL A;  2OVY A;  3HC8 A;  1Y2J A;  5C2H A;  3D3P A;  5C29 A;  1XMY B;  3DYL A;  1TBB A;  3IAD A;  4LM1 A;  5K9R A;  4D08 A;  5EDG B;  1XM6 A;  3SNL A;  4YS7 A;  4MS0 A;  4LKQ A;  4IA0 A;  4OEW A;  1OYN A;  1Y2H A;  2FM0 A;  2H40 A;  3WYL A;  2O8H A;  3O57 A;  3V9B A;  1XMU B;  4PM0 A;  1TBF A;  2H44 A;  2OVV A;  2HD1 A;  3G4I A;  3K3E A;  3O0J A;  3QPO A;  3HMV A;  4PHW A;  4AJF A;  5K1I A;  3G58 A;  1XLZ A;  4DFF A;  4MD6 A;  1ZKN A;  1XM4 B;  1XLX A;  4QGE A;  4TPP A;  3FRG A;  2FM5 A;  4AJG A;  4AJM A;  1Y2C A;  3SL5 A;  4LM2 A;  5K32 A;  3DY8 A;  3HQW A;  3JSI A;  3TGE A;  3BJC A;  4KP6 A;  3WI2 A;  3WS8 A;  4G2W A;  3I8V A;  3UUO A;  5EDI A;  1XOS A;  4YQH A;  1Y2B A;  3G4K A;  5C1W A;  1XMY A;  4MYQ A;  4NW7 A;  3WYK A;  4E90 A;  3ITU A;  2CHM A;  5EDG A;  4LLJ A;  3WD9 A;  4AJD A;  4TPM A;  1Q9M A;  4MSE A;  2QYK A;  1ZKL A;  5C28 A;  2OUQ A;  2OUY A;  5B25 A;  1XMU A;  3SL3 A;  3G45 A;  2OUR A;  1XOT A;  3HR1 A;  3HQZ A;  5DH5 A;  1UHO A;  3SNI A;  4MRZ A;  3SL8 A;  1XM4 A;  3IBJ A;  1XP0 A;  1Y2E A;  5I2R A;  3DYS A;  1UDT A;  3HQY A;  4LLK A;  1ROR A;  4PHL A;  5EDH A;  1XOZ A;  3SHY A;  3SHZ A;  4MSA A;  3IAK A;  4WZI A;  5B4L A;  5AXQ A;  3LY2 A;  4FCB A;  4I9Z A;  4Y86 A;  1RO9 A;  4LM3 A;  3V94 A;  5B4K A;  1Y2K A;  4X0F A;  3ECM A;  4G2L A;  3ITM A;  4HF4 A;  2QYM A;  1UDU A;  4MSN A;  3N3Z A;  4XY2 A;  4MRW A;  2H42 A;  3SN7 A;  4LM0 A;  4OGB A;  4W1O A;  1T9S A;  3TVX A;  3GWT A;  4LLP A;  1TB7 A;  4MSH A;  2QYL A;  1PTW A;  1XON A;  1Y2D A;  1Z1L A;  4MUW A;  5C2E A;  4P1R A;  4ZO5 A;  3SL6 A;  4HTZ A;  3QI4 A;  5EDE B;  1T9R A;  3KKT A;  2PW3 A;  3QPP A;  3QPN A;  4MSC A;  2QYN A;  4AEL A;  4D09 A;  1TAZ A;  2Y0J A;  4LLX A;  4HEU A;  1XN0 A;  3DYN A;  4OEX A;  3WS9 A;  3K3H A;  5C2A A;  3TGG A;  4FCD A;  2YY2 A;  4LM4 A;  4WCU A;  2R8Q A;  2OUS A;  4NPV A;  1SO2 A;  4WN1 A;  4I15 A;  4G2Y A; 
#chains in the Genus database with same CATH topology
 4JIB A;  1RO6 A;  3SL4 A;  2OUU A;  4NPW A;  5AXP A;  3W5E A;  3LXG A;  3QI3 A;  3G4L A;  3ECN A;  2OUV A;  3DYQ A;  3K4S A;  4MVH A;  5DH4 A;  3G4G A;  3SIE A;  4C1I A;  4HTX A;  4Y8C A;  3G3N A;  1SOJ A;  4P0N A;  3B2R A;  3UI7 A;  2OUP A;  4Y2B A;  2OUN A;  4BBX A;  1MKD A;  5EDE A;  3JWQ A;  4Y87 A;  1XOR A;  3HDZ A;  4G2J A;  1XOM A;  3JWR A;  3WYM A;  1F0J A;  1TB5 A;  2WEY A;  4GH6 A;  1RKP A;  1XOQ A;  3JSW A;  3O56 A;  5EDI B;  3V93 A;  4DDL A;  2OVY A;  3HC8 A;  1Y2J A;  5C2H A;  3D3P A;  5C29 A;  1XMY B;  3DYL A;  1TBB A;  3IAD A;  4LM1 A;  5K9R A;  4D08 A;  5EDG B;  1XM6 A;  3SNL A;  4YS7 A;  4MS0 A;  4LKQ A;  4IA0 A;  4OEW A;  1OYN A;  1Y2H A;  2FM0 A;  2H40 A;  3WYL A;  2O8H A;  3O57 A;  3V9B A;  1XMU B;  4PM0 A;  1TBF A;  2H44 A;  2OVV A;  2HD1 A;  3G4I A;  3K3E A;  3O0J A;  3QPO A;  3HMV A;  4PHW A;  4AJF A;  5K1I A;  3G58 A;  1XLZ A;  4DFF A;  4MD6 A;  1ZKN A;  1XM4 B;  1XLX A;  4QGE A;  4TPP A;  3FRG A;  2FM5 A;  4AJG A;  4AJM A;  1Y2C A;  3SL5 A;  4LM2 A;  5K32 A;  3DY8 A;  3HQW A;  3JSI A;  3TGE A;  3BJC A;  4KP6 A;  3WI2 A;  3WS8 A;  4G2W A;  3I8V A;  3UUO A;  5EDI A;  1XOS A;  4YQH A;  1Y2B A;  3G4K A;  5C1W A;  1XMY A;  4MYQ A;  4NW7 A;  3WYK A;  4E90 A;  3ITU A;  2CHM A;  5EDG A;  4LLJ A;  3WD9 A;  4AJD A;  4TPM A;  1Q9M A;  4MSE A;  2QYK A;  1ZKL A;  5C28 A;  2OUQ A;  2OUY A;  5B25 A;  1XMU A;  3SL3 A;  3G45 A;  2OUR A;  1XOT A;  3HR1 A;  3HQZ A;  5DH5 A;  1UHO A;  3SNI A;  4MRZ A;  3SL8 A;  1XM4 A;  3IBJ A;  1XP0 A;  1Y2E A;  5I2R A;  3DYS A;  1UDT A;  3HQY A;  4LLK A;  1ROR A;  4PHL A;  5EDH A;  1XOZ A;  3SHY A;  3SHZ A;  4MSA A;  3IAK A;  4WZI A;  5B4L A;  5AXQ A;  3LY2 A;  4FCB A;  4I9Z A;  4Y86 A;  1RO9 A;  4LM3 A;  3V94 A;  5B4K A;  1Y2K A;  4X0F A;  3ECM A;  4G2L A;  3ITM A;  4HF4 A;  2QYM A;  1UDU A;  4MSN A;  3N3Z A;  4XY2 A;  4MRW A;  2H42 A;  3SN7 A;  4LM0 A;  4OGB A;  4W1O A;  1T9S A;  3TVX A;  3GWT A;  4LLP A;  1TB7 A;  4MSH A;  2QYL A;  1PTW A;  1XON A;  1Y2D A;  1Z1L A;  4MUW A;  5C2E A;  4P1R A;  4ZO5 A;  3SL6 A;  4HTZ A;  3QI4 A;  5EDE B;  1T9R A;  3KKT A;  2PW3 A;  3QPP A;  3QPN A;  4MSC A;  2QYN A;  4AEL A;  4D09 A;  1TAZ A;  2Y0J A;  4LLX A;  4HEU A;  1XN0 A;  3DYN A;  4OEX A;  3WS9 A;  3K3H A;  5C2A A;  3TGG A;  4FCD A;  2YY2 A;  4LM4 A;  4WCU A;  2R8Q A;  2OUS A;  4NPV A;  1SO2 A;  4WN1 A;  4I15 A;  4G2Y A; 
#chains in the Genus database with same CATH homology
 4JIB A;  1RO6 A;  3SL4 A;  2OUU A;  4NPW A;  5AXP A;  3W5E A;  3LXG A;  3QI3 A;  3G4L A;  3ECN A;  2OUV A;  3DYQ A;  3K4S A;  4MVH A;  5DH4 A;  3G4G A;  3SIE A;  4C1I A;  4HTX A;  4Y8C A;  3G3N A;  1SOJ A;  4P0N A;  3B2R A;  3UI7 A;  2OUP A;  4Y2B A;  2OUN A;  4BBX A;  1MKD A;  5EDE A;  3JWQ A;  4Y87 A;  1XOR A;  3HDZ A;  4G2J A;  1XOM A;  3JWR A;  3WYM A;  1F0J A;  1TB5 A;  2WEY A;  4GH6 A;  1RKP A;  1XOQ A;  3JSW A;  3O56 A;  5EDI B;  3V93 A;  4DDL A;  2OVY A;  3HC8 A;  1Y2J A;  5C2H A;  3D3P A;  5C29 A;  1XMY B;  3DYL A;  1TBB A;  3IAD A;  4LM1 A;  5K9R A;  4D08 A;  5EDG B;  1XM6 A;  3SNL A;  4YS7 A;  4MS0 A;  4LKQ A;  4IA0 A;  4OEW A;  1OYN A;  1Y2H A;  2FM0 A;  2H40 A;  3WYL A;  2O8H A;  3O57 A;  3V9B A;  1XMU B;  4PM0 A;  1TBF A;  2H44 A;  2OVV A;  2HD1 A;  3G4I A;  3K3E A;  3O0J A;  3QPO A;  3HMV A;  4PHW A;  4AJF A;  5K1I A;  3G58 A;  1XLZ A;  4DFF A;  4MD6 A;  1ZKN A;  1XM4 B;  1XLX A;  4QGE A;  4TPP A;  3FRG A;  2FM5 A;  4AJG A;  4AJM A;  1Y2C A;  3SL5 A;  4LM2 A;  5K32 A;  3DY8 A;  3HQW A;  3JSI A;  3TGE A;  3BJC A;  4KP6 A;  3WI2 A;  3WS8 A;  4G2W A;  3I8V A;  3UUO A;  5EDI A;  1XOS A;  4YQH A;  1Y2B A;  3G4K A;  5C1W A;  1XMY A;  4MYQ A;  4NW7 A;  3WYK A;  4E90 A;  3ITU A;  2CHM A;  5EDG A;  4LLJ A;  3WD9 A;  4AJD A;  4TPM A;  1Q9M A;  4MSE A;  2QYK A;  1ZKL A;  5C28 A;  2OUQ A;  2OUY A;  5B25 A;  1XMU A;  3SL3 A;  3G45 A;  2OUR A;  1XOT A;  3HR1 A;  3HQZ A;  5DH5 A;  1UHO A;  3SNI A;  4MRZ A;  3SL8 A;  1XM4 A;  3IBJ A;  1XP0 A;  1Y2E A;  5I2R A;  3DYS A;  1UDT A;  3HQY A;  4LLK A;  1ROR A;  4PHL A;  5EDH A;  1XOZ A;  3SHY A;  3SHZ A;  4MSA A;  3IAK A;  4WZI A;  5B4L A;  5AXQ A;  3LY2 A;  4FCB A;  4I9Z A;  4Y86 A;  1RO9 A;  4LM3 A;  3V94 A;  5B4K A;  1Y2K A;  4X0F A;  3ECM A;  4G2L A;  3ITM A;  4HF4 A;  2QYM A;  1UDU A;  4MSN A;  3N3Z A;  4XY2 A;  4MRW A;  2H42 A;  3SN7 A;  4LM0 A;  4OGB A;  4W1O A;  1T9S A;  3TVX A;  3GWT A;  4LLP A;  1TB7 A;  4MSH A;  2QYL A;  1PTW A;  1XON A;  1Y2D A;  1Z1L A;  4MUW A;  5C2E A;  4P1R A;  4ZO5 A;  3SL6 A;  4HTZ A;  3QI4 A;  5EDE B;  1T9R A;  3KKT A;  2PW3 A;  3QPP A;  3QPN A;  4MSC A;  2QYN A;  4AEL A;  4D09 A;  1TAZ A;  2Y0J A;  4LLX A;  4HEU A;  1XN0 A;  3DYN A;  4OEX A;  3WS9 A;  3K3H A;  5C2A A;  3TGG A;  4FCD A;  2YY2 A;  4LM4 A;  4WCU A;  2R8Q A;  2OUS A;  4NPV A;  1SO2 A;  4WN1 A;  4I15 A;  4G2Y A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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