4G8RA

Crystal structure of a novel small molecule inactivator bound to plasminogen activator inhibitor-1
Total Genus 114
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
114
sequence length
374
structure length
357
Chain Sequence
SYVAHLASDFGVRVFQQVAQASKDRNVVFSPYGVASVLAMLQLTTGGETQQQIQAAMGFKIDDKGMAPALRHLYKELMGPWNKDEISTTDAIFVQRDLKLVQGFMPHFFRLFRSTVKQVDFSEVERARFIINDWVKTHTKGMISHLLGTGAVDQLTRLVLVNALYFNGQWKTPFPDSSTHRRLFHKSDGSTVSVPMMAQTNKFNYTEFTTPDGHYYDILELPYHGDTLSMFIAAPYEKEVPLSALTNILSAQLISHWKGNMTRLPRLLVLPKFSLETEVDLRKPLENLGMTDMFRQFQADFTSLSDQEPLHVALALQKVKIEVNESPEEIIIDRPFLFVVRHNPTGTVLFMGQVMEP
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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molecule tags Blood clotting/inhibitor
molecule keywords Plasminogen activator inhibitor-1
publication title Mechanistic characterization and crystal structure of a small molecule inactivator bound to plasminogen activator inhibitor-1.
pubmed doi rcsb
source organism Homo sapiens
total genus 114
structure length 357
sequence length 374
chains with identical sequence B
ec nomenclature
pdb deposition date 2012-07-23

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00079 Serpin Serpin (serine protease inhibitor)
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.30.39.10 Mainly Beta Roll Alpha-1-antitrypsin; domain 1 Alpha-1-antitrypsin, domain 1 4g8rA02
3.30.497.10 Alpha Beta 2-Layer Sandwich Antithrombin; Chain I, domain 2 Antithrombin, subunit I, domain 2 4g8rA01
1DZHL 4RO9A 2ACHA 4IF8A 1OVAB 1DB2A 2VDYA 3STOA 1NQ9I 3UT3A 3CWMA 1QLPA 1D5SA 1R1LI 4DTEA 2XN3A 5CDZA 4R9IA 4DY0A 2BEHL 1F0CA 1OPHA 4C41A 1SEKA 4CAAA 8APIA 4ZK3A 1OVAA 1DZHI 2DUTA 4G8RA 2V95A 4X30A 3F1SA 1ANTI 2ZNHA 1LK6I 2H4QA 5CE0A 2B4XL 2B5TI 2OAYA 1DVMA 4GA7A 1IZ2A 5INWA 4AU3A 1T1FA 2XN6A 3FGQA 4AJUA 1DVNA 1JMOA 3VVJA 4Y40A 1BR8I 4AQHA 1JRRA 2BEHI 2CEOA 3F5NA 1DZGI 1LQ8A 1HLEA 3EVJI 1ATUA 3NDDA 1HP7A 4G8OA 2VH4A 1WZ9A 5CDXA 2ARQA 1OYHI 4AU4A 4AU3B 5IO1A 1M93B 2B4XI 2GD4C 1DZGL 1XQJA 4IC0A 3Q02A 3F02A 1AS4A 3NDFA 2ZV6A 2WXZC 1OYHL 2D26A 3CWLA 1JJOC 4Y3KA 9PAIA 3DRMA 1SNGA 1E05I 2OL2A 4AFXA 1A7CA 2H4PA 4P0FA 2WXXA 1IMVA 3LE2A 1UHGA 5C98A 3CAAA 3DRUA 1JMJA 1OO8A 1LJ5A 3Q03A 5EI0A 1E04I 3KCGI 4RSQA 5HGCA 4DY7C 1PSIA 3H5CA 2RIWA 3OZQA 3ZHAA 2H4RA 2ANTI 2HIJL 4EB1L 1OVAC 4P0OA 5BRRI 1JVQI 4ROBA 1B3KA 2QUGA 3NDAA 3CVMA 3NE4A 1ATTA 2WY0C 4AJTA 1QMBA 1BY7A 1YXAA 2R9YA 3LW2A 1JTIA 4AU2A 4PYWA 1C5GA 4KDSA 1SR5A 4C49A 2PEFA 2WXWA 2ARRA 1K9OI 1QMNA 2HIJI 4EB1I 2WY1A 3DY0A 2XN5A 3PB1I 4YIAA 1OC0A 1TB6I 2VDXA 3DLWA 4ZK0A 1XU8A 1EZXA 1ATHA 1AZXI 1E03I 2WXZA 7APIA 9APIA 3R4LA 2XN7A 4ROAA 2PEEA 3B9FI 3EOXA 1C8OA 1XQGA 2HI9A 3PZFA 1MTPA 4BB2A 3T1PA 2WXYC 2RIVA 1KCTA
chains in the Genus database with same CATH superfamily
1DZHL 4RO9A 2ACHA 4IF8A 1OVAB 1DB2A 2VDYA 3STOA 1NQ9I 3UT3A 3CWMA 1QLPA 1D5SA 1R1LI 4DTEA 2XN3A 5CDZA 4R9IA 4DY0A 2BEHL 1F0CA 1OPHA 4C41A 1SEKA 4CAAA 8APIA 4ZK3A 1OVAA 1DZHI 2DUTA 4G8RA 2V95A 4X30A 3F1SA 1ANTI 2ZNHA 1LK6I 2H4QA 5CE0A 2B4XL 2B5TI 2OAYA 1DVMA 4GA7A 1IZ2A 5INWA 4AU3A 1T1FA 2XN6A 3FGQA 4AJUA 1DVNA 1JMOA 3VVJA 4Y40A 1BR8I 4AQHA 1JRRA 2BEHI 2CEOA 3F5NA 1DZGI 1LQ8A 1HLEA 3EVJI 1ATUA 3NDDA 1HP7A 4G8OA 2VH4A 1WZ9A 5CDXA 2ARQA 1OYHI 4AU4A 4AU3B 5IO1A 1M93B 2B4XI 2GD4C 1DZGL 1XQJA 4IC0A 3Q02A 3F02A 1AS4A 3NDFA 2ZV6A 2WXZC 1OYHL 2D26A 3CWLA 1JJOC 4Y3KA 9PAIA 3DRMA 1SNGA 1E05I 2OL2A 4AFXA 1A7CA 2H4PA 4P0FA 2WXXA 1IMVA 3LE2A 1UHGA 5C98A 3CAAA 3DRUA 1JMJA 1OO8A 1LJ5A 3Q03A 5EI0A 1E04I 3KCGI 4RSQA 5HGCA 4DY7C 1PSIA 3H5CA 2RIWA 3OZQA 3ZHAA 2H4RA 2ANTI 2HIJL 4EB1L 1OVAC 4P0OA 5BRRI 1JVQI 4ROBA 1B3KA 2QUGA 3NDAA 3CVMA 3NE4A 1ATTA 2WY0C 4AJTA 1QMBA 1BY7A 1YXAA 2R9YA 3LW2A 1JTIA 4AU2A 4PYWA 1C5GA 4KDSA 1SR5A 4C49A 2PEFA 2WXWA 2ARRA 1K9OI 1QMNA 2HIJI 4EB1I 2WY1A 3DY0A 2XN5A 3PB1I 4YIAA 1OC0A 1TB6I 2VDXA 3DLWA 4ZK0A 1XU8A 1EZXA 1ATHA 1AZXI 1E03I 2WXZA 7APIA 9APIA 3R4LA 2XN7A 4ROAA 2PEEA 3B9FI 3EOXA 1C8OA 1XQGA 2HI9A 3PZFA 1MTPA 4BB2A 3T1PA 2WXYC 2RIVA 1KCTA
chains in the Genus database with same CATH topology
1DZHL 4RO9A 2ACHA 4IF8A 1OVAB 1DB2A 2VDYA 3STOA 1NQ9I 3UT3A 3CWMA 1QLPA 1D5SA 1R1LI 4DTEA 2XN3A 5CDZA 4R9IA 4DY0A 2BEHL 1F0CA 1OPHA 4C41A 1SEKA 4CAAA 8APIA 4ZK3A 1OVAA 1DZHI 2DUTA 4G8RA 2V95A 4X30A 3F1SA 1ANTI 2ZNHA 1LK6I 2H4QA 5CE0A 2B4XL 2B5TI 2OAYA 1DVMA 4GA7A 1IZ2A 5INWA 4AU3A 1T1FA 2XN6A 3FGQA 4AJUA 1DVNA 1JMOA 3VVJA 4Y40A 1BR8I 4AQHA 1JRRA 2BEHI 2CEOA 3F5NA 1DZGI 1LQ8A 1HLEA 3EVJI 1ATUA 3NDDA 1HP7A 4G8OA 2VH4A 1WZ9A 5CDXA 2ARQA 1OYHI 4AU4A 4AU3B 5IO1A 1M93B 2B4XI 2GD4C 1DZGL 1XQJA 4IC0A 3Q02A 3F02A 1AS4A 3NDFA 2ZV6A 2WXZC 1OYHL 2D26A 3CWLA 1JJOC 4Y3KA 9PAIA 3DRMA 1SNGA 1E05I 2OL2A 4AFXA 1A7CA 2H4PA 4P0FA 2WXXA 1IMVA 3LE2A 1UHGA 5C98A 3CAAA 3DRUA 1JMJA 1OO8A 1LJ5A 3Q03A 5EI0A 1E04I 3KCGI 4RSQA 5HGCA 4DY7C 1PSIA 3H5CA 2RIWA 3OZQA 3ZHAA 2H4RA 2ANTI 2HIJL 4EB1L 1OVAC 4P0OA 5BRRI 1JVQI 4ROBA 1B3KA 2QUGA 3NDAA 3CVMA 3NE4A 1ATTA 2WY0C 4AJTA 1QMBA 1BY7A 1YXAA 2R9YA 3LW2A 1JTIA 4AU2A 4PYWA 1C5GA 4KDSA 1SR5A 4C49A 2PEFA 2WXWA 2ARRA 1K9OI 1QMNA 2HIJI 4EB1I 2WY1A 3DY0A 2XN5A 3PB1I 4YIAA 1OC0A 1TB6I 2VDXA 3DLWA 4ZK0A 1XU8A 1EZXA 1ATHA 1AZXI 1E03I 2WXZA 7APIA 9APIA 3R4LA 2XN7A 4ROAA 2PEEA 3B9FI 3EOXA 1C8OA 1XQGA 2HI9A 3PZFA 1MTPA 4BB2A 3T1PA 2WXYC 2RIVA 1KCTA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1DZH L;  4RO9 A;  2ACH A;  4IF8 A;  1OVA B;  1DB2 A;  2VDY A;  3STO A;  1NQ9 I;  3UT3 A;  3CWM A;  1QLP A;  1D5S A;  1R1L I;  4DTE A;  2XN3 A;  5CDZ A;  4R9I A;  4DY0 A;  2BEH L;  1F0C A;  1OPH A;  4C41 A;  1SEK A;  4CAA A;  8API A;  4ZK3 A;  1OVA A;  1DZH I;  2DUT A;  4G8R A;  2V95 A;  4X30 A;  3F1S A;  1ANT I;  2ZNH A;  1LK6 I;  2H4Q A;  5CE0 A;  2B4X L;  2B5T I;  2OAY A;  1DVM A;  4GA7 A;  1IZ2 A;  5INW A;  4AU3 A;  1T1F A;  2XN6 A;  3FGQ A;  4AJU A;  1DVN A;  1JMO A;  3VVJ A;  4Y40 A;  1BR8 I;  4AQH A;  1JRR A;  2BEH I;  2CEO A;  3F5N A;  1DZG I;  1LQ8 A;  1HLE A;  3EVJ I;  1ATU A;  3NDD A;  1HP7 A;  4G8O A;  2VH4 A;  1WZ9 A;  5CDX A;  2ARQ A;  1OYH I;  4AU4 A;  4AU3 B;  5IO1 A;  1M93 B;  2B4X I;  2GD4 C;  1DZG L;  1XQJ A;  4IC0 A;  3Q02 A;  3F02 A;  1AS4 A;  3NDF A;  2ZV6 A;  2WXZ C;  1OYH L;  2D26 A;  3CWL A;  1JJO C;  4Y3K A;  9PAI A;  3DRM A;  1SNG A;  1E05 I;  2OL2 A;  4AFX A;  1A7C A;  2H4P A;  4P0F A;  2WXX A;  1IMV A;  3LE2 A;  1UHG A;  5C98 A;  3CAA A;  3DRU A;  1JMJ A;  1OO8 A;  1LJ5 A;  3Q03 A;  5EI0 A;  1E04 I;  3KCG I;  4RSQ A;  5HGC A;  4DY7 C;  1PSI A;  3H5C A;  2RIW A;  3OZQ A;  3ZHA A;  2H4R A;  2ANT I;  2HIJ L;  4EB1 L;  1OVA C;  4P0O A;  5BRR I;  1JVQ I;  4ROB A;  1B3K A;  2QUG A;  3NDA A;  3CVM A;  3NE4 A;  1ATT A;  2WY0 C;  4AJT A;  1QMB A;  1BY7 A;  1YXA A;  2R9Y A;  3LW2 A;  1JTI A;  4AU2 A;  4PYW A;  1C5G A;  4KDS A;  1SR5 A;  4C49 A;  2PEF A;  2WXW A;  2ARR A;  1K9O I;  1QMN A;  2HIJ I;  4EB1 I;  2WY1 A;  3DY0 A;  2XN5 A;  3PB1 I;  4YIA A;  1OC0 A;  1TB6 I;  2VDX A;  3DLW A;  4ZK0 A;  1XU8 A;  1EZX A;  1ATH A;  1AZX I;  1E03 I;  2WXZ A;  7API A;  9API A;  3R4L A;  2XN7 A;  4ROA A;  2PEE A;  3B9F I;  3EOX A;  1C8O A;  1XQG A;  2HI9 A;  3PZF A;  1MTP A;  4BB2 A;  3T1P A;  2WXY C;  2RIV A;  1KCT A; 
#chains in the Genus database with same CATH topology
 1DZH L;  4RO9 A;  2ACH A;  4IF8 A;  1OVA B;  1DB2 A;  2VDY A;  3STO A;  1NQ9 I;  3UT3 A;  3CWM A;  1QLP A;  1D5S A;  1R1L I;  4DTE A;  2XN3 A;  5CDZ A;  4R9I A;  4DY0 A;  2BEH L;  1F0C A;  1OPH A;  4C41 A;  1SEK A;  4CAA A;  8API A;  4ZK3 A;  1OVA A;  1DZH I;  2DUT A;  4G8R A;  2V95 A;  4X30 A;  3F1S A;  1ANT I;  2ZNH A;  1LK6 I;  2H4Q A;  5CE0 A;  2B4X L;  2B5T I;  2OAY A;  1DVM A;  4GA7 A;  1IZ2 A;  5INW A;  4AU3 A;  1T1F A;  2XN6 A;  3FGQ A;  4AJU A;  1DVN A;  1JMO A;  3VVJ A;  4Y40 A;  1BR8 I;  4AQH A;  1JRR A;  2BEH I;  2CEO A;  3F5N A;  1DZG I;  1LQ8 A;  1HLE A;  3EVJ I;  1ATU A;  3NDD A;  1HP7 A;  4G8O A;  2VH4 A;  1WZ9 A;  5CDX A;  2ARQ A;  1OYH I;  4AU4 A;  4AU3 B;  5IO1 A;  1M93 B;  2B4X I;  2GD4 C;  1DZG L;  1XQJ A;  4IC0 A;  3Q02 A;  3F02 A;  1AS4 A;  3NDF A;  2ZV6 A;  2WXZ C;  1OYH L;  2D26 A;  3CWL A;  1JJO C;  4Y3K A;  9PAI A;  3DRM A;  1SNG A;  1E05 I;  2OL2 A;  4AFX A;  1A7C A;  2H4P A;  4P0F A;  2WXX A;  1IMV A;  3LE2 A;  1UHG A;  5C98 A;  3CAA A;  3DRU A;  1JMJ A;  1OO8 A;  1LJ5 A;  3Q03 A;  5EI0 A;  1E04 I;  3KCG I;  4RSQ A;  5HGC A;  4DY7 C;  1PSI A;  3H5C A;  2RIW A;  3OZQ A;  3ZHA A;  2H4R A;  2ANT I;  2HIJ L;  4EB1 L;  1OVA C;  4P0O A;  5BRR I;  1JVQ I;  4ROB A;  1B3K A;  2QUG A;  3NDA A;  3CVM A;  3NE4 A;  1ATT A;  2WY0 C;  4AJT A;  1QMB A;  1BY7 A;  1YXA A;  2R9Y A;  3LW2 A;  1JTI A;  4AU2 A;  4PYW A;  1C5G A;  4KDS A;  1SR5 A;  4C49 A;  2PEF A;  2WXW A;  2ARR A;  1K9O I;  1QMN A;  2HIJ I;  4EB1 I;  2WY1 A;  3DY0 A;  2XN5 A;  3PB1 I;  4YIA A;  1OC0 A;  1TB6 I;  2VDX A;  3DLW A;  4ZK0 A;  1XU8 A;  1EZX A;  1ATH A;  1AZX I;  1E03 I;  2WXZ A;  7API A;  9API A;  3R4L A;  2XN7 A;  4ROA A;  2PEE A;  3B9F I;  3EOX A;  1C8O A;  1XQG A;  2HI9 A;  3PZF A;  1MTP A;  4BB2 A;  3T1P A;  2WXY C;  2RIV A;  1KCT A; 
#chains in the Genus database with same CATH homology
 1DZH L;  4RO9 A;  2ACH A;  4IF8 A;  1OVA B;  1DB2 A;  2VDY A;  3STO A;  1NQ9 I;  3UT3 A;  3CWM A;  1QLP A;  1D5S A;  1R1L I;  4DTE A;  2XN3 A;  5CDZ A;  4R9I A;  4DY0 A;  2BEH L;  1F0C A;  1OPH A;  4C41 A;  1SEK A;  4CAA A;  8API A;  4ZK3 A;  1OVA A;  1DZH I;  2DUT A;  4G8R A;  2V95 A;  4X30 A;  3F1S A;  1ANT I;  2ZNH A;  1LK6 I;  2H4Q A;  5CE0 A;  2B4X L;  2B5T I;  2OAY A;  1DVM A;  4GA7 A;  1IZ2 A;  5INW A;  4AU3 A;  1T1F A;  2XN6 A;  3FGQ A;  4AJU A;  1DVN A;  1JMO A;  3VVJ A;  4Y40 A;  1BR8 I;  4AQH A;  1JRR A;  2BEH I;  2CEO A;  3F5N A;  1DZG I;  1LQ8 A;  1HLE A;  3EVJ I;  1ATU A;  3NDD A;  1HP7 A;  4G8O A;  2VH4 A;  1WZ9 A;  5CDX A;  2ARQ A;  1OYH I;  4AU4 A;  4AU3 B;  5IO1 A;  1M93 B;  2B4X I;  2GD4 C;  1DZG L;  1XQJ A;  4IC0 A;  3Q02 A;  3F02 A;  1AS4 A;  3NDF A;  2ZV6 A;  2WXZ C;  1OYH L;  2D26 A;  3CWL A;  1JJO C;  4Y3K A;  9PAI A;  3DRM A;  1SNG A;  1E05 I;  2OL2 A;  4AFX A;  1A7C A;  2H4P A;  4P0F A;  2WXX A;  1IMV A;  3LE2 A;  1UHG A;  5C98 A;  3CAA A;  3DRU A;  1JMJ A;  1OO8 A;  1LJ5 A;  3Q03 A;  5EI0 A;  1E04 I;  3KCG I;  4RSQ A;  5HGC A;  4DY7 C;  1PSI A;  3H5C A;  2RIW A;  3OZQ A;  3ZHA A;  2H4R A;  2ANT I;  2HIJ L;  4EB1 L;  1OVA C;  4P0O A;  5BRR I;  1JVQ I;  4ROB A;  1B3K A;  2QUG A;  3NDA A;  3CVM A;  3NE4 A;  1ATT A;  2WY0 C;  4AJT A;  1QMB A;  1BY7 A;  1YXA A;  2R9Y A;  3LW2 A;  1JTI A;  4AU2 A;  4PYW A;  1C5G A;  4KDS A;  1SR5 A;  4C49 A;  2PEF A;  2WXW A;  2ARR A;  1K9O I;  1QMN A;  2HIJ I;  4EB1 I;  2WY1 A;  3DY0 A;  2XN5 A;  3PB1 I;  4YIA A;  1OC0 A;  1TB6 I;  2VDX A;  3DLW A;  4ZK0 A;  1XU8 A;  1EZX A;  1ATH A;  1AZX I;  1E03 I;  2WXZ A;  7API A;  9API A;  3R4L A;  2XN7 A;  4ROA A;  2PEE A;  3B9F I;  3EOX A;  1C8O A;  1XQG A;  2HI9 A;  3PZF A;  1MTP A;  4BB2 A;  3T1P A;  2WXY C;  2RIV A;  1KCT A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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