4BZ5A

Crystal structure of schistosoma mansoni hdac8
Total Genus 148
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
148
sequence length
434
structure length
404
Chain Sequence
SVGIVYGDQYRQLCCSSPKFGDRYALVMDLINAYKLIPELSRVPPLQWDSPSRMYEAVTAFHSTEYVDALKKLQMLHCEEKELTADDELLMDSFSLNYDCPGFPSVFDYSLAAVQGSLAAASALICRHCEVVINWGGGWHHAKRSEASGFCYLNDIVLAIHRLVSSQTRVLYVDLDLHHGDGVEEAFWYSPRVVTFSVHHASPGFFPGTGTWNMVDNDKLPIFLNGAGRGRFSAFNLPLEEGINDLDWSNAIGPILDSLNIVIQPSYVVVQCGADCLATDPHRIFRLTNFYPLSGYLYAIKKILSWKVPTLILGGGGYNFPDTARLWTRVTALTIEEVKGKKMTISPEIPEHSYFSRYGPDFELDIDYFPDSIQKHHRRILEQLRNYADLNKLIYDYDQVYQLY
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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molecule tags Hydrolase
molecule keywords HISTONE DEACETYLASE 8
publication title Structural Basis for the Inhibition of Histone Deacetylase 8 (Hdac8), a Key Epigenetic Player in the Blood Fluke Schistosoma Mansoni.
pubmed doi rcsb
source organism Schistosoma mansoni
total genus 148
structure length 404
sequence length 434
chains with identical sequence B, C, D
ec nomenclature
pdb deposition date 2013-07-24

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00850 Hist_deacetyl Histone deacetylase domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.800.20 Alpha Beta 3-Layer(aba) Sandwich Arginase; Chain A Histone deacetylase domain 4bz5A00
5G1BA 5G0IA 5G0YA 3Q9EA 5THUA 1ZZ0A 5DC6A 5IX0A 5EEKA 4BZ8A 4QA2A 4CBTA 4RN2A 5EENA 3F07A 4QA5A 4A69A 4QA4A 4ZURA 5G0JA 5D1CA 3SFHA 3EZPA 3ZNRA 4BKXB 5G0GA 2VQQA 5G0XA 2VQVA 5THVA 3EW8A 2V5WA 1ZZ1A 5ICNB 4QA7A 1C3PA 4QA0A 5G1CA 4RN1A 4BZ6A 1ZZ3A 5EEIA 5G3WA 3C0YA 1C3SA 3MENA 3MZ6A 2GH6A 3C0ZA 5EFNA 3F0RA 4ZUPA 5G11A 5DC5A 1T64A 4CBYA 4ZUQA 3SFFA 5LI3A 4QA6A 3C10A 5EFHA 1C3RA 4QA3A 1W22A 4ZUMA 3Q9BA 3MZ4A 2VQJA 5EFKB 3F06A 4LXZA 5G10A 5JI5A 5G0HA 1VKGA 3ZNSA 4RN0A 3Q9CA 3MZ3A 5DC8A 5D1DA 2V5XA 4QA1A 5EEMA 3EZTA 5EF8A 5THTA 3MAXA 5G1AA 5A2SA 4BZ7A 5IWGA 4ZUOA 2VQOA 1T69A 2VCGA 5FUEA 1T67A 5THSA 5BWZA 2VQWG 3EWFA 5D1BA 2VQMA 4CQFA 4ZUNA 4LY1A 5G12A 5FCWA 5G17A 5EFBD 3RQDA 5DC7A 5EEFA 5EFJD 5EFGA 3MZ7A 3Q9FA 5G13A 4BZ5A 5EF7A 4BZ9A
chains in the Genus database with same CATH superfamily
1P8PA 3SKKA 4IE2A 5RLAA 3KV2A 1WOHA 4MYKA 4Q3RC 3PZLA 4ITYA 4Q3VA 5G1BA 5G0IA 5G0YA 3NIQA 3Q9EA 4I06A 4Q40A 5THUA 1ZZ0A 3GN0A 4IU5A 1TBHA 5DC6A 5IX0A 1P8QA 5EEKA 1D3VA 1R1OA 4BZ8A 3MFWA 5HJ9A 4QA2A 1P8RA 4CBTA 4RN2A 4HWWA 2PLLA 1WVAA 5EENA 3F07A 4QA5A 4MYNA 1PQ3A 4Q3TA 4A69A 4QA4A 4ZURA 5G0JA 5HJAA 5D1CA 3SFHA 3EZPA 2PHOA 3ZNRA 3MFVA 4BKXB 5G0GA 2VQQA 5G0XA 4DZ4A 3E8ZA 1WVBA 2VQVA 1HQFA 4GSVA 1P8NA 3DJ8A 5THVA 3EW8A 2V5WA 1ZZ1A 4GWCA 2EF4A 4IE1A 5ICNB 4IU0A 4QA7A 4Q3RA 1RLAA 3LP4A 1C3PA 3RLAA 3GMZA 2CEVA 3NIPA 4FCKA 4QA0A 4RN1A 5G1CA 4BZ6A 1ZZ3A 1T4TA 1XFKA 4IE3A 5EEIA 5G3WA 3C0YA 1C3SA 1WOGA 3MENA 3MZ6A 1T4PA 5CEVA 1HQ5A 2GH6A 3C0ZA 4HXQA 3F0RA 5EFNA 4ZUPA 5DC5A 5G11A 1T4SA 2ZAVA 1T64A 4CBYA 4CEVA 3LP7A 4ZUQA 3NIOA 3SFFA 5LI3A 4QA6A 3C10A 4GSZA 5EFHA 1C3RA 4RHKA 4Q3SA 3CEVA 4QA3A 1W22A 3SL1A 4ZUMA 3Q9BA 1P8SA 3MZ4A 2VQJA 5EFKB 4IU1A 3F06A 3THEA 3E6VA 3E6KA 4IU4A 4LXZA 1ZPGA 1TA1A 5G10A 4Q3UA 3E9BA 4MXRA 5JI5A 5G0HA 1ZPEA 4RHJA 1VKGA 3ZNSA 4RN0A 3Q9CA 3MZ3A 5DC8A 5D1DA 2V5XA 4QA1A 2A0MA 3TF3A 5EEMA 1HQXA 3EZTA 1T5FA 3TH7A 5EF8A 4RLAA 5THTA 3MAXA 3MJLA 4MYLA 5G1AA 5A2SA 4BZ7A 5IWGA 2VQOA 4ZUOA 4Q41A 1WOIA 1T69A 4GSMA 4Q3QA 2VCGA 3F80A 1T67A 5FUEA 1T5GA 5THSA 5BWZA 4MYFA 2VQWG 3EWFA 4Q42A 5D1BA 3THJA 2VQMA 4CQFA 3THHA 3SJTA 1TBJA 2AEBA 4ZUNA 4LY1A 4RHQA 4Q3PA 1TBLA 5G12A 1T4RA 2RLAA 5FCWA 5G17A 1GQ7A 4FCIA 4IXUA 5DC7A 5EFBD 3MMRA 2EIVA 4G3HA 5EEFA 3RQDA 2EF5A 4GWDA 4RHIA 1HQHA 2PHAA 5EFJD 1GQ6A 3LHLA 5EFGA 3MZ7A 3Q9FA 5G13A 3M1RA 4RHLA 4BZ5A 1P8MA 3SL0A 1HQGA 5EF7A 4BZ9A 1CEVA 1P8OA 3E8QA 4IXVA 4HZEA 4RHMA
chains in the Genus database with same CATH topology
5G1BA 5G0IA 5G0YA 3Q9EA 5THUA 1ZZ0A 5DC6A 5IX0A 5EEKA 4BZ8A 4QA2A 4CBTA 4RN2A 5EENA 3F07A 4QA5A 4A69A 4QA4A 4ZURA 5G0JA 5D1CA 3SFHA 3EZPA 3ZNRA 4BKXB 5G0GA 2VQQA 5G0XA 2VQVA 5THVA 3EW8A 2V5WA 1ZZ1A 5ICNB 4QA7A 1C3PA 4QA0A 5G1CA 4RN1A 4BZ6A 1ZZ3A 5EEIA 5G3WA 3C0YA 1C3SA 3MENA 3MZ6A 2GH6A 3C0ZA 5EFNA 3F0RA 4ZUPA 5G11A 5DC5A 1T64A 4CBYA 4ZUQA 3SFFA 5LI3A 4QA6A 3C10A 5EFHA 1C3RA 4QA3A 1W22A 4ZUMA 3Q9BA 3MZ4A 2VQJA 5EFKB 3F06A 4LXZA 5G10A 5JI5A 5G0HA 1VKGA 3ZNSA 4RN0A 3Q9CA 3MZ3A 5DC8A 5D1DA 2V5XA 4QA1A 5EEMA 3EZTA 5EF8A 5THTA 3MAXA 5G1AA 5A2SA 4BZ7A 5IWGA 4ZUOA 2VQOA 1T69A 2VCGA 5FUEA 1T67A 5THSA 5BWZA 2VQWG 3EWFA 5D1BA 2VQMA 4CQFA 4ZUNA 4LY1A 5G12A 5FCWA 5G17A 5EFBD 3RQDA 5DC7A 5EEFA 5EFJD 5EFGA 3MZ7A 3Q9FA 5G13A 4BZ5A 5EF7A 4BZ9A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 5G1B A;  5G0I A;  5G0Y A;  3Q9E A;  5THU A;  1ZZ0 A;  5DC6 A;  5IX0 A;  5EEK A;  4BZ8 A;  4QA2 A;  4CBT A;  4RN2 A;  5EEN A;  3F07 A;  4QA5 A;  4A69 A;  4QA4 A;  4ZUR A;  5G0J A;  5D1C A;  3SFH A;  3EZP A;  3ZNR A;  4BKX B;  5G0G A;  2VQQ A;  5G0X A;  2VQV A;  5THV A;  3EW8 A;  2V5W A;  1ZZ1 A;  5ICN B;  4QA7 A;  1C3P A;  4QA0 A;  5G1C A;  4RN1 A;  4BZ6 A;  1ZZ3 A;  5EEI A;  5G3W A;  3C0Y A;  1C3S A;  3MEN A;  3MZ6 A;  2GH6 A;  3C0Z A;  5EFN A;  3F0R A;  4ZUP A;  5G11 A;  5DC5 A;  1T64 A;  4CBY A;  4ZUQ A;  3SFF A;  5LI3 A;  4QA6 A;  3C10 A;  5EFH A;  1C3R A;  4QA3 A;  1W22 A;  4ZUM A;  3Q9B A;  3MZ4 A;  2VQJ A;  5EFK B;  3F06 A;  4LXZ A;  5G10 A;  5JI5 A;  5G0H A;  1VKG A;  3ZNS A;  4RN0 A;  3Q9C A;  3MZ3 A;  5DC8 A;  5D1D A;  2V5X A;  4QA1 A;  5EEM A;  3EZT A;  5EF8 A;  5THT A;  3MAX A;  5G1A A;  5A2S A;  4BZ7 A;  5IWG A;  4ZUO A;  2VQO A;  1T69 A;  2VCG A;  5FUE A;  1T67 A;  5THS A;  5BWZ A;  2VQW G;  3EWF A;  5D1B A;  2VQM A;  4CQF A;  4ZUN A;  4LY1 A;  5G12 A;  5FCW A;  5G17 A;  5EFB D;  3RQD A;  5DC7 A;  5EEF A;  5EFJ D;  5EFG A;  3MZ7 A;  3Q9F A;  5G13 A;  4BZ5 A;  5EF7 A;  4BZ9 A; 
#chains in the Genus database with same CATH topology
 1P8P A;  3SKK A;  4IE2 A;  5RLA A;  3KV2 A;  1WOH A;  4MYK A;  4Q3R C;  3PZL A;  4ITY A;  4Q3V A;  5G1B A;  5G0I A;  5G0Y A;  3NIQ A;  3Q9E A;  4I06 A;  4Q40 A;  5THU A;  1ZZ0 A;  3GN0 A;  4IU5 A;  1TBH A;  5DC6 A;  5IX0 A;  1P8Q A;  5EEK A;  1D3V A;  1R1O A;  4BZ8 A;  3MFW A;  5HJ9 A;  4QA2 A;  1P8R A;  4CBT A;  4RN2 A;  4HWW A;  2PLL A;  1WVA A;  5EEN A;  3F07 A;  4QA5 A;  4MYN A;  1PQ3 A;  4Q3T A;  4A69 A;  4QA4 A;  4ZUR A;  5G0J A;  5HJA A;  5D1C A;  3SFH A;  3EZP A;  2PHO A;  3ZNR A;  3MFV A;  4BKX B;  5G0G A;  2VQQ A;  5G0X A;  4DZ4 A;  3E8Z A;  1WVB A;  2VQV A;  1HQF A;  4GSV A;  1P8N A;  3DJ8 A;  5THV A;  3EW8 A;  2V5W A;  1ZZ1 A;  4GWC A;  2EF4 A;  4IE1 A;  5ICN B;  4IU0 A;  4QA7 A;  4Q3R A;  1RLA A;  3LP4 A;  1C3P A;  3RLA A;  3GMZ A;  2CEV A;  3NIP A;  4FCK A;  4QA0 A;  4RN1 A;  5G1C A;  4BZ6 A;  1ZZ3 A;  1T4T A;  1XFK A;  4IE3 A;  5EEI A;  5G3W A;  3C0Y A;  1C3S A;  1WOG A;  3MEN A;  3MZ6 A;  1T4P A;  5CEV A;  1HQ5 A;  2GH6 A;  3C0Z A;  4HXQ A;  3F0R A;  5EFN A;  4ZUP A;  5DC5 A;  5G11 A;  1T4S A;  2ZAV A;  1T64 A;  4CBY A;  4CEV A;  3LP7 A;  4ZUQ A;  3NIO A;  3SFF A;  5LI3 A;  4QA6 A;  3C10 A;  4GSZ A;  5EFH A;  1C3R A;  4RHK A;  4Q3S A;  3CEV A;  4QA3 A;  1W22 A;  3SL1 A;  4ZUM A;  3Q9B A;  1P8S A;  3MZ4 A;  2VQJ A;  5EFK B;  4IU1 A;  3F06 A;  3THE A;  3E6V A;  3E6K A;  4IU4 A;  4LXZ A;  1ZPG A;  1TA1 A;  5G10 A;  4Q3U A;  3E9B A;  4MXR A;  5JI5 A;  5G0H A;  1ZPE A;  4RHJ A;  1VKG A;  3ZNS A;  4RN0 A;  3Q9C A;  3MZ3 A;  5DC8 A;  5D1D A;  2V5X A;  4QA1 A;  2A0M A;  3TF3 A;  5EEM A;  1HQX A;  3EZT A;  1T5F A;  3TH7 A;  5EF8 A;  4RLA A;  5THT A;  3MAX A;  3MJL A;  4MYL A;  5G1A A;  5A2S A;  4BZ7 A;  5IWG A;  2VQO A;  4ZUO A;  4Q41 A;  1WOI A;  1T69 A;  4GSM A;  4Q3Q A;  2VCG A;  3F80 A;  1T67 A;  5FUE A;  1T5G A;  5THS A;  5BWZ A;  4MYF A;  2VQW G;  3EWF A;  4Q42 A;  5D1B A;  3THJ A;  2VQM A;  4CQF A;  3THH A;  3SJT A;  1TBJ A;  2AEB A;  4ZUN A;  4LY1 A;  4RHQ A;  4Q3P A;  1TBL A;  5G12 A;  1T4R A;  2RLA A;  5FCW A;  5G17 A;  1GQ7 A;  4FCI A;  4IXU A;  5DC7 A;  5EFB D;  3MMR A;  2EIV A;  4G3H A;  5EEF A;  3RQD A;  2EF5 A;  4GWD A;  4RHI A;  1HQH A;  2PHA A;  5EFJ D;  1GQ6 A;  3LHL A;  5EFG A;  3MZ7 A;  3Q9F A;  5G13 A;  3M1R A;  4RHL A;  4BZ5 A;  1P8M A;  3SL0 A;  1HQG A;  5EF7 A;  4BZ9 A;  1CEV A;  1P8O A;  3E8Q A;  4IXV A;  4HZE A;  4RHM A; 
#chains in the Genus database with same CATH homology
 5G1B A;  5G0I A;  5G0Y A;  3Q9E A;  5THU A;  1ZZ0 A;  5DC6 A;  5IX0 A;  5EEK A;  4BZ8 A;  4QA2 A;  4CBT A;  4RN2 A;  5EEN A;  3F07 A;  4QA5 A;  4A69 A;  4QA4 A;  4ZUR A;  5G0J A;  5D1C A;  3SFH A;  3EZP A;  3ZNR A;  4BKX B;  5G0G A;  2VQQ A;  5G0X A;  2VQV A;  5THV A;  3EW8 A;  2V5W A;  1ZZ1 A;  5ICN B;  4QA7 A;  1C3P A;  4QA0 A;  5G1C A;  4RN1 A;  4BZ6 A;  1ZZ3 A;  5EEI A;  5G3W A;  3C0Y A;  1C3S A;  3MEN A;  3MZ6 A;  2GH6 A;  3C0Z A;  5EFN A;  3F0R A;  4ZUP A;  5G11 A;  5DC5 A;  1T64 A;  4CBY A;  4ZUQ A;  3SFF A;  5LI3 A;  4QA6 A;  3C10 A;  5EFH A;  1C3R A;  4QA3 A;  1W22 A;  4ZUM A;  3Q9B A;  3MZ4 A;  2VQJ A;  5EFK B;  3F06 A;  4LXZ A;  5G10 A;  5JI5 A;  5G0H A;  1VKG A;  3ZNS A;  4RN0 A;  3Q9C A;  3MZ3 A;  5DC8 A;  5D1D A;  2V5X A;  4QA1 A;  5EEM A;  3EZT A;  5EF8 A;  5THT A;  3MAX A;  5G1A A;  5A2S A;  4BZ7 A;  5IWG A;  4ZUO A;  2VQO A;  1T69 A;  2VCG A;  5FUE A;  1T67 A;  5THS A;  5BWZ A;  2VQW G;  3EWF A;  5D1B A;  2VQM A;  4CQF A;  4ZUN A;  4LY1 A;  5G12 A;  5FCW A;  5G17 A;  5EFB D;  3RQD A;  5DC7 A;  5EEF A;  5EFJ D;  5EFG A;  3MZ7 A;  3Q9F A;  5G13 A;  4BZ5 A;  5EF7 A;  4BZ9 A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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