4G8OA

Crystal structure of a novel small molecule inactivator bound to plasminogen activator inhibitor-1
Total Genus 100
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
100
sequence length
376
structure length
359
Chain Sequence
APSYVAHLASDFGVRVFQQVAQASKDRNVVFSPYGVASVLAMLQLTTGGETQQQIQAAMGFKIDDKGMAPALRHLYKELMGPWNKDEISTTDAIFVQRDLKLVQGFMPHFFRLFRSTVKQVDFSEVERARFIINDWVKTHTKGMISHLLGTGAVDQLTRLVLVNALYFNGQWKTPFPDSSTHRRLFHKSDGSTVSVPMMAQTNKFNYTEFTTPDGHYYDILELPYHGDTLSMFIAAPYEKEVPLSALTNILSAQLISHWKGNMTRLPRLLVLPKFSLETEVDLRKPLENLGMTDMFRQFQADFTSLSDQEPLHVALALQKVKIEVNESPEEIIIDRPFLFVVRHNPTGTVLFMGQVMEP
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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molecule tags Blood clotting/inhibitor
molecule keywords Plasminogen activator inhibitor 1
publication title Mechanistic characterization and crystal structure of a small molecule inactivator bound to plasminogen activator inhibitor-1.
pubmed doi rcsb
source organism Homo sapiens
total genus 100
structure length 359
sequence length 376
chains with identical sequence B, C, D
ec nomenclature
pdb deposition date 2012-07-23

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00079 Serpin Serpin (serine protease inhibitor)
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.30.39.10 Mainly Beta Roll Alpha-1-antitrypsin; domain 1 Alpha-1-antitrypsin, domain 1 4g8oA02
3.30.497.10 Alpha Beta 2-Layer Sandwich Antithrombin; Chain I, domain 2 Antithrombin, subunit I, domain 2 4g8oA01
1C8OA 5C98A 1AZXI 2BEHI 1OYHI 2ARQA 2ARRA 2VH4A 4IC0A 1UHGA 2HIJI 1YXAA 3LW2A 1A7CA 1XQJA 7APIA 4AU3B 1DZGI 3CAAA 1JTIA 1QMNA 2ANTI 1JMJA 3NDDA 4R9IA 2PEEA 3B9FI 1BY7A 1ATUA 4BB2A 1MTPA 1F0CA 5EI0A 2XN3A 1JRRA 4RO9A 1B3KA 1BR8I 1OO8A 3DRUA 1K9OI 1QLPA 3UT3A 4DY7C 1SNGA 1DB2A 1DZHL 1M93B 4KDSA 1OVAB 5HGCA 1KCTA 2GD4C 2V95A 3F1SA 2D26A 1OPHA 2B4XL 5CE0A 1JMOA 2WXWA 1IMVA 2WXZC 2WY0C 1E03I 3EVJI 4RSQA 3T1PA 4EB1I 3F5NA 3DRMA 4AFXA 1QMBA 3DY0A 2VDXA 3FGQA 2HI9A 2BEHL 2ZV6A 1OYHL 3ZHAA 2WXXA 1OVAC 1LQ8A 2HIJL 4P0FA 1PSIA 1R1LI 1DZGL 3R4LA 2DUTA 4AU3A 1OC0A 1T1FA 3DLWA 4ROBA 2H4RA 1IZ2A 3NDFA 3Q02A 2WXYC 3NDAA 4ZK3A 1C5GA 2RIWA 1ATHA 3CVMA 1XQGA 1XU8A 4PYWA 2WXZA 8APIA 1AS4A 3KCGI 3F02A 2CEOA 1LJ5A 1SR5A 2WY1A 9APIA 4P0OA 1ANTI 4AJUA 2XN7A 2XN6A 3STOA 1D5SA 5CDZA 1OVAA 2RIVA 2H4PA 1E04I 1HP7A 3OZQA 2QUGA 4G8RA 4C49A 1LK6I 4X30A 2ZNHA 2OAYA 4EB1L 4Y3KA 1NQ9I 4AJTA 4AU4A 3CWLA 1TB6I 2H4QA 1JVQI 2XN5A 4ROAA 3H5CA 1WZ9A 4C41A 3VVJA 4AU2A 3PZFA 4DTEA 4ZK0A 5IO1A 1ATTA 3PB1I 3Q03A 4GA7A 1E05I 4Y40A 1DVMA 1HLEA 1DZHI 2VDYA 3NE4A 3LE2A 3EOXA 4AQHA 4DY0A 1EZXA 1SEKA 2PEFA 2OL2A 4YIAA 2B5TI 5INWA 5CDXA 9PAIA 2B4XI 1DVNA 1JJOC 4IF8A 2R9YA 2ACHA 5BRRI 4G8OA 4CAAA 3CWMA
chains in the Genus database with same CATH superfamily
1C8OA 5C98A 1AZXI 2BEHI 1OYHI 2ARQA 2ARRA 2VH4A 4IC0A 1UHGA 2HIJI 1YXAA 3LW2A 1A7CA 1XQJA 7APIA 4AU3B 1DZGI 3CAAA 1JTIA 1QMNA 2ANTI 1JMJA 3NDDA 4R9IA 2PEEA 3B9FI 1BY7A 1ATUA 4BB2A 1MTPA 1F0CA 5EI0A 2XN3A 1JRRA 4RO9A 1B3KA 1BR8I 1OO8A 3DRUA 1K9OI 1QLPA 3UT3A 4DY7C 1SNGA 1DB2A 1DZHL 1M93B 4KDSA 1OVAB 5HGCA 1KCTA 2GD4C 2V95A 3F1SA 2D26A 1OPHA 2B4XL 5CE0A 1JMOA 2WXWA 1IMVA 2WXZC 2WY0C 1E03I 3EVJI 4RSQA 3T1PA 4EB1I 3F5NA 3DRMA 4AFXA 1QMBA 3DY0A 2VDXA 3FGQA 2HI9A 2BEHL 2ZV6A 1OYHL 3ZHAA 2WXXA 1OVAC 1LQ8A 2HIJL 4P0FA 1PSIA 1R1LI 1DZGL 3R4LA 2DUTA 4AU3A 1OC0A 1T1FA 3DLWA 4ROBA 2H4RA 1IZ2A 3NDFA 3Q02A 2WXYC 3NDAA 4ZK3A 1C5GA 2RIWA 1ATHA 3CVMA 1XQGA 1XU8A 4PYWA 2WXZA 8APIA 1AS4A 3KCGI 3F02A 2CEOA 1LJ5A 1SR5A 2WY1A 9APIA 4P0OA 1ANTI 4AJUA 2XN7A 2XN6A 3STOA 1D5SA 5CDZA 1OVAA 2RIVA 2H4PA 1E04I 1HP7A 3OZQA 2QUGA 4G8RA 4C49A 1LK6I 4X30A 2ZNHA 2OAYA 4EB1L 4Y3KA 1NQ9I 4AJTA 4AU4A 3CWLA 1TB6I 2H4QA 1JVQI 2XN5A 4ROAA 3H5CA 1WZ9A 4C41A 3VVJA 4AU2A 3PZFA 4DTEA 4ZK0A 5IO1A 1ATTA 3PB1I 3Q03A 4GA7A 1E05I 4Y40A 1DVMA 1HLEA 1DZHI 2VDYA 3NE4A 3LE2A 3EOXA 4AQHA 4DY0A 1EZXA 1SEKA 2PEFA 2OL2A 4YIAA 2B5TI 5INWA 5CDXA 9PAIA 2B4XI 1DVNA 1JJOC 4IF8A 2R9YA 2ACHA 5BRRI 4G8OA 4CAAA 3CWMA
chains in the Genus database with same CATH topology
1C8OA 5C98A 1AZXI 2BEHI 1OYHI 2ARQA 2ARRA 2VH4A 4IC0A 1UHGA 2HIJI 1YXAA 3LW2A 1A7CA 1XQJA 7APIA 4AU3B 1DZGI 3CAAA 1JTIA 1QMNA 2ANTI 1JMJA 3NDDA 4R9IA 2PEEA 3B9FI 1BY7A 1ATUA 4BB2A 1MTPA 1F0CA 5EI0A 2XN3A 1JRRA 4RO9A 1B3KA 1BR8I 1OO8A 3DRUA 1K9OI 1QLPA 3UT3A 4DY7C 1SNGA 1DB2A 1DZHL 1M93B 4KDSA 1OVAB 5HGCA 1KCTA 2GD4C 2V95A 3F1SA 2D26A 1OPHA 2B4XL 5CE0A 1JMOA 2WXWA 1IMVA 2WXZC 2WY0C 1E03I 3EVJI 4RSQA 3T1PA 4EB1I 3F5NA 3DRMA 4AFXA 1QMBA 3DY0A 2VDXA 3FGQA 2HI9A 2BEHL 2ZV6A 1OYHL 3ZHAA 2WXXA 1OVAC 1LQ8A 2HIJL 4P0FA 1PSIA 1R1LI 1DZGL 3R4LA 2DUTA 4AU3A 1OC0A 1T1FA 3DLWA 4ROBA 2H4RA 1IZ2A 3NDFA 3Q02A 2WXYC 3NDAA 4ZK3A 1C5GA 2RIWA 1ATHA 3CVMA 1XQGA 1XU8A 4PYWA 2WXZA 8APIA 1AS4A 3KCGI 3F02A 2CEOA 1LJ5A 1SR5A 2WY1A 9APIA 4P0OA 1ANTI 4AJUA 2XN7A 2XN6A 3STOA 1D5SA 5CDZA 1OVAA 2RIVA 2H4PA 1E04I 1HP7A 3OZQA 2QUGA 4G8RA 4C49A 1LK6I 4X30A 2ZNHA 2OAYA 4EB1L 4Y3KA 1NQ9I 4AJTA 4AU4A 3CWLA 1TB6I 2H4QA 1JVQI 2XN5A 4ROAA 3H5CA 1WZ9A 4C41A 3VVJA 4AU2A 3PZFA 4DTEA 4ZK0A 5IO1A 1ATTA 3PB1I 3Q03A 4GA7A 1E05I 4Y40A 1DVMA 1HLEA 1DZHI 2VDYA 3NE4A 3LE2A 3EOXA 4AQHA 4DY0A 1EZXA 1SEKA 2PEFA 2OL2A 4YIAA 2B5TI 5INWA 5CDXA 9PAIA 2B4XI 1DVNA 1JJOC 4IF8A 2R9YA 2ACHA 5BRRI 4G8OA 4CAAA 3CWMA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1C8O A;  5C98 A;  1AZX I;  2BEH I;  1OYH I;  2ARQ A;  2ARR A;  2VH4 A;  4IC0 A;  1UHG A;  2HIJ I;  1YXA A;  3LW2 A;  1A7C A;  1XQJ A;  7API A;  4AU3 B;  1DZG I;  3CAA A;  1JTI A;  1QMN A;  2ANT I;  1JMJ A;  3NDD A;  4R9I A;  2PEE A;  3B9F I;  1BY7 A;  1ATU A;  4BB2 A;  1MTP A;  1F0C A;  5EI0 A;  2XN3 A;  1JRR A;  4RO9 A;  1B3K A;  1BR8 I;  1OO8 A;  3DRU A;  1K9O I;  1QLP A;  3UT3 A;  4DY7 C;  1SNG A;  1DB2 A;  1DZH L;  1M93 B;  4KDS A;  1OVA B;  5HGC A;  1KCT A;  2GD4 C;  2V95 A;  3F1S A;  2D26 A;  1OPH A;  2B4X L;  5CE0 A;  1JMO A;  2WXW A;  1IMV A;  2WXZ C;  2WY0 C;  1E03 I;  3EVJ I;  4RSQ A;  3T1P A;  4EB1 I;  3F5N A;  3DRM A;  4AFX A;  1QMB A;  3DY0 A;  2VDX A;  3FGQ A;  2HI9 A;  2BEH L;  2ZV6 A;  1OYH L;  3ZHA A;  2WXX A;  1OVA C;  1LQ8 A;  2HIJ L;  4P0F A;  1PSI A;  1R1L I;  1DZG L;  3R4L A;  2DUT A;  4AU3 A;  1OC0 A;  1T1F A;  3DLW A;  4ROB A;  2H4R A;  1IZ2 A;  3NDF A;  3Q02 A;  2WXY C;  3NDA A;  4ZK3 A;  1C5G A;  2RIW A;  1ATH A;  3CVM A;  1XQG A;  1XU8 A;  4PYW A;  2WXZ A;  8API A;  1AS4 A;  3KCG I;  3F02 A;  2CEO A;  1LJ5 A;  1SR5 A;  2WY1 A;  9API A;  4P0O A;  1ANT I;  4AJU A;  2XN7 A;  2XN6 A;  3STO A;  1D5S A;  5CDZ A;  1OVA A;  2RIV A;  2H4P A;  1E04 I;  1HP7 A;  3OZQ A;  2QUG A;  4G8R A;  4C49 A;  1LK6 I;  4X30 A;  2ZNH A;  2OAY A;  4EB1 L;  4Y3K A;  1NQ9 I;  4AJT A;  4AU4 A;  3CWL A;  1TB6 I;  2H4Q A;  1JVQ I;  2XN5 A;  4ROA A;  3H5C A;  1WZ9 A;  4C41 A;  3VVJ A;  4AU2 A;  3PZF A;  4DTE A;  4ZK0 A;  5IO1 A;  1ATT A;  3PB1 I;  3Q03 A;  4GA7 A;  1E05 I;  4Y40 A;  1DVM A;  1HLE A;  1DZH I;  2VDY A;  3NE4 A;  3LE2 A;  3EOX A;  4AQH A;  4DY0 A;  1EZX A;  1SEK A;  2PEF A;  2OL2 A;  4YIA A;  2B5T I;  5INW A;  5CDX A;  9PAI A;  2B4X I;  1DVN A;  1JJO C;  4IF8 A;  2R9Y A;  2ACH A;  5BRR I;  4G8O A;  4CAA A;  3CWM A; 
#chains in the Genus database with same CATH topology
 1C8O A;  5C98 A;  1AZX I;  2BEH I;  1OYH I;  2ARQ A;  2ARR A;  2VH4 A;  4IC0 A;  1UHG A;  2HIJ I;  1YXA A;  3LW2 A;  1A7C A;  1XQJ A;  7API A;  4AU3 B;  1DZG I;  3CAA A;  1JTI A;  1QMN A;  2ANT I;  1JMJ A;  3NDD A;  4R9I A;  2PEE A;  3B9F I;  1BY7 A;  1ATU A;  4BB2 A;  1MTP A;  1F0C A;  5EI0 A;  2XN3 A;  1JRR A;  4RO9 A;  1B3K A;  1BR8 I;  1OO8 A;  3DRU A;  1K9O I;  1QLP A;  3UT3 A;  4DY7 C;  1SNG A;  1DB2 A;  1DZH L;  1M93 B;  4KDS A;  1OVA B;  5HGC A;  1KCT A;  2GD4 C;  2V95 A;  3F1S A;  2D26 A;  1OPH A;  2B4X L;  5CE0 A;  1JMO A;  2WXW A;  1IMV A;  2WXZ C;  2WY0 C;  1E03 I;  3EVJ I;  4RSQ A;  3T1P A;  4EB1 I;  3F5N A;  3DRM A;  4AFX A;  1QMB A;  3DY0 A;  2VDX A;  3FGQ A;  2HI9 A;  2BEH L;  2ZV6 A;  1OYH L;  3ZHA A;  2WXX A;  1OVA C;  1LQ8 A;  2HIJ L;  4P0F A;  1PSI A;  1R1L I;  1DZG L;  3R4L A;  2DUT A;  4AU3 A;  1OC0 A;  1T1F A;  3DLW A;  4ROB A;  2H4R A;  1IZ2 A;  3NDF A;  3Q02 A;  2WXY C;  3NDA A;  4ZK3 A;  1C5G A;  2RIW A;  1ATH A;  3CVM A;  1XQG A;  1XU8 A;  4PYW A;  2WXZ A;  8API A;  1AS4 A;  3KCG I;  3F02 A;  2CEO A;  1LJ5 A;  1SR5 A;  2WY1 A;  9API A;  4P0O A;  1ANT I;  4AJU A;  2XN7 A;  2XN6 A;  3STO A;  1D5S A;  5CDZ A;  1OVA A;  2RIV A;  2H4P A;  1E04 I;  1HP7 A;  3OZQ A;  2QUG A;  4G8R A;  4C49 A;  1LK6 I;  4X30 A;  2ZNH A;  2OAY A;  4EB1 L;  4Y3K A;  1NQ9 I;  4AJT A;  4AU4 A;  3CWL A;  1TB6 I;  2H4Q A;  1JVQ I;  2XN5 A;  4ROA A;  3H5C A;  1WZ9 A;  4C41 A;  3VVJ A;  4AU2 A;  3PZF A;  4DTE A;  4ZK0 A;  5IO1 A;  1ATT A;  3PB1 I;  3Q03 A;  4GA7 A;  1E05 I;  4Y40 A;  1DVM A;  1HLE A;  1DZH I;  2VDY A;  3NE4 A;  3LE2 A;  3EOX A;  4AQH A;  4DY0 A;  1EZX A;  1SEK A;  2PEF A;  2OL2 A;  4YIA A;  2B5T I;  5INW A;  5CDX A;  9PAI A;  2B4X I;  1DVN A;  1JJO C;  4IF8 A;  2R9Y A;  2ACH A;  5BRR I;  4G8O A;  4CAA A;  3CWM A; 
#chains in the Genus database with same CATH homology
 1C8O A;  5C98 A;  1AZX I;  2BEH I;  1OYH I;  2ARQ A;  2ARR A;  2VH4 A;  4IC0 A;  1UHG A;  2HIJ I;  1YXA A;  3LW2 A;  1A7C A;  1XQJ A;  7API A;  4AU3 B;  1DZG I;  3CAA A;  1JTI A;  1QMN A;  2ANT I;  1JMJ A;  3NDD A;  4R9I A;  2PEE A;  3B9F I;  1BY7 A;  1ATU A;  4BB2 A;  1MTP A;  1F0C A;  5EI0 A;  2XN3 A;  1JRR A;  4RO9 A;  1B3K A;  1BR8 I;  1OO8 A;  3DRU A;  1K9O I;  1QLP A;  3UT3 A;  4DY7 C;  1SNG A;  1DB2 A;  1DZH L;  1M93 B;  4KDS A;  1OVA B;  5HGC A;  1KCT A;  2GD4 C;  2V95 A;  3F1S A;  2D26 A;  1OPH A;  2B4X L;  5CE0 A;  1JMO A;  2WXW A;  1IMV A;  2WXZ C;  2WY0 C;  1E03 I;  3EVJ I;  4RSQ A;  3T1P A;  4EB1 I;  3F5N A;  3DRM A;  4AFX A;  1QMB A;  3DY0 A;  2VDX A;  3FGQ A;  2HI9 A;  2BEH L;  2ZV6 A;  1OYH L;  3ZHA A;  2WXX A;  1OVA C;  1LQ8 A;  2HIJ L;  4P0F A;  1PSI A;  1R1L I;  1DZG L;  3R4L A;  2DUT A;  4AU3 A;  1OC0 A;  1T1F A;  3DLW A;  4ROB A;  2H4R A;  1IZ2 A;  3NDF A;  3Q02 A;  2WXY C;  3NDA A;  4ZK3 A;  1C5G A;  2RIW A;  1ATH A;  3CVM A;  1XQG A;  1XU8 A;  4PYW A;  2WXZ A;  8API A;  1AS4 A;  3KCG I;  3F02 A;  2CEO A;  1LJ5 A;  1SR5 A;  2WY1 A;  9API A;  4P0O A;  1ANT I;  4AJU A;  2XN7 A;  2XN6 A;  3STO A;  1D5S A;  5CDZ A;  1OVA A;  2RIV A;  2H4P A;  1E04 I;  1HP7 A;  3OZQ A;  2QUG A;  4G8R A;  4C49 A;  1LK6 I;  4X30 A;  2ZNH A;  2OAY A;  4EB1 L;  4Y3K A;  1NQ9 I;  4AJT A;  4AU4 A;  3CWL A;  1TB6 I;  2H4Q A;  1JVQ I;  2XN5 A;  4ROA A;  3H5C A;  1WZ9 A;  4C41 A;  3VVJ A;  4AU2 A;  3PZF A;  4DTE A;  4ZK0 A;  5IO1 A;  1ATT A;  3PB1 I;  3Q03 A;  4GA7 A;  1E05 I;  4Y40 A;  1DVM A;  1HLE A;  1DZH I;  2VDY A;  3NE4 A;  3LE2 A;  3EOX A;  4AQH A;  4DY0 A;  1EZX A;  1SEK A;  2PEF A;  2OL2 A;  4YIA A;  2B5T I;  5INW A;  5CDX A;  9PAI A;  2B4X I;  1DVN A;  1JJO C;  4IF8 A;  2R9Y A;  2ACH A;  5BRR I;  4G8O A;  4CAA A;  3CWM A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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