3MK2A

Placental alkaline phosphatase complexed with phe
Total Genus 184
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
184
Knots found
sequence length
481
structure length
480
Chain Sequence
IIPVEEENPDFWNREAAEALGAAKKLQPAQTAAKNLIIFLGDGMGVSTVTAARILKGQKKDKLGPEIPLAMDRFPYVALSKTYNVDKHVPDGATATAYLCGVKGNFQTIGLSAAARFNQCNTTRGNEVISVMNRAKKAGKSVGVVTTTRVQHASPAGTYAHTVNRNWYSDADVPASARQEGCQDIATQLISNMDIDVILGGGRKYMFRMGTPDPEYPDDYSQGGTRLDGKNLVQEWLAKRQGARYVWNRTELMQASLDPSVTHLMGLFEPGDMKYEIHRDSTLDPSLMEMTEAALRLLSRNPRGFFLFVEGGRIDHGHHESRAYRALTETIMFDDAIERAGQLTSEEDTLSLVTADHSHVFSFGGYPLRGSSIFGLAPGKARDRKAYTVLLYGNGPGYVLKDGARPDVTESESGSPEYRQQSAVPLDEETHAGEDVAVFARGPQAHLVHGVQEQTFIAHVMAFAACLEPYTACDLAPPAG
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

molecule keywords Alkaline phosphatase, placental type
publication title Refined structures of placental alkaline phosphatase show a consistent pattern of interactions at the peripheral site.
pubmed doi rcsb
molecule tags Hydrolase
total genus 184
structure length 480
sequence length 481
other databases KnotProt 2.0: S +31
ec nomenclature ec 3.1.3.1: Alkaline phosphatase.
pdb deposition date 2010-04-13

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00245 Alk_phosphatase Alkaline phosphatase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.720.10 Alpha Beta 3-Layer(aba) Sandwich Alkaline Phosphatase, subunit A Alkaline Phosphatase, subunit A 3mk2A00
1Y6VA 1EQJA 1KHJA 5LRNA 1KH9A 1E33P 5IJQA 3WAWA 4LREA 2IUCA 4MHXA 3UNYA 1KHKA 1ALHA 3NKMA 1HJKA 4NWXA 3UN5A 3M8WA 4UORA 3B5QA 4ZG6A 1N2KA 4GTZA 4KAYA 1N2LA 5C66A 4LRAA 2XR9A 4GTYA 2GLQA 4MY4A 3NVLA 4LRBA 1HQAA 1EI6A 4CYSA 2ZKTA 1ZEDA 2GSNA 4LRCA 4CXSA 3NKRA 3M8YA 1ZEBA 2W8SA 1ALKA 1ED8A 1Y7AA 4UOPA 1AJAA 4CYRA 4UOOA 4NWJA 2W5XA 2W5WA 4UPLA 5AJ9A 5INHA 2X98A 3TG0A 3IDDA 4LR9A 1FSUA 3T00A 3OT9A 1EW8A 1KH5A 2ANHA 1B8JA 1KH4A 3A52A 3NKNA 3Q3QA 5EGEA 2W5SA 2QZUA 4QAXA 1ZEFA 1ANJA 1ED9A 3T01A 3SZYA 4ZG9A 1ALJA 4LRDA 5GOVA 3CMRA 3MK0A 1ELXA 2IUCB 3UN3A 1AJCA 1SHNA 3E2DA 3UO0A 5L0EA 1ELZA 1E2SP 4LRFA 4UPKA 3SZZA 1KHNA 3BDGB 1ELYA 4LR2A 1AUKA 3BDGA 3NKPA 5LRMA 2W5VA 5HRTA 4KAVA 5EGHA 4UPIA 4KJDA 4FDJA 1E1ZP 3M7VA 4GTWA 3TX0A 3UN2A 1KHLA 3MK2A 3DYCA 3DPCA 4LR8A 3BDFA 3T02A 4ZG7A 5KXAA 4MIVA 4KM4A 3ED4A 3WBHA 5L0BA 3WAXA 5LIAA 5GRRA 4YR1A 1O99A 1EJJA 2W8DA 2IFYA 2G9YA 1P49A 1ANIA 2W5QA 4TN0A 2RH6A 2GSUA 2VQRA 3BDHA 3TWZA 2D1GA 1EW9A 1AJDA 5IJSA 2GSOA 3KD8A 1O98A 5DLVA 1ALIA 1KH7A 4CXKA 4KJGA 4UPHA 4ZGAA 1URBA 5DLTA 4B56A 3WAYA 1E3CP 4LQYA 1URAA 2W5TA 5LQQA 2XRGA 3IGYB 4FDIA 4CXUA 4N7TA 5DLWA 5TJ3A 1SHQA 4GTXA 1EW2A 1AJBA 3NKQA 2GA3A 5L0KA 3M8ZA 3WAVA 1K7HA 3IGZB 5K4PA 2W5RA 3MK1A 3NKOA 4LR7A 3LXQA 1HDHA
chains in the Genus database with same CATH superfamily
1Y6VA 1EQJA 1KHJA 5LRNA 1KH9A 1E33P 5IJQA 3WAWA 4LREA 2IUCA 4MHXA 3UNYA 1KHKA 1ALHA 3NKMA 1HJKA 4NWXA 3UN5A 3M8WA 4UORA 3B5QA 4ZG6A 1N2KA 4GTZA 4KAYA 1N2LA 5C66A 4LRAA 2XR9A 4GTYA 2GLQA 4MY4A 3NVLA 4LRBA 1HQAA 1EI6A 4CYSA 2ZKTA 1ZEDA 2GSNA 4LRCA 4CXSA 3NKRA 3M8YA 1ZEBA 2W8SA 1ALKA 1ED8A 1Y7AA 4UOPA 1AJAA 4CYRA 4UOOA 4NWJA 2W5XA 2W5WA 4UPLA 5AJ9A 5INHA 2X98A 3TG0A 3IDDA 4LR9A 1FSUA 3T00A 3OT9A 1EW8A 1KH5A 2ANHA 1B8JA 1KH4A 3A52A 3NKNA 3Q3QA 5EGEA 2W5SA 2QZUA 4QAXA 1ZEFA 1ANJA 1ED9A 3T01A 3SZYA 4ZG9A 1ALJA 4LRDA 5GOVA 3CMRA 3MK0A 1ELXA 2IUCB 3UN3A 1AJCA 1SHNA 3E2DA 3UO0A 5L0EA 1ELZA 1E2SP 4LRFA 4UPKA 3SZZA 1KHNA 3BDGB 1ELYA 4LR2A 1AUKA 3BDGA 3NKPA 5LRMA 2W5VA 5HRTA 4KAVA 5EGHA 4UPIA 4KJDA 4FDJA 1E1ZP 3M7VA 4GTWA 3TX0A 3UN2A 1KHLA 3MK2A 3DYCA 3DPCA 4LR8A 3BDFA 3T02A 4ZG7A 5KXAA 4MIVA 4KM4A 3ED4A 3WBHA 5L0BA 3WAXA 5LIAA 5GRRA 4YR1A 1O99A 1EJJA 2W8DA 2IFYA 2G9YA 1P49A 1ANIA 2W5QA 4TN0A 2RH6A 2GSUA 2VQRA 3BDHA 3TWZA 2D1GA 1EW9A 1AJDA 5IJSA 2GSOA 3KD8A 1O98A 5DLVA 1ALIA 1KH7A 4CXKA 4KJGA 4UPHA 4ZGAA 1URBA 5DLTA 4B56A 3WAYA 1E3CP 4LQYA 1URAA 2W5TA 5LQQA 2XRGA 3IGYB 4FDIA 4CXUA 4N7TA 5DLWA 5TJ3A 1SHQA 4GTXA 1EW2A 1AJBA 3NKQA 2GA3A 5L0KA 3M8ZA 3WAVA 1K7HA 3IGZB 5K4PA 2W5RA 3MK1A 3NKOA 4LR7A 3LXQA 1HDHA
chains in the Genus database with same CATH topology
1Y6VA 1EQJA 1KHJA 5LRNA 1KH9A 1E33P 5IJQA 3WAWA 4LREA 2IUCA 4MHXA 3UNYA 1KHKA 1ALHA 3NKMA 1HJKA 4NWXA 3UN5A 3M8WA 4UORA 3B5QA 4ZG6A 1N2KA 4GTZA 4KAYA 1N2LA 5C66A 4LRAA 2XR9A 4GTYA 2GLQA 4MY4A 3NVLA 4LRBA 1HQAA 1EI6A 4CYSA 2ZKTA 1ZEDA 2GSNA 4LRCA 4CXSA 3NKRA 3M8YA 1ZEBA 2W8SA 1ALKA 1ED8A 1Y7AA 4UOPA 1AJAA 4CYRA 4UOOA 4NWJA 2W5XA 2W5WA 4UPLA 5AJ9A 5INHA 2X98A 3TG0A 3IDDA 4LR9A 1FSUA 3T00A 3OT9A 1EW8A 1KH5A 2ANHA 1B8JA 1KH4A 3A52A 3NKNA 3Q3QA 5EGEA 2W5SA 2QZUA 4QAXA 1ZEFA 1ANJA 1ED9A 3T01A 3SZYA 4ZG9A 1ALJA 4LRDA 5GOVA 3CMRA 3MK0A 1ELXA 2IUCB 3UN3A 1AJCA 1SHNA 3E2DA 3UO0A 5L0EA 1ELZA 1E2SP 4LRFA 4UPKA 3SZZA 1KHNA 3BDGB 1ELYA 4LR2A 1AUKA 3BDGA 3NKPA 5LRMA 2W5VA 5HRTA 4KAVA 5EGHA 4UPIA 4KJDA 4FDJA 1E1ZP 3M7VA 4GTWA 3TX0A 3UN2A 1KHLA 3MK2A 3DYCA 3DPCA 4LR8A 3BDFA 3T02A 4ZG7A 5KXAA 4MIVA 4KM4A 3ED4A 3WBHA 5L0BA 3WAXA 5LIAA 5GRRA 4YR1A 1O99A 1EJJA 2W8DA 2IFYA 2G9YA 1P49A 1ANIA 2W5QA 4TN0A 2RH6A 2GSUA 2VQRA 3BDHA 3TWZA 2D1GA 1EW9A 1AJDA 5IJSA 2GSOA 3KD8A 1O98A 5DLVA 1ALIA 1KH7A 4CXKA 4KJGA 4UPHA 4ZGAA 1URBA 5DLTA 4B56A 3WAYA 1E3CP 4LQYA 1URAA 2W5TA 5LQQA 2XRGA 3IGYB 4FDIA 4CXUA 4N7TA 5DLWA 5TJ3A 1SHQA 4GTXA 1EW2A 1AJBA 3NKQA 2GA3A 5L0KA 3M8ZA 3WAVA 1K7HA 3IGZB 5K4PA 2W5RA 3MK1A 3NKOA 4LR7A 3LXQA 1HDHA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1Y6V A;  1EQJ A;  1KHJ A;  5LRN A;  1KH9 A;  1E33 P;  5IJQ A;  3WAW A;  4LRE A;  2IUC A;  4MHX A;  3UNY A;  1KHK A;  1ALH A;  3NKM A;  1HJK A;  4NWX A;  3UN5 A;  3M8W A;  4UOR A;  3B5Q A;  4ZG6 A;  1N2K A;  4GTZ A;  4KAY A;  1N2L A;  5C66 A;  4LRA A;  2XR9 A;  4GTY A;  2GLQ A;  4MY4 A;  3NVL A;  4LRB A;  1HQA A;  1EI6 A;  4CYS A;  2ZKT A;  1ZED A;  2GSN A;  4LRC A;  4CXS A;  3NKR A;  3M8Y A;  1ZEB A;  2W8S A;  1ALK A;  1ED8 A;  1Y7A A;  4UOP A;  1AJA A;  4CYR A;  4UOO A;  4NWJ A;  2W5X A;  2W5W A;  4UPL A;  5AJ9 A;  5INH A;  2X98 A;  3TG0 A;  3IDD A;  4LR9 A;  1FSU A;  3T00 A;  3OT9 A;  1EW8 A;  1KH5 A;  2ANH A;  1B8J A;  1KH4 A;  3A52 A;  3NKN A;  3Q3Q A;  5EGE A;  2W5S A;  2QZU A;  4QAX A;  1ZEF A;  1ANJ A;  1ED9 A;  3T01 A;  3SZY A;  4ZG9 A;  1ALJ A;  4LRD A;  5GOV A;  3CMR A;  3MK0 A;  1ELX A;  2IUC B;  3UN3 A;  1AJC A;  1SHN A;  3E2D A;  3UO0 A;  5L0E A;  1ELZ A;  1E2S P;  4LRF A;  4UPK A;  3SZZ A;  1KHN A;  3BDG B;  1ELY A;  4LR2 A;  1AUK A;  3BDG A;  3NKP A;  5LRM A;  2W5V A;  5HRT A;  4KAV A;  5EGH A;  4UPI A;  4KJD A;  4FDJ A;  1E1Z P;  3M7V A;  4GTW A;  3TX0 A;  3UN2 A;  1KHL A;  3MK2 A;  3DYC A;  3DPC A;  4LR8 A;  3BDF A;  3T02 A;  4ZG7 A;  5KXA A;  4MIV A;  4KM4 A;  3ED4 A;  3WBH A;  5L0B A;  3WAX A;  5LIA A;  5GRR A;  4YR1 A;  1O99 A;  1EJJ A;  2W8D A;  2IFY A;  2G9Y A;  1P49 A;  1ANI A;  2W5Q A;  4TN0 A;  2RH6 A;  2GSU A;  2VQR A;  3BDH A;  3TWZ A;  2D1G A;  1EW9 A;  1AJD A;  5IJS A;  2GSO A;  3KD8 A;  1O98 A;  5DLV A;  1ALI A;  1KH7 A;  4CXK A;  4KJG A;  4UPH A;  4ZGA A;  1URB A;  5DLT A;  4B56 A;  3WAY A;  1E3C P;  4LQY A;  1URA A;  2W5T A;  5LQQ A;  2XRG A;  3IGY B;  4FDI A;  4CXU A;  4N7T A;  5DLW A;  5TJ3 A;  1SHQ A;  4GTX A;  1EW2 A;  1AJB A;  3NKQ A;  2GA3 A;  5L0K A;  3M8Z A;  3WAV A;  1K7H A;  3IGZ B;  5K4P A;  2W5R A;  3MK1 A;  3NKO A;  4LR7 A;  3LXQ A;  1HDH A; 
#chains in the Genus database with same CATH topology
 1Y6V A;  1EQJ A;  1KHJ A;  5LRN A;  1KH9 A;  1E33 P;  5IJQ A;  3WAW A;  4LRE A;  2IUC A;  4MHX A;  3UNY A;  1KHK A;  1ALH A;  3NKM A;  1HJK A;  4NWX A;  3UN5 A;  3M8W A;  4UOR A;  3B5Q A;  4ZG6 A;  1N2K A;  4GTZ A;  4KAY A;  1N2L A;  5C66 A;  4LRA A;  2XR9 A;  4GTY A;  2GLQ A;  4MY4 A;  3NVL A;  4LRB A;  1HQA A;  1EI6 A;  4CYS A;  2ZKT A;  1ZED A;  2GSN A;  4LRC A;  4CXS A;  3NKR A;  3M8Y A;  1ZEB A;  2W8S A;  1ALK A;  1ED8 A;  1Y7A A;  4UOP A;  1AJA A;  4CYR A;  4UOO A;  4NWJ A;  2W5X A;  2W5W A;  4UPL A;  5AJ9 A;  5INH A;  2X98 A;  3TG0 A;  3IDD A;  4LR9 A;  1FSU A;  3T00 A;  3OT9 A;  1EW8 A;  1KH5 A;  2ANH A;  1B8J A;  1KH4 A;  3A52 A;  3NKN A;  3Q3Q A;  5EGE A;  2W5S A;  2QZU A;  4QAX A;  1ZEF A;  1ANJ A;  1ED9 A;  3T01 A;  3SZY A;  4ZG9 A;  1ALJ A;  4LRD A;  5GOV A;  3CMR A;  3MK0 A;  1ELX A;  2IUC B;  3UN3 A;  1AJC A;  1SHN A;  3E2D A;  3UO0 A;  5L0E A;  1ELZ A;  1E2S P;  4LRF A;  4UPK A;  3SZZ A;  1KHN A;  3BDG B;  1ELY A;  4LR2 A;  1AUK A;  3BDG A;  3NKP A;  5LRM A;  2W5V A;  5HRT A;  4KAV A;  5EGH A;  4UPI A;  4KJD A;  4FDJ A;  1E1Z P;  3M7V A;  4GTW A;  3TX0 A;  3UN2 A;  1KHL A;  3MK2 A;  3DYC A;  3DPC A;  4LR8 A;  3BDF A;  3T02 A;  4ZG7 A;  5KXA A;  4MIV A;  4KM4 A;  3ED4 A;  3WBH A;  5L0B A;  3WAX A;  5LIA A;  5GRR A;  4YR1 A;  1O99 A;  1EJJ A;  2W8D A;  2IFY A;  2G9Y A;  1P49 A;  1ANI A;  2W5Q A;  4TN0 A;  2RH6 A;  2GSU A;  2VQR A;  3BDH A;  3TWZ A;  2D1G A;  1EW9 A;  1AJD A;  5IJS A;  2GSO A;  3KD8 A;  1O98 A;  5DLV A;  1ALI A;  1KH7 A;  4CXK A;  4KJG A;  4UPH A;  4ZGA A;  1URB A;  5DLT A;  4B56 A;  3WAY A;  1E3C P;  4LQY A;  1URA A;  2W5T A;  5LQQ A;  2XRG A;  3IGY B;  4FDI A;  4CXU A;  4N7T A;  5DLW A;  5TJ3 A;  1SHQ A;  4GTX A;  1EW2 A;  1AJB A;  3NKQ A;  2GA3 A;  5L0K A;  3M8Z A;  3WAV A;  1K7H A;  3IGZ B;  5K4P A;  2W5R A;  3MK1 A;  3NKO A;  4LR7 A;  3LXQ A;  1HDH A; 
#chains in the Genus database with same CATH homology
 1Y6V A;  1EQJ A;  1KHJ A;  5LRN A;  1KH9 A;  1E33 P;  5IJQ A;  3WAW A;  4LRE A;  2IUC A;  4MHX A;  3UNY A;  1KHK A;  1ALH A;  3NKM A;  1HJK A;  4NWX A;  3UN5 A;  3M8W A;  4UOR A;  3B5Q A;  4ZG6 A;  1N2K A;  4GTZ A;  4KAY A;  1N2L A;  5C66 A;  4LRA A;  2XR9 A;  4GTY A;  2GLQ A;  4MY4 A;  3NVL A;  4LRB A;  1HQA A;  1EI6 A;  4CYS A;  2ZKT A;  1ZED A;  2GSN A;  4LRC A;  4CXS A;  3NKR A;  3M8Y A;  1ZEB A;  2W8S A;  1ALK A;  1ED8 A;  1Y7A A;  4UOP A;  1AJA A;  4CYR A;  4UOO A;  4NWJ A;  2W5X A;  2W5W A;  4UPL A;  5AJ9 A;  5INH A;  2X98 A;  3TG0 A;  3IDD A;  4LR9 A;  1FSU A;  3T00 A;  3OT9 A;  1EW8 A;  1KH5 A;  2ANH A;  1B8J A;  1KH4 A;  3A52 A;  3NKN A;  3Q3Q A;  5EGE A;  2W5S A;  2QZU A;  4QAX A;  1ZEF A;  1ANJ A;  1ED9 A;  3T01 A;  3SZY A;  4ZG9 A;  1ALJ A;  4LRD A;  5GOV A;  3CMR A;  3MK0 A;  1ELX A;  2IUC B;  3UN3 A;  1AJC A;  1SHN A;  3E2D A;  3UO0 A;  5L0E A;  1ELZ A;  1E2S P;  4LRF A;  4UPK A;  3SZZ A;  1KHN A;  3BDG B;  1ELY A;  4LR2 A;  1AUK A;  3BDG A;  3NKP A;  5LRM A;  2W5V A;  5HRT A;  4KAV A;  5EGH A;  4UPI A;  4KJD A;  4FDJ A;  1E1Z P;  3M7V A;  4GTW A;  3TX0 A;  3UN2 A;  1KHL A;  3MK2 A;  3DYC A;  3DPC A;  4LR8 A;  3BDF A;  3T02 A;  4ZG7 A;  5KXA A;  4MIV A;  4KM4 A;  3ED4 A;  3WBH A;  5L0B A;  3WAX A;  5LIA A;  5GRR A;  4YR1 A;  1O99 A;  1EJJ A;  2W8D A;  2IFY A;  2G9Y A;  1P49 A;  1ANI A;  2W5Q A;  4TN0 A;  2RH6 A;  2GSU A;  2VQR A;  3BDH A;  3TWZ A;  2D1G A;  1EW9 A;  1AJD A;  5IJS A;  2GSO A;  3KD8 A;  1O98 A;  5DLV A;  1ALI A;  1KH7 A;  4CXK A;  4KJG A;  4UPH A;  4ZGA A;  1URB A;  5DLT A;  4B56 A;  3WAY A;  1E3C P;  4LQY A;  1URA A;  2W5T A;  5LQQ A;  2XRG A;  3IGY B;  4FDI A;  4CXU A;  4N7T A;  5DLW A;  5TJ3 A;  1SHQ A;  4GTX A;  1EW2 A;  1AJB A;  3NKQ A;  2GA3 A;  5L0K A;  3M8Z A;  3WAV A;  1K7H A;  3IGZ B;  5K4P A;  2W5R A;  3MK1 A;  3NKO A;  4LR7 A;  3LXQ A;  1HDH A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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