4EB1L

Hyperstable in-frame insertion variant of antithrombin
Total Genus 109
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
109
sequence length
424
structure length
392
Chain Sequence
ICTAKPIPMNPMCIYTNRRVWELSKANSRFATTFYQHLADSKNDNDNIFLSPLSISTAFAMTKLGACNDTLQQLMEVFKFDTISEKTSDQIHFFFAKLNCRLYRKSSKLVSANRLFGDKSLTFNETYQDISELVYGAKLQPLDFKENAEQSRAAINKWVSNKTEGRITDVIPSEAINELTVLVLVNTIYFKGLWKSKFSPENTRKELFYKADGESCSASMMYQEGKFRYRRVAEGTQVLELPFKGDDITMVLILPKPEKSLAKVEKELTPEVLQEWLDELEEMMLVVHMPRFRIEDGFSLKEQLQDMGLVDLFSPEKSKLPGIVAERDDLYVSDAFHKAFLEVNEEGSEAAASTAVVIAGRSLFKANRPFLVFIREVPLNTIIFMGRVANPC
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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molecule tags Blood clotting
molecule keywords Antithrombin-III
publication title Type II antithrombin deficiency caused by a large in-frame insertion: structural, functional and pathological relevance.
pubmed doi rcsb
source organism Homo sapiens
total genus 109
structure length 392
sequence length 424
ec nomenclature
pdb deposition date 2012-03-23

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
L PF00079 Serpin Serpin (serine protease inhibitor)
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.30.39.10 Mainly Beta Roll Alpha-1-antitrypsin; domain 1 Alpha-1-antitrypsin, domain 1 4eb1L02
3.30.497.10 Alpha Beta 2-Layer Sandwich Antithrombin; Chain I, domain 2 Antithrombin, subunit I, domain 2 4eb1L01
1JMJA 4KDSA 2B4XI 2ZNHA 4DY0A 5CDXA 3PB1I 5EI0A 1JJOC 3EVJI 1E05I 3LE2A 3STOA 4P0OA 2VDXA 3CWLA 1OC0A 1K9OI 1XU8A 4G8OA 4PYWA 1QLPA 5CDZA 5HGCA 4BB2A 2WXYC 2VDYA 5IO1A 1JTIA 2ACHA 1B3KA 4C41A 1HLEA 4EB1I 1ATTA 1F0CA 2XN5A 1KCTA 2QUGA 3Q02A 4ROBA 1JRRA 4IF8A 2VH4A 3EOXA 4AU3A 3F1SA 3CVMA 1YXAA 2RIWA 5C98A 9APIA 1JVQI 4AU3B 4C49A 4AU4A 2R9YA 1LQ8A 4P0FA 2HIJI 4ROAA 2B5TI 3NDFA 2PEEA 3DY0A 8APIA 3NDDA 2WXZC 2WXZA 1JMOA 1E03I 3NE4A 4GA7A 3CWMA 3UT3A 4AJUA 4R9IA 1HP7A 1C5GA 2H4RA 2BEHI 1SR5A 2ANTI 1E04I 1T1FA 2WY0C 2D26A 3DRMA 1IMVA 2PEFA 3H5CA 9PAIA 1ATUA 2OAYA 4IC0A 2RIVA 1MTPA 2V95A 2WY1A 4AU2A 1PSIA 4ZK3A 3DRUA 4Y3KA 1XQGA 1C8OA 1D5SA 2HI9A 1OVAC 1OVAA 3F5NA 4AQHA 2GD4C 3KCGI 2B4XL 1XQJA 1OVAB 5BRRI 4CAAA 4Y40A 2H4QA 1IZ2A 4DY7C 1DVMA 1OPHA 2ZV6A 1WZ9A 5INWA 3T1PA 1A7CA 1ATHA 1M93B 1TB6I 1QMBA 4AJTA 2XN6A 5CE0A 1OYHL 2WXWA 2XN3A 4G8RA 1BY7A 1QMNA 3CAAA 1R1LI 2XN7A 3B9FI 4EB1L 1SEKA 1AZXI 4RO9A 3R4LA 3ZHAA 4AFXA 1ANTI 1DZGL 1NQ9I 1AS4A 3PZFA 1DZHL 7APIA 2WXXA 3LW2A 1DB2A 2CEOA 2ARRA 1EZXA 2OL2A 1UHGA 4YIAA 1OYHI 3NDAA 2HIJL 3F02A 4DTEA 1SNGA 1LJ5A 4ZK0A 1DVNA 1DZGI 1BR8I 2H4PA 1LK6I 1OO8A 3OZQA 4RSQA 1DZHI 3Q03A 3FGQA 4X30A 3DLWA 2ARQA 3VVJA 2BEHL 2DUTA
chains in the Genus database with same CATH superfamily
1JMJA 4KDSA 2B4XI 2ZNHA 4DY0A 5CDXA 3PB1I 5EI0A 1JJOC 3EVJI 1E05I 3LE2A 3STOA 4P0OA 2VDXA 3CWLA 1OC0A 1K9OI 1XU8A 4G8OA 4PYWA 1QLPA 5CDZA 5HGCA 4BB2A 2WXYC 2VDYA 5IO1A 1JTIA 2ACHA 1B3KA 4C41A 1HLEA 4EB1I 1ATTA 1F0CA 2XN5A 1KCTA 2QUGA 3Q02A 4ROBA 1JRRA 4IF8A 2VH4A 3EOXA 4AU3A 3F1SA 3CVMA 1YXAA 2RIWA 5C98A 9APIA 1JVQI 4AU3B 4C49A 4AU4A 2R9YA 1LQ8A 4P0FA 2HIJI 4ROAA 2B5TI 3NDFA 2PEEA 3DY0A 8APIA 3NDDA 2WXZC 2WXZA 1JMOA 1E03I 3NE4A 4GA7A 3CWMA 3UT3A 4AJUA 4R9IA 1HP7A 1C5GA 2H4RA 2BEHI 1SR5A 2ANTI 1E04I 1T1FA 2WY0C 2D26A 3DRMA 1IMVA 2PEFA 3H5CA 9PAIA 1ATUA 2OAYA 4IC0A 2RIVA 1MTPA 2V95A 2WY1A 4AU2A 1PSIA 4ZK3A 3DRUA 4Y3KA 1XQGA 1C8OA 1D5SA 2HI9A 1OVAC 1OVAA 3F5NA 4AQHA 2GD4C 3KCGI 2B4XL 1XQJA 1OVAB 5BRRI 4CAAA 4Y40A 2H4QA 1IZ2A 4DY7C 1DVMA 1OPHA 2ZV6A 1WZ9A 5INWA 3T1PA 1A7CA 1ATHA 1M93B 1TB6I 1QMBA 4AJTA 2XN6A 5CE0A 1OYHL 2WXWA 2XN3A 4G8RA 1BY7A 1QMNA 3CAAA 1R1LI 2XN7A 3B9FI 4EB1L 1SEKA 1AZXI 4RO9A 3R4LA 3ZHAA 4AFXA 1ANTI 1DZGL 1NQ9I 1AS4A 3PZFA 1DZHL 7APIA 2WXXA 3LW2A 1DB2A 2CEOA 2ARRA 1EZXA 2OL2A 1UHGA 4YIAA 1OYHI 3NDAA 2HIJL 3F02A 4DTEA 1SNGA 1LJ5A 4ZK0A 1DVNA 1DZGI 1BR8I 2H4PA 1LK6I 1OO8A 3OZQA 4RSQA 1DZHI 3Q03A 3FGQA 4X30A 3DLWA 2ARQA 3VVJA 2BEHL 2DUTA
chains in the Genus database with same CATH topology
1JMJA 4KDSA 2B4XI 2ZNHA 4DY0A 5CDXA 3PB1I 5EI0A 1JJOC 3EVJI 1E05I 3LE2A 3STOA 4P0OA 2VDXA 3CWLA 1OC0A 1K9OI 1XU8A 4G8OA 4PYWA 1QLPA 5CDZA 5HGCA 4BB2A 2WXYC 2VDYA 5IO1A 1JTIA 2ACHA 1B3KA 4C41A 1HLEA 4EB1I 1ATTA 1F0CA 2XN5A 1KCTA 2QUGA 3Q02A 4ROBA 1JRRA 4IF8A 2VH4A 3EOXA 4AU3A 3F1SA 3CVMA 1YXAA 2RIWA 5C98A 9APIA 1JVQI 4AU3B 4C49A 4AU4A 2R9YA 1LQ8A 4P0FA 2HIJI 4ROAA 2B5TI 3NDFA 2PEEA 3DY0A 8APIA 3NDDA 2WXZC 2WXZA 1JMOA 1E03I 3NE4A 4GA7A 3CWMA 3UT3A 4AJUA 4R9IA 1HP7A 1C5GA 2H4RA 2BEHI 1SR5A 2ANTI 1E04I 1T1FA 2WY0C 2D26A 3DRMA 1IMVA 2PEFA 3H5CA 9PAIA 1ATUA 2OAYA 4IC0A 2RIVA 1MTPA 2V95A 2WY1A 4AU2A 1PSIA 4ZK3A 3DRUA 4Y3KA 1XQGA 1C8OA 1D5SA 2HI9A 1OVAC 1OVAA 3F5NA 4AQHA 2GD4C 3KCGI 2B4XL 1XQJA 1OVAB 5BRRI 4CAAA 4Y40A 2H4QA 1IZ2A 4DY7C 1DVMA 1OPHA 2ZV6A 1WZ9A 5INWA 3T1PA 1A7CA 1ATHA 1M93B 1TB6I 1QMBA 4AJTA 2XN6A 5CE0A 1OYHL 2WXWA 2XN3A 4G8RA 1BY7A 1QMNA 3CAAA 1R1LI 2XN7A 3B9FI 4EB1L 1SEKA 1AZXI 4RO9A 3R4LA 3ZHAA 4AFXA 1ANTI 1DZGL 1NQ9I 1AS4A 3PZFA 1DZHL 7APIA 2WXXA 3LW2A 1DB2A 2CEOA 2ARRA 1EZXA 2OL2A 1UHGA 4YIAA 1OYHI 3NDAA 2HIJL 3F02A 4DTEA 1SNGA 1LJ5A 4ZK0A 1DVNA 1DZGI 1BR8I 2H4PA 1LK6I 1OO8A 3OZQA 4RSQA 1DZHI 3Q03A 3FGQA 4X30A 3DLWA 2ARQA 3VVJA 2BEHL 2DUTA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1JMJ A;  4KDS A;  2B4X I;  2ZNH A;  4DY0 A;  5CDX A;  3PB1 I;  5EI0 A;  1JJO C;  3EVJ I;  1E05 I;  3LE2 A;  3STO A;  4P0O A;  2VDX A;  3CWL A;  1OC0 A;  1K9O I;  1XU8 A;  4G8O A;  4PYW A;  1QLP A;  5CDZ A;  5HGC A;  4BB2 A;  2WXY C;  2VDY A;  5IO1 A;  1JTI A;  2ACH A;  1B3K A;  4C41 A;  1HLE A;  4EB1 I;  1ATT A;  1F0C A;  2XN5 A;  1KCT A;  2QUG A;  3Q02 A;  4ROB A;  1JRR A;  4IF8 A;  2VH4 A;  3EOX A;  4AU3 A;  3F1S A;  3CVM A;  1YXA A;  2RIW A;  5C98 A;  9API A;  1JVQ I;  4AU3 B;  4C49 A;  4AU4 A;  2R9Y A;  1LQ8 A;  4P0F A;  2HIJ I;  4ROA A;  2B5T I;  3NDF A;  2PEE A;  3DY0 A;  8API A;  3NDD A;  2WXZ C;  2WXZ A;  1JMO A;  1E03 I;  3NE4 A;  4GA7 A;  3CWM A;  3UT3 A;  4AJU A;  4R9I A;  1HP7 A;  1C5G A;  2H4R A;  2BEH I;  1SR5 A;  2ANT I;  1E04 I;  1T1F A;  2WY0 C;  2D26 A;  3DRM A;  1IMV A;  2PEF A;  3H5C A;  9PAI A;  1ATU A;  2OAY A;  4IC0 A;  2RIV A;  1MTP A;  2V95 A;  2WY1 A;  4AU2 A;  1PSI A;  4ZK3 A;  3DRU A;  4Y3K A;  1XQG A;  1C8O A;  1D5S A;  2HI9 A;  1OVA C;  1OVA A;  3F5N A;  4AQH A;  2GD4 C;  3KCG I;  2B4X L;  1XQJ A;  1OVA B;  5BRR I;  4CAA A;  4Y40 A;  2H4Q A;  1IZ2 A;  4DY7 C;  1DVM A;  1OPH A;  2ZV6 A;  1WZ9 A;  5INW A;  3T1P A;  1A7C A;  1ATH A;  1M93 B;  1TB6 I;  1QMB A;  4AJT A;  2XN6 A;  5CE0 A;  1OYH L;  2WXW A;  2XN3 A;  4G8R A;  1BY7 A;  1QMN A;  3CAA A;  1R1L I;  2XN7 A;  3B9F I;  4EB1 L;  1SEK A;  1AZX I;  4RO9 A;  3R4L A;  3ZHA A;  4AFX A;  1ANT I;  1DZG L;  1NQ9 I;  1AS4 A;  3PZF A;  1DZH L;  7API A;  2WXX A;  3LW2 A;  1DB2 A;  2CEO A;  2ARR A;  1EZX A;  2OL2 A;  1UHG A;  4YIA A;  1OYH I;  3NDA A;  2HIJ L;  3F02 A;  4DTE A;  1SNG A;  1LJ5 A;  4ZK0 A;  1DVN A;  1DZG I;  1BR8 I;  2H4P A;  1LK6 I;  1OO8 A;  3OZQ A;  4RSQ A;  1DZH I;  3Q03 A;  3FGQ A;  4X30 A;  3DLW A;  2ARQ A;  3VVJ A;  2BEH L;  2DUT A; 
#chains in the Genus database with same CATH topology
 1JMJ A;  4KDS A;  2B4X I;  2ZNH A;  4DY0 A;  5CDX A;  3PB1 I;  5EI0 A;  1JJO C;  3EVJ I;  1E05 I;  3LE2 A;  3STO A;  4P0O A;  2VDX A;  3CWL A;  1OC0 A;  1K9O I;  1XU8 A;  4G8O A;  4PYW A;  1QLP A;  5CDZ A;  5HGC A;  4BB2 A;  2WXY C;  2VDY A;  5IO1 A;  1JTI A;  2ACH A;  1B3K A;  4C41 A;  1HLE A;  4EB1 I;  1ATT A;  1F0C A;  2XN5 A;  1KCT A;  2QUG A;  3Q02 A;  4ROB A;  1JRR A;  4IF8 A;  2VH4 A;  3EOX A;  4AU3 A;  3F1S A;  3CVM A;  1YXA A;  2RIW A;  5C98 A;  9API A;  1JVQ I;  4AU3 B;  4C49 A;  4AU4 A;  2R9Y A;  1LQ8 A;  4P0F A;  2HIJ I;  4ROA A;  2B5T I;  3NDF A;  2PEE A;  3DY0 A;  8API A;  3NDD A;  2WXZ C;  2WXZ A;  1JMO A;  1E03 I;  3NE4 A;  4GA7 A;  3CWM A;  3UT3 A;  4AJU A;  4R9I A;  1HP7 A;  1C5G A;  2H4R A;  2BEH I;  1SR5 A;  2ANT I;  1E04 I;  1T1F A;  2WY0 C;  2D26 A;  3DRM A;  1IMV A;  2PEF A;  3H5C A;  9PAI A;  1ATU A;  2OAY A;  4IC0 A;  2RIV A;  1MTP A;  2V95 A;  2WY1 A;  4AU2 A;  1PSI A;  4ZK3 A;  3DRU A;  4Y3K A;  1XQG A;  1C8O A;  1D5S A;  2HI9 A;  1OVA C;  1OVA A;  3F5N A;  4AQH A;  2GD4 C;  3KCG I;  2B4X L;  1XQJ A;  1OVA B;  5BRR I;  4CAA A;  4Y40 A;  2H4Q A;  1IZ2 A;  4DY7 C;  1DVM A;  1OPH A;  2ZV6 A;  1WZ9 A;  5INW A;  3T1P A;  1A7C A;  1ATH A;  1M93 B;  1TB6 I;  1QMB A;  4AJT A;  2XN6 A;  5CE0 A;  1OYH L;  2WXW A;  2XN3 A;  4G8R A;  1BY7 A;  1QMN A;  3CAA A;  1R1L I;  2XN7 A;  3B9F I;  4EB1 L;  1SEK A;  1AZX I;  4RO9 A;  3R4L A;  3ZHA A;  4AFX A;  1ANT I;  1DZG L;  1NQ9 I;  1AS4 A;  3PZF A;  1DZH L;  7API A;  2WXX A;  3LW2 A;  1DB2 A;  2CEO A;  2ARR A;  1EZX A;  2OL2 A;  1UHG A;  4YIA A;  1OYH I;  3NDA A;  2HIJ L;  3F02 A;  4DTE A;  1SNG A;  1LJ5 A;  4ZK0 A;  1DVN A;  1DZG I;  1BR8 I;  2H4P A;  1LK6 I;  1OO8 A;  3OZQ A;  4RSQ A;  1DZH I;  3Q03 A;  3FGQ A;  4X30 A;  3DLW A;  2ARQ A;  3VVJ A;  2BEH L;  2DUT A; 
#chains in the Genus database with same CATH homology
 1JMJ A;  4KDS A;  2B4X I;  2ZNH A;  4DY0 A;  5CDX A;  3PB1 I;  5EI0 A;  1JJO C;  3EVJ I;  1E05 I;  3LE2 A;  3STO A;  4P0O A;  2VDX A;  3CWL A;  1OC0 A;  1K9O I;  1XU8 A;  4G8O A;  4PYW A;  1QLP A;  5CDZ A;  5HGC A;  4BB2 A;  2WXY C;  2VDY A;  5IO1 A;  1JTI A;  2ACH A;  1B3K A;  4C41 A;  1HLE A;  4EB1 I;  1ATT A;  1F0C A;  2XN5 A;  1KCT A;  2QUG A;  3Q02 A;  4ROB A;  1JRR A;  4IF8 A;  2VH4 A;  3EOX A;  4AU3 A;  3F1S A;  3CVM A;  1YXA A;  2RIW A;  5C98 A;  9API A;  1JVQ I;  4AU3 B;  4C49 A;  4AU4 A;  2R9Y A;  1LQ8 A;  4P0F A;  2HIJ I;  4ROA A;  2B5T I;  3NDF A;  2PEE A;  3DY0 A;  8API A;  3NDD A;  2WXZ C;  2WXZ A;  1JMO A;  1E03 I;  3NE4 A;  4GA7 A;  3CWM A;  3UT3 A;  4AJU A;  4R9I A;  1HP7 A;  1C5G A;  2H4R A;  2BEH I;  1SR5 A;  2ANT I;  1E04 I;  1T1F A;  2WY0 C;  2D26 A;  3DRM A;  1IMV A;  2PEF A;  3H5C A;  9PAI A;  1ATU A;  2OAY A;  4IC0 A;  2RIV A;  1MTP A;  2V95 A;  2WY1 A;  4AU2 A;  1PSI A;  4ZK3 A;  3DRU A;  4Y3K A;  1XQG A;  1C8O A;  1D5S A;  2HI9 A;  1OVA C;  1OVA A;  3F5N A;  4AQH A;  2GD4 C;  3KCG I;  2B4X L;  1XQJ A;  1OVA B;  5BRR I;  4CAA A;  4Y40 A;  2H4Q A;  1IZ2 A;  4DY7 C;  1DVM A;  1OPH A;  2ZV6 A;  1WZ9 A;  5INW A;  3T1P A;  1A7C A;  1ATH A;  1M93 B;  1TB6 I;  1QMB A;  4AJT A;  2XN6 A;  5CE0 A;  1OYH L;  2WXW A;  2XN3 A;  4G8R A;  1BY7 A;  1QMN A;  3CAA A;  1R1L I;  2XN7 A;  3B9F I;  4EB1 L;  1SEK A;  1AZX I;  4RO9 A;  3R4L A;  3ZHA A;  4AFX A;  1ANT I;  1DZG L;  1NQ9 I;  1AS4 A;  3PZF A;  1DZH L;  7API A;  2WXX A;  3LW2 A;  1DB2 A;  2CEO A;  2ARR A;  1EZX A;  2OL2 A;  1UHG A;  4YIA A;  1OYH I;  3NDA A;  2HIJ L;  3F02 A;  4DTE A;  1SNG A;  1LJ5 A;  4ZK0 A;  1DVN A;  1DZG I;  1BR8 I;  2H4P A;  1LK6 I;  1OO8 A;  3OZQ A;  4RSQ A;  1DZH I;  3Q03 A;  3FGQ A;  4X30 A;  3DLW A;  2ARQ A;  3VVJ A;  2BEH L;  2DUT A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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