4I06A

Crystal structure of human arginase-2 complexed with inhibitor 14
Total Genus 116
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
116
sequence length
306
structure length
306
Chain Sequence
HSVAVIGAPFSQGQKRKGVEHGPAAIREAGLMKRLSSLGCHLKDFGDLSFTPVPKDDLYNNLIVNPRSVGLANQELAEVVSRAVSDGYSCVTLGGDHSLAIGTISGHARHCPDLCVVWVDAHADINTPLTTSSGNLHGQPVSFLLRELQDKVPQLPGFSWIKPCISSASIVYIGLRDVDPPEHFILKNYDIQYFSMRDIDRLGIQKVMERTFDLLIGKRQRPIHLSFDIDAFDPTLAPATGTPVVGGLTYREGMYIAEEIHNTGLLSALDLVEVNPQLATSEEEAKTTANLAVDVIASSFGQTREG
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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molecule tags Hydrolase
molecule keywords Arginase-2, mitochondrial
publication title Discovery of (R)-2-Amino-6-borono-2-(2-(piperidin-1-yl)ethyl)hexanoic Acid and Congeners As Highly Potent Inhibitors of Human Arginases I and II for Treatment of Myocardial Reperfusion Injury.
pubmed doi rcsb
source organism Homo sapiens
total genus 116
structure length 306
sequence length 306
chains with identical sequence B, C
ec nomenclature ec 3.5.3.1: Arginase.
pdb deposition date 2012-11-16

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00491 Arginase Arginase family
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.800.10 Alpha Beta 3-Layer(aba) Sandwich Arginase; Chain A Ureohydrolase domain 4i06A00
3E8QA 3CEVA 3NIOA 5CEVA 2AEBA 1GQ6A 1WVBA 3E6VA 4Q3VA 4Q40A 4RHLA 1D3VA 2PHOA 1CEVA 1WVAA 1ZPEA 1RLAA 4HWWA 2PLLA 1GQ7A 3E9BA 3MFVA 1WOHA 1HQGA 1P8PA 4GSVA 1P8NA 1T4TA 2EIVA 2ZAVA 4IE1A 2CEVA 3F80A 1XFKA 3GMZA 4DZ4A 1PQ3A 4CEVA 2A0MA 4Q3RA 3DJ8A 3THEA 1HQ5A 5HJAA 3RLAA 3GN0A 1HQFA 3TH7A 3THHA 4GSMA 1TBLA 4Q42A 3MMRA 1TA1A 1WOGA 4MYNA 4RHQA 2EF5A 1HQXA 4MYFA 3E8ZA 4MXRA 4FCKA 2EF4A 4GWCA 3MJLA 3MFWA 1T4RA 3LP7A 4IE3A 4IXUA 1ZPGA 3LP4A 3TF3A 3SL1A 4Q3UA 4HZEA 2RLAA 3LHLA 4GSZA 1P8SA 4FCIA 4GWDA 3SJTA 4Q3RC 1T4SA 4RHMA 4Q3PA 3PZLA 4IU4A 3E6KA 4IXVA 4Q3TA 4RHJA 3SKKA 4I06A 1P8MA 1R1OA 4Q3SA 4RHKA 4Q41A 1T4PA 4MYLA 4RLAA 1HQHA 3NIPA 1TBHA 4IU1A 1TBJA 1P8RA 4HXQA 1WOIA 4Q3QA 4IE2A 4ITYA 3NIQA 3M1RA 1P8QA 3KV2A 4MYKA 4G3HA 4RHIA 1T5FA 4IU0A 1T5GA 4IU5A 5HJ9A 1P8OA 3THJA 2PHAA 5RLAA 3SL0A
chains in the Genus database with same CATH superfamily
3E8QA 4CQFA 5G12A 5A2SA 1C3SA 3CEVA 5G0JA 5JI5A 3NIOA 5CEVA 5EFJD 2AEBA 1GQ6A 2VCGA 1WVBA 4BZ8A 5G0GA 3E6VA 4Q3VA 3EWFA 4Q40A 4RHLA 5G13A 1D3VA 2PHOA 1CEVA 1WVAA 1ZPEA 1RLAA 2V5XA 4HWWA 3MZ3A 2PLLA 1GQ7A 3E9BA 4ZUMA 4QA5A 3MFVA 1WOHA 5FUEA 3EZPA 1HQGA 4QA4A 3Q9EA 4RN2A 1P8PA 4GSVA 1P8NA 4QA3A 5EENA 3RQDA 1T4TA 1ZZ0A 2VQQA 5G17A 5DC6A 2EIVA 2ZAVA 4BZ9A 4IE1A 5G11A 2CEVA 5D1BA 5D1DA 5EEMA 3F80A 1XFKA 3GMZA 4DZ4A 1PQ3A 3F06A 5THTA 4CEVA 4ZUOA 5EFBD 4ZUQA 2A0MA 2VQOA 4Q3RA 4ZUNA 3DJ8A 5EFHA 3THEA 4CBYA 1HQ5A 5G1CA 5HJAA 5LI3A 3RLAA 3GN0A 1HQFA 5D1CA 3TH7A 5G0IA 4GSMA 3THHA 1TBLA 4ZUPA 1ZZ3A 5THVA 1C3RA 4Q42A 4QA6A 3MMRA 3C0ZA 4QA0A 1TA1A 4QA7A 1T64A 3EZTA 1WOGA 4MYNA 4RHQA 4QA2A 5EFNA 4BZ5A 4LY1A 2EF5A 5DC8A 1HQXA 4MYFA 2VQWG 3E8ZA 4MXRA 5DC7A 5G0YA 3SFHA 4FCKA 2EF4A 4BKXB 4GWCA 3MJLA 3MFWA 1T4RA 3LP7A 4BZ6A 4IE3A 1T69A 4IXUA 1ZPGA 5G10A 5IX0A 3LP4A 3F0RA 3TF3A 3SL1A 4CBTA 3C10A 3MZ7A 1T67A 4Q3UA 4HZEA 5G3WA 3F07A 3Q9FA 4A69A 2VQMA 2RLAA 3LHLA 4ZURA 4GSZA 5EEKA 2V5WA 1P8SA 2VQJA 4FCIA 4GWDA 3SJTA 4Q3RC 1T4SA 4RHMA 5EF7A 4Q3PA 3PZLA 4IU4A 3E6KA 5EEFA 4IXVA 4Q3TA 4RHJA 1VKGA 3SKKA 1W22A 4I06A 1P8MA 1R1OA 4Q3SA 4RHKA 4Q41A 1T4PA 4MYLA 4RLAA 3Q9CA 1HQHA 3NIPA 5IWGA 5THUA 3MZ6A 4LXZA 5EFGA 4RN1A 1TBHA 3C0YA 4IU1A 5G1BA 5DC5A 5ICNB 2GH6A 3MENA 1TBJA 1P8RA 4HXQA 5EF8A 5EFKB 1WOIA 3Q9BA 5G0XA 4Q3QA 4IE2A 1C3PA 1ZZ1A 3EW8A 3NIQA 4ITYA 4RN0A 5EEIA 5G1AA 3M1RA 3SFFA 3MZ4A 5THSA 1P8QA 3KV2A 4MYKA 5FCWA 3ZNSA 4G3HA 4RHIA 1T5FA 4QA1A 4IU0A 3MAXA 5G0HA 3ZNRA 1T5GA 4IU5A 5HJ9A 2VQVA 5BWZA 1P8OA 3THJA 2PHAA 5RLAA 4BZ7A 3SL0A
chains in the Genus database with same CATH topology
3E8QA 3CEVA 3NIOA 5CEVA 2AEBA 1GQ6A 1WVBA 3E6VA 4Q3VA 4Q40A 4RHLA 1D3VA 2PHOA 1CEVA 1WVAA 1ZPEA 1RLAA 4HWWA 2PLLA 1GQ7A 3E9BA 3MFVA 1WOHA 1HQGA 1P8PA 4GSVA 1P8NA 1T4TA 2EIVA 2ZAVA 4IE1A 2CEVA 3F80A 1XFKA 3GMZA 4DZ4A 1PQ3A 4CEVA 2A0MA 4Q3RA 3DJ8A 3THEA 1HQ5A 5HJAA 3RLAA 3GN0A 1HQFA 3TH7A 3THHA 4GSMA 1TBLA 4Q42A 3MMRA 1TA1A 1WOGA 4MYNA 4RHQA 2EF5A 1HQXA 4MYFA 3E8ZA 4MXRA 4FCKA 2EF4A 4GWCA 3MJLA 3MFWA 1T4RA 3LP7A 4IE3A 4IXUA 1ZPGA 3LP4A 3TF3A 3SL1A 4Q3UA 4HZEA 2RLAA 3LHLA 4GSZA 1P8SA 4FCIA 4GWDA 3SJTA 4Q3RC 1T4SA 4RHMA 4Q3PA 3PZLA 4IU4A 3E6KA 4IXVA 4Q3TA 4RHJA 3SKKA 4I06A 1P8MA 1R1OA 4Q3SA 4RHKA 4Q41A 1T4PA 4MYLA 4RLAA 1HQHA 3NIPA 1TBHA 4IU1A 1TBJA 1P8RA 4HXQA 1WOIA 4Q3QA 4IE2A 4ITYA 3NIQA 3M1RA 1P8QA 3KV2A 4MYKA 4G3HA 4RHIA 1T5FA 4IU0A 1T5GA 4IU5A 5HJ9A 1P8OA 3THJA 2PHAA 5RLAA 3SL0A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 3E8Q A;  3CEV A;  3NIO A;  5CEV A;  2AEB A;  1GQ6 A;  1WVB A;  3E6V A;  4Q3V A;  4Q40 A;  4RHL A;  1D3V A;  2PHO A;  1CEV A;  1WVA A;  1ZPE A;  1RLA A;  4HWW A;  2PLL A;  1GQ7 A;  3E9B A;  3MFV A;  1WOH A;  1HQG A;  1P8P A;  4GSV A;  1P8N A;  1T4T A;  2EIV A;  2ZAV A;  4IE1 A;  2CEV A;  3F80 A;  1XFK A;  3GMZ A;  4DZ4 A;  1PQ3 A;  4CEV A;  2A0M A;  4Q3R A;  3DJ8 A;  3THE A;  1HQ5 A;  5HJA A;  3RLA A;  3GN0 A;  1HQF A;  3TH7 A;  3THH A;  4GSM A;  1TBL A;  4Q42 A;  3MMR A;  1TA1 A;  1WOG A;  4MYN A;  4RHQ A;  2EF5 A;  1HQX A;  4MYF A;  3E8Z A;  4MXR A;  4FCK A;  2EF4 A;  4GWC A;  3MJL A;  3MFW A;  1T4R A;  3LP7 A;  4IE3 A;  4IXU A;  1ZPG A;  3LP4 A;  3TF3 A;  3SL1 A;  4Q3U A;  4HZE A;  2RLA A;  3LHL A;  4GSZ A;  1P8S A;  4FCI A;  4GWD A;  3SJT A;  4Q3R C;  1T4S A;  4RHM A;  4Q3P A;  3PZL A;  4IU4 A;  3E6K A;  4IXV A;  4Q3T A;  4RHJ A;  3SKK A;  4I06 A;  1P8M A;  1R1O A;  4Q3S A;  4RHK A;  4Q41 A;  1T4P A;  4MYL A;  4RLA A;  1HQH A;  3NIP A;  1TBH A;  4IU1 A;  1TBJ A;  1P8R A;  4HXQ A;  1WOI A;  4Q3Q A;  4IE2 A;  4ITY A;  3NIQ A;  3M1R A;  1P8Q A;  3KV2 A;  4MYK A;  4G3H A;  4RHI A;  1T5F A;  4IU0 A;  1T5G A;  4IU5 A;  5HJ9 A;  1P8O A;  3THJ A;  2PHA A;  5RLA A;  3SL0 A; 
#chains in the Genus database with same CATH topology
 3E8Q A;  4CQF A;  5G12 A;  5A2S A;  1C3S A;  3CEV A;  5G0J A;  5JI5 A;  3NIO A;  5CEV A;  5EFJ D;  2AEB A;  1GQ6 A;  2VCG A;  1WVB A;  4BZ8 A;  5G0G A;  3E6V A;  4Q3V A;  3EWF A;  4Q40 A;  4RHL A;  5G13 A;  1D3V A;  2PHO A;  1CEV A;  1WVA A;  1ZPE A;  1RLA A;  2V5X A;  4HWW A;  3MZ3 A;  2PLL A;  1GQ7 A;  3E9B A;  4ZUM A;  4QA5 A;  3MFV A;  1WOH A;  5FUE A;  3EZP A;  1HQG A;  4QA4 A;  3Q9E A;  4RN2 A;  1P8P A;  4GSV A;  1P8N A;  4QA3 A;  5EEN A;  3RQD A;  1T4T A;  1ZZ0 A;  2VQQ A;  5G17 A;  5DC6 A;  2EIV A;  2ZAV A;  4BZ9 A;  4IE1 A;  5G11 A;  2CEV A;  5D1B A;  5D1D A;  5EEM A;  3F80 A;  1XFK A;  3GMZ A;  4DZ4 A;  1PQ3 A;  3F06 A;  5THT A;  4CEV A;  4ZUO A;  5EFB D;  4ZUQ A;  2A0M A;  2VQO A;  4Q3R A;  4ZUN A;  3DJ8 A;  5EFH A;  3THE A;  4CBY A;  1HQ5 A;  5G1C A;  5HJA A;  5LI3 A;  3RLA A;  3GN0 A;  1HQF A;  5D1C A;  3TH7 A;  5G0I A;  4GSM A;  3THH A;  1TBL A;  4ZUP A;  1ZZ3 A;  5THV A;  1C3R A;  4Q42 A;  4QA6 A;  3MMR A;  3C0Z A;  4QA0 A;  1TA1 A;  4QA7 A;  1T64 A;  3EZT A;  1WOG A;  4MYN A;  4RHQ A;  4QA2 A;  5EFN A;  4BZ5 A;  4LY1 A;  2EF5 A;  5DC8 A;  1HQX A;  4MYF A;  2VQW G;  3E8Z A;  4MXR A;  5DC7 A;  5G0Y A;  3SFH A;  4FCK A;  2EF4 A;  4BKX B;  4GWC A;  3MJL A;  3MFW A;  1T4R A;  3LP7 A;  4BZ6 A;  4IE3 A;  1T69 A;  4IXU A;  1ZPG A;  5G10 A;  5IX0 A;  3LP4 A;  3F0R A;  3TF3 A;  3SL1 A;  4CBT A;  3C10 A;  3MZ7 A;  1T67 A;  4Q3U A;  4HZE A;  5G3W A;  3F07 A;  3Q9F A;  4A69 A;  2VQM A;  2RLA A;  3LHL A;  4ZUR A;  4GSZ A;  5EEK A;  2V5W A;  1P8S A;  2VQJ A;  4FCI A;  4GWD A;  3SJT A;  4Q3R C;  1T4S A;  4RHM A;  5EF7 A;  4Q3P A;  3PZL A;  4IU4 A;  3E6K A;  5EEF A;  4IXV A;  4Q3T A;  4RHJ A;  1VKG A;  3SKK A;  1W22 A;  4I06 A;  1P8M A;  1R1O A;  4Q3S A;  4RHK A;  4Q41 A;  1T4P A;  4MYL A;  4RLA A;  3Q9C A;  1HQH A;  3NIP A;  5IWG A;  5THU A;  3MZ6 A;  4LXZ A;  5EFG A;  4RN1 A;  1TBH A;  3C0Y A;  4IU1 A;  5G1B A;  5DC5 A;  5ICN B;  2GH6 A;  3MEN A;  1TBJ A;  1P8R A;  4HXQ A;  5EF8 A;  5EFK B;  1WOI A;  3Q9B A;  5G0X A;  4Q3Q A;  4IE2 A;  1C3P A;  1ZZ1 A;  3EW8 A;  3NIQ A;  4ITY A;  4RN0 A;  5EEI A;  5G1A A;  3M1R A;  3SFF A;  3MZ4 A;  5THS A;  1P8Q A;  3KV2 A;  4MYK A;  5FCW A;  3ZNS A;  4G3H A;  4RHI A;  1T5F A;  4QA1 A;  4IU0 A;  3MAX A;  5G0H A;  3ZNR A;  1T5G A;  4IU5 A;  5HJ9 A;  2VQV A;  5BWZ A;  1P8O A;  3THJ A;  2PHA A;  5RLA A;  4BZ7 A;  3SL0 A; 
#chains in the Genus database with same CATH homology
 3E8Q A;  3CEV A;  3NIO A;  5CEV A;  2AEB A;  1GQ6 A;  1WVB A;  3E6V A;  4Q3V A;  4Q40 A;  4RHL A;  1D3V A;  2PHO A;  1CEV A;  1WVA A;  1ZPE A;  1RLA A;  4HWW A;  2PLL A;  1GQ7 A;  3E9B A;  3MFV A;  1WOH A;  1HQG A;  1P8P A;  4GSV A;  1P8N A;  1T4T A;  2EIV A;  2ZAV A;  4IE1 A;  2CEV A;  3F80 A;  1XFK A;  3GMZ A;  4DZ4 A;  1PQ3 A;  4CEV A;  2A0M A;  4Q3R A;  3DJ8 A;  3THE A;  1HQ5 A;  5HJA A;  3RLA A;  3GN0 A;  1HQF A;  3TH7 A;  3THH A;  4GSM A;  1TBL A;  4Q42 A;  3MMR A;  1TA1 A;  1WOG A;  4MYN A;  4RHQ A;  2EF5 A;  1HQX A;  4MYF A;  3E8Z A;  4MXR A;  4FCK A;  2EF4 A;  4GWC A;  3MJL A;  3MFW A;  1T4R A;  3LP7 A;  4IE3 A;  4IXU A;  1ZPG A;  3LP4 A;  3TF3 A;  3SL1 A;  4Q3U A;  4HZE A;  2RLA A;  3LHL A;  4GSZ A;  1P8S A;  4FCI A;  4GWD A;  3SJT A;  4Q3R C;  1T4S A;  4RHM A;  4Q3P A;  3PZL A;  4IU4 A;  3E6K A;  4IXV A;  4Q3T A;  4RHJ A;  3SKK A;  4I06 A;  1P8M A;  1R1O A;  4Q3S A;  4RHK A;  4Q41 A;  1T4P A;  4MYL A;  4RLA A;  1HQH A;  3NIP A;  1TBH A;  4IU1 A;  1TBJ A;  1P8R A;  4HXQ A;  1WOI A;  4Q3Q A;  4IE2 A;  4ITY A;  3NIQ A;  3M1R A;  1P8Q A;  3KV2 A;  4MYK A;  4G3H A;  4RHI A;  1T5F A;  4IU0 A;  1T5G A;  4IU5 A;  5HJ9 A;  1P8O A;  3THJ A;  2PHA A;  5RLA A;  3SL0 A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
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#similar chains, but unknotted
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