4D8EA

High resolution structures of monomeric s. pyogenes speb reveals role of glycine-rich active site loop
Total Genus 79
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
79
sequence length
254
structure length
254
Chain Sequence
QPVVKSLLNSKGIHYNQGNPYNLLTPVIEKVKPGEQSFVGQHAATGCVATATAQIMKYHNYPNKGLKDYTYTLSSNNPYFNHPKNLFAAISTRQYNWNNILPTYSGRESNVQKMAISELMADVGISVDMDYGPSSGSAGSSRVQRALKENFGYNQSVHQINRSDFSKQDWEAQIDKELSQNQPVYYQGVGKVGGHAFVIDGADGRNFYHVNWGWGGVSDGFFRLDALNPSALGTGGGAGGFNGYQSAVVGIKPL
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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molecule tags Hydrolase
molecule keywords Streptopain
publication title Ultrahigh and High Resolution Structures and Mutational Analysis of Monomeric Streptococcus pyogenes SpeB Reveal a Functional Role for the Glycine-rich C-terminal Loop.
pubmed doi rcsb
source organism Streptococcus pyogenes
total genus 79
structure length 254
sequence length 254
ec nomenclature ec 3.4.22.10: Streptopain.
pdb deposition date 2012-01-10
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.90.70.50 Alpha Beta Alpha-Beta Complex Cathepsin B; Chain A Cathepsin B; Chain A 4d8eA00
4D8IA 4RKXA 4D8EA 3BBAA 2UZJA 1DKIA 3BB7A 4D8BA 2JTCA 1PVJA
chains in the Genus database with same CATH superfamily
1PPPA 2DC6A 4AXLA 4BPVA 4R3DA 1CQDA 2HH5A 3KWBX 1EWOA 3BBAA 2NQDB 2DC7A 1TLOA 2ACTA 1CVZA 5JZEA 3W30A 2OP3A 3MP2A 4D8BA 4BS6A 1U9WA 2AU1A 4M0WA 3V6EA 4XR7A 3PHWA 4PP2E 2AGAA 2CIOA 4OELA 4YYRA 3PHXA 2YJ2A 1ZIVA 4DMXA 1Y08A 1CB5A 1GLOA 1YT7A 2VHFA 3KKUA 4YYQA 4P16A 3E9SA 1AYVA 1EWPA 4IP3A 4MZSA 2P7UA 3V6CA 2ARYA 1CS8A 2JQFR 1KHQA 5A24A 3KX1A 4FK5A 1AIMA 1ICFA 1PIPA 4CDDB 3IOQA 2AIMA 1VSNA 1QDQA 4IUMA 4I04A 1AU2A 5K16A 3MHSA 3LFYA 4QBBA 5JH3A 4PADA 5J94A 4REZA 3IUTA 1CSBB 1PPDA 3H6SA 3MTNA 1NQCA 1YALA 2HD5A 3BPFA 4MSXA 1AYUA 5JA7A 2CB5A 5KO3A 2HXZA 2AVWA 3PT2A 2BDLA 1GCBA 2FE8A 1ME4A 2Y6EA 2DCDA 3BOWA 4DMYA 2JRIA 8PCHA 1K3BB 3GCBA 1QXPA 7PCKA 3CH2X 1YK7A 3PW3A 1EWMA 3BY4A 4ZTBA 3PDFA 4MZOA 2DC8A 4RNAA 1U9VA 1STFE 1A6RA 4QRXA 3F5VA 5CHTA 1PADA 2FUDA 2FQ9A 2NQAA 4W5CA 1MEGA 3MORA 3MTVA 4CDEB 4BOUA 2YJ9A 3CBKA 2YJCA 4D8EA 1SNKA 3RVXA 3OVXA 4MM3B 4HWYA 1AU4A 3H8CA 3PRPA 1MDWA 3O1GA 4I05A 2YJ8A 3QT4A 4N4ZA 4YYWA 6PADA 3RVVA 2J7QA 1NL6A 3B79A 3D6SA 3I06A 1F2BA 4P6GA 3F75A 2BU3A 2R9MA 2Y5BA 4N79A 4RF1A 2J7QC 3KFQA 3TNXA 3BPMA 3H89A 4PT5A 4W5BA 1GMYA 4Q8HA 2R6NA 3HHIA 4FJCA 3P5VA 2FRQA 2NQIA 1S4VA 2AS8A 5CVNB 1ATKA 2BTWB 1CTEA 1PCIA 4RKXA 2Z84A 2F1GA 2R9FA 3CBJA 4X6IA 1BQIA 3TRKA 1F29A 2B1NA 4YVAA 3O65A 1UKFA 4OVZA 3S3QA 1AYWA 4ZUXU 3PNRA 1QOLA 1MEMA 3BC3A 2AYNA 3OQCA 4QH6A 2B1MA 1U9QX 2YJBA 5CVMA 1EWLA 1NB5A 3QJ3A 3K9MA 2G8JA 4QRVA 1HUCB 1XKGA 3AI8A 4I07A 9PAPA 2IPPB 4BOQA 1CPJA 1F2AA 3HD3A 1FH0A 1PPOA 3U8EA 4N8WA 1AU3A 3I3TA 5F02A 1EF7A 4X6JA 2JTCA 1F2CA 5EF4A 1DEUA 4D8IA 3ZNHA 3MJ5A 1ITOA 1MHWA 2O6XA 4RF0A 3CH3X 2PNSA 3TMPA 3PRMA 4CZWA 2DCBA 3P5UA 2DZYA 3ZUAA 2DCAA 2F7DA 1CV8A 3HHAA 3E1ZB 1BY8A 1DF0A 2GFOA 2DZZA 4YYSA 1MS6A 1BP4A 4BS5A 5FPWA 2R9NA 1TU6A 2E02A 1KHPA 2FTDA 2GHUA 1PVJA 1IWDA 4YV8A 3BCNA 4BOPA 1KFUL 4BSQA 2PREA 3C9EA 3IFUA 1ZCMA 4PP1A 1PE6A 3IHPA 3NHEA 3OISA 1ME3A 3B21A 3HWNA 2XU5A 1GECE 1M6DA 1U5IA 2FYEA 2XU3A 1CJLA 3M99A 4BOZA 3K8UA 2XU4A 1AECA 3N3GA 2WBFX 3LXSA 2FT2A 3IV2A 3DF0A 2DOSA 1VJVA 2E03A 3WXGA 2R9OA 3P5XA 1THEA 1KXRA 5EZSA 4WA6A 1NPZA 4FIPA 5CVOB 1NB3A 4BQVA 2AUZA 3P5WA 2P0RA 3OF8A 3RNVA 2AUXA 1U9XA 4YYVA 4BOSA 3PHUA 1YZBA 3WXEA 1PXVA 1KFXL 2NQGA 2UZJA 3BB7A 3K24A 4OW0A 2FO5A 2AYOA 3IEJA 1PPNA 2E00A 4AXMA 3KW9A 1X9YA 3W31A 3N3KA 2DC9A 4XZXA 4OEMA 3H8BA 4HXDB 5PADA 2IBIA 3USVA 3C0RA 3S3RA 4K7CA 3PSEA 3PBHA 1AU0A 1O0EA 5E6JA 2DJFB 3IMAA 3BWKA 2PBHA 1BGOA 3N4CA 1DKIA 4X6HA 2DCCA 1POPA 2HHNA 2R9CA 2XU1A 1Y4HA 3KWZA 2DJGB 2G7YA 5CHVA 1YVBA 2BDZA 4QRGA 2G6DA 2FRAA 3O0UA 4OVZB 4MI7A 3RVWA 1PBHA 4YYUA 4XUIA 3MHHA 5EZQA 2OZ2A 4G54A 1TL9A 1YK8A 2BTWA 4KLBA 4W4UA 3H7DA 1SP4B 3OVZA 2P86A 2VHSA 4GUAA 4Q8GA 4PI3A 2C0YA 2E01A 4WURA 1MIRA 1Q6KA 3ERVA 2JQGR 3QSDA 3OF9A 1NLJA 4CDCB 4A5UA 4CDFB 3WXFA 2G8EA 2H7JA 5EGWA 2ATOA 2OULA 4P6EA 2HWKA 3KSEA 1QMYA 4RY2A 1JQPA 2PADA
chains in the Genus database with same CATH topology
4D8IA 3ZNHA 4RNAA 3MJ5A 4R3DA 2UZJA 3BB7A 4RF0A 4OW0A 3TMPA 3PRMA 3BBAA 3MTVA 5JZEA 4BOUA 3W30A 3W31A 3MP2A 4D8BA 4M0WA 4XZXA 4HXDB 4D8EA 4MM3B 3PHWA 3C0RA 2AGAA 3PRPA 3PSEA 3PHXA 5E6JA 2J7QA 4P16A 3E9SA 4IP3A 1PVJA 2BU3A 4RF1A 2J7QC 4PT5A 1DKIA 4BOPA 3IFUA 4OVZB 4MI7A 3B21A 2BTWB 4IUMA 4RKXA 2Z84A 5EZQA 3TRKA 4REZA 3O65A 1UKFA 4OVZA 4BOZA 2BTWA 4GUAA 3OQCA 2DOSA 4WURA 5KO3A 5EZSA 3PT2A 2FE8A 4BOQA 4A5UA 2JRIA 3RNVA 2HWKA 4BOSA 3BY4A 4ZTBA 2JTCA 3PHUA 1YZBA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4D8I A;  4RKX A;  4D8E A;  3BBA A;  2UZJ A;  1DKI A;  3BB7 A;  4D8B A;  2JTC A;  1PVJ A; 
#chains in the Genus database with same CATH topology
 1PPP A;  2DC6 A;  4AXL A;  4BPV A;  4R3D A;  1CQD A;  2HH5 A;  3KWB X;  1EWO A;  3BBA A;  2NQD B;  2DC7 A;  1TLO A;  2ACT A;  1CVZ A;  5JZE A;  3W30 A;  2OP3 A;  3MP2 A;  4D8B A;  4BS6 A;  1U9W A;  2AU1 A;  4M0W A;  3V6E A;  4XR7 A;  3PHW A;  4PP2 E;  2AGA A;  2CIO A;  4OEL A;  4YYR A;  3PHX A;  2YJ2 A;  1ZIV A;  4DMX A;  1Y08 A;  1CB5 A;  1GLO A;  1YT7 A;  2VHF A;  3KKU A;  4YYQ A;  4P16 A;  3E9S A;  1AYV A;  1EWP A;  4IP3 A;  4MZS A;  2P7U A;  3V6C A;  2ARY A;  1CS8 A;  2JQF R;  1KHQ A;  5A24 A;  3KX1 A;  4FK5 A;  1AIM A;  1ICF A;  1PIP A;  4CDD B;  3IOQ A;  2AIM A;  1VSN A;  1QDQ A;  4IUM A;  4I04 A;  1AU2 A;  5K16 A;  3MHS A;  3LFY A;  4QBB A;  5JH3 A;  4PAD A;  5J94 A;  4REZ A;  3IUT A;  1CSB B;  1PPD A;  3H6S A;  3MTN A;  1NQC A;  1YAL A;  2HD5 A;  3BPF A;  4MSX A;  1AYU A;  5JA7 A;  2CB5 A;  5KO3 A;  2HXZ A;  2AVW A;  3PT2 A;  2BDL A;  1GCB A;  2FE8 A;  1ME4 A;  2Y6E A;  2DCD A;  3BOW A;  4DMY A;  2JRI A;  8PCH A;  1K3B B;  3GCB A;  1QXP A;  7PCK A;  3CH2 X;  1YK7 A;  3PW3 A;  1EWM A;  3BY4 A;  4ZTB A;  3PDF A;  4MZO A;  2DC8 A;  4RNA A;  1U9V A;  1STF E;  1A6R A;  4QRX A;  3F5V A;  5CHT A;  1PAD A;  2FUD A;  2FQ9 A;  2NQA A;  4W5C A;  1MEG A;  3MOR A;  3MTV A;  4CDE B;  4BOU A;  2YJ9 A;  3CBK A;  2YJC A;  4D8E A;  1SNK A;  3RVX A;  3OVX A;  4MM3 B;  4HWY A;  1AU4 A;  3H8C A;  3PRP A;  1MDW A;  3O1G A;  4I05 A;  2YJ8 A;  3QT4 A;  4N4Z A;  4YYW A;  6PAD A;  3RVV A;  2J7Q A;  1NL6 A;  3B79 A;  3D6S A;  3I06 A;  1F2B A;  4P6G A;  3F75 A;  2BU3 A;  2R9M A;  2Y5B A;  4N79 A;  4RF1 A;  2J7Q C;  3KFQ A;  3TNX A;  3BPM A;  3H89 A;  4PT5 A;  4W5B A;  1GMY A;  4Q8H A;  2R6N A;  3HHI A;  4FJC A;  3P5V A;  2FRQ A;  2NQI A;  1S4V A;  2AS8 A;  5CVN B;  1ATK A;  2BTW B;  1CTE A;  1PCI A;  4RKX A;  2Z84 A;  2F1G A;  2R9F A;  3CBJ A;  4X6I A;  1BQI A;  3TRK A;  1F29 A;  2B1N A;  4YVA A;  3O65 A;  1UKF A;  4OVZ A;  3S3Q A;  1AYW A;  4ZUX U;  3PNR A;  1QOL A;  1MEM A;  3BC3 A;  2AYN A;  3OQC A;  4QH6 A;  2B1M A;  1U9Q X;  2YJB A;  5CVM A;  1EWL A;  1NB5 A;  3QJ3 A;  3K9M A;  2G8J A;  4QRV A;  1HUC B;  1XKG A;  3AI8 A;  4I07 A;  9PAP A;  2IPP B;  4BOQ A;  1CPJ A;  1F2A A;  3HD3 A;  1FH0 A;  1PPO A;  3U8E A;  4N8W A;  1AU3 A;  3I3T A;  5F02 A;  1EF7 A;  4X6J A;  2JTC A;  1F2C A;  5EF4 A;  1DEU A;  4D8I A;  3ZNH A;  3MJ5 A;  1ITO A;  1MHW A;  2O6X A;  4RF0 A;  3CH3 X;  2PNS A;  3TMP A;  3PRM A;  4CZW A;  2DCB A;  3P5U A;  2DZY A;  3ZUA A;  2DCA A;  2F7D A;  1CV8 A;  3HHA A;  3E1Z B;  1BY8 A;  1DF0 A;  2GFO A;  2DZZ A;  4YYS A;  1MS6 A;  1BP4 A;  4BS5 A;  5FPW A;  2R9N A;  1TU6 A;  2E02 A;  1KHP A;  2FTD A;  2GHU A;  1PVJ A;  1IWD A;  4YV8 A;  3BCN A;  4BOP A;  1KFU L;  4BSQ A;  2PRE A;  3C9E A;  3IFU A;  1ZCM A;  4PP1 A;  1PE6 A;  3IHP A;  3NHE A;  3OIS A;  1ME3 A;  3B21 A;  3HWN A;  2XU5 A;  1GEC E;  1M6D A;  1U5I A;  2FYE A;  2XU3 A;  1CJL A;  3M99 A;  4BOZ A;  3K8U A;  2XU4 A;  1AEC A;  3N3G A;  2WBF X;  3LXS A;  2FT2 A;  3IV2 A;  3DF0 A;  2DOS A;  1VJV A;  2E03 A;  3WXG A;  2R9O A;  3P5X A;  1THE A;  1KXR A;  5EZS A;  4WA6 A;  1NPZ A;  4FIP A;  5CVO B;  1NB3 A;  4BQV A;  2AUZ A;  3P5W A;  2P0R A;  3OF8 A;  3RNV A;  2AUX A;  1U9X A;  4YYV A;  4BOS A;  3PHU A;  1YZB A;  3WXE A;  1PXV A;  1KFX L;  2NQG A;  2UZJ A;  3BB7 A;  3K24 A;  4OW0 A;  2FO5 A;  2AYO A;  3IEJ A;  1PPN A;  2E00 A;  4AXM A;  3KW9 A;  1X9Y A;  3W31 A;  3N3K A;  2DC9 A;  4XZX A;  4OEM A;  3H8B A;  4HXD B;  5PAD A;  2IBI A;  3USV A;  3C0R A;  3S3R A;  4K7C A;  3PSE A;  3PBH A;  1AU0 A;  1O0E A;  5E6J A;  2DJF B;  3IMA A;  3BWK A;  2PBH A;  1BGO A;  3N4C A;  1DKI A;  4X6H A;  2DCC A;  1POP A;  2HHN A;  2R9C A;  2XU1 A;  1Y4H A;  3KWZ A;  2DJG B;  2G7Y A;  5CHV A;  1YVB A;  2BDZ A;  4QRG A;  2G6D A;  2FRA A;  3O0U A;  4OVZ B;  4MI7 A;  3RVW A;  1PBH A;  4YYU A;  4XUI A;  3MHH A;  5EZQ A;  2OZ2 A;  4G54 A;  1TL9 A;  1YK8 A;  2BTW A;  4KLB A;  4W4U A;  3H7D A;  1SP4 B;  3OVZ A;  2P86 A;  2VHS A;  4GUA A;  4Q8G A;  4PI3 A;  2C0Y A;  2E01 A;  4WUR A;  1MIR A;  1Q6K A;  3ERV A;  2JQG R;  3QSD A;  3OF9 A;  1NLJ A;  4CDC B;  4A5U A;  4CDF B;  3WXF A;  2G8E A;  2H7J A;  5EGW A;  2ATO A;  2OUL A;  4P6E A;  2HWK A;  3KSE A;  1QMY A;  4RY2 A;  1JQP A;  2PAD A; 
#chains in the Genus database with same CATH homology
 4D8I A;  3ZNH A;  4RNA A;  3MJ5 A;  4R3D A;  2UZJ A;  3BB7 A;  4RF0 A;  4OW0 A;  3TMP A;  3PRM A;  3BBA A;  3MTV A;  5JZE A;  4BOU A;  3W30 A;  3W31 A;  3MP2 A;  4D8B A;  4M0W A;  4XZX A;  4HXD B;  4D8E A;  4MM3 B;  3PHW A;  3C0R A;  2AGA A;  3PRP A;  3PSE A;  3PHX A;  5E6J A;  2J7Q A;  4P16 A;  3E9S A;  4IP3 A;  1PVJ A;  2BU3 A;  4RF1 A;  2J7Q C;  4PT5 A;  1DKI A;  4BOP A;  3IFU A;  4OVZ B;  4MI7 A;  3B21 A;  2BTW B;  4IUM A;  4RKX A;  2Z84 A;  5EZQ A;  3TRK A;  4REZ A;  3O65 A;  1UKF A;  4OVZ A;  4BOZ A;  2BTW A;  4GUA A;  3OQC A;  2DOS A;  4WUR A;  5KO3 A;  5EZS A;  3PT2 A;  2FE8 A;  4BOQ A;  4A5U A;  2JRI A;  3RNV A;  2HWK A;  4BOS A;  3BY4 A;  4ZTB A;  2JTC A;  3PHU A;  1YZB A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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