4HWWA

Crystal structure of human arginase-1 complexed with inhibitor 9
Total Genus 119
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
119
sequence length
314
structure length
314
Chain Sequence
SRTIGIIGAPFSKGQPRGGVEEGPTVLRKAGLLEKLKEQECDVKDYGDLPFADIPNDSPFQIVKNPRSVGKASEQLAGKVAEVKKNGRISLVLGGDHSLAIGSISGHARVHPDLGVIWVDAHTDINTPLTTTSGNLHGQPVSFLLKELKGKIPDVPGFSWVTPCISAKDIVYIGLRDVDPGEHYILKTLGIKYFSMTEVDRLGIGKVMEETLSYLLGRKKRPIHLSFDVDGLDPSFTPATGTPVVGGLTYREGLYITEEIYKTGLLSGLDIMEVNPSLGKTPEEVTRTVNTAVAITLACFGLAREGNHKPIDYL
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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molecule tags Hydrolase/hydrolase inhibitor
molecule keywords Arginase-1
publication title Discovery of (R)-2-Amino-6-borono-2-(2-(piperidin-1-yl)ethyl)hexanoic Acid and Congeners As Highly Potent Inhibitors of Human Arginases I and II for Treatment of Myocardial Reperfusion Injury.
pubmed doi rcsb
source organism Homo sapiens
total genus 119
structure length 314
sequence length 314
chains with identical sequence B
ec nomenclature ec 3.5.3.1: Arginase.
pdb deposition date 2012-11-09

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00491 Arginase Arginase family
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.800.10 Alpha Beta 3-Layer(aba) Sandwich Arginase; Chain A Ureohydrolase domain 4hwwA00
4MYLA 3SL1A 2AEBA 4I06A 3SL0A 1CEVA 4IE3A 1ZPGA 3NIOA 1TBJA 1GQ6A 3E8QA 1P8QA 3F80A 1GQ7A 4DZ4A 1T5GA 3THHA 4RHKA 4CEVA 1T4RA 4Q41A 4MXRA 3KV2A 4Q3QA 1XFKA 1WOHA 1R1OA 1P8RA 4IU1A 3NIQA 3MJLA 1ZPEA 1P8NA 4G3HA 1TA1A 3MMRA 4Q3PA 4RHJA 1RLAA 4MYKA 3E9BA 2EIVA 4Q3VA 3LHLA 5HJ9A 4IE1A 5RLAA 3RLAA 4GSZA 4FCKA 1WVAA 1T4SA 4Q3SA 1P8SA 1HQ5A 4Q42A 4RHLA 4Q3TA 1TBLA 4IXVA 4ITYA 1WOIA 4RHQA 5HJAA 3PZLA 3CEVA 3DJ8A 5CEVA 2PHOA 4GSVA 3GMZA 3GN0A 1P8OA 2RLAA 4HZEA 4HXQA 2EF4A 1TBHA 4GSMA 1T4TA 1T4PA 4MYNA 4HWWA 2PHAA 1WVBA 4IU0A 4RHIA 3TH7A 2EF5A 4Q3UA 3SKKA 1WOGA 4RLAA 1P8PA 3E6VA 2ZAVA 1D3VA 1HQHA 3THJA 2CEVA 1HQFA 3LP7A 3TF3A 3THEA 4Q3RA 2PLLA 1T5FA 4MYFA 3LP4A 3MFVA 3SJTA 4IXUA 4Q3RC 3E6KA 1P8MA 3NIPA 3E8ZA 4Q40A 4GWCA 3MFWA 4IU4A 4RHMA 1PQ3A 4GWDA 4IE2A 4FCIA 3M1RA 1HQXA 1HQGA 2A0MA 4IU5A
chains in the Genus database with same CATH superfamily
4MYLA 4QA3A 3SL1A 2AEBA 4QA6A 4I06A 5EFJD 1T64A 3SL0A 5A2SA 1CEVA 4IE3A 5DC7A 1ZPGA 4A69A 5EEIA 4CBTA 3NIOA 5LI3A 4RN2A 1TBJA 5THVA 1GQ6A 4CQFA 3E8QA 1P8QA 5G0JA 3F80A 1GQ7A 3ZNRA 1C3SA 4DZ4A 1T5GA 3THHA 3MENA 4QA5A 4ZUOA 4RHKA 4CEVA 1T4RA 3F0RA 4Q41A 4MXRA 3KV2A 4Q3QA 4BZ8A 1XFKA 5G13A 3EWFA 2VQVA 2VQWG 3MZ6A 1WOHA 1R1OA 1P8RA 4IU1A 3Q9EA 5JI5A 3NIQA 5EEMA 3MJLA 1ZPEA 1P8NA 4G3HA 1TA1A 3MMRA 4Q3PA 3C0YA 3SFFA 4RHJA 5ICNB 1RLAA 4MYKA 5IX0A 3E9BA 1ZZ1A 2EIVA 4Q3VA 3LHLA 5HJ9A 3EW8A 3MZ7A 4IE1A 2VQJA 5RLAA 3RLAA 5EENA 4GSZA 5EF7A 4FCKA 5G12A 1WVAA 1T4SA 4Q3SA 1W22A 5EFBD 2VQQA 1P8SA 1HQ5A 4ZUMA 1C3RA 4Q42A 5G10A 4RHLA 4Q3TA 5G1AA 4BKXB 1TBLA 4IXVA 5THSA 3MZ3A 4LXZA 5G0XA 4ZUQA 4ITYA 4BZ5A 1WOIA 4RHQA 5HJAA 3PZLA 3EZTA 3CEVA 4QA4A 4RN0A 3DJ8A 5EEFA 5G0IA 5CEVA 2PHOA 2VQOA 4GSVA 4QA0A 5DC8A 5THUA 4QA2A 3GMZA 5D1BA 2V5XA 5G1BA 3F07A 3GN0A 1P8OA 2RLAA 4BZ6A 3Q9CA 4BZ9A 4HZEA 4HXQA 5EEKA 3C10A 5DC6A 3MZ4A 2EF4A 3EZPA 1TBHA 4GSMA 1T4TA 1T4PA 5BWZA 4MYNA 4HWWA 2PHAA 1WVBA 3F06A 4IU0A 4RHIA 2EF5A 3TH7A 3ZNSA 5EFHA 5G11A 4Q3UA 2V5WA 1T67A 3SKKA 5IWGA 1WOGA 4RLAA 1HQGA 1P8PA 4ZURA 3E6VA 5G17A 2ZAVA 3RQDA 4BZ7A 1D3VA 1HQHA 5G1CA 3THJA 5G0HA 2CEVA 1HQFA 3LP7A 3SFHA 5FUEA 5THTA 4RN1A 3TF3A 3C0ZA 4ZUNA 4ZUPA 3THEA 4Q3RA 1ZZ0A 2PLLA 1T5FA 4MYFA 5G0GA 5FCWA 5G0YA 3Q9FA 3MAXA 3LP4A 5EFKB 4LY1A 5D1DA 1C3PA 5D1CA 3MFVA 5G3WA 4IXUA 5EFNA 3SJTA 5EF8A 4Q3RC 3Q9BA 3E6KA 1P8MA 2VCGA 3NIPA 3E8ZA 2VQMA 4Q40A 4GWCA 4QA1A 3MFWA 4IU4A 4QA7A 4RHMA 1VKGA 5DC5A 1PQ3A 4GWDA 5EFGA 4IE2A 4CBYA 1T69A 4FCIA 3M1RA 1HQXA 1ZZ3A 2GH6A 2A0MA 4IU5A
chains in the Genus database with same CATH topology
4MYLA 3SL1A 2AEBA 4I06A 3SL0A 1CEVA 4IE3A 1ZPGA 3NIOA 1TBJA 1GQ6A 3E8QA 1P8QA 3F80A 1GQ7A 4DZ4A 1T5GA 3THHA 4RHKA 4CEVA 1T4RA 4Q41A 4MXRA 3KV2A 4Q3QA 1XFKA 1WOHA 1R1OA 1P8RA 4IU1A 3NIQA 3MJLA 1ZPEA 1P8NA 4G3HA 1TA1A 3MMRA 4Q3PA 4RHJA 1RLAA 4MYKA 3E9BA 2EIVA 4Q3VA 3LHLA 5HJ9A 4IE1A 5RLAA 3RLAA 4GSZA 4FCKA 1WVAA 1T4SA 4Q3SA 1P8SA 1HQ5A 4Q42A 4RHLA 4Q3TA 1TBLA 4IXVA 4ITYA 1WOIA 4RHQA 5HJAA 3PZLA 3CEVA 3DJ8A 5CEVA 2PHOA 4GSVA 3GMZA 3GN0A 1P8OA 2RLAA 4HZEA 4HXQA 2EF4A 1TBHA 4GSMA 1T4TA 1T4PA 4MYNA 4HWWA 2PHAA 1WVBA 4IU0A 4RHIA 3TH7A 2EF5A 4Q3UA 3SKKA 1WOGA 4RLAA 1P8PA 3E6VA 2ZAVA 1D3VA 1HQHA 3THJA 2CEVA 1HQFA 3LP7A 3TF3A 3THEA 4Q3RA 2PLLA 1T5FA 4MYFA 3LP4A 3MFVA 3SJTA 4IXUA 4Q3RC 3E6KA 1P8MA 3NIPA 3E8ZA 4Q40A 4GWCA 3MFWA 4IU4A 4RHMA 1PQ3A 4GWDA 4IE2A 4FCIA 3M1RA 1HQXA 1HQGA 2A0MA 4IU5A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4MYL A;  3SL1 A;  2AEB A;  4I06 A;  3SL0 A;  1CEV A;  4IE3 A;  1ZPG A;  3NIO A;  1TBJ A;  1GQ6 A;  3E8Q A;  1P8Q A;  3F80 A;  1GQ7 A;  4DZ4 A;  1T5G A;  3THH A;  4RHK A;  4CEV A;  1T4R A;  4Q41 A;  4MXR A;  3KV2 A;  4Q3Q A;  1XFK A;  1WOH A;  1R1O A;  1P8R A;  4IU1 A;  3NIQ A;  3MJL A;  1ZPE A;  1P8N A;  4G3H A;  1TA1 A;  3MMR A;  4Q3P A;  4RHJ A;  1RLA A;  4MYK A;  3E9B A;  2EIV A;  4Q3V A;  3LHL A;  5HJ9 A;  4IE1 A;  5RLA A;  3RLA A;  4GSZ A;  4FCK A;  1WVA A;  1T4S A;  4Q3S A;  1P8S A;  1HQ5 A;  4Q42 A;  4RHL A;  4Q3T A;  1TBL A;  4IXV A;  4ITY A;  1WOI A;  4RHQ A;  5HJA A;  3PZL A;  3CEV A;  3DJ8 A;  5CEV A;  2PHO A;  4GSV A;  3GMZ A;  3GN0 A;  1P8O A;  2RLA A;  4HZE A;  4HXQ A;  2EF4 A;  1TBH A;  4GSM A;  1T4T A;  1T4P A;  4MYN A;  4HWW A;  2PHA A;  1WVB A;  4IU0 A;  4RHI A;  3TH7 A;  2EF5 A;  4Q3U A;  3SKK A;  1WOG A;  4RLA A;  1P8P A;  3E6V A;  2ZAV A;  1D3V A;  1HQH A;  3THJ A;  2CEV A;  1HQF A;  3LP7 A;  3TF3 A;  3THE A;  4Q3R A;  2PLL A;  1T5F A;  4MYF A;  3LP4 A;  3MFV A;  3SJT A;  4IXU A;  4Q3R C;  3E6K A;  1P8M A;  3NIP A;  3E8Z A;  4Q40 A;  4GWC A;  3MFW A;  4IU4 A;  4RHM A;  1PQ3 A;  4GWD A;  4IE2 A;  4FCI A;  3M1R A;  1HQX A;  1HQG A;  2A0M A;  4IU5 A; 
#chains in the Genus database with same CATH topology
 4MYL A;  4QA3 A;  3SL1 A;  2AEB A;  4QA6 A;  4I06 A;  5EFJ D;  1T64 A;  3SL0 A;  5A2S A;  1CEV A;  4IE3 A;  5DC7 A;  1ZPG A;  4A69 A;  5EEI A;  4CBT A;  3NIO A;  5LI3 A;  4RN2 A;  1TBJ A;  5THV A;  1GQ6 A;  4CQF A;  3E8Q A;  1P8Q A;  5G0J A;  3F80 A;  1GQ7 A;  3ZNR A;  1C3S A;  4DZ4 A;  1T5G A;  3THH A;  3MEN A;  4QA5 A;  4ZUO A;  4RHK A;  4CEV A;  1T4R A;  3F0R A;  4Q41 A;  4MXR A;  3KV2 A;  4Q3Q A;  4BZ8 A;  1XFK A;  5G13 A;  3EWF A;  2VQV A;  2VQW G;  3MZ6 A;  1WOH A;  1R1O A;  1P8R A;  4IU1 A;  3Q9E A;  5JI5 A;  3NIQ A;  5EEM A;  3MJL A;  1ZPE A;  1P8N A;  4G3H A;  1TA1 A;  3MMR A;  4Q3P A;  3C0Y A;  3SFF A;  4RHJ A;  5ICN B;  1RLA A;  4MYK A;  5IX0 A;  3E9B A;  1ZZ1 A;  2EIV A;  4Q3V A;  3LHL A;  5HJ9 A;  3EW8 A;  3MZ7 A;  4IE1 A;  2VQJ A;  5RLA A;  3RLA A;  5EEN A;  4GSZ A;  5EF7 A;  4FCK A;  5G12 A;  1WVA A;  1T4S A;  4Q3S A;  1W22 A;  5EFB D;  2VQQ A;  1P8S A;  1HQ5 A;  4ZUM A;  1C3R A;  4Q42 A;  5G10 A;  4RHL A;  4Q3T A;  5G1A A;  4BKX B;  1TBL A;  4IXV A;  5THS A;  3MZ3 A;  4LXZ A;  5G0X A;  4ZUQ A;  4ITY A;  4BZ5 A;  1WOI A;  4RHQ A;  5HJA A;  3PZL A;  3EZT A;  3CEV A;  4QA4 A;  4RN0 A;  3DJ8 A;  5EEF A;  5G0I A;  5CEV A;  2PHO A;  2VQO A;  4GSV A;  4QA0 A;  5DC8 A;  5THU A;  4QA2 A;  3GMZ A;  5D1B A;  2V5X A;  5G1B A;  3F07 A;  3GN0 A;  1P8O A;  2RLA A;  4BZ6 A;  3Q9C A;  4BZ9 A;  4HZE A;  4HXQ A;  5EEK A;  3C10 A;  5DC6 A;  3MZ4 A;  2EF4 A;  3EZP A;  1TBH A;  4GSM A;  1T4T A;  1T4P A;  5BWZ A;  4MYN A;  4HWW A;  2PHA A;  1WVB A;  3F06 A;  4IU0 A;  4RHI A;  2EF5 A;  3TH7 A;  3ZNS A;  5EFH A;  5G11 A;  4Q3U A;  2V5W A;  1T67 A;  3SKK A;  5IWG A;  1WOG A;  4RLA A;  1HQG A;  1P8P A;  4ZUR A;  3E6V A;  5G17 A;  2ZAV A;  3RQD A;  4BZ7 A;  1D3V A;  1HQH A;  5G1C A;  3THJ A;  5G0H A;  2CEV A;  1HQF A;  3LP7 A;  3SFH A;  5FUE A;  5THT A;  4RN1 A;  3TF3 A;  3C0Z A;  4ZUN A;  4ZUP A;  3THE A;  4Q3R A;  1ZZ0 A;  2PLL A;  1T5F A;  4MYF A;  5G0G A;  5FCW A;  5G0Y A;  3Q9F A;  3MAX A;  3LP4 A;  5EFK B;  4LY1 A;  5D1D A;  1C3P A;  5D1C A;  3MFV A;  5G3W A;  4IXU A;  5EFN A;  3SJT A;  5EF8 A;  4Q3R C;  3Q9B A;  3E6K A;  1P8M A;  2VCG A;  3NIP A;  3E8Z A;  2VQM A;  4Q40 A;  4GWC A;  4QA1 A;  3MFW A;  4IU4 A;  4QA7 A;  4RHM A;  1VKG A;  5DC5 A;  1PQ3 A;  4GWD A;  5EFG A;  4IE2 A;  4CBY A;  1T69 A;  4FCI A;  3M1R A;  1HQX A;  1ZZ3 A;  2GH6 A;  2A0M A;  4IU5 A; 
#chains in the Genus database with same CATH homology
 4MYL A;  3SL1 A;  2AEB A;  4I06 A;  3SL0 A;  1CEV A;  4IE3 A;  1ZPG A;  3NIO A;  1TBJ A;  1GQ6 A;  3E8Q A;  1P8Q A;  3F80 A;  1GQ7 A;  4DZ4 A;  1T5G A;  3THH A;  4RHK A;  4CEV A;  1T4R A;  4Q41 A;  4MXR A;  3KV2 A;  4Q3Q A;  1XFK A;  1WOH A;  1R1O A;  1P8R A;  4IU1 A;  3NIQ A;  3MJL A;  1ZPE A;  1P8N A;  4G3H A;  1TA1 A;  3MMR A;  4Q3P A;  4RHJ A;  1RLA A;  4MYK A;  3E9B A;  2EIV A;  4Q3V A;  3LHL A;  5HJ9 A;  4IE1 A;  5RLA A;  3RLA A;  4GSZ A;  4FCK A;  1WVA A;  1T4S A;  4Q3S A;  1P8S A;  1HQ5 A;  4Q42 A;  4RHL A;  4Q3T A;  1TBL A;  4IXV A;  4ITY A;  1WOI A;  4RHQ A;  5HJA A;  3PZL A;  3CEV A;  3DJ8 A;  5CEV A;  2PHO A;  4GSV A;  3GMZ A;  3GN0 A;  1P8O A;  2RLA A;  4HZE A;  4HXQ A;  2EF4 A;  1TBH A;  4GSM A;  1T4T A;  1T4P A;  4MYN A;  4HWW A;  2PHA A;  1WVB A;  4IU0 A;  4RHI A;  3TH7 A;  2EF5 A;  4Q3U A;  3SKK A;  1WOG A;  4RLA A;  1P8P A;  3E6V A;  2ZAV A;  1D3V A;  1HQH A;  3THJ A;  2CEV A;  1HQF A;  3LP7 A;  3TF3 A;  3THE A;  4Q3R A;  2PLL A;  1T5F A;  4MYF A;  3LP4 A;  3MFV A;  3SJT A;  4IXU A;  4Q3R C;  3E6K A;  1P8M A;  3NIP A;  3E8Z A;  4Q40 A;  4GWC A;  3MFW A;  4IU4 A;  4RHM A;  1PQ3 A;  4GWD A;  4IE2 A;  4FCI A;  3M1R A;  1HQX A;  1HQG A;  2A0M A;  4IU5 A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
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