4HXQA

Crystal structure of human arginase-1 complexed with inhibitor 14
Total Genus 118
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
118
sequence length
314
structure length
314
Chain Sequence
SRTIGIIGAPFSKGQPRGGVEEGPTVLRKAGLLEKLKEQECDVKDYGDLPFADIPNDSPFQIVKNPRSVGKASEQLAGKVAEVKKNGRISLVLGGDHSLAIGSISGHARVHPDLGVIWVDAHTDINTPLTTTSGNLHGQPVSFLLKELKGKIPDVPGFSWVTPCISAKDIVYIGLRDVDPGEHYILKTLGIKYFSMTEVDRLGIGKVMEETLSYLLGRKKRPIHLSFDVDGLDPSFTPATGTPVVGGLTYREGLYITEEIYKTGLLSGLDIMEVNPSLGKTPEEVTRTVNTAVAITLACFGLAREGNHKPIDYL
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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molecule tags Hydrolase/hydrolase inhibitor
molecule keywords Arginase-1
publication title Discovery of (R)-2-Amino-6-borono-2-(2-(piperidin-1-yl)ethyl)hexanoic Acid and Congeners As Highly Potent Inhibitors of Human Arginases I and II for Treatment of Myocardial Reperfusion Injury.
pubmed doi rcsb
source organism Homo sapiens
total genus 118
structure length 314
sequence length 314
chains with identical sequence B
ec nomenclature ec 3.5.3.1: Arginase.
pdb deposition date 2012-11-12

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00491 Arginase Arginase family
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.800.10 Alpha Beta 3-Layer(aba) Sandwich Arginase; Chain A Ureohydrolase domain 4hxqA00
2A0MA 3SL0A 3THHA 3E8QA 3TF3A 1P8QA 1P8SA 4CEVA 1R1OA 3NIPA 1P8PA 5RLAA 3M1RA 5CEVA 4FCKA 3LHLA 1WOHA 1GQ7A 4RLAA 4DZ4A 4Q41A 1GQ6A 1TBHA 4Q3TA 2CEVA 4Q3PA 4G3HA 3NIOA 3NIQA 4Q3SA 4HXQA 3E9BA 1HQHA 3LP4A 4HWWA 1T4TA 2EF4A 2EIVA 4RHLA 4IU0A 1WVAA 1XFKA 3MMRA 3GN0A 3MFVA 3E6KA 1TA1A 4GWDA 1HQXA 2ZAVA 3E6VA 4RHJA 4IXVA 4I06A 3SKKA 3KV2A 4IU5A 1P8RA 3SJTA 3GMZA 4MYLA 2AEBA 1T5FA 4MYNA 4RHKA 1WOGA 4RHIA 5HJ9A 1ZPEA 4MYKA 2EF5A 1CEVA 1P8OA 4Q3UA 2PHAA 4Q42A 4Q3QA 3E8ZA 5HJAA 4GSMA 3THEA 2PLLA 4IXUA 4IE3A 3MJLA 4IE2A 4GWCA 4Q3RC 4MYFA 1WOIA 1PQ3A 1T4PA 4IU1A 1HQGA 3CEVA 2RLAA 3DJ8A 1HQFA 1RLAA 4IU4A 1TBJA 2PHOA 4GSZA 1P8NA 1ZPGA 4IE1A 1TBLA 1T4RA 1P8MA 1WVBA 3SL1A 4HZEA 4FCIA 4MXRA 4Q40A 3MFWA 1D3VA 3PZLA 1HQ5A 4ITYA 4GSVA 3RLAA 4Q3VA 3F80A 4Q3RA 3THJA 3LP7A 4RHMA 1T5GA 1T4SA 3TH7A 4RHQA
chains in the Genus database with same CATH superfamily
2A0MA 2V5XA 3F06A 5G10A 3SL0A 3THHA 3E8QA 3MENA 3TF3A 5JI5A 1P8QA 1W22A 1P8SA 4CEVA 3C0YA 5EFKB 5G11A 1R1OA 4QA6A 3NIPA 2VQJA 1P8PA 4CBTA 4A69A 5G0HA 4BKXB 5RLAA 3M1RA 5D1BA 4RN1A 4CQFA 5CEVA 4FCKA 3C10A 2VCGA 3LHLA 1WOHA 1GQ7A 4RLAA 5G0XA 4DZ4A 4Q41A 1GQ6A 1TBHA 4Q3TA 2VQMA 2CEVA 4Q3PA 4G3HA 3NIOA 3NIQA 4Q3SA 4HXQA 3Q9CA 3E9BA 1HQHA 5G12A 3LP4A 4HWWA 1T4TA 2EF4A 2EIVA 5DC7A 4ZUMA 4QA5A 4RHLA 4IU0A 5EFGA 1WVAA 1XFKA 3MMRA 3MZ4A 5LI3A 4QA0A 3GN0A 3MFVA 5EF8A 3E6KA 1TA1A 3ZNSA 4GWDA 5EEFA 1HQXA 5G1CA 2ZAVA 3E6VA 4RHJA 1T64A 3C0ZA 5EEMA 4ZURA 4ZUNA 4IXVA 3MZ3A 4I06A 5FCWA 2VQOA 3KV2A 5IWGA 2VQVA 4ZUOA 3EZPA 4IU5A 3SKKA 5G0IA 3SFHA 5G1AA 5G0JA 3MZ7A 1P8RA 3SJTA 3GMZA 4MYLA 5EF7A 5G0YA 4BZ9A 3ZNRA 4BZ8A 2AEBA 1T5FA 4MYNA 4RHKA 1WOGA 2VQQA 4QA1A 4QA2A 1T67A 4RHIA 1C3SA 1ZPEA 5HJ9A 4MYKA 2EF5A 1CEVA 5EEIA 5FUEA 5DC8A 5EEKA 3EWFA 1P8OA 5G3WA 3Q9FA 3Q9BA 4Q3UA 4BZ7A 2PHAA 1C3PA 4QA4A 5THTA 4Q42A 4Q3QA 4LXZA 3E8ZA 4LY1A 5DC6A 1ZZ3A 3RQDA 4GSMA 5HJAA 4RN2A 3THEA 2PLLA 4BZ5A 4QA7A 5THUA 4IXUA 3F0RA 4RN0A 4IE3A 3MJLA 4IE2A 4GWCA 3F07A 4Q3RC 5EENA 5DC5A 1T69A 4MYFA 5THSA 1WOIA 1ZZ0A 1PQ3A 1T4PA 4IU1A 2V5WA 1HQGA 3CEVA 2RLAA 3DJ8A 1HQFA 1RLAA 4IU4A 5THVA 1TBJA 2PHOA 4GSZA 3SFFA 1P8NA 1ZPGA 4IE1A 2VQWG 5BWZA 1TBLA 1T4RA 4ZUQA 3MZ6A 5G0GA 2GH6A 3Q9EA 1VKGA 5EFNA 1P8MA 1WVBA 3SL1A 4HZEA 3EW8A 3MAXA 4FCIA 5EFBD 4MXRA 4Q40A 3MFWA 1D3VA 3PZLA 4ZUPA 1HQ5A 5IX0A 5EFJD 1ZZ1A 4ITYA 5ICNB 1C3RA 4GSVA 3RLAA 5G13A 4Q3VA 4QA3A 3F80A 5G17A 4Q3RA 5D1DA 5EFHA 3THJA 3LP7A 3EZTA 5D1CA 4RHMA 4CBYA 1T5GA 5A2SA 1T4SA 3TH7A 4RHQA 5G1BA 4BZ6A
chains in the Genus database with same CATH topology
2A0MA 3SL0A 3THHA 3E8QA 3TF3A 1P8QA 1P8SA 4CEVA 1R1OA 3NIPA 1P8PA 5RLAA 3M1RA 5CEVA 4FCKA 3LHLA 1WOHA 1GQ7A 4RLAA 4DZ4A 4Q41A 1GQ6A 1TBHA 4Q3TA 2CEVA 4Q3PA 4G3HA 3NIOA 3NIQA 4Q3SA 4HXQA 3E9BA 1HQHA 3LP4A 4HWWA 1T4TA 2EF4A 2EIVA 4RHLA 4IU0A 1WVAA 1XFKA 3MMRA 3GN0A 3MFVA 3E6KA 1TA1A 4GWDA 1HQXA 2ZAVA 3E6VA 4RHJA 4IXVA 4I06A 3SKKA 3KV2A 4IU5A 1P8RA 3SJTA 3GMZA 4MYLA 2AEBA 1T5FA 4MYNA 4RHKA 1WOGA 4RHIA 5HJ9A 1ZPEA 4MYKA 2EF5A 1CEVA 1P8OA 4Q3UA 2PHAA 4Q42A 4Q3QA 3E8ZA 5HJAA 4GSMA 3THEA 2PLLA 4IXUA 4IE3A 3MJLA 4IE2A 4GWCA 4Q3RC 4MYFA 1WOIA 1PQ3A 1T4PA 4IU1A 1HQGA 3CEVA 2RLAA 3DJ8A 1HQFA 1RLAA 4IU4A 1TBJA 2PHOA 4GSZA 1P8NA 1ZPGA 4IE1A 1TBLA 1T4RA 1P8MA 1WVBA 3SL1A 4HZEA 4FCIA 4MXRA 4Q40A 3MFWA 1D3VA 3PZLA 1HQ5A 4ITYA 4GSVA 3RLAA 4Q3VA 3F80A 4Q3RA 3THJA 3LP7A 4RHMA 1T5GA 1T4SA 3TH7A 4RHQA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 2A0M A;  3SL0 A;  3THH A;  3E8Q A;  3TF3 A;  1P8Q A;  1P8S A;  4CEV A;  1R1O A;  3NIP A;  1P8P A;  5RLA A;  3M1R A;  5CEV A;  4FCK A;  3LHL A;  1WOH A;  1GQ7 A;  4RLA A;  4DZ4 A;  4Q41 A;  1GQ6 A;  1TBH A;  4Q3T A;  2CEV A;  4Q3P A;  4G3H A;  3NIO A;  3NIQ A;  4Q3S A;  4HXQ A;  3E9B A;  1HQH A;  3LP4 A;  4HWW A;  1T4T A;  2EF4 A;  2EIV A;  4RHL A;  4IU0 A;  1WVA A;  1XFK A;  3MMR A;  3GN0 A;  3MFV A;  3E6K A;  1TA1 A;  4GWD A;  1HQX A;  2ZAV A;  3E6V A;  4RHJ A;  4IXV A;  4I06 A;  3SKK A;  3KV2 A;  4IU5 A;  1P8R A;  3SJT A;  3GMZ A;  4MYL A;  2AEB A;  1T5F A;  4MYN A;  4RHK A;  1WOG A;  4RHI A;  5HJ9 A;  1ZPE A;  4MYK A;  2EF5 A;  1CEV A;  1P8O A;  4Q3U A;  2PHA A;  4Q42 A;  4Q3Q A;  3E8Z A;  5HJA A;  4GSM A;  3THE A;  2PLL A;  4IXU A;  4IE3 A;  3MJL A;  4IE2 A;  4GWC A;  4Q3R C;  4MYF A;  1WOI A;  1PQ3 A;  1T4P A;  4IU1 A;  1HQG A;  3CEV A;  2RLA A;  3DJ8 A;  1HQF A;  1RLA A;  4IU4 A;  1TBJ A;  2PHO A;  4GSZ A;  1P8N A;  1ZPG A;  4IE1 A;  1TBL A;  1T4R A;  1P8M A;  1WVB A;  3SL1 A;  4HZE A;  4FCI A;  4MXR A;  4Q40 A;  3MFW A;  1D3V A;  3PZL A;  1HQ5 A;  4ITY A;  4GSV A;  3RLA A;  4Q3V A;  3F80 A;  4Q3R A;  3THJ A;  3LP7 A;  4RHM A;  1T5G A;  1T4S A;  3TH7 A;  4RHQ A; 
#chains in the Genus database with same CATH topology
 2A0M A;  2V5X A;  3F06 A;  5G10 A;  3SL0 A;  3THH A;  3E8Q A;  3MEN A;  3TF3 A;  5JI5 A;  1P8Q A;  1W22 A;  1P8S A;  4CEV A;  3C0Y A;  5EFK B;  5G11 A;  1R1O A;  4QA6 A;  3NIP A;  2VQJ A;  1P8P A;  4CBT A;  4A69 A;  5G0H A;  4BKX B;  5RLA A;  3M1R A;  5D1B A;  4RN1 A;  4CQF A;  5CEV A;  4FCK A;  3C10 A;  2VCG A;  3LHL A;  1WOH A;  1GQ7 A;  4RLA A;  5G0X A;  4DZ4 A;  4Q41 A;  1GQ6 A;  1TBH A;  4Q3T A;  2VQM A;  2CEV A;  4Q3P A;  4G3H A;  3NIO A;  3NIQ A;  4Q3S A;  4HXQ A;  3Q9C A;  3E9B A;  1HQH A;  5G12 A;  3LP4 A;  4HWW A;  1T4T A;  2EF4 A;  2EIV A;  5DC7 A;  4ZUM A;  4QA5 A;  4RHL A;  4IU0 A;  5EFG A;  1WVA A;  1XFK A;  3MMR A;  3MZ4 A;  5LI3 A;  4QA0 A;  3GN0 A;  3MFV A;  5EF8 A;  3E6K A;  1TA1 A;  3ZNS A;  4GWD A;  5EEF A;  1HQX A;  5G1C A;  2ZAV A;  3E6V A;  4RHJ A;  1T64 A;  3C0Z A;  5EEM A;  4ZUR A;  4ZUN A;  4IXV A;  3MZ3 A;  4I06 A;  5FCW A;  2VQO A;  3KV2 A;  5IWG A;  2VQV A;  4ZUO A;  3EZP A;  4IU5 A;  3SKK A;  5G0I A;  3SFH A;  5G1A A;  5G0J A;  3MZ7 A;  1P8R A;  3SJT A;  3GMZ A;  4MYL A;  5EF7 A;  5G0Y A;  4BZ9 A;  3ZNR A;  4BZ8 A;  2AEB A;  1T5F A;  4MYN A;  4RHK A;  1WOG A;  2VQQ A;  4QA1 A;  4QA2 A;  1T67 A;  4RHI A;  1C3S A;  1ZPE A;  5HJ9 A;  4MYK A;  2EF5 A;  1CEV A;  5EEI A;  5FUE A;  5DC8 A;  5EEK A;  3EWF A;  1P8O A;  5G3W A;  3Q9F A;  3Q9B A;  4Q3U A;  4BZ7 A;  2PHA A;  1C3P A;  4QA4 A;  5THT A;  4Q42 A;  4Q3Q A;  4LXZ A;  3E8Z A;  4LY1 A;  5DC6 A;  1ZZ3 A;  3RQD A;  4GSM A;  5HJA A;  4RN2 A;  3THE A;  2PLL A;  4BZ5 A;  4QA7 A;  5THU A;  4IXU A;  3F0R A;  4RN0 A;  4IE3 A;  3MJL A;  4IE2 A;  4GWC A;  3F07 A;  4Q3R C;  5EEN A;  5DC5 A;  1T69 A;  4MYF A;  5THS A;  1WOI A;  1ZZ0 A;  1PQ3 A;  1T4P A;  4IU1 A;  2V5W A;  1HQG A;  3CEV A;  2RLA A;  3DJ8 A;  1HQF A;  1RLA A;  4IU4 A;  5THV A;  1TBJ A;  2PHO A;  4GSZ A;  3SFF A;  1P8N A;  1ZPG A;  4IE1 A;  2VQW G;  5BWZ A;  1TBL A;  1T4R A;  4ZUQ A;  3MZ6 A;  5G0G A;  2GH6 A;  3Q9E A;  1VKG A;  5EFN A;  1P8M A;  1WVB A;  3SL1 A;  4HZE A;  3EW8 A;  3MAX A;  4FCI A;  5EFB D;  4MXR A;  4Q40 A;  3MFW A;  1D3V A;  3PZL A;  4ZUP A;  1HQ5 A;  5IX0 A;  5EFJ D;  1ZZ1 A;  4ITY A;  5ICN B;  1C3R A;  4GSV A;  3RLA A;  5G13 A;  4Q3V A;  4QA3 A;  3F80 A;  5G17 A;  4Q3R A;  5D1D A;  5EFH A;  3THJ A;  3LP7 A;  3EZT A;  5D1C A;  4RHM A;  4CBY A;  1T5G A;  5A2S A;  1T4S A;  3TH7 A;  4RHQ A;  5G1B A;  4BZ6 A; 
#chains in the Genus database with same CATH homology
 2A0M A;  3SL0 A;  3THH A;  3E8Q A;  3TF3 A;  1P8Q A;  1P8S A;  4CEV A;  1R1O A;  3NIP A;  1P8P A;  5RLA A;  3M1R A;  5CEV A;  4FCK A;  3LHL A;  1WOH A;  1GQ7 A;  4RLA A;  4DZ4 A;  4Q41 A;  1GQ6 A;  1TBH A;  4Q3T A;  2CEV A;  4Q3P A;  4G3H A;  3NIO A;  3NIQ A;  4Q3S A;  4HXQ A;  3E9B A;  1HQH A;  3LP4 A;  4HWW A;  1T4T A;  2EF4 A;  2EIV A;  4RHL A;  4IU0 A;  1WVA A;  1XFK A;  3MMR A;  3GN0 A;  3MFV A;  3E6K A;  1TA1 A;  4GWD A;  1HQX A;  2ZAV A;  3E6V A;  4RHJ A;  4IXV A;  4I06 A;  3SKK A;  3KV2 A;  4IU5 A;  1P8R A;  3SJT A;  3GMZ A;  4MYL A;  2AEB A;  1T5F A;  4MYN A;  4RHK A;  1WOG A;  4RHI A;  5HJ9 A;  1ZPE A;  4MYK A;  2EF5 A;  1CEV A;  1P8O A;  4Q3U A;  2PHA A;  4Q42 A;  4Q3Q A;  3E8Z A;  5HJA A;  4GSM A;  3THE A;  2PLL A;  4IXU A;  4IE3 A;  3MJL A;  4IE2 A;  4GWC A;  4Q3R C;  4MYF A;  1WOI A;  1PQ3 A;  1T4P A;  4IU1 A;  1HQG A;  3CEV A;  2RLA A;  3DJ8 A;  1HQF A;  1RLA A;  4IU4 A;  1TBJ A;  2PHO A;  4GSZ A;  1P8N A;  1ZPG A;  4IE1 A;  1TBL A;  1T4R A;  1P8M A;  1WVB A;  3SL1 A;  4HZE A;  4FCI A;  4MXR A;  4Q40 A;  3MFW A;  1D3V A;  3PZL A;  1HQ5 A;  4ITY A;  4GSV A;  3RLA A;  4Q3V A;  3F80 A;  4Q3R A;  3THJ A;  3LP7 A;  4RHM A;  1T5G A;  1T4S A;  3TH7 A;  4RHQ A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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