4IXUA

Crystal structure of human arginase-2 complexed with inhibitor 11d: {(5r)-5-amino-5-carboxy-5-[(3-endo)-8-(3,4-dichlorobenzyl)-8-azabicyclo[3.2.1]oct-3-yl]pentyl}(trihydroxy)borate(1-)
Total Genus 120
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
120
sequence length
306
structure length
306
Chain Sequence
HSVAVIGAPFSQGQKRKGVEHGPAAIREAGLMKRLSSLGCHLKDFGDLSFTPVPKDDLYNNLIVNPRSVGLANQELAEVVSRAVSDGYSCVTLGGDHSLAIGTISGHARHCPDLCVVWVDAHADINTPLTTSSGNLHGQPVSFLLRELQDKVPQLPGFSWIKPCISSASIVYIGLRDVDPPEHFILKNYDIQYFSMRDIDRLGIQKVMERTFDLLIGKRQRPIHLSFDIDAFDPTLAPATGTPVVGGLTYREGMYIAEEIHNTGLLSALDLVEVNPQLATSEEEAKTTANLAVDVIASSFGQTREG
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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molecule tags Hydrolase/hydrolase inhibitor
molecule keywords Arginase-2, mitochondrial
publication title Synthesis of quaternary alpha-amino acid-based arginase inhibitors via the Ugi reaction.
pubmed doi rcsb
source organism Homo sapiens
total genus 120
structure length 306
sequence length 306
chains with identical sequence B, C
ec nomenclature ec 3.5.3.1: Arginase.
pdb deposition date 2013-01-28

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00491 Arginase Arginase family
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.800.10 Alpha Beta 3-Layer(aba) Sandwich Arginase; Chain A Ureohydrolase domain 4ixuA00
4I06A 3NIQA 3SKKA 2EF5A 4MYLA 4Q3PA 4RHMA 3THJA 1P8PA 1XFKA 5HJ9A 3F80A 4GSMA 3E6KA 1WVBA 1GQ7A 1HQHA 3PZLA 4MXRA 4IU4A 1WOHA 4IU5A 4CEVA 3SJTA 1HQXA 3LP7A 2PHOA 4MYFA 3THEA 1T5GA 3MFWA 5CEVA 3DJ8A 3GN0A 1ZPEA 3KV2A 1P8QA 4IU1A 3MFVA 1WOIA 1P8RA 3E6VA 3E8ZA 3SL0A 4GSVA 4FCKA 3TF3A 1TBLA 4RHKA 4RHIA 2PLLA 1T5FA 4RHQA 4Q41A 1GQ6A 4ITYA 5HJAA 4G3HA 3MJLA 4Q3RC 3GMZA 3THHA 4IE3A 4HWWA 1T4SA 1WVAA 4MYNA 4MYKA 4IU0A 1R1OA 1PQ3A 3SL1A 2A0MA 4GWCA 2PHAA 4HZEA 4GWDA 4IXUA 3RLAA 2EF4A 1WOGA 4Q3UA 1TBJA 2RLAA 1T4PA 4Q3VA 3TH7A 4DZ4A 4Q3TA 4Q3RA 4RHJA 1TA1A 1ZPGA 1T4RA 4Q3QA 3NIOA 1CEVA 5RLAA 3CEVA 1P8NA 3E8QA 1RLAA 4IXVA 1T4TA 1HQGA 4FCIA 1D3VA 1HQFA 2AEBA 3LP4A 4Q3SA 3LHLA 4RHLA 4GSZA 2ZAVA 1TBHA 1P8SA 3NIPA 4RLAA 4IE2A 4Q42A 4HXQA 1P8MA 3M1RA 1P8OA 4IE1A 2CEVA 4Q40A 3E9BA 1HQ5A 3MMRA 2EIVA
chains in the Genus database with same CATH superfamily
2VCGA 3NIQA 2VQQA 2EF5A 3MAXA 4I06A 3MMRA 4MYLA 4Q3PA 4RHMA 5IX0A 3THJA 5EF8A 1P8PA 5EENA 1XFKA 5A2SA 3Q9CA 5HJ9A 3SFHA 3F80A 5JI5A 4GSMA 3E6KA 1WVBA 1GQ7A 5G0IA 1HQHA 3PZLA 4MXRA 3EW8A 1WOHA 4IU4A 5FCWA 4RN2A 3MZ6A 4IU5A 4CEVA 3C0YA 5D1CA 3SJTA 5G0XA 3C10A 2GH6A 1HQXA 4BZ6A 4BZ5A 5EFGA 2VQOA 3LP7A 2PHOA 1C3PA 3MZ4A 3C0ZA 4MYFA 5THVA 4ZUMA 3THEA 2V5WA 1T5GA 3MFWA 5CEVA 5G0YA 3DJ8A 3MENA 4ZUQA 3GN0A 1ZPEA 3KV2A 5G12A 3RQDA 3EZPA 1ZZ3A 1P8QA 4IU1A 5DC6A 3MFVA 4QA0A 1WOIA 5EFJD 5DC8A 1P8RA 4BZ9A 3E6VA 3E8ZA 5LI3A 3SL0A 4GSVA 2VQJA 1T64A 4FCKA 5D1DA 3TF3A 1VKGA 1TBLA 4QA7A 5EF7A 5THSA 4RHKA 4RHIA 5G10A 1ZZ0A 5G0HA 5G17A 3F0RA 2PLLA 1T5FA 4RHQA 2VQWG 4ZUPA 4Q41A 1GQ6A 5EEMA 4ITYA 4BZ7A 5HJAA 3MZ7A 4G3HA 3MJLA 3EWFA 4Q3RC 3SKKA 5EEKA 1ZZ1A 5DC5A 3GMZA 3F06A 4CBTA 3THHA 1C3SA 4IE3A 3EZTA 1T4SA 4HWWA 5EEIA 1WVAA 4MYNA 3Q9EA 4MYKA 4IU0A 3Q9FA 1R1OA 1PQ3A 3SL1A 2A0MA 4LXZA 4GWCA 3ZNRA 5IWGA 3ZNSA 2VQVA 2PHAA 4HZEA 3SFFA 5G3WA 4GWDA 4IXUA 1T69A 5DC7A 3RLAA 4LY1A 1C3RA 2EF4A 5ICNB 1WOGA 5G0GA 4Q3UA 1TBJA 4QA5A 4QA2A 1T4PA 4Q3VA 3TH7A 4ZURA 4DZ4A 5THTA 4Q3TA 4Q3RA 4RHJA 1TA1A 1ZPGA 1T4RA 4Q3QA 3NIOA 5G13A 1CEVA 5RLAA 5EFKB 3CEVA 1P8NA 3E8QA 5THUA 1RLAA 4IXVA 1T4TA 1HQGA 5D1BA 4BKXB 4FCIA 1W22A 5EFBD 1D3VA 4CBYA 1HQFA 2AEBA 3LP4A 4Q3SA 4BZ8A 5EFNA 5G11A 4A69A 4RN1A 3LHLA 1T67A 4RHLA 5G1CA 5G1AA 5FUEA 4GSZA 2ZAVA 4ZUNA 4QA4A 4QA3A 5EFHA 1TBHA 4ZUOA 4CQFA 4QA6A 1P8SA 3NIPA 4RLAA 4IE2A 4Q42A 5G1BA 4HXQA 1P8MA 2V5XA 3M1RA 1P8OA 2VQMA 4IE1A 2CEVA 3MZ3A 5EEFA 5G0JA 4Q40A 3E9BA 4QA1A 1HQ5A 4RN0A 5BWZA 2RLAA 3F07A 3Q9BA 2EIVA
chains in the Genus database with same CATH topology
4I06A 3NIQA 3SKKA 2EF5A 4MYLA 4Q3PA 4RHMA 3THJA 1P8PA 1XFKA 5HJ9A 3F80A 4GSMA 3E6KA 1WVBA 1GQ7A 1HQHA 3PZLA 4MXRA 4IU4A 1WOHA 4IU5A 4CEVA 3SJTA 1HQXA 3LP7A 2PHOA 4MYFA 3THEA 1T5GA 3MFWA 5CEVA 3DJ8A 3GN0A 1ZPEA 3KV2A 1P8QA 4IU1A 3MFVA 1WOIA 1P8RA 3E6VA 3E8ZA 3SL0A 4GSVA 4FCKA 3TF3A 1TBLA 4RHKA 4RHIA 2PLLA 1T5FA 4RHQA 4Q41A 1GQ6A 4ITYA 5HJAA 4G3HA 3MJLA 4Q3RC 3GMZA 3THHA 4IE3A 4HWWA 1T4SA 1WVAA 4MYNA 4MYKA 4IU0A 1R1OA 1PQ3A 3SL1A 2A0MA 4GWCA 2PHAA 4HZEA 4GWDA 4IXUA 3RLAA 2EF4A 1WOGA 4Q3UA 1TBJA 2RLAA 1T4PA 4Q3VA 3TH7A 4DZ4A 4Q3TA 4Q3RA 4RHJA 1TA1A 1ZPGA 1T4RA 4Q3QA 3NIOA 1CEVA 5RLAA 3CEVA 1P8NA 3E8QA 1RLAA 4IXVA 1T4TA 1HQGA 4FCIA 1D3VA 1HQFA 2AEBA 3LP4A 4Q3SA 3LHLA 4RHLA 4GSZA 2ZAVA 1TBHA 1P8SA 3NIPA 4RLAA 4IE2A 4Q42A 4HXQA 1P8MA 3M1RA 1P8OA 4IE1A 2CEVA 4Q40A 3E9BA 1HQ5A 3MMRA 2EIVA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4I06 A;  3NIQ A;  3SKK A;  2EF5 A;  4MYL A;  4Q3P A;  4RHM A;  3THJ A;  1P8P A;  1XFK A;  5HJ9 A;  3F80 A;  4GSM A;  3E6K A;  1WVB A;  1GQ7 A;  1HQH A;  3PZL A;  4MXR A;  4IU4 A;  1WOH A;  4IU5 A;  4CEV A;  3SJT A;  1HQX A;  3LP7 A;  2PHO A;  4MYF A;  3THE A;  1T5G A;  3MFW A;  5CEV A;  3DJ8 A;  3GN0 A;  1ZPE A;  3KV2 A;  1P8Q A;  4IU1 A;  3MFV A;  1WOI A;  1P8R A;  3E6V A;  3E8Z A;  3SL0 A;  4GSV A;  4FCK A;  3TF3 A;  1TBL A;  4RHK A;  4RHI A;  2PLL A;  1T5F A;  4RHQ A;  4Q41 A;  1GQ6 A;  4ITY A;  5HJA A;  4G3H A;  3MJL A;  4Q3R C;  3GMZ A;  3THH A;  4IE3 A;  4HWW A;  1T4S A;  1WVA A;  4MYN A;  4MYK A;  4IU0 A;  1R1O A;  1PQ3 A;  3SL1 A;  2A0M A;  4GWC A;  2PHA A;  4HZE A;  4GWD A;  4IXU A;  3RLA A;  2EF4 A;  1WOG A;  4Q3U A;  1TBJ A;  2RLA A;  1T4P A;  4Q3V A;  3TH7 A;  4DZ4 A;  4Q3T A;  4Q3R A;  4RHJ A;  1TA1 A;  1ZPG A;  1T4R A;  4Q3Q A;  3NIO A;  1CEV A;  5RLA A;  3CEV A;  1P8N A;  3E8Q A;  1RLA A;  4IXV A;  1T4T A;  1HQG A;  4FCI A;  1D3V A;  1HQF A;  2AEB A;  3LP4 A;  4Q3S A;  3LHL A;  4RHL A;  4GSZ A;  2ZAV A;  1TBH A;  1P8S A;  3NIP A;  4RLA A;  4IE2 A;  4Q42 A;  4HXQ A;  1P8M A;  3M1R A;  1P8O A;  4IE1 A;  2CEV A;  4Q40 A;  3E9B A;  1HQ5 A;  3MMR A;  2EIV A; 
#chains in the Genus database with same CATH topology
 2VCG A;  3NIQ A;  2VQQ A;  2EF5 A;  3MAX A;  4I06 A;  3MMR A;  4MYL A;  4Q3P A;  4RHM A;  5IX0 A;  3THJ A;  5EF8 A;  1P8P A;  5EEN A;  1XFK A;  5A2S A;  3Q9C A;  5HJ9 A;  3SFH A;  3F80 A;  5JI5 A;  4GSM A;  3E6K A;  1WVB A;  1GQ7 A;  5G0I A;  1HQH A;  3PZL A;  4MXR A;  3EW8 A;  1WOH A;  4IU4 A;  5FCW A;  4RN2 A;  3MZ6 A;  4IU5 A;  4CEV A;  3C0Y A;  5D1C A;  3SJT A;  5G0X A;  3C10 A;  2GH6 A;  1HQX A;  4BZ6 A;  4BZ5 A;  5EFG A;  2VQO A;  3LP7 A;  2PHO A;  1C3P A;  3MZ4 A;  3C0Z A;  4MYF A;  5THV A;  4ZUM A;  3THE A;  2V5W A;  1T5G A;  3MFW A;  5CEV A;  5G0Y A;  3DJ8 A;  3MEN A;  4ZUQ A;  3GN0 A;  1ZPE A;  3KV2 A;  5G12 A;  3RQD A;  3EZP A;  1ZZ3 A;  1P8Q A;  4IU1 A;  5DC6 A;  3MFV A;  4QA0 A;  1WOI A;  5EFJ D;  5DC8 A;  1P8R A;  4BZ9 A;  3E6V A;  3E8Z A;  5LI3 A;  3SL0 A;  4GSV A;  2VQJ A;  1T64 A;  4FCK A;  5D1D A;  3TF3 A;  1VKG A;  1TBL A;  4QA7 A;  5EF7 A;  5THS A;  4RHK A;  4RHI A;  5G10 A;  1ZZ0 A;  5G0H A;  5G17 A;  3F0R A;  2PLL A;  1T5F A;  4RHQ A;  2VQW G;  4ZUP A;  4Q41 A;  1GQ6 A;  5EEM A;  4ITY A;  4BZ7 A;  5HJA A;  3MZ7 A;  4G3H A;  3MJL A;  3EWF A;  4Q3R C;  3SKK A;  5EEK A;  1ZZ1 A;  5DC5 A;  3GMZ A;  3F06 A;  4CBT A;  3THH A;  1C3S A;  4IE3 A;  3EZT A;  1T4S A;  4HWW A;  5EEI A;  1WVA A;  4MYN A;  3Q9E A;  4MYK A;  4IU0 A;  3Q9F A;  1R1O A;  1PQ3 A;  3SL1 A;  2A0M A;  4LXZ A;  4GWC A;  3ZNR A;  5IWG A;  3ZNS A;  2VQV A;  2PHA A;  4HZE A;  3SFF A;  5G3W A;  4GWD A;  4IXU A;  1T69 A;  5DC7 A;  3RLA A;  4LY1 A;  1C3R A;  2EF4 A;  5ICN B;  1WOG A;  5G0G A;  4Q3U A;  1TBJ A;  4QA5 A;  4QA2 A;  1T4P A;  4Q3V A;  3TH7 A;  4ZUR A;  4DZ4 A;  5THT A;  4Q3T A;  4Q3R A;  4RHJ A;  1TA1 A;  1ZPG A;  1T4R A;  4Q3Q A;  3NIO A;  5G13 A;  1CEV A;  5RLA A;  5EFK B;  3CEV A;  1P8N A;  3E8Q A;  5THU A;  1RLA A;  4IXV A;  1T4T A;  1HQG A;  5D1B A;  4BKX B;  4FCI A;  1W22 A;  5EFB D;  1D3V A;  4CBY A;  1HQF A;  2AEB A;  3LP4 A;  4Q3S A;  4BZ8 A;  5EFN A;  5G11 A;  4A69 A;  4RN1 A;  3LHL A;  1T67 A;  4RHL A;  5G1C A;  5G1A A;  5FUE A;  4GSZ A;  2ZAV A;  4ZUN A;  4QA4 A;  4QA3 A;  5EFH A;  1TBH A;  4ZUO A;  4CQF A;  4QA6 A;  1P8S A;  3NIP A;  4RLA A;  4IE2 A;  4Q42 A;  5G1B A;  4HXQ A;  1P8M A;  2V5X A;  3M1R A;  1P8O A;  2VQM A;  4IE1 A;  2CEV A;  3MZ3 A;  5EEF A;  5G0J A;  4Q40 A;  3E9B A;  4QA1 A;  1HQ5 A;  4RN0 A;  5BWZ A;  2RLA A;  3F07 A;  3Q9B A;  2EIV A; 
#chains in the Genus database with same CATH homology
 4I06 A;  3NIQ A;  3SKK A;  2EF5 A;  4MYL A;  4Q3P A;  4RHM A;  3THJ A;  1P8P A;  1XFK A;  5HJ9 A;  3F80 A;  4GSM A;  3E6K A;  1WVB A;  1GQ7 A;  1HQH A;  3PZL A;  4MXR A;  4IU4 A;  1WOH A;  4IU5 A;  4CEV A;  3SJT A;  1HQX A;  3LP7 A;  2PHO A;  4MYF A;  3THE A;  1T5G A;  3MFW A;  5CEV A;  3DJ8 A;  3GN0 A;  1ZPE A;  3KV2 A;  1P8Q A;  4IU1 A;  3MFV A;  1WOI A;  1P8R A;  3E6V A;  3E8Z A;  3SL0 A;  4GSV A;  4FCK A;  3TF3 A;  1TBL A;  4RHK A;  4RHI A;  2PLL A;  1T5F A;  4RHQ A;  4Q41 A;  1GQ6 A;  4ITY A;  5HJA A;  4G3H A;  3MJL A;  4Q3R C;  3GMZ A;  3THH A;  4IE3 A;  4HWW A;  1T4S A;  1WVA A;  4MYN A;  4MYK A;  4IU0 A;  1R1O A;  1PQ3 A;  3SL1 A;  2A0M A;  4GWC A;  2PHA A;  4HZE A;  4GWD A;  4IXU A;  3RLA A;  2EF4 A;  1WOG A;  4Q3U A;  1TBJ A;  2RLA A;  1T4P A;  4Q3V A;  3TH7 A;  4DZ4 A;  4Q3T A;  4Q3R A;  4RHJ A;  1TA1 A;  1ZPG A;  1T4R A;  4Q3Q A;  3NIO A;  1CEV A;  5RLA A;  3CEV A;  1P8N A;  3E8Q A;  1RLA A;  4IXV A;  1T4T A;  1HQG A;  4FCI A;  1D3V A;  1HQF A;  2AEB A;  3LP4 A;  4Q3S A;  3LHL A;  4RHL A;  4GSZ A;  2ZAV A;  1TBH A;  1P8S A;  3NIP A;  4RLA A;  4IE2 A;  4Q42 A;  4HXQ A;  1P8M A;  3M1R A;  1P8O A;  4IE1 A;  2CEV A;  4Q40 A;  3E9B A;  1HQ5 A;  3MMR A;  2EIV A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
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